Fever, and Arthralgia

Diseases related with Fever and Arthralgia

In the following list you will find some of the most common rare diseases related to Fever and Arthralgia that can help you solving undiagnosed cases.

Top matches:

WNV is an enveloped, neurotropic, single-stranded sense RNA flavivirus that is naturally maintained in a zoonotic cycle between avian hosts and mosquito vectors. The virus was first isolated from a Ugandan woman in 1937 and subsequently emerged in Europe and, in 1999, in New York, with eventual spread throughout North America. WNV causes a spectrum of disease ranging from acute fever to lethal encephalitis. Susceptibility to WNV is increased in the elderly and in immunocompromised individuals (summary by Diamond and Klein (2006) and Glass et al. (2005)).

WEST NILE VIRUS, SUSCEPTIBILITY TO Is also known as wnv, susceptibility to

Related symptoms:

  • Pain
  • Fever
  • Fatigue
  • Headache
  • Arthralgia


SOURCES: OMIM MENDELIAN

More info about WEST NILE VIRUS, SUSCEPTIBILITY TO

Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). Genetic Heterogeneity of Acute Lymphoblastic LeukemiaA susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 (OMIM ), which has been mapped to chromosome 7p12.2; and ALL3 (OMIM ), which is caused by mutation in the PAX5 gene (OMIM ) on chromosome 9p.

Related symptoms:

  • Neoplasm
  • Pain
  • Fever
  • Fatigue
  • Arthralgia


SOURCES: OMIM ORPHANET MENDELIAN

More info about LEUKEMIA, ACUTE LYMPHOBLASTIC; ALL

Related symptoms:

  • Fever
  • Hyperkeratosis
  • Arthralgia
  • Arthritis
  • Ichthyosis


SOURCES: OMIM MENDELIAN

More info about PSORIASIS 2; PSORS2

Other less relevant matches:

DFNA34 is an autosomal dominant form of postlingual, slowly progressive sensorineural hearing loss with variable severity and variable additional features. Some patients have pure hearing loss without significant additional features, whereas some patients have features of an autoinflammatory disorder with systemic manifestations, including periodic fevers, arthralgias, and episodic urticaria. The disorder results from abnormally increased activation of the inflammatory pathway, and treatment with an IL1 receptor antagonist (see {147679}) may be effective if started early (summary by Nakanishi et al., 2017).

Related symptoms:

  • Hearing impairment
  • Sensorineural hearing impairment
  • Fever
  • Edema
  • Headache


SOURCES: OMIM MENDELIAN

More info about DEAFNESS, AUTOSOMAL DOMINANT 34, WITH OR WITHOUT INFLAMMATION; DFNA34

MAJEED SYNDROME; MJDS Is also known as chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anemia, and neutrophilic dermatosis

Related symptoms:

  • Growth delay
  • Anemia
  • Flexion contracture
  • Fever
  • Delayed skeletal maturation


SOURCES: OMIM MENDELIAN

More info about MAJEED SYNDROME; MJDS

Autoinflammation, panniculitis, and dermatosis syndrome (AIPDS) is an autosomal recessive autoinflammatory disease characterized by neonatal onset of recurrent fever, erythematous rash with painful nodules, painful joints, and lipodystrophy. Additional features may include diarrhea, increased serum C-reactive protein, leukocytosis, and neutrophilia in the absence of any infection. Patients exhibit no overt primary immunodeficiency (Damgaard et al., 2016 and Zhou et al., 2016).

INFANTILE-ONSET PERIODIC FEVER-PANNICULITIS-DERMATOSIS SYNDROME Is also known as otulipenia|oras|otulin deficiency|otulin-related autoinflammatory syndrome

Related symptoms:

  • Failure to thrive
  • Fever
  • Diarrhea
  • Immunodeficiency
  • Arthralgia


SOURCES: ORPHANET OMIM MENDELIAN

More info about INFANTILE-ONSET PERIODIC FEVER-PANNICULITIS-DERMATOSIS SYNDROME

FAMILIAL MEDITERRANEAN FEVER, AUTOSOMAL DOMINANT Is also known as fmf, autosomal dominant

Related symptoms:

  • Pain
  • Fever
  • Renal insufficiency
  • Abdominal pain
  • Arthralgia


SOURCES: MESH OMIM MENDELIAN

More info about FAMILIAL MEDITERRANEAN FEVER, AUTOSOMAL DOMINANT

PLCG2-associated antibody deficiency and immune dysregulation is a rare, hereditary, immune deficiency with skin involvement characterized by early-onset cold urticaria after generalized exposure to cold air or evaporative cooling and not after contact with cold objects. Additional immunologic abnormalities are often present - antibody deficiency, recurrent infections, autoimmune disease and symptomatic allergic disease.

PLCG2-ASSOCIATED ANTIBODY DEFICIENCY AND IMMUNE DYSREGULATION Is also known as facu|familial cold urticaria with common variable immunodeficiency|antibody deficiency and immune dysregulation, plcg2-associated|plaid|familial atypical cold urticaria

Related symptoms:

  • Pain
  • Fever
  • Recurrent infections
  • Arthralgia
  • Erythema


SOURCES: OMIM ORPHANET MENDELIAN

More info about PLCG2-ASSOCIATED ANTIBODY DEFICIENCY AND IMMUNE DYSREGULATION

Familial cold urticaria (FCAS) is the mildest form of cryopyrin-associated periodic syndrome (CAPS; see this term) and is characterized by recurrent episodes of urticaria-like skin rash triggered by exposure to cold associated with low-grade fever, general malaise, eye redness and arthralgia/myalgia.

FAMILIAL COLD URTICARIA Is also known as fcas|familial cold autoinflammatory syndrome|fcu

Related symptoms:

  • Sensorineural hearing impairment
  • Fever
  • Fatigue
  • Headache
  • Hyperhidrosis


SOURCES: ORPHANET MENDELIAN

More info about FAMILIAL COLD URTICARIA

Pyogenic arthritis-pyoderma gangrenosum-acne syndrome is a rare pleiotropic autoinflammatory disorder of childhood, primarily affecting the joints and skin.

PYOGENIC ARTHRITIS-PYODERMA GANGRENOSUM-ACNE SYNDROME Is also known as familial recurrent arthritis|papa syndrome|fra

Related symptoms:

  • Fever
  • Fatigue
  • Arthralgia
  • Arthritis
  • Proteinuria


SOURCES: ORPHANET MENDELIAN

More info about PYOGENIC ARTHRITIS-PYODERMA GANGRENOSUM-ACNE SYNDROME

Top 5 symptoms//phenotypes associated to Fever and Arthralgia

Symptoms // Phenotype % cases
Arthritis Uncommon - Between 30% and 50% cases
Pain Uncommon - Between 30% and 50% cases
Fatigue Uncommon - Between 30% and 50% cases
Headache Uncommon - Between 30% and 50% cases
Lymphadenopathy Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Fever and Arthralgia. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Urticaria

Rare Symptoms - Less than 30% cases

Pruritus Sensorineural hearing impairment Erythema Skin rash Psoriasiform dermatitis Inflammatory abnormality of the skin Episodic fever Conjunctivitis Myalgia Proteinuria Abdominal pain Recurrent infections Neutrophilia Autoimmunity Panniculitis Renal insufficiency Amyloidosis Polyarticular arthritis Chest pain Erysipelas Pleuritis Peritonitis Stage 5 chronic kidney disease Renal amyloidosis Hashimoto thyroiditis Asthma Polydipsia Crohn's disease Myositis Pustule Increased antibody level in blood Acne Type I diabetes mellitus Skin ulcer Limitation of joint mobility Dysesthesia Dehydration Syncope Nausea and vomiting Hyperhidrosis Cold urticaria Angioedema Chills Allergic rhinitis Immune dysregulation Vitiligo Leukocytosis Joint swelling Chronic recurrent multifocal osteomyelitis Lipodystrophy Ichthyosis Orthokeratosis Atopic dermatitis Parakeratosis Rheumatoid arthritis Scaling skin Dermal atrophy Epidermal acanthosis Hyperkeratosis Hearing impairment Acute leukemia Acute lymphoblastic leukemia Bruising susceptibility Leukemia Neoplasm Encephalitis Meningitis Paralysis Diffuse skin atrophy Edema Vasculitis Microcytic anemia Scarring Immunodeficiency Diarrhea Failure to thrive Low-grade fever Congenital hypoplastic anemia Decreased mean corpuscular volume Anemia of inadequate production Osteomyelitis Migraine Bone pain Hepatosplenomegaly Delayed skeletal maturation Flexion contracture Anemia Growth delay Cervical lymphadenopathy Progressive hearing impairment Increased inflammatory response


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