Dysarthria, and Migraine

Diseases related with Dysarthria and Migraine

In the following list you will find some of the most common rare diseases related to Dysarthria and Migraine that can help you solving undiagnosed cases.


Top matches:

Medium match BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 5; IBGC5


Idiopathic basal ganglia calcification-5 (IBGC5) is an autosomal dominant disorder characterized by progressive neurologic symptoms that are associated with brain calcifications mainly affecting the basal ganglia. Calcifications may also occur in the thalamus, cerebellum, or white matter. Affected individuals have motor symptoms, such as dyskinesias or parkinsonism, headache, cognitive impairment, and psychiatric manifestations, including apathy and depression. Some patients are asymptomatic. The age at symptom onset ranges from late childhood to adulthood; the disorder is progressive (summary by Keller et al., 2013).For a detailed phenotypic description and a discussion of genetic heterogeneity of IBGC, see IBGC1 (OMIM ).

Related symptoms:

  • Cognitive impairment
  • Dysarthria
  • Gait disturbance
  • Dystonia
  • Headache


SOURCES: OMIM MENDELIAN

More info about BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 5; IBGC5

Medium match ALTERNATING HEMIPLEGIA OF CHILDHOOD 2; AHC2


Alternating hemiplegia of childhood is a rare syndrome characterized by infantile onset of episodic hemi-or quadriplegia. Most cases are accompanied by dystonic posturing, choreoathetoid movements, abnormal ocular movements, developmental delay, and progressive cognitive impairment (summary by Heinzen et al., 2012).For discussion of genetic heterogeneity of alternating hemiplegia of childhood, see AHC1 (OMIM ).

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Ataxia


SOURCES: OMIM MENDELIAN

More info about ALTERNATING HEMIPLEGIA OF CHILDHOOD 2; AHC2

Medium match PAROXYSMAL DYSTONIC CHOREATHETOSIS WITH EPISODIC ATAXIA AND SPASTICITY


Dystonia-9 is an autosomal dominant neurologic disorder characterized by childhood onset of paroxysmal choreoathetosis and progressive spastic paraplegia. Most show some degree of cognitive impairment. Other variable features may include seizures, migraine headaches, and ataxia (summary by Weber et al., 2011).

PAROXYSMAL DYSTONIC CHOREATHETOSIS WITH EPISODIC ATAXIA AND SPASTICITY Is also known as dyt9|cse choreoathetosis, paroxysmal, with episodic ataxia|episodic choreoathetosis/spasticity|choreoathetosis, kinesigenic, with episodic ataxia and spasticity|choreoathetosis/spasticity, episodic

Related symptoms:

  • Intellectual disability
  • Seizures
  • Ataxia
  • Spasticity
  • Cognitive impairment


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about PAROXYSMAL DYSTONIC CHOREATHETOSIS WITH EPISODIC ATAXIA AND SPASTICITY

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Other less relevant matches:

Medium match TREMOR, HEREDITARY ESSENTIAL, 1; ETM1


Essential tremor may be the most common human movement disorder. The main feature of essential tremor is postural tremor of the arms, but the head, legs, trunk, voice, jaw, and facial muscles also may be involved. Aggravated by emotions, hunger, fatigue, and temperature extremes, the condition may cause a functional disability or even incapacitation. Autosomal dominant inheritance can be demonstrated in most families (summary by Higgins et al., 1997).Deng et al. (2007) provided a detailed review of the genetics of essential tremor. Genetic Heterogeneity of Essential TremorOther forms of hereditary essential tremor include ETM2 (OMIM ), mapped to chromosome 2p25-p22; ETM3 (OMIM ), mapped to chromosome 6p23; ETM4 (OMIM ), caused by mutation in the FUS gene (OMIM ) on chromosome 16p11; and ETM5 (OMIM ), caused by mutation in the TENM4 gene (OMIM ) on chromosome 11q14.

TREMOR, HEREDITARY ESSENTIAL, 1; ETM1 Is also known as fet1|tremor, familial essential, 1

Related symptoms:

  • Hearing impairment
  • Ataxia
  • Cognitive impairment
  • Dysarthria
  • Fever


SOURCES: OMIM MENDELIAN

More info about TREMOR, HEREDITARY ESSENTIAL, 1; ETM1

Medium match FAMILIAL PAROXYSMAL ATAXIA


Episodic ataxia type 2 (EA2) is the most frequent form of Hereditary episodic ataxia (EA; see this term) characterized by paroxysmal episodes of ataxia lasting hours, with interictal nystagmus and mildly progressive ataxia.

FAMILIAL PAROXYSMAL ATAXIA Is also known as episodic ataxia type 2

Related symptoms:

  • Intellectual disability
  • Ataxia
  • Nystagmus
  • Dysarthria
  • Behavioral abnormality


SOURCES: ORPHANET MENDELIAN

More info about FAMILIAL PAROXYSMAL ATAXIA

Medium match MIGRAINE, FAMILIAL HEMIPLEGIC, 2; FHM2


MIGRAINE, FAMILIAL HEMIPLEGIC, 2; FHM2 Is also known as mhp2

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Hearing impairment
  • Ataxia


SOURCES: OMIM MENDELIAN

More info about MIGRAINE, FAMILIAL HEMIPLEGIC, 2; FHM2

Medium match PAROXYSMAL NON-KINESIGENIC DYSKINESIA


Paroxysmal non-kinesigenic dyskinesia (PNKD) is a form of paroxysmal dyskinesia (see this term), characterized by attacks of dystonic or choreathetotic movements precipitated by stress, fatigue, coffee or alcohol intake or menstruation.

PAROXYSMAL NON-KINESIGENIC DYSKINESIA Is also known as paroxysmal dystonic choreoathetosis|choreoathetosis, nonkinesigenic|pdc|dystonia 8|paroxystic non-kinesigenic choreoathetosis|dyt8|choreoathetosis, familial paroxysmal|mount-reback syndrome|fpd1

Related symptoms:

  • Seizures
  • Ataxia
  • Spasticity
  • Dysarthria
  • Fatigue


SOURCES: OMIM ORPHANET MENDELIAN

More info about PAROXYSMAL NON-KINESIGENIC DYSKINESIA

Medium match EPISODIC ATAXIA, TYPE 6; EA6


Related symptoms:

  • Seizures
  • Generalized hypotonia
  • Ataxia
  • Nystagmus
  • Motor delay


SOURCES: OMIM MENDELIAN

More info about EPISODIC ATAXIA, TYPE 6; EA6

Medium match PAROXYSMAL EXERTION-INDUCED DYSKINESIA


Paroxysmal exertion-induced dyskinesia (PED) is a form of paroxysmal dyskinesia (see this term), characterized by painless attacks of dystonia of the extremities triggered by prolonged physical activities.

PAROXYSMAL EXERTION-INDUCED DYSKINESIA Is also known as ped with or without epilepsy and/or hemolytic anemia|paroxysmal exertion-induced dystonia with or without epilepsy and/or hemolytic anemia|dyt18|dystonia 18|ped|paroxysmal exercise-induced dyskinesia with or without epilepsy and/or hemolytic anemia

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Microcephaly


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about PAROXYSMAL EXERTION-INDUCED DYSKINESIA

Medium match SPINOCEREBELLAR ATAXIA TYPE 36


Spinocerebellar ataxia type 36 (SCA36) is a subtype of autosomal dominant cerebellar ataxia type 1 (ADCA type 1; see this term) characterized by gait and limb ataxia, lower limb spasticity, dysarthria, muscle fasiculations, tongue atrophy and hyperreflexia.

SPINOCEREBELLAR ATAXIA TYPE 36 Is also known as sca36|asidan

Related symptoms:

  • Hearing impairment
  • Ataxia
  • Nystagmus
  • Spasticity
  • Ptosis


SOURCES: OMIM ORPHANET MENDELIAN

More info about SPINOCEREBELLAR ATAXIA TYPE 36

Top 5 symptoms//phenotypes associated to Dysarthria and Migraine

Symptoms // Phenotype % cases
Ataxia Very Common - Between 80% and 100% cases
Dystonia Common - Between 50% and 80% cases
Headache Common - Between 50% and 80% cases
Nystagmus Common - Between 50% and 80% cases
Seizures Common - Between 50% and 80% cases
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Other less frequent symptoms

Patients with Dysarthria and Migraine. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Cognitive impairment Intellectual disability Hemiplegia Vertigo Diplopia Episodic ataxia Abnormality of movement Spasticity Choreoathetosis Chorea Gait ataxia Parkinsonism Dyskinesia Depressivity Gait disturbance Hemiparesis Hearing impairment Fatigue Hand tremor Paroxysmal dyskinesia Involuntary movements Paresthesia Hyperreflexia Dysphagia Tremor Dysmetria Anxiety Generalized tonic-clonic seizures Rigidity Mental deterioration Global developmental delay Generalized hypotonia

Rare Symptoms - Less than 30% cases


Nausea Photophobia Paroxysmal choreoathetosis Fever Phonophobia Cerebral atrophy Blurred vision Intellectual disability, moderate Lower limb spasticity Cerebellar vermis atrophy Limb ataxia Head tremor Intellectual disability, mild Behavioral abnormality Torticollis Cerebellar atrophy Vomiting Intention tremor Tinnitus Migraine without aura Truncal ataxia Babinski sign Abnormality of eye movement Slurred speech Spastic paraplegia Loss of consciousness Paroxysmal dystonia Myoclonus Generalized-onset seizure Dementia Paraplegia Focal impaired awareness seizure Absence seizures Horizontal nystagmus Urinary urgency Progressive microcephaly Irritability Aggressive behavior Hypometric saccades Microcephaly Muscle weakness Frequent falls Specific learning disability Focal-onset seizure Hemolytic anemia Anemia EEG abnormality Falls Impulsivity Gaze-evoked nystagmus Tetraparesis Atonic seizures Attention deficit hyperactivity disorder Loss of Purkinje cells in the cerebellar vermis Tongue atrophy Olivopontocerebellar atrophy Tongue fasciculations Slow saccadic eye movements Impaired smooth pursuit Bowel incontinence Amyotrophic lateral sclerosis Dysdiadochokinesis Incoordination Progressive hearing impairment Fasciculations Neuronal loss in central nervous system Neurodegeneration Difficulty walking Hyperactive deep tendon reflexes Hypertonia Skeletal muscle atrophy Peripheral neuropathy Ptosis Generalized tonic-clonic seizures without focal onset Hypoglycorrhachia Upper limb dysmetria Focal aware seizure Jerky head movements Limb dysmetria Abnormality of the head Torsion dystonia Action tremor Reticulocytosis Cerebellar hypoplasia Personality disorder Motor delay Progressive spastic paraparesis Nausea and vomiting Kinetic tremor Apathy Resting tremor Personality changes Postural tremor Abnormality of extrapyramidal motor function Memory impairment Hypoglycemia Athetosis Basal ganglia calcification Motor tics Morphological abnormality of the pyramidal tract Edema Progressive spastic paraplegia Brisk reflexes Spastic paraparesis Paraparesis Clonus Dehydration Postural instability Abnormality of the eye Abnormal pyramidal sign Episodic quadriplegia Tetraplegia Abnormal autonomic nervous system physiology Delayed speech and language development Blindness Staring gaze Borderline personality disorder Kernicterus Facial grimacing Myokymia Trismus Encephalitis Hyperkinesis Generalized muscle weakness Neurological speech impairment Joint stiffness Dyspnea Transient unilateral blurring of vision Status epilepticus Migraine with aura Psychosis Drowsiness Restlessness Severe hearing impairment Dysphasia Aphasia Apraxia Abnormal cerebellum morphology Coma Confusion Stroke Autistic behavior Developmental regression Limb myoclonus



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