Congestive heart failure, and Arthritis

Diseases related with Congestive heart failure and Arthritis

In the following list you will find some of the most common rare diseases related to Congestive heart failure and Arthritis that can help you solving undiagnosed cases.


Top matches:

Low match CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE II


Congenital dyserythropoietic anemia type II (CDA II) is the most common form of CDA (see this term) characterized by anemia, jaundice and splenomegaly and often leading to liver iron overload and gallstones.

CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE II Is also known as dyserythropoietic anemia, congenital, type ii|cda ii|sec23b-cdg|hempas|hereditary erythroblastic multinuclearity with positive acidified-serum test|cda type ii|cda type 2|hereditary erythroblastic multinuclearity with a positive acidified-serum test (hemp

Related symptoms:

  • Anemia
  • Hepatomegaly
  • Congestive heart failure
  • Splenomegaly
  • Arrhythmia


SOURCES: ORPHANET OMIM MENDELIAN

More info about CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE II

Low match MILD SPONDYLOEPIPHYSEAL DYSPLASIA DUE TO COL2A1 MUTATION WITH EARLY-ONSET OSTEOARTHRITIS


Mild spondyloepiphyseal dysplasia due to COL2A1 mutation with early-onset osteoarthritis is a type 2 collagen-related bone disorder characterized by precocious, generalized osteoarthritis (with onset as early as childhood) and mild, dysplastic spinal changes (flattening of vertebrae, irregular endplates and wedge-shaped deformities) resulting in a mildly short trunk.

MILD SPONDYLOEPIPHYSEAL DYSPLASIA DUE TO COL2A1 MUTATION WITH EARLY-ONSET OSTEOARTHRITIS Is also known as namaqualand hip dysplasia|nhd

Related symptoms:

  • Intellectual disability
  • Short stature
  • Pain
  • Congestive heart failure
  • Pneumonia


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about MILD SPONDYLOEPIPHYSEAL DYSPLASIA DUE TO COL2A1 MUTATION WITH EARLY-ONSET OSTEOARTHRITIS

Low match CONGENITAL ATRANSFERRINEMIA


Congenital atransferrinemia is a very rare hematologic disease caused by a transferrin (TF) deficiency and characterized by microcytic, hypochromic anemia (manifesting with pallor, fatigue and growth retardation) and iron overload, and that can be fatal if left untreated.

CONGENITAL ATRANSFERRINEMIA Is also known as hypotransferrinemia, familial|congenital hypotransferrinemia

Related symptoms:

  • Growth delay
  • Anemia
  • Hepatomegaly
  • Fatigue
  • Congestive heart failure


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about CONGENITAL ATRANSFERRINEMIA

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Other less relevant matches:

Low match HEMOCHROMATOSIS TYPE 2


Hemochromatosis type 2 (juvenile) is the early-onset and most severe form of rare hereditary hemochromatosis (HH; see this term), a group of diseases characterized by excessive tissue iron deposition of genetic origin.

HEMOCHROMATOSIS TYPE 2 Is also known as juvenile hemochromatosis

Related symptoms:

  • Muscle weakness
  • Pain
  • Hypertension
  • Hepatomegaly
  • Cardiomyopathy


SOURCES: OMIM ORPHANET MENDELIAN

More info about HEMOCHROMATOSIS TYPE 2

Low match DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS


Diffuse cutaneous systemic sclerosis (dcSSc) is a subtype of Systemic Sclerosis (SSc; see this term) characterized by truncal and acral skin fibrosis with an early and significant incidence of diffuse involvement (interstitial lung disease, oliguric renal failure, diffuse gastrointestinal disease, and myocardial involvement).

DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS Is also known as progressive cutaneous systemic scleroderma|diffuse cutaneous systemic scleroderma|progressive cutaneous systemic sclerosis

Related symptoms:

  • Muscle weakness
  • Pain
  • Flexion contracture
  • Hypertension
  • Dysphagia


SOURCES: ORPHANET MENDELIAN

More info about DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS

Low match WHIM SYNDROME


WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a congenital autosomal dominant immune deficiency characterized by abnormal retention of mature neutrophils in the bone marrow (myelokathexis) and occasional hypogammaglobulinemia, associated with an increased risk for bacterial infections and a susceptibility to human papillomavirus (HPV) induced lesions (cutaneous warts, genital dysplasia and invasive mucosal carcinoma).

WHIM SYNDROME Is also known as warts, hypogammaglobulinemia, infections, and myelokathexis syndrome|warts-infections-leukopenia-myelokatexis syndrome|wilm|warts-hypogammaglobulinemia-infections-myelokathexis syndrome

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Fever
  • Congestive heart failure
  • Immunodeficiency


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about WHIM SYNDROME

Low match HEMOCHROMATOSIS, TYPE 1; HFE1


Hereditary hemochromatosis is an autosomal recessive disorder of iron metabolism wherein the body accumulates excess iron (summary by Feder et al., 1996). Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading. Removal of excess iron by therapeutic phlebotomy decreases morbidity and mortality if instituted early in the course of the disease. Classic hemochromatosis (HFE) is most often caused by mutation in a gene designated HFE on chromosome 6p21.3.Adams and Barton (2007) reviewed the clinical features, pathophysiology, and management of hemochromatosis. Genetic Heterogeneity of HemochromatosisAt least 4 additional iron overload disorders labeled hemochromatosis have been identified on the basis of clinical, biochemical, and genetic characteristics. Juvenile hemochromatosis, or hemochromatosis type 2 (HFE2), is autosomal recessive and is divided into 2 forms: HFE2A (OMIM ), caused by mutation in the HJV gene (OMIM ) on chromosome 1q21, and HFE2B (OMIM ), caused by mutation in the HAMP gene (OMIM ) on chromosome 19q13. Hemochromatosis type 3 (HFE3 ), an autosomal recessive disorder, is caused by mutation in the TFR2 gene (OMIM ) on chromosome 7q22. Hemochromatosis type 4 (HFE4 ), an autosomal dominant disorder, is caused by mutation in the SLC40A1 gene (OMIM ) on chromosome 2q32. Hemochromatosis type 5 (HFE5 ) is caused by mutation in the FTH1 gene (OMIM ) on chromosome 11q12.

HEMOCHROMATOSIS, TYPE 1; HFE1 Is also known as hfe|hemochromatosis, hereditary|hemochromatosis|hh

Related symptoms:

  • Ataxia
  • Neoplasm
  • Pain
  • Anemia
  • Hepatomegaly


SOURCES: ORPHANET OMIM MENDELIAN

More info about HEMOCHROMATOSIS, TYPE 1; HFE1

Low match ATTRV30M AMYLOIDOSIS


Familial amyloid polyneuropathy (FAP) or transthyretin (TTR) amyloid polyneuropathy is a progressive sensorimotor and autonomic neuropathy of adulthood onset. Weight loss and cardiac involvement are frequent; ocular or renal complications may also occur.

ATTRV30M AMYLOIDOSIS Is also known as familial amyloid polyneuropathy type i|ttr amyloid neuropathy|attrv30m-related amyloidosis|hereditary amyloidosis, transthyretin-related|transthyretin amyloid polyneuropathy|familial amyloid polyneuropathy, portuguese-swedish-japanese type|fap|amyloid pol

Related symptoms:

  • Seizures
  • Hearing impairment
  • Ataxia
  • Nystagmus
  • Sensorineural hearing impairment


SOURCES: OMIM ORPHANET MENDELIAN

More info about ATTRV30M AMYLOIDOSIS

Low match COMBINED IMMUNODEFICIENCY DUE TO LRBA DEFICIENCY


Common variable immunodeficiency-8 with autoimmunity is an autosomal recessive disorder of immune dysregulation. Affected individuals have early childhood onset of recurrent infections, particularly respiratory infections, and also develop variable autoimmune disorders, including idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and inflammatory bowel disease. The presentation and phenotype are highly variable, even within families (summary by Lopez-Herrera et al., 2012 and Alangari et al., 2012). Immunologic findings are also variable and may include decreased B cells, hypogammaglobulinemia, and deficiency of CD4+ T regulatory (Treg) cells (Charbonnier et al., 2015).For a general description and a discussion of genetic heterogeneity of common variable immunodeficiency, see CVID1 (OMIM ).

COMBINED IMMUNODEFICIENCY DUE TO LRBA DEFICIENCY Is also known as cid due to lrba deficiency

Related symptoms:

  • Growth delay
  • Neoplasm
  • Failure to thrive
  • Anemia
  • Diarrhea


SOURCES: OMIM ORPHANET MENDELIAN

More info about COMBINED IMMUNODEFICIENCY DUE TO LRBA DEFICIENCY

Low match KAWASAKI DISEASE


Kawasaki disease (KD) is a febrile, systemic, self-limiting vasculitis affecting children and characterized by inflammation in the medium sized vessels associated with coronary arterial aneurysms (CAA) that may be life threatening when untreated. KD is the most common cause of acquired heart disease in children in developed countries and is a risk factor for ischemic heart disease in adulthood.

KAWASAKI DISEASE Is also known as kd|infantile polyarteritis|mucocutaneous lymph node syndrome

Related symptoms:

  • Sensorineural hearing impairment
  • Ptosis
  • Fever
  • Fatigue
  • Edema


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about KAWASAKI DISEASE

Top 5 symptoms//phenotypes associated to Congestive heart failure and Arthritis

Symptoms // Phenotype % cases
Arrhythmia Uncommon - Between 30% and 50% cases
Pain Uncommon - Between 30% and 50% cases
Anemia Uncommon - Between 30% and 50% cases
Cirrhosis Uncommon - Between 30% and 50% cases
Hepatomegaly Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Congestive heart failure and Arthritis. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Diarrhea Abnormality of the liver Splenomegaly Pneumonia Neoplasm Arthralgia Fever Impotence Abdominal pain Cardiomyopathy Muscle weakness Respiratory tract infection Recurrent infections Fatigue Arthropathy Diabetes mellitus

Rare Symptoms - Less than 30% cases


Sensorineural hearing impairment Lymphadenopathy Autoimmunity Migraine Weight loss Constipation Renal insufficiency Vomiting Elevated transferrin saturation Malabsorption Increased serum iron Increased serum ferritin Ataxia Azoospermia Hypogonadotrophic hypogonadism Hyperpigmentation of the skin Amenorrhea Carious teeth Nausea and vomiting Elevated hepatic transaminase Hearing impairment Lymphoma Neutropenia Jaundice Carcinoma Respiratory failure Immunodeficiency Hepatosplenomegaly Interstitial pulmonary abnormality Verrucae Bronchiectasis Meningitis Recurrent upper respiratory tract infections Leukocytosis Combined immunodeficiency Conjunctivitis Telangiectasia Dilated cardiomyopathy Decreased antibody level in blood Vasculitis Hypertension Cardiomegaly Pericarditis Hepatitis Headache Hypothyroidism Restrictive cardiomyopathy Otitis media Osteoporosis Growth delay Hypogonadism Abnormal intestine morphology Multiple myeloma Purpura Increased CSF protein Chronic diarrhea Syringomyelia Abnormal lung morphology Type I diabetes mellitus Decreased number of peripheral myelinated nerve fibers Amyloidosis Clubbing Inflammation of the large intestine Paraparesis Orthostatic hypotension Urinary incontinence Axonal degeneration Aphasia Malnutrition Cerebral hemorrhage Rheumatoid arthritis Spastic paraparesis Atrioventricular block Stroke-like episode Peripheral demyelination Recurrent otitis media Thrombocytopenia Orthostatic hypotension due to autonomic dysfunction Vitreous floaters Cardiac amyloidosis Bilateral sensorineural hearing impairment Hemiparesis Psychomotor deterioration Cachexia Amyloid deposition in the vitreous humor Urinary retention Failure to thrive Recurrent respiratory infections Constrictive median neuropathy Sensory ataxia Hemolytic anemia Asthma Abnormal renal physiology Hypotension Myelopathy Hallucinations Pancytopenia Inflammatory abnormality of the skin Abnormal autonomic nervous system physiology Neuronal loss in central nervous system Gastritis Colitis Cholecystitis Elevated erythrocyte sedimentation rate Abnormal heart valve morphology Acute kidney injury Aortic root aneurysm Tubulointerstitial nephritis Myocarditis Allergy Abnormal myocardium morphology Recurrent pharyngitis Inflammatory abnormality of the eye Elevated C-reactive protein level Cheilitis Synovitis Ascending tubular aorta aneurysm Abnormal oral mucosa morphology Hyponatremia Glossitis Arteritis Abnormal pericardium morphology Conjunctival hyperemia CSF pleocytosis Cervical lymphadenopathy Coronary artery aneurysm Abnormality of nail color Arthralgia/arthritis Pyuria Abnormal emotion/affect behavior Double outlet right ventricle with subpulmonary ventricular septal defect without pulmonary stenosis Strawberry tongue Aseptic leukocyturia Coronary artery atherosclerosis Scaling skin Autoimmune hemolytic anemia Generalized lymphadenopathy Recurrent sinusitis IgA deficiency Fatigable weakness Autoimmune thrombocytopenia Exocrine pancreatic insufficiency Chronic lung disease Clubbing of fingers Villous atrophy Brain neoplasm Cor pulmonale Immune dysregulation IgM deficiency Coma Interstitial pneumonitis Follicular hyperplasia Hypoalbuminemia Hematuria Ischemic stroke Cranial nerve paralysis Decreased liver function Cholestasis Mitral regurgitation Myocardial infarction Skin rash Burkitt lymphoma Erythema Irritability Proteinuria Dilatation Edema Ptosis Gliosis Pleural effusion Polyneuropathy Generalized hyperpigmentation Pallor Scarring Abnormality of the cardiovascular system Microcytic anemia Abnormality of the pancreas Hypochromic microcytic anemia Hypochromic anemia Atransferrinemia Lethargy Delayed puberty Infertility Portal hypertension Congenital hepatic fibrosis Heberden's node Abnormality of iron homeostasis Abnormality of the anterior pituitary Abnormality of endocrine pancreas physiology Flexion contracture Dysphagia Dyspnea Gastroesophageal reflux Abnormality of the skin Pulmonary arterial hypertension Skin ulcer Osteolysis Pulmonary fibrosis Telangiectasia of the skin Schmorl's node Knee osteoarthritis Xerostomia Endopolyploidy on chromosome studies of bone marrow Leukemia Hyperbilirubinemia Cholelithiasis Prolonged neonatal jaundice Reticulocytosis Gout Anemia of inadequate production Chronic myelogenous leukemia Congenital hypoplastic anemia Increased total bilirubin Increased hemoglobin Increased red cell osmotic fragility Reduced activity of N-acetylglucosaminyltransferase II Morphological abnormality of the central nervous system Intellectual disability Short stature Joint stiffness Platyspondyly Joint hypermobility Hip dysplasia Osteoarthritis Pathologic fracture Irregular vertebral endplates Exostoses Beaking of vertebral bodies Hip osteoarthritis Hip pain Scleroderma Pulmonary infiltrates Nephropathy Seizures Osteomalacia Hepatocellular carcinoma Increased reactive oxygen species production Acute hepatic failure Neoplasm of the liver Testicular atrophy Alcoholism Abnormal glucose tolerance Microvesicular hepatic steatosis Cholangiocarcinoma Constrictive pericarditis Aceruloplasminemia Nystagmus Insulin resistance Spasticity Visual impairment Peripheral neuropathy Dysarthria Tremor Hydrocephalus Areflexia Hyporeflexia Dementia Facial palsy Paraplegia Paresthesia Peripheral axonal neuropathy Abnormal joint morphology Hepatic fibrosis Osteolytic defects of the phalanges of the hand B-cell lymphoma Oliguria Dyspareunia Decreased urine output Hypertensive crisis Narrow foramen obturatorium Abnormal bowel sounds Recurrent urinary tract infections Sinusitis Recurrent bacterial infections Osteomyelitis Cellulitis IgG deficiency Periodontitis Atelectasis Ascites Abnormality of female internal genitalia Abnormality of female external genitalia Abnormality of bone marrow cell morphology Folliculitis Septic arthritis Tonsillitis Hypersegmentation of neutrophil nuclei Bone marrow hypercellularity Myelokathexis Alopecia Osteopenia Hepatic failure Hepatic steatosis Abnormal gallbladder morphology



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