Fever, and Cirrhosis

Diseases related with Fever and Cirrhosis

In the following list you will find some of the most common rare diseases related to Fever and Cirrhosis that can help you solving undiagnosed cases.

Top matches:

Progressive familial intrahepatic cholestasis type 3 (PFIC3), a type of progressive familial intrahepatic cholestasis (PFIC, see this term), is a late-onset hereditary disorder in bile formation that is hepatocellular in origin. Onset may occur from infancy to young adulthood.

PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 3 Is also known as cholestasis, progressive familial intrahepatic, with elevated serum gamma-glutamyltransferase|mdr3 deficiency|pfic3

Related symptoms:

  • Failure to thrive
  • Hypertension
  • Hepatomegaly
  • Fever
  • Diarrhea


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 3

Medium match CIRRHOSIS, FAMILIAL

Related symptoms:

  • Hypertension
  • Fever
  • Jaundice
  • Abnormality of the liver
  • Lethargy


SOURCES: OMIM MENDELIAN

More info about CIRRHOSIS, FAMILIAL

HBV is a DNA virus that enters the liver via the bloodstream, and replication occurs only in liver tissue. Transmission occurs by percutaneous or mucosal exposure to infected blood or other body fluids. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma (HCC ) can be attributed to chronic HBV infection. Worldwide, 2 billion people have been infected with HBV, 360 million have chronic infection, and 600,000 die each year from HBV-related liver disease or HCC. However, there is marked geographic variability in HBV prevalence, with chronic infection affecting less than 2% of the populations of North America and western and northern Europe; between 2 and 7% of the populations of eastern and central Europe, the Amazon basin, the Middle East, and the Indian subcontinent; and more than 8% of the populations of Asia, sub-Saharan Africa, and the Pacific (Seeff and Hoofnagle, 2006; Shepard et al., 2006).

HEPATITIS B VIRUS, SUSCEPTIBILITY TO Is also known as hbv, susceptibility to

Related symptoms:

  • Pain
  • Hepatomegaly
  • Fever
  • Vomiting
  • Splenomegaly


SOURCES: OMIM MENDELIAN

More info about HEPATITIS B VIRUS, SUSCEPTIBILITY TO

Other less relevant matches:

G6PD deficiency is the most common genetic cause of chronic and drug-, food-, or infection-induced hemolytic anemia. G6PD catalyzes the first reaction in the pentose phosphate pathway, which is the only NADPH-generation process in mature red cells; therefore, defense against oxidative damage is dependent on G6PD. Most G6PD-deficient patients are asymptomatic throughout their life, but G6PD deficiency can be life-threatening. The most common clinical manifestations of G6PD deficiency are neonatal jaundice and acute hemolytic anemia, which in most patients is triggered by an exogenous agent, e.g., primaquine or fava beans. Acute hemolysis is characterized by fatigue, back pain, anemia, and jaundice. Increased unconjugated bilirubin, lactate dehydrogenase, and reticulocytosis are markers of the disorder. The striking similarity between the areas where G6PD deficiency is common and Plasmodium falciparum malaria (see {611162}) is endemic provided evidence that G6PD deficiency confers resistance against malaria (summary by Cappellini and Fiorelli, 2008).

ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY Is also known as favism, susceptibility to

Related symptoms:

  • Intellectual disability
  • Neoplasm
  • Muscle weakness
  • Pain
  • Anemia


SOURCES: OMIM MENDELIAN

More info about ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY

Idiopathic pulmonary fibrosis (IPF) is a nonneoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known cause.

IDIOPATHIC PULMONARY FIBROSIS Is also known as cfa|uip|usual interstitial pneumonia|interstitial pneumonitis, usual|idiopathic pulmonary fibrosis, familial|cryptogenic fibrosing alveolitis|fibrosing alveolitis, cryptogenic|fibrocystic pulmonary dysplasia

Related symptoms:

  • Neoplasm
  • Hypertension
  • Fever
  • Respiratory insufficiency
  • Respiratory distress


SOURCES: OMIM ORPHANET MENDELIAN

More info about IDIOPATHIC PULMONARY FIBROSIS

SEVERE COMBINED IMMUNODEFICIENCY WITH SENSITIVITY TO IONIZING RADIATION Is also known as rs-scid|scid, autosomal recessive, t cell-negative, b cell-negative, nk cell-positive, with sensitivity to ionizing radiation

Related symptoms:

  • Failure to thrive
  • Fever
  • Abnormality of the skeletal system
  • Diarrhea
  • Immunodeficiency


SOURCES: OMIM ORPHANET MENDELIAN

More info about SEVERE COMBINED IMMUNODEFICIENCY WITH SENSITIVITY TO IONIZING RADIATION

Medium match BUDD-CHIARI SYNDROME

Budd-Chiari syndrome (BCS) is caused by obstruction of hepatic venous outflow involving either the hepatic veins or the terminal segment of the inferior vena cava.

Related symptoms:

  • Neoplasm
  • Pain
  • Hypertension
  • Hepatomegaly
  • Fever


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about BUDD-CHIARI SYNDROME

Deficiency of lysosomal acid lipase causes 2 distinct phenotypes in humans: Wolman disease and cholesteryl ester storage disease (CESD). Wolman disease is an early-onset fulminant disorder of infancy with massive infiltration of the liver, spleen, and other organs by macrophages filled with cholesteryl esters and triglycerides. Death occurs early in life. Wolman disease is very rare, with an incidence of less than one in 100,000 live births. CESD is a milder, later-onset disorder with primary hepatic involvement by macrophages engorged with cholesteryl esters. This slowly progressive visceral disease has a very wide spectrum of involvement ranging from early onset with severe cirrhosis to later onset of more slowly progressive hepatic disease with survival into adulthood (summary by Du et al., 2001).

LYSOSOMAL ACID LIPASE DEFICIENCY Is also known as lal deficiency|cholesterol ester hydrolase deficiency|cholesteryl ester storage disease|lipa deficiency|cesd

Related symptoms:

  • Short stature
  • Generalized hypotonia
  • Failure to thrive
  • Anemia
  • Hypertension


SOURCES: ORPHANET OMIM MENDELIAN

More info about LYSOSOMAL ACID LIPASE DEFICIENCY

Medium match REYNOLDS SYNDROME

Reynolds syndrome (RS) is an autoimmune disorder characterized by the association of primary biliary cirrhosis (PBC) with limited cutaneous systemic sclerosis (lcSSc) (see these terms).

REYNOLDS SYNDROME Is also known as primary biliary cirrhosis and systemic scleroderma|primary biliary cirrhosis, scleroderma, raynaud disease, and telangiectasia

Related symptoms:

  • Pain
  • Hepatomegaly
  • Fever
  • Fatigue
  • Dysphagia


SOURCES: OMIM ORPHANET MENDELIAN

More info about REYNOLDS SYNDROME

Medium match COG4-CDG

COG4-CDG is an extremely rare form of CDG syndrome (see this term) characterized clinically in the single reported case to date by seizures, some dysmorphic features, axial hyponia, slight peripheral hypertonia and hyperreflexia.

COG4-CDG Is also known as carbohydrate deficient glycoprotein syndrome type iij|cdg-iij|cdg syndrome type iij|cdg2j|congenital disorder of glycosylation type iij|congenital disorder of glycosylation type 2j|cdgiij|cdg iij

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Microcephaly
  • Ataxia


SOURCES: ORPHANET OMIM MENDELIAN

More info about COG4-CDG

Top 5 symptoms//phenotypes associated to Fever and Cirrhosis

Symptoms // Phenotype % cases
Jaundice Common - Between 50% and 80% cases
Hepatomegaly Common - Between 50% and 80% cases
Splenomegaly Common - Between 50% and 80% cases
Hypertension Uncommon - Between 30% and 50% cases
Failure to thrive Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Fever and Cirrhosis. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Diarrhea Elevated hepatic transaminase Pain Esophageal varix Abnormality of the liver Respiratory tract infection Pulmonary arterial hypertension Neoplasm Portal hypertension Ascites Carcinoma Hepatic failure Malabsorption Hepatosplenomegaly Scarring

Rare Symptoms - Less than 30% cases

Lymphoma Hyperbilirubinemia Myalgia Respiratory insufficiency Pneumonia Gastroesophageal reflux Fatigue Steatorrhea Polycythemia Elevated alkaline phosphatase Chronic diarrhea Recurrent upper respiratory tract infections Hypercholesterolemia Weight loss Gastrointestinal hemorrhage Acute hepatic failure Anemia Generalized hypotonia Vomiting Cholestasis Abdominal distention Pruritus Nausea Abdominal pain Hepatocellular carcinoma Vacuolated lymphocytes Low-grade fever Periportal fibrosis Frontotemporal cerebral atrophy Bone-marrow foam cells Dysphagia Adrenal calcification Arthritis Skin rash Telangiectasia Skin ulcer Encephalitis Recurrent infection of the gastrointestinal tract Elevated erythrocyte sedimentation rate Telangiectasia of the skin Neonatal sepsis Abnormality of lipid metabolism Hyperlipoproteinemia Atherosclerosis Hernia Umbilical hernia Developmental regression Hepatic steatosis Hypertriglyceridemia Hepatic fibrosis Leukodystrophy Increased body weight Fatal liver failure in infancy Foam cells Hyperlipidemia Abnormal protein O-linked glycosylation Type II transferrin isoform profile Cachexia Malnutrition Complex febrile seizures Protuberant abdomen Keratoconjunctivitis sicca Scleroderma Sloping forehead Irregular hyperpigmentation Thick hair Feeding difficulties Hyperreflexia Hypoplasia of the corpus callosum Hypertonia Cerebral atrophy Recurrent infections Absent speech Thrombocytopenia Nystagmus Recurrent respiratory infections Diffuse cerebral atrophy Muscular hypotonia of the trunk Irritability Limb hypertonia Abnormality of the coagulation cascade Failure to thrive in infancy Sepsis Abnormal facial shape Growth delay Shock Sclerodactyly Xerostomia Raynaud phenomenon Antinuclear antibody positivity Calcinosis Biliary cirrhosis Lichenification Abnormality of the gastric mucosa Mucosal telangiectasiae Lip telangiectasia Ataxia Generalized neonatal hypotonia Palmar telangiectasia Calcinosis cutis Intermittent diarrhea Generalized abnormality of skin Seizures Short stature Microcephaly Global developmental delay Increased sensitivity to ionizing radiation Hepatic vein thrombosis Nonspherocytic hemolytic anemia Leukocytosis Osteomyelitis Prolonged neonatal jaundice Hodgkin lymphoma Reticulocytosis Anisocytosis Poikilocytosis Hemoglobinuria Unconjugated hyperbilirubinemia Meningitis Kernicterus Fava bean-induced hemolytic anemia Respiratory distress Congestive heart failure Respiratory failure Dyspnea Cough Cyanosis Back pain Abnormality of the cardiovascular system Bronchiectasis Glomerulonephritis Intrahepatic cholestasis Bile duct proliferation Portal fibrosis Lethargy Micronodular cirrhosis Increased level of L-fucose in urine Increased level of propylene glycol in blood Hepatitis Membranoproliferative glomerulonephritis Hemolytic anemia Dark urine Chronic infection Membranous nephropathy Acute hepatitis Fulminant hepatitis Intellectual disability Muscle weakness Pallor Abnormal lung morphology Scaling skin Reduced protein C activity Myocardial infarction Severe combined immunodeficiency Oral ulcer Aplasia of the thymus Panhypogammaglobulinemia Genital ulcers Lymph node hypoplasia Absent tonsils Stroke Intestinal obstruction Recurrent skin infections Thromboembolism Varicose veins Hypercoagulability Peritonitis Cholecystitis Gastrointestinal infarctions Portal vein thrombosis Budd-Chiari syndrome Combined immunodeficiency Recurrent pneumonia Clubbing Crackles Pulmonary fibrosis Increased antibody level in blood Interstitial pulmonary abnormality Exertional dyspnea Pulmonary infiltrates Clubbing of fingers Right ventricular failure Pulmonary insufficiency Alveolar cell carcinoma Lymphopenia Hypocapnia Reticular pattern on pulmonary HRCT Honeycomb lung Ground-glass opacification on pulmonary HRCT Abnormality of the skeletal system Immunodeficiency Decreased antibody level in blood Otitis media Abnormal protein N-linked glycosylation


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