Edema, and Lymphadenopathy

Diseases related with Edema and Lymphadenopathy

In the following list you will find some of the most common rare diseases related to Edema and Lymphadenopathy that can help you solving undiagnosed cases.

Top matches:

Hereditary elliptocytosis-3 is a hemolytic disorder characterized by the presence of elliptical erythrocytes and resulting in some cases in hemolytic anemia (summary by Qualtieri et al., 1997).For a general description and a discussion of genetic heterogeneity of hereditary elliptocytosis (HE), see EL1 (OMIM ).

Related symptoms:

  • Anemia
  • Edema
  • Jaundice
  • Hepatosplenomegaly
  • Lymphadenopathy


SOURCES: MESH OMIM MENDELIAN

More info about ELLIPTOCYTOSIS 3; EL3

DFNA34 is an autosomal dominant form of postlingual, slowly progressive sensorineural hearing loss with variable severity and variable additional features. Some patients have pure hearing loss without significant additional features, whereas some patients have features of an autoinflammatory disorder with systemic manifestations, including periodic fevers, arthralgias, and episodic urticaria. The disorder results from abnormally increased activation of the inflammatory pathway, and treatment with an IL1 receptor antagonist (see {147679}) may be effective if started early (summary by Nakanishi et al., 2017).

Related symptoms:

  • Hearing impairment
  • Sensorineural hearing impairment
  • Fever
  • Edema
  • Headache


SOURCES: OMIM MENDELIAN

More info about DEAFNESS, AUTOSOMAL DOMINANT 34, WITH OR WITHOUT INFLAMMATION; DFNA34

Autoinflammation, panniculitis, and dermatosis syndrome (AIPDS) is an autosomal recessive autoinflammatory disease characterized by neonatal onset of recurrent fever, erythematous rash with painful nodules, painful joints, and lipodystrophy. Additional features may include diarrhea, increased serum C-reactive protein, leukocytosis, and neutrophilia in the absence of any infection. Patients exhibit no overt primary immunodeficiency (Damgaard et al., 2016 and Zhou et al., 2016).

INFANTILE-ONSET PERIODIC FEVER-PANNICULITIS-DERMATOSIS SYNDROME Is also known as otulipenia|oras|otulin deficiency|otulin-related autoinflammatory syndrome

Related symptoms:

  • Failure to thrive
  • Fever
  • Diarrhea
  • Immunodeficiency
  • Arthralgia


SOURCES: ORPHANET OMIM MENDELIAN

More info about INFANTILE-ONSET PERIODIC FEVER-PANNICULITIS-DERMATOSIS SYNDROME

Other less relevant matches:

Follicular lymphoma is a form of non-Hodgkin lymphoma (see this term) characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved.

FOLLICULAR LYMPHOMA Is also known as oncogene b-cell leukemia 2

Related symptoms:

  • Neoplasm
  • Fever
  • Fatigue
  • Diarrhea
  • Splenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about FOLLICULAR LYMPHOMA

Classical mycosis fungoides is the most common type of mycosis fungoides (MF; see this term), a form of cutaneous T-cell lymphoma, and is characterized by slow progression from patches to more infiltrated plaques and eventually to tumors.

CLASSIC MYCOSIS FUNGOIDES Is also known as mycosis fungoides, alibert-bazin type

Related symptoms:

  • Hepatomegaly
  • Edema
  • Splenomegaly
  • Alopecia
  • Hyperkeratosis


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about CLASSIC MYCOSIS FUNGOIDES

Systemic-onset juvenile idiopathic arthritis is marked by the severity of the extra-articular manifestations (fever, cutaneous eruptions) and by an equal sex ratio.

SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITIS Is also known as systemic-onset jia|systemic juvenile rheumatoid arthritis|still disease|systemic polyarthritis

Related symptoms:

  • Visual impairment
  • Hepatomegaly
  • Fever
  • Splenomegaly
  • Visual loss


SOURCES: ORPHANET OMIM MENDELIAN

More info about SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITIS

Lymphoproliferative syndrome-1 is an autosomal recessive primary immunodeficiency characterized by onset in early childhood of Epstein-Barr virus (EBV)-associated immune dysregulation, manifest as lymphoma, lymphomatoid granulomatosis, hemophagocytic lymphohistiocytosis, Hodgkin disease, and/or hypogammaglobulinemia. Autoimmune disorders, such as autoimmune hemolytic anemia or renal disease, may also occur. Patients show a high EBV viral load and decreased invariant natural killer T cells. It is unknown whether patients with ITK mutations are intrinsically susceptible to development of lymphoma or dysgammaglobulinemia in the absence of EBV infection (summary by Stepensky et al., 2011; Linka et al., 2012).For a discussion of genetic heterogeneity of lymphoproliferative syndrome, see XLP1 (OMIM ).

Related symptoms:

  • Anemia
  • Hepatomegaly
  • Fever
  • Splenomegaly
  • Immunodeficiency


SOURCES: OMIM MESH MENDELIAN

More info about LYMPHOPROLIFERATIVE SYNDROME 1; LPFS1

Malignant mesothelioma is a fatal asbestos-associated malignancy arising in the lining cells (mesothelium) of the pleural and peritoneal cavities, as well as in the pericardium and the tunica vaginalis.

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Hepatomegaly
  • Fever


SOURCES: OMIM ORPHANET MENDELIAN

More info about PLEURAL MESOTHELIOMA

Low match KAPOSI SARCOMA

Kaposi sarcoma (KS) is a rare human herpes virus 8 (HHV-8)-induced endothelial inflammatory neoplasm that develops is various clinically distinct settings, manifesting mostly as cutaneous lesions, or mucosal or visceral involvement.

KAPOSI SARCOMA Is also known as multiple idiopathic pigmented hemangiosarcoma, susceptibility to

Related symptoms:

  • Neoplasm
  • Hypertension
  • Fever
  • Fatigue
  • Edema


SOURCES: OMIM ORPHANET MENDELIAN

More info about KAPOSI SARCOMA

Autoimmune lymphoproliferative syndrome (ALPS) is a rare, inherited disorder characterized by non-malignant lymphoproliferation, multilineage cytopenias, and a lifelong increased risk of Hodgkin's and non-Hodgkin's lymphoma.

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME Is also known as alps|autoimmune lymphoproliferative syndrome, type i, autosomal dominant|fas deficiency|canale-smith syndrome

Related symptoms:

  • Neoplasm
  • Anemia
  • Hepatomegaly
  • Edema
  • Splenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME

Top 5 symptoms//phenotypes associated to Edema and Lymphadenopathy

Symptoms // Phenotype % cases
Fever Common - Between 50% and 80% cases
Splenomegaly Uncommon - Between 30% and 50% cases
Lymphoma Uncommon - Between 30% and 50% cases
Hepatomegaly Uncommon - Between 30% and 50% cases
Anemia Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Edema and Lymphadenopathy. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Skin rash Diarrhea Pleural effusion Neoplasm Hepatosplenomegaly Autoimmunity Weight loss Immunodeficiency Hemolytic anemia Arthralgia

Rare Symptoms - Less than 30% cases

Thrombocytopenia Lymphedema Fatigue Lymphoproliferative disorder Leukemia Nausea Hodgkin lymphoma Chronic lymphatic leukemia Autoimmune hemolytic anemia Pneumonia Generalized lymphadenopathy Skin nodule Abnormal lung morphology Ascites Joint swelling Skin plaque Abdominal pain Elevated erythrocyte sedimentation rate Uveitis Neoplasm of the skin Night sweats Urticaria Arthritis Vasculitis Myalgia Cervical lymphadenopathy Extramedullary hematopoiesis Increased IgG level Rheumatoid factor positive Abnormality of cardiovascular system physiology Functional respiratory abnormality Fourth cranial nerve palsy Constitutional symptom Autoimmune thrombocytopenia Malignant mesothelioma Coombs-positive hemolytic anemia Obstruction of the superior vena cava Reduced delayed hypersensitivity Autoimmune neutropenia Pleural mesothelioma Peritoneal mesothelioma Pericardial mesothelioma Abnormality of the pleura Intestinal obstruction Platelet antibody positive Chest pain Dysphagia Respiratory distress Vomiting Dyspnea Cough Increased proportion of HLA DR+ T cells Hypotension Decreased lymphocyte apoptosis Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells Smooth muscle antibody positivity Antineutrophil antibody positivity Abnormality of the thorax Oral-pharyngeal dysphagia Increased IgM level Hypertension Gastrointestinal hemorrhage Encephalopathy Generalized edema Increased IgA level Chronic noninfectious lymphadenopathy Hepatitis Purpura Lymphocytosis Eosinophilia Glomerulonephritis Renal insufficiency Increased antibody level in blood Multiple myeloma Petechiae Antinuclear antibody positivity Hepatocellular carcinoma Basal cell carcinoma Carcinoma Antiphospholipid antibody positivity Abnormality of the liver Follicular hyperplasia Papule Iron deficiency anemia Pulmonary arterial hypertension Hemangioma Sarcoma Hypermelanotic macule Abnormal retinal morphology Neoplasm by anatomical site Macule Abnormality of the gastrointestinal tract Abnormality of the lower limb Abnormality of the spleen Cellular immunodeficiency Venous insufficiency Susceptibility to herpesvirus Pain Serositis Dysgammaglobulinemia Neutropenia Scarring Lipodystrophy Leukocytosis Neutrophilia Panniculitis Respiratory tract infection Insulin resistance Progressive hearing impairment Meningitis Glucose intolerance B-cell lymphoma Mediastinal lymphadenopathy Abnormality of the peritoneum Alopecia Failure to thrive Conjunctivitis Erythema Poikilocytosis Jaundice Hydrops fetalis Hyperbilirubinemia Cholelithiasis Prolonged neonatal jaundice Spherocytosis Elliptocytosis Migraine Decreased mean corpuscular volume Intermittent jaundice Asthenia Pigment gallstones Hearing impairment Sensorineural hearing impairment Headache Hyperkeratosis Pruritus Granulomatosis Lymphopenia Juvenile rheumatoid arthritis Elevated C-reactive protein level Anterior uveitis Recurrent infections Decreased antibody level in blood Pancytopenia Pericardial effusion Rheumatoid arthritis IgG deficiency Pulmonary infiltrates Immune dysregulation Stomatitis Recurrent aphthous stomatitis Histiocytosis Hemophagocytosis Pericarditis Falls Hypotrichosis Erythroderma Dry skin Eczema Skin ulcer Abnormality of the nail Hypopigmented skin patches Psoriasiform dermatitis Irregular hyperpigmentation Visual loss Abnormal eyelid morphology Poikiloderma Abnormality of bone marrow cell morphology T-cell lymphoma Abnormal lymphocyte morphology Cutaneous T-cell lymphoma Visual impairment Intermediate uveitis


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