Congestive heart failure, and Mental deterioration

Diseases related with Congestive heart failure and Mental deterioration

In the following list you will find some of the most common rare diseases related to Congestive heart failure and Mental deterioration that can help you solving undiagnosed cases.

Top matches:

Combined oxidative phosphorylation deficiency-23 is an autosomal recessive disorder characterized by early childhood onset of hypertrophic cardiomyopathy and/or neurologic symptoms, including hypotonia and delayed psychomotor development. Laboratory investigations are consistent with a defect in mitochondrial function resulting in lactic acidosis, impaired activities of respiratory complexes I and IV, and defective translation of mitochondrial proteins. Brain imaging shows abnormal lesions in the basal ganglia, thalamus, and brainstem. The severity of the disorder is variable, ranging from death in early infancy to survival into the second decade (summary by Kopajtich et al., 2014).For a discussion of genetic heterogeneity of combined oxidative phosphorylation deficiency, see COXPD1 (OMIM ).

COMBINED OXIDATIVE PHOSPHORYLATION DEFECT TYPE 23 Is also known as coxpd23

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Cognitive impairment


SOURCES: ORPHANET OMIM MENDELIAN

More info about COMBINED OXIDATIVE PHOSPHORYLATION DEFECT TYPE 23

Related symptoms:

  • Cardiomyopathy
  • Congestive heart failure
  • Dementia
  • Dilated cardiomyopathy
  • Syncope


SOURCES: OMIM MESH MENDELIAN

More info about CARDIOMYOPATHY, DILATED, 1U; CMD1U

Related symptoms:

  • Cardiomyopathy
  • Congestive heart failure
  • Dementia
  • Dilated cardiomyopathy
  • Syncope


SOURCES: OMIM MESH MENDELIAN

More info about CARDIOMYOPATHY, DILATED, 1V; CMD1V

Other less relevant matches:

Spinocerebellar ataxia type 7 (SCA7), currently the only known form of autosomal dominant cerebellar ataxia type 2 (ADCA2; see this term), is a neurodegenerative disorder characterized by progressive ataxia, motor system abnormalities, dysarthria, dysphagia and retinal degeneration leading to progressive blindness.

SPINOCEREBELLAR ATAXIA TYPE 7 Is also known as ataxia with pigmentary retinopathy|sca7|cerebellar syndrome-pigmentary maculopathy syndrome

Related symptoms:

  • Global developmental delay
  • Ataxia
  • Nystagmus
  • Failure to thrive
  • Muscle weakness


SOURCES: ORPHANET MENDELIAN

More info about SPINOCEREBELLAR ATAXIA TYPE 7

Maternally inherited cardiomyopathy and hearing loss is a mitochondrial disease described in two unrelated families to date that has a heterogeneous clinical presentation characterized by the association of progressive sensorineural hearing loss with hypertrophic cardiomyopathy and, in the majority of cases, encephalomyopathy symptoms such as ataxia, slurred speech, progressive external opthalmoparesis (PEO), muscle weakness, myalgia, and exercise intolerance.

MITOCHONDRIAL DNA-RELATED CARDIOMYOPATHY AND HEARING LOSS Is also known as mtdna-related cardiomyopathy and hearing loss|trna-lys-related cardiomyopathy-hearing loss syndrome|maternally-inherited cardiomyopathy and deafness

Related symptoms:

  • Ataxia
  • Sensorineural hearing impairment
  • Muscle weakness
  • Hypertension
  • Peripheral neuropathy


SOURCES: ORPHANET MENDELIAN

More info about MITOCHONDRIAL DNA-RELATED CARDIOMYOPATHY AND HEARING LOSS

Aceruloplasminemia is an adult-onset disorder of neurodegeneration with brain iron accumulation (NBIA; see this term) characterized by anemia, retinal degeneration, diabetes and various neurological symptoms.

ACERULOPLASMINEMIA Is also known as hereditary ceruloplasmin deficiency

Related symptoms:

  • Ataxia
  • Spasticity
  • Cognitive impairment
  • Anemia
  • Delayed speech and language development


SOURCES: OMIM ORPHANET MENDELIAN

More info about ACERULOPLASMINEMIA

Glycogen storage disease due to LAMP-2 (Lysosomal-Associated Membrane Protein 2) deficiency is a lysosomal glycogen storage disease characterised by severe cardiomyopathy and variable degrees of muscle weakness, frequently associated with intellectual deficit.

GLYCOGEN STORAGE DISEASE DUE TO LAMP-2 DEFICIENCY Is also known as vacuolar cardiomyopathy and myopathy, x-linked|antopol disease|gsd due to lamp-2 deficiency|lysosomal glycogen storage disease without acid maltase deficiency, formerly|glycogenosis due to lamp-2 deficiency|gsd2b, formerly|gsd iib, formerly|glycogen stora

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Muscle weakness
  • Pain
  • Cognitive impairment


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about GLYCOGEN STORAGE DISEASE DUE TO LAMP-2 DEFICIENCY

McLeod neuroacanthocytosis syndrome (MLS) is a form of neuroacanthocytosis (see this term) and is characterized clinically by a Huntington's disease-like phenotype with an involuntary hyperkinetic movement disorder, psychiatric manifestations and cognitive alterations, and biochemically by absence of the Kx antigen and by weak expression of the Kell antigens.

MCLEOD NEUROACANTHOCYTOSIS SYNDROME Is also known as mls|x-linked mcleod syndrome

Related symptoms:

  • Seizures
  • Short stature
  • Muscle weakness
  • Cognitive impairment
  • Anemia


SOURCES: ORPHANET OMIM MENDELIAN

More info about MCLEOD NEUROACANTHOCYTOSIS SYNDROME

Myotonic dystrophy (DM) is a multisystem disorder and the most common form of muscular dystrophy in adults. Individuals with DM2 have muscle pain and stiffness, progressive muscle weakness, myotonia, male hypogonadism, cardiac arrhythmias, diabetes, and early cataracts. Other features may include cognitive dysfunction, hypersomnia, tremor, and hearing loss (summary by Heatwole et al., 2011).See also myotonic dystrophy-1 (DM1 ), caused by an expanded CTG repeat in the dystrophia myotonica protein kinase gene (DMPK ) on 19q13.Although originally reported as 2 disorders, myotonic dystrophy-2 and proximal myotonic myopathy are now referred to collectively as DM2 (Udd et al., 2003).

MYOTONIC DYSTROPHY 2; DM2 Is also known as promm|proximal myotonic myopathy|dystrophia myotonica 2|myotonic myopathy, proximal|ricker syndrome

Related symptoms:

  • Intellectual disability
  • Hearing impairment
  • Muscle weakness
  • Pain
  • Cataract


SOURCES: ORPHANET OMIM MENDELIAN

More info about MYOTONIC DYSTROPHY 2; DM2

Top 5 symptoms//phenotypes associated to Congestive heart failure and Mental deterioration

Symptoms // Phenotype % cases
Cognitive impairment Common - Between 50% and 80% cases
Dilated cardiomyopathy Common - Between 50% and 80% cases
Cardiomyopathy Common - Between 50% and 80% cases
Dementia Uncommon - Between 30% and 50% cases
Muscle weakness Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Congestive heart failure and Mental deterioration. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Ataxia Gait disturbance Dysphagia Dysarthria Arrhythmia Hypertension Chorea Rigidity Babinski sign Depressivity Confusion Cerebral atrophy Myopathy Elevated serum creatine phosphokinase Skeletal muscle atrophy Intellectual disability Fatigue Hypertrophic cardiomyopathy Global developmental delay

Rare Symptoms - Less than 30% cases

Hyperreflexia Hepatomegaly Visual loss Reduced visual acuity Pain Diabetes mellitus Seizures Psychosis Cone/cone-rod dystrophy Ophthalmoparesis Orofacial dyskinesia Lower limb muscle weakness Peripheral neuropathy Involuntary movements Myocardial fibrosis Myalgia Chest pain Memory impairment Exercise intolerance Parkinsonism Slurred speech Spasticity Feeding difficulties Anemia Tremor Respiratory distress Hypertonia Behavioral abnormality Dystonia Dyspnea Visual impairment Respiratory insufficiency due to muscle weakness Increased serum lactate Insomnia Syncope Left ventricular hypertrophy Palpitations Limb muscle weakness Emotional lability Respiratory insufficiency Neuronal loss in central nervous system Personality changes Ventricular arrhythmia Atrial fibrillation Proximal muscle weakness Cardiac arrest Generalized-onset seizure Myofibrillar myopathy Increased cerebral lipofuscin Hallucinations Sensorimotor neuropathy Skeletal myopathy Obsessive-compulsive behavior Ventricular fibrillation Wolff-Parkinson-White syndrome Sensory axonal neuropathy Reduced ejection fraction Abnormality of the gastrointestinal tract Cardiorespiratory arrest Sleep apnea Hemolytic anemia Sensory neuropathy Exercise-induced muscle cramps Insulin insensitivity Macular hypopigmentation Glycogen accumulation in muscle fiber lysosomes Left ventricular systolic dysfunction Myocardial necrosis Ventricular preexcitation Impaired myocardial contractility Splenomegaly Areflexia Hyperhidrosis Dyskinesia Hepatosplenomegaly Retinal pigment epithelial mottling Elevated hepatic transaminase Muscle flaccidity Autophagic vacuoles Anxiety Abnormality of the cerebral white matter Abnormality of movement Paresthesia Suicidal ideation Short stature Motor axonal neuropathy Bowel incontinence Leukoencephalopathy Ptosis Hypogonadism Distal muscle weakness Muscular dystrophy Infertility Tachycardia Sudden cardiac death Decreased antibody level in blood Progressive muscle weakness Spontaneous abortion Hypercholesterolemia Myotonia Hearing impairment Epiphora Increased variability in muscle fiber diameter Neurofibrillary tangles Type 2 muscle fiber atrophy IgG deficiency Hypersomnia Oligospermia Male hypogonadism Arteriosclerosis Neck flexor weakness IgM deficiency Elevated circulating follicle stimulating hormone level Cataract Abnormality of the astrocytes Rhabdomyolysis Increased muscle fatiguability Impaired vibration sensation in the lower limbs Impaired pain sensation Restlessness Bipolar affective disorder Ventricular extrasystoles Left bundle branch block Supraventricular tachycardia Acanthocytosis Tics Excessive salivation Hyporeflexia of lower limbs Abnormal retinal morphology Hyporeflexia of upper limbs Diffuse leukoencephalopathy Personality disorder Generalized limb muscle atrophy Impaired temperature sensation Abnormal social behavior Abnormal lactate dehydrogenase activity Caudate atrophy Abnormal corpus striatum morphology Recurrent singultus Blood group antigen abnormality Frontal balding Abnormal facial expression Hypokinesia Decreased serum ceruloplasmin Generalized amyotrophy Dysmetria Semantic dementia Nystagmus Failure to thrive Motor delay Blindness Cerebellar atrophy Photophobia Neonatal hypotonia Ophthalmoplegia Sensory impairment Perseveration Macular degeneration Dysdiadochokinesis Restless legs Hemeralopia Abnormal fundus morphology Sensorineural hearing impairment Intellectual disability, severe Abnormality of cardiovascular system morphology Encephalopathy Febrile seizures Bulimia Primitive reflex Ragged-red muscle fibers Edema Generalized hypotonia Intrauterine growth retardation Acidosis Feeding difficulties in infancy Lactic acidosis Abnormality of the cardiovascular system Myocardial infarction Bundle branch block Abnormal EKG Cerebral cortical atrophy Disinhibition Aggressive behavior Stereotypy Apathy Amyotrophic lateral sclerosis Agitation Global brain atrophy Frontotemporal dementia Abnormal lower motor neuron morphology Supranuclear gaze palsy Pulmonary edema EMG abnormality Multiple lipomas Neurodevelopmental delay Distal amyotrophy Decreased serum iron Aceruloplasminemia Myopia Pes cavus Hyperactivity Abnormality of the eye Abnormality of the liver Scarring Retinopathy Distal sensory impairment Refractory anemia Progressive visual loss Pigmentary retinopathy Cardiomegaly Ventricular hypertrophy Decreased liver function Hyperlipidemia Ventricular tachycardia EMG: myopathic abnormalities Abnormal electroretinogram Back pain Elevated hepatic iron concentration Scanning speech Progressive sensorineural hearing impairment Retinal degeneration Progressive external ophthalmoplegia Mild global developmental delay Lower limb pain Increased serum pyruvate Increased adipose tissue Delayed speech and language development Gait ataxia Hypothyroidism Difficulty walking Poor speech Cirrhosis Cogwheel rigidity Neurodegeneration Abnormality of extrapyramidal motor function Type I diabetes mellitus Torticollis Cerebral palsy Hyperkinesis Polyuria Muscle fibrillation Increased serum ferritin Blepharospasm Iridescent posterior subcapsular cataract


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