Dysarthria, and Anxiety

Diseases related with Dysarthria and Anxiety

In the following list you will find some of the most common rare diseases related to Dysarthria and Anxiety that can help you solving undiagnosed cases.

Top matches:

Myoclonic dystonia-26 is an autosomal dominant neurologic disorder characterized by onset of myoclonic jerks affecting the upper limbs in the first or second decade of life. The disorder is progressive, and patients later develop dystonia with predominant involvement of the craniocervical regions and sometimes the trunk and/or lower limbs. Dystonia dominates the clinical picture (summary by Mencacci et al., 2015).

Related symptoms:

  • Dysarthria
  • Tremor
  • Dystonia
  • Depressivity
  • Myoclonus


SOURCES: OMIM MENDELIAN

More info about DYSTONIA 26, MYOCLONIC; DYT26

CHOREA, BENIGN HEREDITARY; BHC Is also known as hereditary progressive chorea without dementia|bch

Related symptoms:

  • Ataxia
  • Cognitive impairment
  • Motor delay
  • Dysarthria
  • Gait disturbance


SOURCES: OMIM MENDELIAN

More info about CHOREA, BENIGN HEREDITARY; BHC

Idiopathic basal ganglia calcification-5 (IBGC5) is an autosomal dominant disorder characterized by progressive neurologic symptoms that are associated with brain calcifications mainly affecting the basal ganglia. Calcifications may also occur in the thalamus, cerebellum, or white matter. Affected individuals have motor symptoms, such as dyskinesias or parkinsonism, headache, cognitive impairment, and psychiatric manifestations, including apathy and depression. Some patients are asymptomatic. The age at symptom onset ranges from late childhood to adulthood; the disorder is progressive (summary by Keller et al., 2013).For a detailed phenotypic description and a discussion of genetic heterogeneity of IBGC, see IBGC1 (OMIM ).

Related symptoms:

  • Cognitive impairment
  • Dysarthria
  • Gait disturbance
  • Dystonia
  • Headache


SOURCES: OMIM MENDELIAN

More info about BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 5; IBGC5

Other less relevant matches:

SCA48 is an autosomal dominant neurodegenerative disorder characterized by onset of gait ataxia and/or cognitive-affective symptoms in mid-adulthood. Patients may present with involvement of either system, but most eventually develop impairment in both. Features include gait ataxia, dysarthria, and dysphagia, as well as anxiety and deficits in executive function. Brain imaging shows selective atrophy of the posterior areas of the cerebellar vermis (summary by Genis et al., 2018).

Related symptoms:

  • Ataxia
  • Dysarthria
  • Dysphagia
  • Cerebellar atrophy
  • Gait ataxia


SOURCES: OMIM MENDELIAN

More info about SPINOCEREBELLAR ATAXIA 48; SCA48

Alternating hemiplegia of childhood is a rare syndrome characterized by infantile onset of episodic hemi-or quadriplegia. Most cases are accompanied by dystonic posturing, choreoathetoid movements, abnormal ocular movements, developmental delay, and progressive cognitive impairment (summary by Heinzen et al., 2012).For discussion of genetic heterogeneity of alternating hemiplegia of childhood, see AHC1 (OMIM ).

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Ataxia


SOURCES: OMIM MENDELIAN

More info about ALTERNATING HEMIPLEGIA OF CHILDHOOD 2; AHC2

Familial dyskinesia and facial myokymia is a rare paroxysmal movement disorder, with childhood or adolescent onset, characterized by paroxysmal choreiform, dystonic, and myoclonic movements involving the limbs (mostly distal upper limbs), neck and/or face, which can progressively increase in both frequency and severity until they become nearly constant. Patients may also present with delayed motor milestones, perioral and periorbital dyskinesias, dysarthria, hypotonia, and weakness.

FAMILIAL DYSKINESIA AND FACIAL MYOKYMIA Is also known as fdfm

Related symptoms:

  • Intellectual disability
  • Generalized hypotonia
  • Motor delay
  • Hyperreflexia
  • Dysarthria


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about FAMILIAL DYSKINESIA AND FACIAL MYOKYMIA

Essential tremor may be the most common human movement disorder. The main feature of essential tremor is postural tremor of the arms, but the head, legs, trunk, voice, jaw, and facial muscles also may be involved. Aggravated by emotions, hunger, fatigue, and temperature extremes, the condition may cause a functional disability or even incapacitation. Autosomal dominant inheritance can be demonstrated in most families (summary by Higgins et al., 1997).Deng et al. (2007) provided a detailed review of the genetics of essential tremor. Genetic Heterogeneity of Essential TremorOther forms of hereditary essential tremor include ETM2 (OMIM ), mapped to chromosome 2p25-p22; ETM3 (OMIM ), mapped to chromosome 6p23; ETM4 (OMIM ), caused by mutation in the FUS gene (OMIM ) on chromosome 16p11; and ETM5 (OMIM ), caused by mutation in the TENM4 gene (OMIM ) on chromosome 11q14.

TREMOR, HEREDITARY ESSENTIAL, 1; ETM1 Is also known as fet1|tremor, familial essential, 1

Related symptoms:

  • Hearing impairment
  • Ataxia
  • Cognitive impairment
  • Dysarthria
  • Fever


SOURCES: OMIM MENDELIAN

More info about TREMOR, HEREDITARY ESSENTIAL, 1; ETM1

Related symptoms:

  • Ataxia
  • Dysarthria
  • Gait disturbance
  • Cerebral atrophy
  • Depressivity


SOURCES: MESH OMIM MENDELIAN

More info about SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES

Related symptoms:

  • Ataxia
  • Peripheral neuropathy
  • Hyperreflexia
  • Dysarthria
  • Tremor


SOURCES: OMIM MENDELIAN

More info about SPINOCEREBELLAR ATAXIA 12; SCA12

Huntington disease-like 2 (HDL2) is a severe neurodegenerative disorder considered part of the neuroacanthocytosis syndromes (see this term) characterized by a triad of movement, psychiatric, and cognitive abnormalities.

HUNTINGTON DISEASE-LIKE 2 Is also known as hdl2

Related symptoms:

  • Seizures
  • Ataxia
  • Hyperreflexia
  • Dysarthria
  • Gait disturbance


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about HUNTINGTON DISEASE-LIKE 2

Top 5 symptoms//phenotypes associated to Dysarthria and Anxiety

Symptoms // Phenotype % cases
Dystonia Common - Between 50% and 80% cases
Ataxia Common - Between 50% and 80% cases
Depressivity Common - Between 50% and 80% cases
Dementia Uncommon - Between 30% and 50% cases
Abnormality of movement Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Dysarthria and Anxiety. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Gait disturbance Parkinsonism Chorea Cognitive impairment Mental deterioration Tremor Migraine Apathy Rigidity Hyperreflexia Personality changes Delusions Memory impairment Head tremor Myoclonus

Rare Symptoms - Less than 30% cases

Urinary incontinence Choreoathetosis Seizures Generalized hypotonia Cerebral cortical atrophy Abnormality of the eye Neuronal loss in central nervous system Hallucinations Cerebral atrophy Neurodegeneration Involuntary movements Resting tremor Myokymia Facial myokymia Abnormality of extrapyramidal motor function Intellectual disability Abnormality of eye movement Dysmetria Axial dystonia Motor delay Dyskinesia Headache Behavioral abnormality Cerebellar atrophy Action tremor Gait ataxia Postural tremor Falls Hand tremor Acanthocytosis Kinetic tremor Irritability Encephalopathy Aggressive behavior Abnormal cerebellum morphology Gliosis Stereotypy Mutism Abnormal corpus striatum morphology Violent behavior Progressive cerebellar ataxia Dysdiadochokinesis Primitive reflex Spinocerebellar tract degeneration Peripheral neuropathy Limb tremor Hyperorality Caudate atrophy Paranoia Auditory hallucinations Functional motor deficit Weight loss Bowel incontinence Impulsivity Sensorimotor neuropathy Bradykinesia Episodic quadriplegia Hypoglycemia Psychosis Nystagmus Global developmental delay Agoraphobia Dysphagia Motor tics Basal ganglia calcification Athetosis Vertigo Tetraplegia Astrocytosis Asthma Laryngeal dystonia Generalized dystonia Blepharospasm Dysphonia Torticollis Generalized tonic-clonic seizures Generalized-onset seizure Fatigue Muscular hypotonia of the trunk Fever Hearing impairment Paroxysmal dyskinesia Orofacial dyskinesia Limb hypertonia Delayed gross motor development Dilated cardiomyopathy Difficulty walking Status epilepticus Hypertonia Congestive heart failure Cardiomyopathy Loss of consciousness Hemiplegia Abnormal autonomic nervous system physiology Hemiparesis Tetraparesis Abnormality of the cerebrum


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