Dysarthria, and Cough

Diseases related with Dysarthria and Cough

In the following list you will find some of the most common rare diseases related to Dysarthria and Cough that can help you solving undiagnosed cases.

Top matches:

Charcot-Marie-Tooth disease type 2Y is an autosomal dominant peripheral neuropathy characterized by distal muscle weakness and atrophy associated with length-dependent sensory loss. Most patients have involvement of both the lower and upper limbs. The age at onset and the severity of the disorder are highly variable (summary by Gonzalez et al., 2014).For a phenotypic description and a discussion of genetic heterogeneity of axonal CMT, see CMT2A1 (OMIM ).

AUTOSOMAL DOMINANT CHARCOT-MARIE-TOOTH DISEASE TYPE 2Y Is also known as charcot-marie-tooth disease, axonal, autosomal dominant, type 2y|cmt2y|autosomal dominant charcot-marie-tooth disease type 2 due to vcp mutation|cmt2 due to vcp mutation|charcot-marie-tooth neuropathy, type 2y

Related symptoms:

  • Muscle weakness
  • Peripheral neuropathy
  • Dysarthria
  • Skeletal muscle atrophy
  • Behavioral abnormality


SOURCES: ORPHANET OMIM MENDELIAN

More info about AUTOSOMAL DOMINANT CHARCOT-MARIE-TOOTH DISEASE TYPE 2Y

CLASSIC PANTOTHENATE KINASE-ASSOCIATED NEURODEGENERATION Is also known as neurodegeneration with brain iron accumulation type 1, classic form|nbia1, classic form|pkan, classic form

Related symptoms:

  • Seizures
  • Global developmental delay
  • Spasticity
  • Cognitive impairment
  • Hyperreflexia


SOURCES: ORPHANET MENDELIAN

More info about CLASSIC PANTOTHENATE KINASE-ASSOCIATED NEURODEGENERATION

Classical progressive supranuclear palsy, also known as Richardson's syndrome, is the most common clinical variant of progressive supranuclear palsy (PSP; see this term), a rare late-onset neurodegenerative disease characterized by postural instability, progressive rigidity, supranuclear gaze palsy and mild dementia.

CLASSIC PROGRESSIVE SUPRANUCLEAR PALSY SYNDROME Is also known as psp|steele-richardson-olszewski disease|steele-richardson-olszewski syndrome|classic psp syndrome|richardson syndrome

Related symptoms:

  • Seizures
  • Cognitive impairment
  • Hyperreflexia
  • Dysarthria
  • Tremor


SOURCES: OMIM ORPHANET MENDELIAN

More info about CLASSIC PROGRESSIVE SUPRANUCLEAR PALSY SYNDROME

Other less relevant matches:

Autosomal recessive spastic paraplegia type 18 (SPG18) is a rare, complex type of hereditary spastic paraplegia characterized by progressive spastic paraplegia (presenting in early childhood) associated with delayed motor development, severe intellectual disability and joint contractures. A thin corpus callosum is equally noted on brain magnetic resonance imaging. SPG18 is caused by a mutation in the ERLIN2 gene (8p11.2) encoding the protein, Erlin-2.

AUTOSOMAL RECESSIVE SPASTIC PARAPLEGIA TYPE 18 Is also known as spg18|intellectual disability, motor dysfunction, and joint contractures|idmdc

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Scoliosis
  • Strabismus


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about AUTOSOMAL RECESSIVE SPASTIC PARAPLEGIA TYPE 18

Arnold-Chiari malformation type I is a central nervous system malformation characterized by caudal displacement of the cerebellar tonsils exceeding 5mm below the foramen magnum with or without syringomyelia. Symptoms vary in onset and severity and include suboccipital headache, neck pain, vertigo, tinnitus, ocular symptoms (diplopia, blurred vision, photofobia, nystagmus), lower cranial nerve signs, cerebellar ataxia, and spasticity. Some affected individuals can be asymptomatic.

ARNOLD-CHIARI MALFORMATION TYPE I Is also known as cm1|arnold-chiari malformation type 1|chiari malformation type 1|chiari malformation type i

Related symptoms:

  • Hearing impairment
  • Scoliosis
  • Ataxia
  • Nystagmus
  • Muscle weakness


SOURCES: OMIM ORPHANET MENDELIAN

More info about ARNOLD-CHIARI MALFORMATION TYPE I

Juvenile Huntington disease (JHD) is a form of Huntington disease (HD; see this term), characterized by onset of signs and symptoms before 20 years of age.

JUVENILE HUNTINGTON DISEASE Is also known as huntington chorea|jhd|juvenile huntington chorea

Related symptoms:

  • Seizures
  • Ataxia
  • Cognitive impairment
  • Anemia
  • Delayed speech and language development


SOURCES: OMIM ORPHANET MENDELIAN

More info about JUVENILE HUNTINGTON DISEASE

In decreasing order of frequency, 3 forms of Alexander disease are recognized, based on age of onset: infantile, juvenile, and adult. Younger patients typically present with seizures, megalencephaly, developmental delay, and spasticity. In older patients, bulbar or pseudobulbar symptoms predominate, frequently accompanied by spasticity. The disease is progressive, with most patients dying within 10 years of onset. Imaging studies of the brain typically show cerebral white matter abnormalities, preferentially affecting the frontal region (Gorospe et al., 2002). All 3 forms have been shown to be caused by mutations in the GFAP gene.

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Scoliosis
  • Ataxia


SOURCES: ORPHANET OMIM MENDELIAN

More info about ALEXANDER DISEASE; ALXDRD

Tourette syndrome is a neurobehavioral disorder manifest particularly by motor and vocal tics and associated with behavioral abnormalities. Tics are sudden, brief, intermittent, involuntary or semi-voluntary movements (motor tics) or sounds (phonic or vocal tics). They typically consist of simple, coordinated, repetitive movements, gestures, or utterances that mimic fragments of normal behavior. Motor tics may range from simple blinking, nose twitching, and head jerking to more complex throwing, hitting, or making rude gestures. Phonic tics include sniffling, throat clearing, blowing, coughing, echolalia, or coprolalia. Males are affected about 3 times more often than females, and onset usually occurs between 3 and 8 years of age. By age 18 years, more than half of affected individuals are free of tics, but they may persist into adulthood (review by Jankovic, 2001).

GILLES DE LA TOURETTE SYNDROME; GTS Is also known as ts|tourette syndrome|tourette disorder

Related symptoms:

  • Behavioral abnormality
  • Depressivity
  • Pectus excavatum
  • Myoclonus
  • Hyperactivity


SOURCES: MESH OMIM MENDELIAN

More info about GILLES DE LA TOURETTE SYNDROME; GTS

Familial acute necrotizing encephalopathy or ADANE is a potentially fatal neurological disease characterised by neuropathological lesions principally involving the brainstem, thalamus and putamen.

FAMILIAL ACUTE NECROTIZING ENCEPHALOPATHY Is also known as adane|recurrent acute necrotizing encephalopathy|ane|encephalopathy, acute necrotizing, susceptibility to

Related symptoms:

  • Intellectual disability
  • Seizures
  • Generalized hypotonia
  • Ataxia
  • Spasticity


SOURCES: OMIM ORPHANET MENDELIAN

More info about FAMILIAL ACUTE NECROTIZING ENCEPHALOPATHY

Low match LASSA FEVER

Lassa fever (LF) is a potentially severe viral hemorrhagic disease caused by Lassa virus and characterized by initial fever and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock and multi-organ system failure.

LASSA FEVER Is also known as lassa hemorrhagic fever|lf

Related symptoms:

  • Seizures
  • Hearing impairment
  • Fever
  • Fatigue
  • Diarrhea


SOURCES: MESH ORPHANET MENDELIAN

More info about LASSA FEVER

Top 5 symptoms//phenotypes associated to Dysarthria and Cough

Symptoms // Phenotype % cases
Seizures Common - Between 50% and 80% cases
Gait disturbance Common - Between 50% and 80% cases
Hyperreflexia Common - Between 50% and 80% cases
Spasticity Uncommon - Between 30% and 50% cases
Dysphagia Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Dysarthria and Cough. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Muscle weakness Ataxia Behavioral abnormality Dementia Cognitive impairment Gliosis Global developmental delay Muscle fibrillation Babinski sign Weight loss Tremor Frequent falls Myoclonus Diplopia Intellectual disability Scoliosis Hypertonia Abnormality of eye movement Toe walking Rigidity Depressivity Falls

Rare Symptoms - Less than 30% cases

Broad-based gait Akinesia Progressive cerebellar ataxia Migraine Abnormality of movement Tics Arnold-Chiari malformation Increased intracranial pressure Vomiting Aphasia Slurred speech Oral-pharyngeal dysphagia Vertigo Arthralgia Clumsiness Sensory impairment Neuronal loss in central nervous system Brain atrophy Difficulty walking Fever Postural instability Neurodegeneration Neuronal loss in basal ganglia Dyspnea Abnormal pyramidal sign Abnormality of the cerebral white matter Encephalitis Self-injurious behavior Tetraplegia Sleep disturbance Hearing impairment Clonus Lower limb spasticity Skeletal muscle atrophy Increased CSF protein Nystagmus Irritability Nausea and vomiting Neurological speech impairment Headache Kyphosis Aggressive behavior Motor delay High palate Hyperhidrosis Gait ataxia Pes cavus Diarrhea Bradykinesia Muscle stiffness Involuntary movements Limb muscle weakness Mental deterioration Chorea Lower limb muscle weakness Unsteady gait Paresthesia Hyperactivity Aspiration pneumonia Diabetes mellitus Obsessive-compulsive behavior Gait imbalance Incoordination Hyperkinesis Attention deficit hyperactivity disorder Abnormal posturing Distal muscle weakness Pneumonia Hypertension Hyperlordosis Dystonia Photophobia Respiratory failure Anxiety Abnormality of the nervous system Bronchitis Peripheral demyelination Amenorrhea Developmental regression Dysmetria Generalized-onset seizure Progressive neurologic deterioration Hypokinesia Type II diabetes mellitus Personality changes Rheumatoid arthritis Sudden cardiac death Schizophrenia Hypotension Frequent temper tantrums Cerebellar vermis atrophy Respiratory insufficiency Leukodystrophy Oral motor hypotonia Growth delay Suicidal ideation Failure to thrive Muscular hypotonia Ptosis Feeding difficulties Abnormal involuntary eye movements Macrocephaly Mania Frontal bossing Short neck Hydrocephalus Restlessness Paranoia Testicular atrophy Hyporeflexia Constipation Dilated fourth ventricle Agenesis of corpus callosum Chronic bronchitis Hypothyroidism Osteopenia Head tremor EEG abnormality Upper limb undergrowth Facial palsy Cerebral calcification Diffuse demyelination of the cerebral white matter Abnormal autonomic nervous system physiology Severe vision loss Polyneuritis Necrotizing encephalopathy Abnormal muscle tone Acute encephalopathy Abducens palsy Cerebral edema Foot dorsiflexor weakness Fatigue Hallucinations Spastic tetraplegia Coma Polyneuropathy Pallor Encephalopathy Visual impairment Acute necrotizing encephalopathy Thrombocytopenia Hair-pulling Conjunctivitis Menometrorrhagia Recurrent pharyngitis Cardiorespiratory arrest Palpebral edema Pleural effusion Leukopenia Spontaneous abortion Abdominal pain Subcutaneous nodule Gastrointestinal hemorrhage Chest pain Lymphadenopathy Lethargy Skin rash Myalgia Generalized hypotonia Phonic tics Leukoencephalopathy Drowsiness Hypersomnia Aqueductal stenosis Bulbar signs Hypothermia Megalencephaly Poor coordination Atrophy/Degeneration affecting the brainstem Pseudobulbar signs Progressive spasticity Bowel incontinence Dysphasia Emotional lability Precocious puberty Dysphonia Sleep apnea Large face Progressive macrocephaly Jerky head movements Echolalia Motor tics Stuttering Restless legs Facial grimacing Alcoholism Disinhibition Dyslexia Self-mutilation Recurrent singultus Impulsivity Stereotypy Autistic behavior Autism Pectus excavatum Microcoria Hyperpigmented nevi Abnormal cerebellum morphology Arnold-Chiari type I malformation Infertility Frontotemporal dementia Syncope Memory impairment Apraxia Aspiration Mutism Eosinophilia Apathy Postural tremor Stridor Alzheimer disease Blurred vision Neurofibrillary tangles Limb dystonia Hypoventilation Supranuclear gaze palsy Stroke Granulovacuolar degeneration Severe global developmental delay Absent speech Hypoplasia of the corpus callosum Flexion contracture Strabismus Frontolimbic dementia Eyelid apraxia Central apnea Frontal release signs Retrocollis Abnormal saccadic eye movements Vertical supranuclear gaze palsy Axial dystonia Parkinsonism with favorable response to dopaminergic medication Parkinsonism Apnea Paraplegia Absent Achilles reflex Areflexia Elevated serum creatine phosphokinase Proximal muscle weakness Abnormality of the foot Peripheral axonal neuropathy Distal amyotrophy Distal sensory impairment Sensorimotor neuropathy Scapular winging Hammertoe Amyotrophic lateral sclerosis Abnormal joint morphology Impaired vibration sensation in the lower limbs Myositis Abnormality of peripheral nerve conduction Cerebral atrophy Increased susceptibility to fractures Iron accumulation in brain Eye of the tiger anomaly of globus pallidus Abnormality of the tongue Generalized dystonia Opisthotonus Mask-like facies Optic disc pallor Poor fine motor coordination Pigmentary retinopathy Inability to walk Rod-cone dystrophy Blindness Abnormality of hand joint mobility Abnormal nerve conduction velocity Spastic paraplegia Febrile seizures Arthritis Distal peripheral sensory neuropathy Dysesthesia Stiff neck Central sleep apnea Basilar impression Cervical C2/C3 vertebral fusion Cranial nerve compression Hyperacusis Horner syndrome Recurrent paroxysmal headache Neck pain Basilar invagination Small posterior fossa Adult onset sensorineural hearing impairment Brain stem compression Fatigable weakness of swallowing muscles Fused cervical vertebrae Abnormality of the twelfth cranial nerve Cerebellar atrophy Ventriculomegaly Delayed speech and language development Anemia Functional abnormality of the inner ear Abnormality of the eleventh cranial nerve Abnormality of the clivus Areflexia of upper limbs Flat posterior fossa Small flat posterior fossa Abnormality of the musculature of the lower limbs Anteriorly placed odontoid process Abnormality of the vestibulocochlear nerve Enlarged sagittal diameter of the cervical canal Myelopathy Vocal cord paralysis Elbow flexion contracture Difficulty in tongue movements Knee flexion contracture Delayed gross motor development Language impairment Ankle clonus Progressive spastic paraplegia Delayed ability to walk Hip contracture Ankle contracture Limb hypertonia Upper motor neuron dysfunction Upper limb spasticity Pseudobulbar paralysis Wrist flexion contracture Flexion contracture of toe Narrow maxilla Peripheral neuropathy Spastic gait Syringomyelia Lower limb hyperreflexia Urinary urgency Tinnitus Cranial nerve paralysis Fasciculations Urinary incontinence Flexion contracture of finger Nausea Dilatation Pain Parietal hypometabolism in FDG PET Abnormality of jaw muscles Glabellar reflex Chemosis


If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Rod-cone dystrophy and Micropenis, related diseases and genetic alterations