Congestive heart failure, and Alzheimer disease

Diseases related with Congestive heart failure and Alzheimer disease

In the following list you will find some of the most common rare diseases related to Congestive heart failure and Alzheimer disease that can help you solving undiagnosed cases.

Top matches:

Inclusion body myopathy with Paget disease of bone and frontotemporal dementia (IBMPFD) is a multisystem degenerative genetic disorder characterized by adult-onset proximal and distal muscle weakness (clinically resembling limb-girdle muscular dystrophy; see this term); early-onset Paget disease of bone (see this term), manifesting with bone pain, deformity and enlargement of the long-bones; and premature frontotemporal dementia (see this term), manifesting first with dysnomia, dyscalculia and comprehension deficits followed by progressive aphasia, alexia, and agraphia. As the disease progresses, muscle weakness begins to affect the other limbs and respiratory muscles, ultimately resulting in respiratory or cardiac failure.

INCLUSION BODY MYOPATHY WITH PAGET DISEASE OF BONE AND FRONTOTEMPORAL DEMENTIA Is also known as pagetoid neuroskeletal syndrome|msp1|pagetoid amyotrophic lateral sclerosis|multisystem proteinopathy 1|muscular dystrophy, limb-girdle, with paget disease of bone|limb-girdle muscular dystrophy with paget disease of bone|ibmpfd|lower motor neuron degener

Related symptoms:

  • Intellectual disability
  • Short stature
  • Muscle weakness
  • Cataract
  • Skeletal muscle atrophy


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about INCLUSION BODY MYOPATHY WITH PAGET DISEASE OF BONE AND FRONTOTEMPORAL DEMENTIA

A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxia and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques, neurofibrillary tangles, and neuropil threads. [HPO:probinson]

ALZHEIMER DISEASE 2; AD2 Is also known as alzheimer disease associated with apoe4|alzheimer disease 2, late-onset

Related symptoms:

  • Hypertension
  • Dementia
  • Diabetes mellitus
  • Stroke
  • Parkinsonism


SOURCES: OMIM MESH MENDELIAN

More info about ALZHEIMER DISEASE 2; AD2

Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D) is a form of HCHWA (see this term), a group of familial central nervous system disorders, characterized by severe cerebral amyloid angiopathy (CAA), hemorrhagic and non-hemorrhagic strokes and dementia.

ABETA AMYLOIDOSIS, DUTCH TYPE Is also known as hchwad|amyloidosis, hereditary, with cerebral hemorrhage, dutch variant|hereditary cerebral hemorrhage with amyloidosis, dutch type|cerebral amyloid angiopathy, app-related, iowa variant|cerebral amyloid angiopathy, app-related, italian variant|hchwa, dut

Related symptoms:

  • Seizures
  • Cognitive impairment
  • Hypertension
  • Behavioral abnormality
  • Headache


SOURCES: ORPHANET OMIM MENDELIAN

More info about ABETA AMYLOIDOSIS, DUTCH TYPE

Other less relevant matches:

Alzheimer's disease with an early onset (starts before the age of 65). It is caused by mutations in the PSEN2 gene.

ALZHEIMER DISEASE 4 Is also known as ad4|alzheimer disease, familial, 4

Related symptoms:

  • Seizures
  • Tremor
  • Depressivity
  • Dementia
  • Myoclonus


SOURCES: MESH OMIM MENDELIAN

More info about ALZHEIMER DISEASE 4

Parkinson disease was first described by James Parkinson in 1817. It is the second most common neurodegenerative disorder after Alzheimer disease (AD ), affecting approximately 1% of the population over age 50 (Polymeropoulos et al., 1996). ReviewsWarner and Schapira (2003) reviewed the genetic and environmental causes of Parkinson disease. Feany (2004) reviewed the genetics of Parkinson disease and provided a speculative model of interactions among proteins implicated in PD. Lees et al. (2009) provided a review of Parkinson disease, with emphasis on diagnosis, neuropathology, and treatment. Genetic Heterogeneity of Parkinson DiseaseSeveral loci for autosomal dominant Parkinson disease have been identified, including PARK1 (OMIM ) and PARK4, caused by mutation in or triplication of the alpha-synuclein gene (SNCA ), respectively, on 4q22; PARK5 (OMIM ), caused by mutation in the UCHL1 gene on 4p13; PARK8 (OMIM ), caused by mutation in the LRRK2 gene (OMIM ) on 12q12; PARK11 (OMIM ), caused by mutation in the GIGYF2 gene (OMIM ) on 2q37; PARK13 (OMIM ), caused by mutation in the HTRA2 gene (OMIM ) on 2p13; PARK17 (OMIM ), caused by mutation in the VPS35 gene (OMIM ) on 16q11; and PARK18 (OMIM ), caused by mutation in the EIF4G1 gene (OMIM ) on 3q27.Several loci for autosomal recessive early-onset Parkinson disease have been identified: PARK2 (OMIM ), caused by mutation in the gene encoding parkin (PARK2 ) on 6q26; PARK6 (OMIM ), caused by mutation in the PINK1 gene (OMIM ) on 1p36; PARK7 (OMIM ), caused by mutation in the DJ1 gene (PARK7 ) on 1p36; PARK14 (OMIM ), caused by mutation in the PLA2G6 gene (OMIM ) on 22q13; PARK15 (OMIM ), caused by mutation in the FBXO7 gene (OMIM ) on 22q12-q13; PARK19A (OMIM ) and PARK19B (see {615528}), caused by mutation in the DNAJC6 gene (OMIM ) on 1p32; and PARK20 (OMIM ), caused by mutation in the SYNJ1 gene (OMIM ) on 21q22.PARK3 (OMIM ) has been mapped to chromosome 2p13; PARK10 (OMIM ) has been mapped to chromosome 1p34-p32; PARK16 (OMIM ) has been mapped to chromosome 1q32. See also PARK21 (OMIM ). A locus on the X chromosome has been identified (PARK12 ). There is also evidence that mitochondrial mutations may cause or contribute to Parkinson disease (see {556500}). Susceptibility to the development of the more common late-onset form of Parkinson disease has been associated with polymorphisms or mutations in several genes, including GBA (OMIM ), MAPT (OMIM ), MC1R (OMIM ), ADH1C (OMIM ), and genes at the HLA locus (see, e.g., HLA-DRA, {142860}). Each of these risk factors independently may have a modest effect on disease development, but together may have a substantial cumulative effect (Hamza et al., 2010).Susceptibility to PD may also be conferred by expanded trinucleotide repeats in several genes causing other neurologic disorders usually characterized by spinocerebellar ataxia (SCA), including the ATXN2 (OMIM ), ATXN3 (OMIM ), TBP (OMIM ), and ATXN8OS (OMIM ) genes.

PARKINSON DISEASE, LATE-ONSET; PD Is also known as park

Related symptoms:

  • Ataxia
  • Cognitive impairment
  • Dysarthria
  • Tremor
  • Dysphagia


SOURCES: OMIM MENDELIAN

More info about PARKINSON DISEASE, LATE-ONSET; PD

Trimethylaminuria results from the abnormal presence of large amounts of volatile and malodorous trimethylamine within the body. This chemical, a tertiary aliphatic amine, is excreted in the urine, sweat (ichthyohidrosis), and breath, which take on the offensive odor of decaying fish (Mitchell, 1996).

TRIMETHYLAMINURIA; TMAU Is also known as fish-odor syndrome

Related symptoms:

  • Anemia
  • Hypertension
  • Splenomegaly
  • Depressivity
  • Hyperhidrosis


SOURCES: OMIM ORPHANET MENDELIAN

More info about TRIMETHYLAMINURIA; TMAU

Dementia with Lewy bodies (DLB) is a neurodegenerative disorder clinically characterized by dementia and parkinsonism, often with fluctuating cognitive function, visual hallucinations, falls, syncopal episodes, and sensitivity to neuroleptic medication. Pathologically, Lewy bodies are present in a pattern more widespread than usually observed in Parkinson disease (see PD; {168600}). Alzheimer disease (AD )-associated pathology and spongiform changes may also be seen (McKeith et al., 1996; Mizutani, 2000; McKeith et al., 2005).

DEMENTIA, LEWY BODY; DLB Is also known as lewy body dementia|diffuse lewy body disease

Related symptoms:

  • Cognitive impairment
  • Dysarthria
  • Depressivity
  • Pneumonia
  • Dementia


SOURCES: ORPHANET OMIM MENDELIAN

More info about DEMENTIA, LEWY BODY; DLB

Parkinson disease is the second most common neurogenic disorder after Alzheimer disease (AD ), affecting approximately 1% of the population over age 50. Clinical manifestations include resting tremor, muscular rigidity, bradykinesia, and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia (Polymeropoulos et al., 1996).For a general phenotypic description and a discussion of genetic heterogeneity of Parkinson disease, see {168600}.

PARKINSON DISEASE 1, AUTOSOMAL DOMINANT; PARK1 Is also known as parkinson disease 1, autosomal dominant lewy body

Related symptoms:

  • Spasticity
  • Delayed speech and language development
  • Hyperreflexia
  • Dysarthria
  • Tremor


SOURCES: OMIM MESH MENDELIAN

More info about PARKINSON DISEASE 1, AUTOSOMAL DOMINANT; PARK1

Classical progressive supranuclear palsy, also known as Richardson's syndrome, is the most common clinical variant of progressive supranuclear palsy (PSP; see this term), a rare late-onset neurodegenerative disease characterized by postural instability, progressive rigidity, supranuclear gaze palsy and mild dementia.

CLASSIC PROGRESSIVE SUPRANUCLEAR PALSY SYNDROME Is also known as psp|steele-richardson-olszewski disease|steele-richardson-olszewski syndrome|classic psp syndrome|richardson syndrome

Related symptoms:

  • Seizures
  • Cognitive impairment
  • Hyperreflexia
  • Dysarthria
  • Tremor


SOURCES: OMIM ORPHANET MENDELIAN

More info about CLASSIC PROGRESSIVE SUPRANUCLEAR PALSY SYNDROME

Myotonic dystrophy is an autosomal dominant disorder characterized mainly by myotonia, muscular dystrophy, cataracts, hypogonadism, frontal balding, and ECG changes. The genetic defect in DM1 results from an amplified trinucleotide repeat in the 3-prime untranslated region of a protein kinase gene. Disease severity varies with the number of repeats: normal individuals have 5 to 37 repeats, mildly affected persons have 50 to 150 repeats, patients with classic DM have 100 to 1,000 repeats, and those with congenital onset can have more than 2,000 repeats. The disorder shows genetic anticipation, with expansion of the repeat number dependent on the sex of the transmitting parent. Alleles of 40 to 80 repeats are usually expanded when transmitted by males, whereas only alleles longer than 80 repeats tend to expand in maternal transmissions. Repeat contraction events occur 4.2 to 6.4% of the time (Musova et al., 2009). Genetic Heterogeneity of Myotonic DystrophySee also myotonic dystrophy-2 (DM2 ), which is caused by mutation in the ZNF9 gene (OMIM ) on chromosome 3q21.

MYOTONIC DYSTROPHY 1; DM1 Is also known as dystrophia myotonica 1|dystrophia myotonica|steinert disease|dm

Related symptoms:

  • Intellectual disability
  • Seizures
  • Generalized hypotonia
  • Muscle weakness
  • Muscular hypotonia


SOURCES: OMIM MENDELIAN

More info about MYOTONIC DYSTROPHY 1; DM1

Top 5 symptoms//phenotypes associated to Congestive heart failure and Alzheimer disease

Symptoms // Phenotype % cases
Dementia Very Common - Between 80% and 100% cases
Parkinsonism Common - Between 50% and 80% cases
Neurofibrillary tangles Common - Between 50% and 80% cases
Stroke Uncommon - Between 30% and 50% cases
Bradykinesia Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Congestive heart failure and Alzheimer disease. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Cognitive impairment Rigidity Mental deterioration Depressivity Neuronal loss in central nervous system Dysphagia Hallucinations Postural instability Lewy bodies Tremor Dystonia Seizures Dysarthria Senile plaques Myoclonus Anxiety Frontotemporal dementia Apraxia Memory impairment Resting tremor Hypertension Respiratory failure Brain atrophy Gliosis Cerebral cortical atrophy

Rare Symptoms - Less than 30% cases

Hypoventilation Behavioral abnormality Cerebral hemorrhage Micrographia Encephalopathy Tachycardia Vertical supranuclear gaze palsy Supranuclear gaze palsy Delusions Syncope Pneumonia Abnormal pyramidal sign Delayed speech and language development Cerebral atrophy Cerebral amyloid angiopathy Parkinsonism with favorable response to dopaminergic medication Hyperreflexia Babinski sign Orthostatic hypotension Urinary urgency Irritability Abnormal autonomic nervous system physiology Hypotension Sleep disturbance Apathy Personality changes Falls Visual hallucinations Intellectual disability Dyskinesia Dysphasia Aphasia Dilatation Myopathy Progressive muscle weakness Muscular dystrophy Gait disturbance Skeletal muscle atrophy Cataract Muscle weakness Mutism Shuffling gait Thin ribs Atrioventricular block Central hypoventilation Myotonia Cholelithiasis Peripheral neuropathy Ventricular tachycardia Intellectual disability, progressive Hypokinesia Spontaneous abortion Cardiac arrest Insulin resistance Hydrops fetalis Atrial fibrillation Centrally nucleated skeletal muscle fibers Nonimmune hydrops fetalis Abnormal EKG Spasticity Muscle stiffness Paraparesis Spastic paraparesis Loss of consciousness Percussion myotonia Obsessive-compulsive trait Narcolepsy Fluctuations in consciousness Excessive daytime sleepiness Heart block Frontal balding First degree atrioventricular block Testicular atrophy Atrial flutter Inability to walk Mitral valve prolapse Facial diplegia Urinary incontinence Decreased fetal movement Dyspnea Premature birth Abnormal saccadic eye movements Stridor Edema Blurred vision Respiratory distress Aspiration pneumonia Central apnea Tics Gait imbalance Axial dystonia Retrocollis Arrhythmia Frontal release signs Eyelid apraxia Neuronal loss in basal ganglia Granulovacuolar degeneration Frontolimbic dementia Generalized hypotonia Muscular hypotonia Pain Ptosis Intellectual disability, severe Hypogonadism Motor delay Eosinophilia Photophobia Sensory neuropathy Apnea Cough Neurodegeneration Clumsiness Frequent falls Diplopia Aspiration Unsteady gait Polyhydramnios Lower limb muscle weakness Slurred speech Talipes Feeding difficulties in infancy Myalgia Oral-pharyngeal dysphagia Akinesia Neonatal hypotonia Postural tremor Limb dystonia Ataxia Confusion Progressive proximal muscle weakness Increased variability in muscle fiber diameter Sensory axonal neuropathy Amyotrophic lateral sclerosis Generalized amyotrophy Difficulty climbing stairs Pathologic fracture Abnormality of the vertebral column Rimmed vacuoles Urinary bladder sphincter dysfunction EMG: neuropathic changes Language impairment Motor axonal neuropathy Shoulder girdle muscle weakness Upper motor neuron dysfunction Pelvic girdle muscle weakness Hip pain Shoulder girdle muscle atrophy EMG: chronic denervation signs Abnormality of calvarial morphology Dyscalculia Fatty replacement of skeletal muscle Spinal muscular atrophy Limb-girdle muscular dystrophy Calvarial hyperostosis Distal amyotrophy Ventriculomegaly Cardiomyopathy Elevated serum creatine phosphokinase Proximal muscle weakness Facial palsy Hyperlordosis Distal muscle weakness Limb muscle weakness Hepatic steatosis Back pain Waddling gait Lumbar hyperlordosis Tetraparesis Fasciculations Osteolysis Scapular winging EMG: myopathic abnormalities Abnormality of pelvic girdle bone morphology Elevated alkaline phosphatase Increased susceptibility to fractures Motor neuron atrophy Cranial nerve compression Ophthalmoplegia Substantia nigra gliosis Hypomimic face Delirium Sleep-wake cycle disturbance Abulia Short stature Constipation Mask-like facies Kinetic tremor Weak voice Short stepped shuffling gait Recurrent cerebral hemorrhage Anemia Splenomegaly Hyperhidrosis Neutropenia Abnormal bleeding Abnormality of the cardiovascular system Recurrent pneumonia Body odor Fish odor Trimethylaminuria Tortuous cerebral arteries Cerebellar hemorrhage Pelvic girdle muscle atrophy Diabetes mellitus Frontal cortical atrophy Elevated alkaline phosphatase of bone origin Scapuloperoneal weakness Semantic dementia Abnormality of long bone morphology Pelvic girdle amyotrophy Temporal cortical atrophy Ubiquitin-positive cerebral inclusion bodies Abnormal motor neuron morphology Weakness of muscles of respiration Myocardial infarction Cerebral ischemia Long-tract signs Agnosia Headache Abnormality of the cerebral white matter Cerebral calcification Progressive neurologic deterioration Leukoencephalopathy Intracranial hemorrhage Amyloidosis Transient ischemic attack Ring fibers


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