Fever, and Acute lymphoblastic leukemia

Diseases related with Fever and Acute lymphoblastic leukemia

In the following list you will find some of the most common rare diseases related to Fever and Acute lymphoblastic leukemia that can help you solving undiagnosed cases.

Top matches:

Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). Genetic Heterogeneity of Acute Lymphoblastic LeukemiaA susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 (OMIM ), which has been mapped to chromosome 7p12.2; and ALL3 (OMIM ), which is caused by mutation in the PAX5 gene (OMIM ) on chromosome 9p.

Related symptoms:

  • Neoplasm
  • Pain
  • Fever
  • Fatigue
  • Arthralgia


SOURCES: OMIM ORPHANET MENDELIAN

More info about LEUKEMIA, ACUTE LYMPHOBLASTIC; ALL

Chronic myeloid leukaemia (CML) is the most common myeloproliferative disorder accounting for 15-20% of all leukaemia cases.

CHRONIC MYELOID LEUKEMIA Is also known as chronic granulocytic leukemia|cml|leukemia, chronic myelogenous|chronic myelogenous leukemia

Related symptoms:

  • Neoplasm
  • Fever
  • Fatigue
  • Splenomegaly
  • Thrombocytopenia


SOURCES: ORPHANET OMIM MENDELIAN

More info about CHRONIC MYELOID LEUKEMIA

Medium match EWING SARCOMA

Ewing's sarcoma is a malignant small round cell bone tumor with strong metastatic potential.

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Fever
  • Weight loss


SOURCES: OMIM ORPHANET MENDELIAN

More info about EWING SARCOMA

Other less relevant matches:

Nonimmune chronic idiopathic neutropenia of adults (NI-CINA) is a relatively mild form of neutropenia diagnosed in adults but predisposing to leukemia in a subset of patients (Papadaki et al., 2002).

ADULT IDIOPATHIC NEUTROPENIA Is also known as nonimmune chronic idiopathic neutropenia of adults|ni-cina

Related symptoms:

  • Fever
  • Recurrent infections
  • Leukemia
  • Neutropenia
  • Acute myeloid leukemia


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about ADULT IDIOPATHIC NEUTROPENIA

Psoriasis (psoriasis vulgaris; PV) is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin patches that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age (summary by Matthews et al., 1996).Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein (OMIM ) (summary by Marrakchi et al., 2011). GPP often presents in patients with existing or prior psoriasis vulgaris; however, GPP can develop without a history of PV (Sugiura et al., 2013). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP (summary by Setta-Kaffetzi et al., 2013).Nestle et al. (2009) provided a detailed review of the pathogenesis and genetics of psoriasis. Genetic Heterogeneity of Psoriasis and Psoriasis SusceptibilityPSORS2 (OMIM ) is caused by mutation in the CARD14 gene (OMIM ) on chromosome 17q25, and PSORS14 (OMIM ) is caused by mutation in the IL36RN gene (OMIM ) on chromosome 2q14.Psoriasis susceptibility loci include PSORS1 on 6p21.3; PSORS3 (OMIM ) on 4q; PSORS4 on 1q21; PSORS5 (OMIM ) on 3q21; PSORS6 (OMIM ) on 19p; PSORS7 (OMIM ) on 1p; PSORS8 (OMIM ) on 16q; PSORS9 (OMIM ) on 4q31; PSORS10 (OMIM ) on 18p11; PSORS11 (OMIM ) on 5q31-q33; PSORS12 (OMIM ) on 20q13; PSORS13 (OMIM ), conferred by variation in the TRAF3IP2 gene (OMIM ) on 6q21; and PSORS15 (OMIM ), conferred by variation in the AP1S3 gene (OMIM ) on 2q36.An additional putative psoriasis candidate locus has been reported on 20p (Nair et al., 1997).

Related symptoms:

  • Fever
  • Arthritis
  • Skin rash
  • Scaling skin
  • Psoriasiform dermatitis


SOURCES: OMIM MENDELIAN

More info about PSORIASIS 1, SUSCEPTIBILITY TO; PSORS1

LEUKEMIA, ACUTE MYELOID; AML Is also known as leukemia, acute myelogenous

Related symptoms:

  • Seizures
  • Neoplasm
  • Pain
  • Anemia
  • Fever


SOURCES: OMIM ORPHANET MENDELIAN

More info about LEUKEMIA, ACUTE MYELOID; AML

Cardiofaciocutaneous (CFC) syndrome is a multiple congenital anomaly disorder in which individuals have characteristic craniofacial features, cardiac defects, ectodermal anomalies, gastrointestinal dysfunction, and neurocognitive delay (summary by Rauen et al., 2010).

Related symptoms:

  • Global developmental delay
  • Short stature
  • Generalized hypotonia
  • Scoliosis
  • Nystagmus


SOURCES: OMIM MENDELIAN

More info about CARDIOFACIOCUTANEOUS SYNDROME 4; CFC4

Zur Stadt et al. (2005) summarized the clinical features of hemophagocytic lymphohistiocytosis (HLH), a rare autosomal recessive disorder characterized by massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently central nervous system involvement. In FHL, the familial form of the disease, first episodes occur mostly during infancy, with a rapidly fatal outcome if untreated. Diagnostic criteria also include low fibrinogen and high triglyceride and ferritin levels. Chemoimmunotherapy based on corticosteroids, epipodophyllotoxins, and cyclosporin succeeds in controlling the disease in the majority of patients, although remission is rarely obtained (Henter et al., 2002). Most patients suffer an early death unless they are treated by hematopoietic stem cell transplantation (Durken et al., 1999). Genetic Heterogeneity of Familial Hemophagocytic LymphohistiocytosisFamilial hemophagocytic lymphohistiocytosis exhibits genetic heterogeneity. In some families, familial hemophagocytic lymphohistiocytosis has been found to be linked to chromosome 9q (HPLH1, FHL1). FHL2 (OMIM ) is caused by mutation in the PRF1 gene (OMIM ) on chromosome 10q22; FHL3 (OMIM ) is caused by mutation in the UNC13D gene (OMIM ) on chromosome 17q25; FHL4 (OMIM ) is caused by mutation in the syntaxin-11 gene (STX11 ) on chromosome 6q24; and FHL5 (OMIM ) is caused by mutation in the syntaxin-binding protein-2 (STXBP2 ), which is an interaction partner of STX11, on chromosome 19p13.Furthermore, before the identification of mutations in the RAG1 (OMIM ) and RAG2 (OMIM ) genes, both of which map to 11p, Omenn syndrome (familial reticuloendotheliosis with eosinophilia; {603554}) was not thought to be clearly distinct from other reported cases of hemophagocytic lymphohistiocytosis.

HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1 Is also known as hemophagocytic reticulosis, familial|hlh1|hemophagocytic lymphohistiocytosis, familial|erythrophagocytic lymphohistiocytosis, familial|reticulosis, familial histiocytic|hplh1|fhl|fhlh|hplh|fel

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Ataxia
  • Neoplasm


SOURCES: OMIM MENDELIAN

More info about HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1

Deafness - lymphedema - leukemia is a very rare, serious syndromic genetic disorder characterized by primary lymphedema, immunodeficiency, and hematological disorders.

DEAFNESS-LYMPHEDEMA-LEUKEMIA SYNDROME Is also known as emberger syndrome

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Sensorineural hearing impairment
  • Anemia
  • Epicanthus


SOURCES: OMIM ORPHANET MENDELIAN

More info about DEAFNESS-LYMPHEDEMA-LEUKEMIA SYNDROME

Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disease characterized by microthrombocytopenia, eczema, infections and an increased risk for autoimmune manifestations and malignancies.

WISKOTT-ALDRICH SYNDROME Is also known as aldrich syndrome|imd2|immunodeficiency 2|eczema-thrombocytopenia-immunodeficiency syndrome|was|was1|wiskott-aldrich syndrome 1

Related symptoms:

  • Neoplasm
  • Anemia
  • Peripheral neuropathy
  • Fever
  • Fatigue


SOURCES: OMIM ORPHANET MENDELIAN

More info about WISKOTT-ALDRICH SYNDROME

Top 5 symptoms//phenotypes associated to Fever and Acute lymphoblastic leukemia

Symptoms // Phenotype % cases
Leukemia Very Common - Between 80% and 100% cases
Neoplasm Common - Between 50% and 80% cases
Recurrent infections Uncommon - Between 30% and 50% cases
Anemia Uncommon - Between 30% and 50% cases
Thrombocytopenia Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Fever and Acute lymphoblastic leukemia. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Fatigue Bruising susceptibility Acute leukemia Splenomegaly Pancytopenia Myeloid leukemia Lymphadenopathy Lymphoma Hemolytic anemia Immunodeficiency Leukopenia Acute myeloid leukemia Sarcoma Weight loss Pain Myelodysplasia Leukocytosis

Rare Symptoms - Less than 30% cases

Generalized hypotonia Skin rash Sepsis Acute monocytic leukemia Purpura Combined immunodeficiency Coma Seizures Intracranial hemorrhage Chronic otitis media Respiratory failure Dyspnea Hepatosplenomegaly Arthritis Neutropenia Confusion Global developmental delay Granulocytopenia Recurrent respiratory infections Hepatomegaly Chronic myelogenous leukemia Myeloproliferative disorder Neuroblastoma Prolonged bleeding time Meningitis Muscular hypotonia Cellulitis Gingival bleeding Petechiae Scarring Abnormal neutrophil count Macronodular cirrhosis Syndactyly Peripheral neuropathy Diarrhea Arrhythmia Pneumonia Proteinuria Respiratory tract infection Autoimmunity Cough Nephropathy Abnormal bleeding Sensorineural hearing impairment Chest pain Sudden cardiac death Renal insufficiency Epicanthus Erysipelas Migraine Cerebellar atrophy Pallor Neurological speech impairment Nausea and vomiting Vertigo Cirrhosis Hematuria Tapered finger Edema Abnormality of the optic nerve Respiratory insufficiency Webbed neck Hypotelorism Lymphedema Bone marrow hypocellularity Specific learning disability Visual loss Hypercoagulability Verrucae Otitis media Glomerulopathy Eczema Abnormal platelet function Abnormality of the menstrual cycle Membranoproliferative glomerulonephritis Interstitial pneumonitis Increased IgA level Hematemesis Melena Spontaneous hematomas Bloody diarrhea Generalized lymphadenopathy Abnormal eosinophil morphology Internal hemorrhage Decreased mean platelet volume Recurrent ear infections Abnormal platelet morphology Congenital thrombocytopenia Reduced delayed hypersensitivity Large vessel vasculitis Small vessel vasculitis Recurrent intrapulmonary hemorrhage Chronic leukemia Absent microvilli on the surface of peripheral blood lymphocytes Abnormal delayed hypersensitivity skin test Reduced lymphocyte surface expression of CD43 Specific anti-polysaccharide antibody deficiency Increased IgE level IgM deficiency Epistaxis Rheumatoid arthritis Recurrent otitis media Chronic diarrhea Sinusitis Lymphopenia Skin ulcer Vasculitis Conjunctivitis Recurrent upper respiratory tract infections Chronic kidney disease Urticaria Glomerulosclerosis Glomerulonephritis Hypoplasia of the thymus Inflammation of the large intestine Hyperostosis Keratitis Focal segmental glomerulosclerosis Microcytic anemia Abnormal natural killer cell physiology Iron deficiency anemia Hodgkin lymphoma Blepharitis Recurrent lower respiratory tract infections Hematochezia Chronic obstructive pulmonary disease Hearing impairment Increased antibody level in blood Lipogranulomatosis Myopia Ecchymosis Night sweats Chronic pain Acute promyelocytic leukemia Short stature Scoliosis Nystagmus Strabismus Cataract Motor delay Hypoplasia of the corpus callosum Headache Cerebellar hypoplasia Hyperhidrosis High forehead Telecanthus Congenital cataract Pulmonic stenosis Growth hormone deficiency Narrow forehead Optic nerve hypoplasia Hyperextensible skin Menorrhagia Respiratory distress Abnormality of the sternum Pleural effusion Arthralgia Abnormality of blood and blood-forming tissues Poor appetite Thrombocytosis Abnormal granulocyte morphology Reduced leukocyte alkaline phosphatase Abnormal basophil morphology Ph-positive acute lymphoblastic leukemia Paralysis Paraplegia Meningioma Onychomadesis Burkitt lymphoma Primitive neuroectodermal tumor Ewing sarcoma Peripheral neuroepithelioma Neoplasm of the peripheral nervous system Scaling skin Psoriasiform dermatitis Pustule Nail pits Palmoplantar pustulosis Absent eyebrow Heat intolerance Plasmacytosis Prolonged prothrombin time Abnormality of the coagulation cascade Episodic fever Severe combined immunodeficiency Pulmonary infiltrates Increased CSF protein Increased serum ferritin Hypoproteinemia Prolonged partial thromboplastin time Generalized edema Decreased HDL cholesterol concentration Cellular immunodeficiency Hyponatremia Histiocytosis Hemophagocytosis Increased LDL cholesterol concentration Partial albinism Increased total bilirubin T-cell lymphoma Increased VLDL cholesterol concentration Hypofibrinogenemia CSF pleocytosis Polyneuritis Albinism Hemiplegia B-cell lymphoma Abnormality of the nervous system Abnormal aortic valve morphology Multiple lentigines Abnormality of lateral ventricle Abnormal ventricular septum morphology Ataxia Failure to thrive Hypertonia Encephalopathy Jaundice Elevated hepatic transaminase Irritability Hypoalbuminemia Abnormality of the liver Hepatic failure Tetraplegia Gliosis Peripheral demyelination Hypertriglyceridemia Aspiration Hyperbilirubinemia Increased intracranial pressure Eosinophilia Encephalitis Oral bleeding


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