Congestive heart failure, and Dementia

Diseases related with Congestive heart failure and Dementia

In the following list you will find some of the most common rare diseases related to Congestive heart failure and Dementia that can help you solving undiagnosed cases.


Top matches:

Medium match CARDIOMYOPATHY, DILATED, 1U; CMD1U


Related symptoms:

  • Cardiomyopathy
  • Congestive heart failure
  • Dementia
  • Dilated cardiomyopathy
  • Syncope


SOURCES: OMIM MESH MENDELIAN

More info about CARDIOMYOPATHY, DILATED, 1U; CMD1U

Medium match CARDIOMYOPATHY, DILATED, 1V; CMD1V


Related symptoms:

  • Cardiomyopathy
  • Congestive heart failure
  • Dementia
  • Dilated cardiomyopathy
  • Syncope


SOURCES: OMIM MESH MENDELIAN

More info about CARDIOMYOPATHY, DILATED, 1V; CMD1V

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Other less relevant matches:

Medium match ACERULOPLASMINEMIA


Aceruloplasminemia is an adult-onset disorder of neurodegeneration with brain iron accumulation (NBIA; see this term) characterized by anemia, retinal degeneration, diabetes and various neurological symptoms.

ACERULOPLASMINEMIA Is also known as hereditary ceruloplasmin deficiency

Related symptoms:

  • Ataxia
  • Spasticity
  • Cognitive impairment
  • Anemia
  • Delayed speech and language development


SOURCES: OMIM ORPHANET MENDELIAN

More info about ACERULOPLASMINEMIA

Medium match MCLEOD NEUROACANTHOCYTOSIS SYNDROME


McLeod neuroacanthocytosis syndrome (MLS) is a form of neuroacanthocytosis (see this term) and is characterized clinically by a Huntington's disease-like phenotype with an involuntary hyperkinetic movement disorder, psychiatric manifestations and cognitive alterations, and biochemically by absence of the Kx antigen and by weak expression of the Kell antigens.

MCLEOD NEUROACANTHOCYTOSIS SYNDROME Is also known as mls|x-linked mcleod syndrome

Related symptoms:

  • Seizures
  • Short stature
  • Muscle weakness
  • Cognitive impairment
  • Anemia


SOURCES: ORPHANET OMIM MENDELIAN

More info about MCLEOD NEUROACANTHOCYTOSIS SYNDROME

Medium match COMBINED OXIDATIVE PHOSPHORYLATION DEFECT TYPE 23


Combined oxidative phosphorylation deficiency-23 is an autosomal recessive disorder characterized by early childhood onset of hypertrophic cardiomyopathy and/or neurologic symptoms, including hypotonia and delayed psychomotor development. Laboratory investigations are consistent with a defect in mitochondrial function resulting in lactic acidosis, impaired activities of respiratory complexes I and IV, and defective translation of mitochondrial proteins. Brain imaging shows abnormal lesions in the basal ganglia, thalamus, and brainstem. The severity of the disorder is variable, ranging from death in early infancy to survival into the second decade (summary by Kopajtich et al., 2014).For a discussion of genetic heterogeneity of combined oxidative phosphorylation deficiency, see COXPD1 (OMIM ).

COMBINED OXIDATIVE PHOSPHORYLATION DEFECT TYPE 23 Is also known as coxpd23

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Cognitive impairment


SOURCES: ORPHANET OMIM MENDELIAN

More info about COMBINED OXIDATIVE PHOSPHORYLATION DEFECT TYPE 23

Medium match INCLUSION BODY MYOPATHY WITH PAGET DISEASE OF BONE AND FRONTOTEMPORAL DEMENTIA


Inclusion body myopathy with Paget disease of bone and frontotemporal dementia (IBMPFD) is a multisystem degenerative genetic disorder characterized by adult-onset proximal and distal muscle weakness (clinically resembling limb-girdle muscular dystrophy; see this term); early-onset Paget disease of bone (see this term), manifesting with bone pain, deformity and enlargement of the long-bones; and premature frontotemporal dementia (see this term), manifesting first with dysnomia, dyscalculia and comprehension deficits followed by progressive aphasia, alexia, and agraphia. As the disease progresses, muscle weakness begins to affect the other limbs and respiratory muscles, ultimately resulting in respiratory or cardiac failure.

INCLUSION BODY MYOPATHY WITH PAGET DISEASE OF BONE AND FRONTOTEMPORAL DEMENTIA Is also known as pagetoid neuroskeletal syndrome|msp1|pagetoid amyotrophic lateral sclerosis|multisystem proteinopathy 1|muscular dystrophy, limb-girdle, with paget disease of bone|limb-girdle muscular dystrophy with paget disease of bone|ibmpfd|lower motor neuron degener

Related symptoms:

  • Intellectual disability
  • Short stature
  • Muscle weakness
  • Cataract
  • Skeletal muscle atrophy


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about INCLUSION BODY MYOPATHY WITH PAGET DISEASE OF BONE AND FRONTOTEMPORAL DEMENTIA

Medium match ATTRV30M AMYLOIDOSIS


Familial amyloid polyneuropathy (FAP) or transthyretin (TTR) amyloid polyneuropathy is a progressive sensorimotor and autonomic neuropathy of adulthood onset. Weight loss and cardiac involvement are frequent; ocular or renal complications may also occur.

ATTRV30M AMYLOIDOSIS Is also known as familial amyloid polyneuropathy type i|ttr amyloid neuropathy|attrv30m-related amyloidosis|hereditary amyloidosis, transthyretin-related|transthyretin amyloid polyneuropathy|familial amyloid polyneuropathy, portuguese-swedish-japanese type|fap|amyloid pol

Related symptoms:

  • Seizures
  • Hearing impairment
  • Ataxia
  • Nystagmus
  • Sensorineural hearing impairment


SOURCES: OMIM ORPHANET MENDELIAN

More info about ATTRV30M AMYLOIDOSIS

Medium match ISOLATED SUCCINATE-COQ REDUCTASE DEFICIENCY


Mitochondrial complex II deficiency is an autosomal recessive disorder with a highly variable phenotype. Some patients have multisystem involvement of the brain, heart, muscle, liver, and kidneys resulting in death in infancy, whereas others have only isolated cardiac or muscle involvement with onset in adulthood and normal cognition. Measurement of complex II activity in muscle is the most reliable means of diagnosis; however, there is no clear correlation between residual complex II activity and severity or clinical outcome. In some cases, treatment with riboflavin may have clinical benefit (summary by Jain-Ghai et al., 2013).

ISOLATED SUCCINATE-COQ REDUCTASE DEFICIENCY Is also known as isolated succinate-ubiquinone reductase deficiency|isolated succinate-coenzyme q reductase deficiency|isolated mitochondrial respiratory chain complex ii deficiency|succinate coq reductase deficiency

Related symptoms:

  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia
  • Microcephaly


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about ISOLATED SUCCINATE-COQ REDUCTASE DEFICIENCY

Medium match MERRF


MERRF (Myoclonic Epilepsy with Ragged Red Fibers) syndrome is a mitochondrial encephalomyopathy characterized by myoclonic seizures.

MERRF Is also known as fukuhara syndrome|myoclonus epilepsy associated with ragged-red fibres|merrf syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Hearing impairment


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about MERRF

Top 5 symptoms//phenotypes associated to Congestive heart failure and Dementia

Symptoms // Phenotype % cases
Cardiomyopathy Common - Between 50% and 80% cases
Cognitive impairment Common - Between 50% and 80% cases
Muscle weakness Uncommon - Between 30% and 50% cases
Arrhythmia Uncommon - Between 30% and 50% cases
Seizures Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Congestive heart failure and Dementia. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Ataxia Spasticity Myopathy Dystonia Neuronal loss in central nervous system Short stature Dysarthria Dilated cardiomyopathy Hypertrophic cardiomyopathy Peripheral neuropathy Elevated serum creatine phosphokinase Sensory axonal neuropathy Depressivity Behavioral abnormality Hypertonia Tremor Motor axonal neuropathy Skeletal muscle atrophy Global developmental delay Visual impairment Acidosis Intellectual disability Lactic acidosis Chorea Gait disturbance Dysphagia Increased serum lactate Rigidity Babinski sign

Rare Symptoms - Less than 30% cases


Fatty replacement of skeletal muscle Mental deterioration Left ventricular hypertrophy Generalized-onset seizure Sensory neuropathy Paresthesia Abnormality of movement Abnormality of the cerebral white matter Dyspnea Sensorineural hearing impairment Aphasia Areflexia Vomiting Hearing impairment Proximal muscle weakness Respiratory failure Hallucinations EMG: myopathic abnormalities Optic atrophy Ventricular extrasystoles Myoclonus Developmental regression Ophthalmoplegia Generalized myoclonic seizures Migraine Facial palsy Exercise intolerance Ragged-red muscle fibers Generalized hypotonia External ophthalmoplegia Rhabdomyolysis Hepatic steatosis Ptosis Diarrhea Stroke-like episode Supraventricular tachycardia Nystagmus Insomnia Involuntary movements Amyotrophic lateral sclerosis Frontotemporal dementia Cerebral cortical atrophy Cerebral atrophy Edema Semantic dementia Anemia Fatigue Respiratory insufficiency Personality changes Confusion Parkinsonism Memory impairment Emotional lability Hyperkinesis Syncope Muscle fibrillation Fever Lacticaciduria Decreased number of peripheral myelinated nerve fibers Amyloidosis Global systolic dysfunction Syringomyelia Increased CSF protein Restrictive cardiomyopathy Multiple myeloma Hydrocephalus Constrictive median neuropathy Myelopathy Abnormal renal physiology Malabsorption Renal insufficiency Sensory ataxia Urinary retention Psychomotor deterioration Orthostatic hypotension due to autonomic dysfunction Vitreous floaters EEG with photoparoxysmal response Diffuse cerebellar atrophy Cytochrome C oxidase-negative muscle fibers Pain Cardiac amyloidosis Amyloid deposition in the vitreous humor Microcephaly Sinus tachycardia Orthostatic hypotension Malnutrition Axonal degeneration Peripheral demyelination Arthritis Weakness of facial musculature Peripheral axonal neuropathy Nephropathy Polyneuropathy Coma Weight loss Constipation Gliosis Urinary incontinence Abnormality of thalamus morphology Hypotension Bilateral sensorineural hearing impairment Paraplegia Cardiomegaly Hemiparesis Vasculitis Abnormal autonomic nervous system physiology Paraparesis Spastic paraparesis Hyporeflexia EEG with irregular generalized spike and wave complexes Cachexia Rheumatoid arthritis Cerebral hemorrhage Impotence Headache Atrioventricular block Status epilepticus Growth delay Ophthalmoparesis Mitochondrial myopathy Left ventricular noncompaction Lipoma Hyperthyroidism Paraganglioma Multiple lipomas Hemolytic-uremic syndrome Increased intramyocellular lipid droplets Mildly elevated creatine phosphokinase Progressive leukoencephalopathy Right bundle branch block Decreased activity of mitochondrial complex II Abnormal mitochondria in muscle tissue Left ventricular systolic dysfunction Stress/infection-induced lactic acidosis Ketosis Abnormality of mitochondrial metabolism Delayed gross motor development Muscular hypotonia Ventricular tachycardia Hypoplasia of the corpus callosum EMG abnormality Palpitations Hypogonadism EEG abnormality Abnormality of the liver Neurological speech impairment Generalized tonic-clonic seizures Hepatic failure Hepatitis Preeclampsia Oral-pharyngeal dysphagia Failure to thrive Retinopathy Abnormality of brainstem morphology Decreased activity of mitochondrial respiratory chain Pulmonary arterial hypertension Increased serum pyruvate Flexion contracture Motor delay Hyperreflexia Abnormal echocardiogram Blindness Absent speech Portal fibrosis Neonatal hypotonia Right ventricular cardiomyopathy Respiratory tract infection Gait imbalance Easy fatigability Tetraplegia Generalized muscle weakness Wolff-Parkinson-White syndrome Pigmentary retinopathy Spastic tetraplegia Mitral regurgitation Increased CSF lactate Leukodystrophy Congenital hip dislocation Abnormality of the endocrine system Leukoencephalopathy Diffuse cerebral atrophy Intrahepatic cholestasis Progressive external ophthalmoplegia Ketonuria Limb-girdle muscular dystrophy Weakness of muscles of respiration Hemolytic anemia Cogwheel rigidity Scanning speech Refractory anemia Decreased serum ceruloplasmin Elevated hepatic iron concentration Decreased serum iron Aceruloplasminemia Hepatomegaly Splenomegaly Hyperhidrosis Hepatosplenomegaly Elevated hepatic transaminase Anxiety Lower limb muscle weakness Dyskinesia Increased serum ferritin Impaired vibration sensation in the lower limbs Tics Acanthocytosis Left bundle branch block Bipolar affective disorder Restlessness Impaired pain sensation Bowel incontinence Atrial fibrillation Ventricular fibrillation Obsessive-compulsive behavior Ventricular arrhythmia Sleep apnea Cardiac arrest Sensorimotor neuropathy Blepharospasm Polyuria Excessive salivation Respiratory insufficiency due to muscle weakness Pulmonary edema Supranuclear gaze palsy Abnormal lower motor neuron morphology Global brain atrophy Agitation Apathy Stereotypy Primitive reflex Aggressive behavior Myocardial fibrosis Abnormal EKG Bundle branch block Myocardial infarction Abnormality of the cardiovascular system Disinhibition Perseveration Slurred speech Retinal degeneration Cerebral palsy Torticollis Type I diabetes mellitus Abnormality of extrapyramidal motor function Neurodegeneration Cirrhosis Poor speech Bulimia Difficulty walking Hypothyroidism Gait ataxia Diabetes mellitus Respiratory distress Delayed speech and language development Orofacial dyskinesia Hyporeflexia of lower limbs Abnormal motor neuron morphology Pathologic fracture Shoulder girdle muscle weakness EMG: neuropathic changes Progressive proximal muscle weakness Urinary bladder sphincter dysfunction Rimmed vacuoles Abnormality of the vertebral column Difficulty climbing stairs Pelvic girdle muscle weakness Generalized amyotrophy Dysphasia Alzheimer disease Increased variability in muscle fiber diameter Spinal muscular atrophy Language impairment Upper motor neuron dysfunction Hip pain Increased susceptibility to fractures Frontal cortical atrophy Ubiquitin-positive cerebral inclusion bodies Temporal cortical atrophy Pelvic girdle amyotrophy Abnormality of long bone morphology Scapuloperoneal weakness Elevated alkaline phosphatase of bone origin Pelvic girdle muscle atrophy Shoulder girdle muscle atrophy Cranial nerve compression Calvarial hyperostosis Motor neuron atrophy Dyscalculia Abnormality of calvarial morphology EMG: chronic denervation signs Back pain Elevated alkaline phosphatase Increased muscle fatiguability Recurrent singultus Intrauterine growth retardation Feeding difficulties Abnormality of the astrocytes Hyporeflexia of upper limbs Abnormal facial expression Blood group antigen abnormality Abnormal corpus striatum morphology Cataract Caudate atrophy Abnormal lactate dehydrogenase activity Abnormal social behavior Impaired temperature sensation Generalized limb muscle atrophy Personality disorder Feeding difficulties in infancy Ventriculomegaly Abnormality of pelvic girdle bone morphology Lumbar hyperlordosis Mutism Scapular winging Osteolysis Fasciculations Progressive muscle weakness Tetraparesis Waddling gait Dilatation Brain atrophy Distal amyotrophy Limb muscle weakness Muscular dystrophy Distal muscle weakness Hyperlordosis Basal ganglia necrosis



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