Edema, and B-cell lymphoma

Diseases related with Edema and B-cell lymphoma

In the following list you will find some of the most common rare diseases related to Edema and B-cell lymphoma that can help you solving undiagnosed cases.


Top matches:

Medium match FOLLICULAR LYMPHOMA


Follicular lymphoma is a form of non-Hodgkin lymphoma (see this term) characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved.

FOLLICULAR LYMPHOMA Is also known as oncogene b-cell leukemia 2

Related symptoms:

  • Neoplasm
  • Fever
  • Fatigue
  • Diarrhea
  • Splenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about FOLLICULAR LYMPHOMA

Medium match NOONAN SYNDROME-LIKE DISORDER WITH JUVENILE MYELOMONOCYTIC LEUKEMIA


Noonan syndrome-like disorder with juvenile myelomonocytic leukemia is a rare, genetic, polymalformative syndrome with increased risk of developing cancer characterized by a Noonan-like phenotype, including typical dysmorphic facial features (i.e. high forehead, hypertelorism, downslanting palpebral fissures, ptosis, low-set ears, prominent philtrum and short neck with or without pterygium colli), thoracic abnormalities, congenital heart defects and short stature, associated with a very frequent ocurrence of juvenile myelomonocytic leukemia. Developmental delay, ectodermal anomalies, joint laxity, and hypotonia may also be associated.

NOONAN SYNDROME-LIKE DISORDER WITH JUVENILE MYELOMONOCYTIC LEUKEMIA Is also known as cbl mutation-associated syndrome|noonan syndrome-like disorder with jmml|cbl syndrome

Related symptoms:

  • Global developmental delay
  • Short stature
  • Generalized hypotonia
  • Microcephaly
  • Growth delay


SOURCES: ORPHANET OMIM MENDELIAN

More info about NOONAN SYNDROME-LIKE DISORDER WITH JUVENILE MYELOMONOCYTIC LEUKEMIA

Low match EWING SARCOMA


Ewing's sarcoma is a malignant small round cell bone tumor with strong metastatic potential.

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Fever
  • Weight loss


SOURCES: OMIM ORPHANET MENDELIAN

More info about EWING SARCOMA

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Other less relevant matches:

Low match CLASSIC MYCOSIS FUNGOIDES


Classical mycosis fungoides is the most common type of mycosis fungoides (MF; see this term), a form of cutaneous T-cell lymphoma, and is characterized by slow progression from patches to more infiltrated plaques and eventually to tumors.

CLASSIC MYCOSIS FUNGOIDES Is also known as mycosis fungoides, alibert-bazin type

Related symptoms:

  • Hepatomegaly
  • Edema
  • Splenomegaly
  • Alopecia
  • Hyperkeratosis


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about CLASSIC MYCOSIS FUNGOIDES

Low match SÉZARY SYNDROME


Sézary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sézary cells).

SÉZARY SYNDROME Is also known as sÉzary lymphoma

Related symptoms:

  • Neoplasm
  • Abnormal facial shape
  • Peripheral neuropathy
  • Hepatomegaly
  • Fever


SOURCES: MESH ORPHANET MENDELIAN

More info about SÉZARY SYNDROME

Low match HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1


Zur Stadt et al. (2005) summarized the clinical features of hemophagocytic lymphohistiocytosis (HLH), a rare autosomal recessive disorder characterized by massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently central nervous system involvement. In FHL, the familial form of the disease, first episodes occur mostly during infancy, with a rapidly fatal outcome if untreated. Diagnostic criteria also include low fibrinogen and high triglyceride and ferritin levels. Chemoimmunotherapy based on corticosteroids, epipodophyllotoxins, and cyclosporin succeeds in controlling the disease in the majority of patients, although remission is rarely obtained (Henter et al., 2002). Most patients suffer an early death unless they are treated by hematopoietic stem cell transplantation (Durken et al., 1999). Genetic Heterogeneity of Familial Hemophagocytic LymphohistiocytosisFamilial hemophagocytic lymphohistiocytosis exhibits genetic heterogeneity. In some families, familial hemophagocytic lymphohistiocytosis has been found to be linked to chromosome 9q (HPLH1, FHL1). FHL2 (OMIM ) is caused by mutation in the PRF1 gene (OMIM ) on chromosome 10q22; FHL3 (OMIM ) is caused by mutation in the UNC13D gene (OMIM ) on chromosome 17q25; FHL4 (OMIM ) is caused by mutation in the syntaxin-11 gene (STX11 ) on chromosome 6q24; and FHL5 (OMIM ) is caused by mutation in the syntaxin-binding protein-2 (STXBP2 ), which is an interaction partner of STX11, on chromosome 19p13.Furthermore, before the identification of mutations in the RAG1 (OMIM ) and RAG2 (OMIM ) genes, both of which map to 11p, Omenn syndrome (familial reticuloendotheliosis with eosinophilia; {603554}) was not thought to be clearly distinct from other reported cases of hemophagocytic lymphohistiocytosis.

HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1 Is also known as hemophagocytic reticulosis, familial|hlh1|hemophagocytic lymphohistiocytosis, familial|erythrophagocytic lymphohistiocytosis, familial|reticulosis, familial histiocytic|hplh1|fhl|fhlh|hplh|fel

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Ataxia
  • Neoplasm


SOURCES: OMIM MENDELIAN

More info about HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1

Low match LYMPHOPROLIFERATIVE SYNDROME 1; LPFS1


Lymphoproliferative syndrome-1 is an autosomal recessive primary immunodeficiency characterized by onset in early childhood of Epstein-Barr virus (EBV)-associated immune dysregulation, manifest as lymphoma, lymphomatoid granulomatosis, hemophagocytic lymphohistiocytosis, Hodgkin disease, and/or hypogammaglobulinemia. Autoimmune disorders, such as autoimmune hemolytic anemia or renal disease, may also occur. Patients show a high EBV viral load and decreased invariant natural killer T cells. It is unknown whether patients with ITK mutations are intrinsically susceptible to development of lymphoma or dysgammaglobulinemia in the absence of EBV infection (summary by Stepensky et al., 2011; Linka et al., 2012).For a discussion of genetic heterogeneity of lymphoproliferative syndrome, see XLP1 (OMIM ).

Related symptoms:

  • Anemia
  • Hepatomegaly
  • Fever
  • Splenomegaly
  • Immunodeficiency


SOURCES: OMIM MESH MENDELIAN

More info about LYMPHOPROLIFERATIVE SYNDROME 1; LPFS1

Low match BURULI ULCER, SUSCEPTIBILITY TO


Buruli ulcer is an infectious disease prevalent in many tropical and subtropical regions caused by infection with Mycobacterium ulcerans. It is the third most frequent mycobacterial disease in humans worldwide, after tuberculosis (OMIM ) and leprosy (OMIM ). Lesions are most common on exposed parts of the body, especially the limbs. Buruli ulcer derives its name from a county in Uganda, East Africa, north of Kampala, where the disease was found in the late 1950s in hundreds of people living near marshes and riverine areas near the Nile River (Clancey et al., 1961; Barker, 1971). The disease was first described in the medical literature in 1948 in a report on patients in Australia (MacCallum et al., 1948). Patients have also been reported from tropical areas in Latin America and Asia (Stienstra et al., 2006; van der Werf et al., 2005).

BURULI ULCER, SUSCEPTIBILITY TO Is also known as mycobacterium ulcerans, susceptibility to

Related symptoms:

  • Edema


SOURCES: OMIM MENDELIAN

More info about BURULI ULCER, SUSCEPTIBILITY TO

Low match NON-HODGKIN LYMPHOMA


Non-Hodgkin malignant lymphomas(NHL) is a heterogeneous group of malignant tumors of the lymphoid system.

NON-HODGKIN LYMPHOMA Is also known as nhl|non-hodgkin lymphoma

Related symptoms:

  • Neoplasm
  • Leukemia
  • Lymphoma
  • Hodgkin lymphoma
  • B-cell lymphoma


SOURCES: ORPHANET OMIM MENDELIAN

More info about NON-HODGKIN LYMPHOMA

Low match KAPOSI SARCOMA


Kaposi sarcoma (KS) is a rare human herpes virus 8 (HHV-8)-induced endothelial inflammatory neoplasm that develops is various clinically distinct settings, manifesting mostly as cutaneous lesions, or mucosal or visceral involvement.

KAPOSI SARCOMA Is also known as multiple idiopathic pigmented hemangiosarcoma, susceptibility to

Related symptoms:

  • Neoplasm
  • Hypertension
  • Fever
  • Fatigue
  • Edema


SOURCES: OMIM ORPHANET MENDELIAN

More info about KAPOSI SARCOMA

Top 5 symptoms//phenotypes associated to Edema and B-cell lymphoma

Symptoms // Phenotype % cases
Lymphoma Very Common - Between 80% and 100% cases
Neoplasm Common - Between 50% and 80% cases
Fever Common - Between 50% and 80% cases
Splenomegaly Common - Between 50% and 80% cases
Lymphadenopathy Common - Between 50% and 80% cases
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Other less frequent symptoms

Patients with Edema and B-cell lymphoma. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Leukemia Pleural effusion Skin rash T-cell lymphoma Immunodeficiency Hepatosplenomegaly Hepatomegaly Weight loss Lymphedema Neoplasm of the skin Anemia Thrombocytopenia

Rare Symptoms - Less than 30% cases


Hypotrichosis Encephalopathy Hemophagocytosis Histiocytosis Cellular immunodeficiency Alopecia Meningitis Ascites Pancytopenia Hemolytic anemia Abnormality of the liver Abnormality of the spleen Recurrent infections Dry skin Cutaneous T-cell lymphoma Pneumonia Skin plaque Fatigue Irregular hyperpigmentation Pruritus Erythroderma Diarrhea Sarcoma Abnormal lymphocyte morphology Pulmonary infiltrates Failure to thrive Generalized hypotonia Global developmental delay Lymphoproliferative disorder Hodgkin lymphoma Abnormal facial shape Skin nodule Muscular hypotonia Generalized lymphadenopathy Chronic lymphatic leukemia Hypertension Gangrene Ectropion Non-Hodgkin lymphoma Abnormality of the pleura Thickened skin Lichenification Abnormality of the face Seizures Abnormal immunoglobulin level Nail dystrophy Ataxia Hypertonia Jaundice Elevated hepatic transaminase Abnormality of the nervous system Irritability Dysgammaglobulinemia Confusion Palmoplantar keratoderma Pericardial effusion Susceptibility to herpesvirus Hypermelanotic macule Erythema Abnormality of the gastrointestinal tract Macule Abnormal retinal morphology Eczema Skin ulcer Abnormality of the nail Hypopigmented skin patches Psoriasiform dermatitis Hemangioma Tremor Abnormal lung morphology Abnormal eyelid morphology Poikiloderma Abnormality of bone marrow cell morphology Pulmonary arterial hypertension Gastrointestinal hemorrhage Papule Peripheral neuropathy Skeletal muscle atrophy Hepatic failure Sepsis Coma Increased VLDL cholesterol concentration Prolonged partial thromboplastin time Generalized edema Decreased HDL cholesterol concentration Prolonged prothrombin time Venous insufficiency IgG deficiency Increased LDL cholesterol concentration Partial albinism Increased total bilirubin Granulocytopenia Hypofibrinogenemia Acute leukemia CSF pleocytosis Polyneuritis Abnormality of the lower limb Plasmacytosis Lipogranulomatosis Abnormal natural killer cell physiology Autoimmune hemolytic anemia Autoimmunity Decreased antibody level in blood Lymphopenia Hypoproteinemia Increased serum ferritin Tetraplegia Eosinophilia Elevated erythrocyte sedimentation rate Gliosis Peripheral demyelination Granulomatosis Hypertriglyceridemia Aspiration Hyperbilirubinemia Purpura Leukopenia Increased intracranial pressure Encephalitis Increased CSF protein Hypoalbuminemia Hemiplegia Recurrent aphthous stomatitis Stomatitis Albinism Abnormality of the coagulation cascade Combined immunodeficiency Increased antibody level in blood Episodic fever Severe combined immunodeficiency Immune dysregulation Hyponatremia Paraplegia Hyperkeratosis Joint laxity Atrial septal defect Myopathy Long philtrum Abnormality of cardiovascular system morphology Pectus excavatum Inguinal hernia Posteriorly rotated ears Prominent forehead Polyhydramnios Gastroesophageal reflux High forehead Macrotia Low-set, posteriorly rotated ears Respiratory distress Feeding difficulties in infancy Postnatal growth retardation Sparse hair Pectus carinatum Broad forehead Hypermetropia Pulmonic stenosis Abnormality of the foot Astigmatism Joint hypermobility Falls Bruising susceptibility Thick vermilion border Cardiomyopathy Short neck Triangular face Strabismus Respiratory tract infection Nausea Neutropenia Insulin resistance Glucose intolerance Night sweats Mediastinal lymphadenopathy Abnormality of the peritoneum Short stature Microcephaly Growth delay Hypertelorism Cryptorchidism Anteverted nares Ptosis Low-set ears Cognitive impairment Feeding difficulties Delayed speech and language development Depressed nasal bridge Motor delay Epicanthus Macrocephaly Optic atrophy Downslanted palpebral fissures Gait disturbance Frontal bossing Highly arched eyebrow Abnormal bleeding Neoplasm of the peripheral nervous system Reduced prothrombin activity Hypochromic microcytic anemia Chylothorax Prominent fingertip pads Broad toe Monocytosis Pulmonary lymphangiectasia Arteritis Abnormality of the mediastinum Reduced factor IX activity Hypoplasia of olfactory tract Reduced factor XII activity Juvenile myelomonocytic leukemia Reduced factor X activity Hydrocele testis Abnormality of the subarachnoid space Pain Paralysis Leukocytosis Myeloid leukemia Neuroblastoma Acute lymphoblastic leukemia Meningioma Chronic myelogenous leukemia Burkitt lymphoma Primitive neuroectodermal tumor Ewing sarcoma Peripheral neuroepithelioma Short attention span Facial hypotonia Webbed neck Bilateral single transverse palmar creases Esotropia Wide intermamillary distance Hip dysplasia Cyanosis Epistaxis Low posterior hairline Fine hair Mitral regurgitation Hyperpigmentation of the skin Cafe-au-lait spot Hydrops fetalis Aortic valve stenosis Vasculitis Abnormal eyebrow morphology Torticollis Bicuspid aortic valve Deep philtrum Poor suck Cholelithiasis Failure to thrive in infancy Bilateral ptosis Abnormality of the thorax Cubitus valgus Overfolded helix Proximal placement of thumb Decreased muscle mass Neurodevelopmental delay Neoplasm by anatomical site



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