Fever, and Burkitt lymphoma

Diseases related with Fever and Burkitt lymphoma

In the following list you will find some of the most common rare diseases related to Fever and Burkitt lymphoma that can help you solving undiagnosed cases.

Top matches:

High match EWING SARCOMA

Ewing's sarcoma is a malignant small round cell bone tumor with strong metastatic potential.

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Fever
  • Weight loss


SOURCES: OMIM ORPHANET MENDELIAN

More info about EWING SARCOMA

X-linked lymphoproliferative disease is a hereditary immunodeficiency characterized, in the majority of cases, by an inadequate immune response to infection with the Epstein-Barr virus (EBV).

X-LINKED LYMPHOPROLIFERATIVE DISEASE Is also known as xlpd|duncan disease|xlp|immunodeficiency 5|infectious mononucleosis, severe, susceptibility to|purtilo syndrome|imd5|ebvs|lymphoproliferative disease, x-linked|epstein-barr virus infection, familial fatal|lyp|ebv infection, severe, susceptibility to|immun

Related symptoms:

  • Seizures
  • Neoplasm
  • Anemia
  • Hepatomegaly
  • Fever


SOURCES: ORPHANET OMIM MENDELIAN

More info about X-LINKED LYMPHOPROLIFERATIVE DISEASE

Medium match MANTLE CELL LYMPHOMA

Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma (see this term) affecting B lymphocytes in the lymph nodes in a region called the ``mantle zone''.

MANTLE CELL LYMPHOMA Is also known as mantle zone lymphoma|lcm|mcl

Related symptoms:

  • Neoplasm
  • Fever
  • Fatigue
  • Splenomegaly
  • Weight loss


SOURCES: ORPHANET MENDELIAN

More info about MANTLE CELL LYMPHOMA

Other less relevant matches:

Lymphoproliferative syndrome-2, also known as CD27 deficiency, is an autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impairment in specific antibody function resulting from impaired T cell-dependent B-cell responses and T-cell dysfunction (summary by van Montfrans et al., 2012). The phenotype can vary significantly, from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation (summary by Salzer et al., 2013).For a discussion of genetic heterogeneity of lymphoproliferative syndrome, see XLP1 (OMIM ).

LYMPHOPROLIFERATIVE SYNDROME 2; LPFS2 Is also known as cd27 deficiency

Related symptoms:

  • Neoplasm
  • Anemia
  • Hepatomegaly
  • Fever
  • Splenomegaly


SOURCES: OMIM MENDELIAN

More info about LYMPHOPROLIFERATIVE SYNDROME 2; LPFS2

Medium match FOLLICULAR LYMPHOMA

Follicular lymphoma is a form of non-Hodgkin lymphoma (see this term) characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved.

FOLLICULAR LYMPHOMA Is also known as oncogene b-cell leukemia 2

Related symptoms:

  • Neoplasm
  • Fever
  • Fatigue
  • Diarrhea
  • Splenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about FOLLICULAR LYMPHOMA

Medium match MALT LYMPHOMA

MALT (mucosa-associated lymphoid tissue) lymphoma is a rare form of malignant non-Hodgkin lymphoma (see this term) that affects B cells and grows at the expense of lymphoid tissue associated with mucous membranes, but also occurs, more rarely, in lymph nodes.

MALT LYMPHOMA Is also known as maltoma|mucosa-associated lymphatic tissue lymphoma|extranodal marginal zone b-cell lymphoma|mucosa-associated lymphoid tissue lymphoma

Related symptoms:

  • Anemia
  • Visual impairment
  • Fever
  • Fatigue
  • Constipation


SOURCES: ORPHANET MENDELIAN

More info about MALT LYMPHOMA

Medium match SÉZARY SYNDROME

Sézary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sézary cells).

SÉZARY SYNDROME Is also known as sÉzary lymphoma

Related symptoms:

  • Neoplasm
  • Abnormal facial shape
  • Peripheral neuropathy
  • Hepatomegaly
  • Fever


SOURCES: MESH ORPHANET MENDELIAN

More info about SÉZARY SYNDROME

Medium match WHIM SYNDROME

WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a congenital autosomal dominant immune deficiency characterized by abnormal retention of mature neutrophils in the bone marrow (myelokathexis) and occasional hypogammaglobulinemia, associated with an increased risk for bacterial infections and a susceptibility to human papillomavirus (HPV) induced lesions (cutaneous warts, genital dysplasia and invasive mucosal carcinoma).

WHIM SYNDROME Is also known as warts, hypogammaglobulinemia, infections, and myelokathexis syndrome|warts-infections-leukopenia-myelokatexis syndrome|wilm|warts-hypogammaglobulinemia-infections-myelokathexis syndrome

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Fever
  • Congestive heart failure
  • Immunodeficiency


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about WHIM SYNDROME

Zur Stadt et al. (2005) summarized the clinical features of hemophagocytic lymphohistiocytosis (HLH), a rare autosomal recessive disorder characterized by massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently central nervous system involvement. In FHL, the familial form of the disease, first episodes occur mostly during infancy, with a rapidly fatal outcome if untreated. Diagnostic criteria also include low fibrinogen and high triglyceride and ferritin levels. Chemoimmunotherapy based on corticosteroids, epipodophyllotoxins, and cyclosporin succeeds in controlling the disease in the majority of patients, although remission is rarely obtained (Henter et al., 2002). Most patients suffer an early death unless they are treated by hematopoietic stem cell transplantation (Durken et al., 1999). Genetic Heterogeneity of Familial Hemophagocytic LymphohistiocytosisFamilial hemophagocytic lymphohistiocytosis exhibits genetic heterogeneity. In some families, familial hemophagocytic lymphohistiocytosis has been found to be linked to chromosome 9q (HPLH1, FHL1). FHL2 (OMIM ) is caused by mutation in the PRF1 gene (OMIM ) on chromosome 10q22; FHL3 (OMIM ) is caused by mutation in the UNC13D gene (OMIM ) on chromosome 17q25; FHL4 (OMIM ) is caused by mutation in the syntaxin-11 gene (STX11 ) on chromosome 6q24; and FHL5 (OMIM ) is caused by mutation in the syntaxin-binding protein-2 (STXBP2 ), which is an interaction partner of STX11, on chromosome 19p13.Furthermore, before the identification of mutations in the RAG1 (OMIM ) and RAG2 (OMIM ) genes, both of which map to 11p, Omenn syndrome (familial reticuloendotheliosis with eosinophilia; {603554}) was not thought to be clearly distinct from other reported cases of hemophagocytic lymphohistiocytosis.

HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1 Is also known as hemophagocytic reticulosis, familial|hlh1|hemophagocytic lymphohistiocytosis, familial|erythrophagocytic lymphohistiocytosis, familial|reticulosis, familial histiocytic|hplh1|fhl|fhlh|hplh|fel

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Ataxia
  • Neoplasm


SOURCES: OMIM MENDELIAN

More info about HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1

G6PD deficiency is the most common genetic cause of chronic and drug-, food-, or infection-induced hemolytic anemia. G6PD catalyzes the first reaction in the pentose phosphate pathway, which is the only NADPH-generation process in mature red cells; therefore, defense against oxidative damage is dependent on G6PD. Most G6PD-deficient patients are asymptomatic throughout their life, but G6PD deficiency can be life-threatening. The most common clinical manifestations of G6PD deficiency are neonatal jaundice and acute hemolytic anemia, which in most patients is triggered by an exogenous agent, e.g., primaquine or fava beans. Acute hemolysis is characterized by fatigue, back pain, anemia, and jaundice. Increased unconjugated bilirubin, lactate dehydrogenase, and reticulocytosis are markers of the disorder. The striking similarity between the areas where G6PD deficiency is common and Plasmodium falciparum malaria (see {611162}) is endemic provided evidence that G6PD deficiency confers resistance against malaria (summary by Cappellini and Fiorelli, 2008).

ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY Is also known as favism, susceptibility to

Related symptoms:

  • Intellectual disability
  • Neoplasm
  • Muscle weakness
  • Pain
  • Anemia


SOURCES: OMIM MENDELIAN

More info about ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY

Top 5 symptoms//phenotypes associated to Fever and Burkitt lymphoma

Symptoms // Phenotype % cases
Neoplasm Very Common - Between 80% and 100% cases
Lymphoma Very Common - Between 80% and 100% cases
Lymphadenopathy Common - Between 50% and 80% cases
Anemia Common - Between 50% and 80% cases
Splenomegaly Common - Between 50% and 80% cases

Other less frequent symptoms

Patients with Fever and Burkitt lymphoma. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Weight loss B-cell lymphoma Meningitis Immunodeficiency Hepatomegaly Hepatosplenomegaly Fatigue Pancytopenia T-cell lymphoma Decreased antibody level in blood Combined immunodeficiency Leukocytosis Leukemia

Rare Symptoms - Less than 30% cases

Histiocytosis Encephalitis Increased antibody level in blood Hodgkin lymphoma IgG deficiency Neutropenia Cellular immunodeficiency Hyperbilirubinemia Pain Skin rash Pulmonary infiltrates Hemolytic anemia Night sweats Abnormality of bone marrow cell morphology Mediastinal lymphadenopathy Hemophagocytosis Respiratory tract infection Jaundice Aplastic anemia Bronchiectasis Sarcoma Osteomyelitis Seizures Thrombocytopenia Pneumonia Respiratory failure Pleural effusion Hepatic failure Myelokathexis Hypersegmentation of neutrophil nuclei Periodontitis Cellulitis Coma Tetraplegia Sepsis Gliosis Recurrent upper respiratory tract infections Confusion Peripheral demyelination Tonsillitis Hypertriglyceridemia Recurrent bacterial infections Aspiration Sinusitis Folliculitis Irritability Abnormality of the liver Failure to thrive Global developmental delay Generalized hypotonia Abnormality of female internal genitalia Ataxia Abnormality of female external genitalia Atelectasis Muscular hypotonia Bone marrow hypercellularity Hypertonia Recurrent infections Encephalopathy Septic arthritis Elevated hepatic transaminase Abnormality of the nervous system Verrucae Hemoglobinuria Episodic fever Purpura Muscle weakness Hypofibrinogenemia CSF pleocytosis Polyneuritis Kernicterus Plasmacytosis Lipogranulomatosis Abnormal natural killer cell physiology Intellectual disability Myalgia Granulocytopenia Unconjugated hyperbilirubinemia Pallor Nonspherocytic hemolytic anemia Cirrhosis Abnormality of the cardiovascular system Back pain Prolonged neonatal jaundice Reticulocytosis Anisocytosis Increased VLDL cholesterol concentration Increased total bilirubin Leukopenia Severe combined immunodeficiency Increased intracranial pressure Eosinophilia Hypoalbuminemia Hemiplegia Hyponatremia Albinism Abnormality of the coagulation cascade Poikilocytosis Increased CSF protein Partial albinism Increased serum ferritin Otitis media Acute leukemia Hypoproteinemia Prolonged partial thromboplastin time Generalized edema Decreased HDL cholesterol concentration Prolonged prothrombin time Increased LDL cholesterol concentration Recurrent urinary tract infections Pruritus Carious teeth Reduced natural killer cell activity Granulomatosis Chorioretinitis Increased IgM level Dysgammaglobulinemia Pure red cell aplasia Hepatic necrosis Non-Hodgkin lymphoma Pharyngitis Fulminant hepatitis Lymphocytosis Anorexia Abnormality of the gastrointestinal tract Intestinal polyposis Intestinal polyp Intussusception Autoimmunity Ascites Uveitis Hepatic encephalopathy Recurrent pharyngitis Impaired T cell function Ewing sarcoma Paralysis Paraplegia Myeloid leukemia Neuroblastoma Acute lymphoblastic leukemia Meningioma Chronic myelogenous leukemia Primitive neuroectodermal tumor Peripheral neuroepithelioma Immune dysregulation Neoplasm of the peripheral nervous system Dilatation Falls Memory impairment Hemiparesis Vasculitis Bone marrow hypocellularity Agammaglobulinemia Lymphoproliferative disorder Diarrhea Arthritis Irregular hyperpigmentation Hypotrichosis Dry skin Palmoplantar keratoderma Abnormality of the face Thickened skin Neoplasm of the skin Ectropion Erythroderma Gangrene Alopecia Abnormality of the pleura Lichenification Abnormal lymphocyte morphology Abnormal immunoglobulin level Cutaneous T-cell lymphoma Hearing impairment Congestive heart failure Carcinoma Nail dystrophy Edema Nausea Recurrent respiratory infections Insulin resistance Lymphedema Glucose intolerance Chronic lymphatic leukemia Skin nodule Abnormality of the peritoneum Visual impairment Constipation Hyperhidrosis Tremor Abdominal pain Nausea and vomiting Abnormality of the thyroid gland Abnormal nasolacrimal system morphology Posterior uveitis Abnormal facial shape Peripheral neuropathy Skeletal muscle atrophy Fava bean-induced hemolytic anemia


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