Cleft palate, and Stomach cancer

Diseases related with Cleft palate and Stomach cancer

In the following list you will find some of the most common rare diseases related to Cleft palate and Stomach cancer that can help you solving undiagnosed cases.


Top matches:

Medium match HEREDITARY DIFFUSE GASTRIC CANCER


Hereditary diffuse gastric cancer is a rare epithelial tumor of the stomach, characterized by the development of diffuse (signet ring cell) gastric cancer at a young age, associated with germline heterozygous mutations of CDH1, MAP3K6 and CTNNA1 genes. In early stages it presents with non-specific and vague symptoms, in advanced stages it may cause nausea and vomiting, dysphagia, loss of appetite, abdominal mass or weight loss. Women have an increased risk of lobular breast cancer as well.

HEREDITARY DIFFUSE GASTRIC CANCER Is also known as hereditary diffuse cancer of stomach|hereditary diffuse gastric adenocarcinoma|familial diffuse cancer of stomach|familial diffuse gastric cancer|gastric cancer, familial diffuse|fdgc|hdgc|gastric cancer, hereditary diffuse

Related symptoms:

  • Neoplasm
  • Cleft palate
  • Carcinoma
  • Cleft lip
  • Cleft upper lip


SOURCES: OMIM ORPHANET MENDELIAN

More info about HEREDITARY DIFFUSE GASTRIC CANCER

Medium match MOSAIC VARIEGATED ANEUPLOIDY SYNDROME


Mosaic variegated aneuploidy (MVA) syndrome is a chromosomal anomaly characterized by multiple mosaic aneuploidies that leads to a variety of phenotypic abnormalities and cancer predisposition.

MOSAIC VARIEGATED ANEUPLOIDY SYNDROME Is also known as warburton-anyane-yeboa syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: ORPHANET OMIM MENDELIAN

More info about MOSAIC VARIEGATED ANEUPLOIDY SYNDROME

Medium match FANCONI ANEMIA, COMPLEMENTATION GROUP S; FANCS


Fanconi anemia complementation group S is an autosomal recessive disorder characterized by developmental delay apparent from infancy, short stature, microcephaly, and coarse dysmorphic features. Laboratory studies show defective DNA repair and increased chromosomal breakage during stress. Some patients may have radial ray anomalies, anemia, and increased risk of cancer; patients often have a family history of cancer in family members who have heterozygous mutations (summary by Freire et al., 2018).For additional general information and a discussion of genetic heterogeneity of Fanconi anemia, see {227650}.

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Short stature
  • Hearing impairment
  • Microcephaly


SOURCES: OMIM MENDELIAN

More info about FANCONI ANEMIA, COMPLEMENTATION GROUP S; FANCS

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Other less relevant matches:

Low match BASAL CELL NEVUS SYNDROME; BCNS


BASAL CELL NEVUS SYNDROME; BCNS Is also known as nevoid basal cell carcinoma syndrome|gorlin-goltz syndrome|gorlin syndrome|nbccs|multiple basal cell nevi, odontogenic keratocysts, and skeletal anomalies

Related symptoms:

  • Intellectual disability
  • Hearing impairment
  • Microcephaly
  • Scoliosis
  • Ataxia


SOURCES: OMIM MENDELIAN

More info about BASAL CELL NEVUS SYNDROME; BCNS

Low match PALMOPLANTAR KERATODERMA-ESOPHAGEAL CARCINOMA SYNDROME


Palmoplantar keratoderma (PPK) is a complex group of hereditary syndromes that have been classified into diffuse, punctate, and focal forms according to the pattern of hyperkeratosis on the palms and soles (Lucker et al., 1994).For a discussion of phenotypic and genetic heterogeneity of palmoplantar keratoderma, see epidermolytic PPK (OMIM ).

PALMOPLANTAR KERATODERMA-ESOPHAGEAL CARCINOMA SYNDROME Is also known as howell-evans syndrome|keratosis palmaris et plantaris with esophageal cancer|palmoplantar hyperkeratosis-esophageal carcinoma syndrome|palmoplantar keratoderma with esophageal cancer|tylosis-oesophageal carcinoma syndrome|bennion-patterson syndrome|kerato

Related symptoms:

  • Neoplasm
  • Hepatomegaly
  • Dysphagia
  • Edema
  • Hernia


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about PALMOPLANTAR KERATODERMA-ESOPHAGEAL CARCINOMA SYNDROME

Low match PEUTZ-JEGHERS SYNDROME


Peutz-Jeghers syndrome (PJS) is an inherited gastrointestinal disorder characterized by development of characteristic hamartomatous polyps throughout the gastrointestinal (GI) tract, and by mucocutaneous pigmentation. PJS carries a considerably increased risk of GI and extra-GI malignancies.

PEUTZ-JEGHERS SYNDROME Is also known as hamartomatous intestinal polyposis|polyps and spots syndrome|pjs

Related symptoms:

  • Neoplasm
  • Anemia
  • Vomiting
  • Abdominal pain
  • Gastrointestinal hemorrhage


SOURCES: OMIM ORPHANET MENDELIAN

More info about PEUTZ-JEGHERS SYNDROME

Low match CRONKHITE-CANADA SYNDROME


Cronkhite-Canada syndrome (CCS) is a rare gastrointestinal (GI) polyposis syndrome characterized by the association of non-hereditary GI polyposis with the cutaneous triad of alopecia, nail changes and hyperpigmentation.

CRONKHITE-CANADA SYNDROME Is also known as gastrointestinal polyposis-skin pigmentation-alopecia-fingernail changes syndrome|gastrointestinal polyposis-ectodermal changes syndrome|cronkhite-canada syndrome

Related symptoms:

  • Seizures
  • Neoplasm
  • Muscle weakness
  • Pain
  • Cataract


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about CRONKHITE-CANADA SYNDROME

Low match AURICULOCONDYLAR SYNDROME 2; ARCND2


Auriculocondylar syndrome (ARCND), also known as 'question-mark ear syndrome' or 'dysgnathia complex,' is an autosomal dominant craniofacial malformation syndrome characterized by highly variable mandibular anomalies, including mild to severe micrognathia, often with temporomandibular joint ankylosis, cleft palate, and a distinctive ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark. Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia (summary by Rieder et al., 2012).For a discussion of genetic heterogeneity of auriculocondylar syndrome, see ARCND1 (OMIM ).

Related symptoms:

  • Global developmental delay
  • Generalized hypotonia
  • Hearing impairment
  • Micrognathia
  • Cleft palate


SOURCES: OMIM MENDELIAN

More info about AURICULOCONDYLAR SYNDROME 2; ARCND2

Low match SWEENEY-COX SYNDROME; SWCOS


Sweeney-Cox syndrome is characterized by striking facial dysostosis, including hypertelorism, deficiencies of the eyelids and facial bones, cleft palate/velopharyngeal insufficiency, and low-set cupped ears (Kim et al., 2017).

Related symptoms:

  • Global developmental delay
  • Hearing impairment
  • Hypertelorism
  • Micrognathia
  • Abnormal facial shape


SOURCES: OMIM MENDELIAN

More info about SWEENEY-COX SYNDROME; SWCOS

Low match EARLY-ONSET MYOPATHY-AREFLEXIA-RESPIRATORY DISTRESS-DYSPHAGIA SYNDROME


EMARDD is a congenital myopathy characterized by proximal and generalized muscle weakness, respiratory difficulties, joint contractures, and scoliosis. More variable features include cleft palate and feeding difficulties. There is variable severity: some patients become ventilator-dependent, never achieve walking, and die in childhood, whereas others have a longer and more favorable course (summary by Logan et al., 2011 and Boyden et al., 2012).

EARLY-ONSET MYOPATHY-AREFLEXIA-RESPIRATORY DISTRESS-DYSPHAGIA SYNDROME Is also known as emardd

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Scoliosis
  • Growth delay


SOURCES: ORPHANET OMIM MENDELIAN

More info about EARLY-ONSET MYOPATHY-AREFLEXIA-RESPIRATORY DISTRESS-DYSPHAGIA SYNDROME

Top 5 symptoms//phenotypes associated to Cleft palate and Stomach cancer

Symptoms // Phenotype % cases
Neoplasm Common - Between 50% and 80% cases
Hearing impairment Uncommon - Between 30% and 50% cases
Global developmental delay Uncommon - Between 30% and 50% cases
Micrognathia Uncommon - Between 30% and 50% cases
Gastroesophageal reflux Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Cleft palate and Stomach cancer. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Carcinoma Abnormal facial shape Macrocephaly Microphthalmia Abdominal pain Long fingers Epicanthus Low-set ears Cataract Anemia Breast carcinoma Growth delay Microcephaly Hypertelorism Generalized hypotonia Seizures Intellectual disability

Rare Symptoms - Less than 30% cases


Narrow mouth Ovarian carcinoma Colon cancer Weight loss Intestinal polyposis Respiratory distress Dental malocclusion Sparse hair Neonatal hypotonia Hirsutism Failure to thrive Coarse facial features Bulbar palsy Delayed speech and language development Pain Cupped ear Scoliosis Brachycephaly Cryptorchidism Vomiting Edema Dysphagia Hepatomegaly Gastrointestinal hemorrhage Poor suck Hamartomatous polyposis Esophageal neoplasm Gastrointestinal carcinoma Motor delay Muscle weakness Hyperpigmentation of the skin Palmoplantar keratoderma Facial palsy Talipes equinovarus Pectus excavatum Syndactyly Wide nasal bridge High palate Feeding difficulties Apnea Cleft upper lip Glaucoma Cleft lip Low-set, posteriorly rotated ears Ascites Clinodactyly Frontal bossing Abnormality of the skeletal system Muscular hypotonia Muscular dystrophy Abnormality of skin pigmentation Intrauterine growth retardation Blepharophimosis Craniosynostosis Oral cleft Downslanted palpebral fissures Short stature Gastrointestinal infarctions Rectal prolapse Abnormality of the nose Enlarged polycystic ovaries Pancreatic adenocarcinoma Abnormality of the gallbladder Nasal polyposis Neoplasm of the small intestine Neoplasm of the rectum Multiple lentigines Abnormality of the gastrointestinal tract Arteriovenous fistula Short clavicles Neoplasm of the colon Nail dystrophy Anorexia Nail dysplasia Tapered finger Paresthesia Nasal speech Malabsorption Autoimmunity Biliary tract neoplasm Alopecia Splenomegaly Diarrhea Fatigue Neoplasm of the nose Cervix cancer Abnormal pigmentation of the oral mucosa Melanonychia Neoplasm of the lung Abnormality of the respiratory system Oral-pharyngeal dysphagia Esophagitis Hiatus hernia Abnormality of the mouth Parakeratosis Poor appetite Squamous cell carcinoma Palmoplantar hyperkeratosis Oral leukoplakia Thickened skin Epidermal acanthosis Ectodermal dysplasia Postural instability Nausea and vomiting Increased connective tissue Diaphragmatic paralysis Follicular hyperkeratosis Hypergranulosis Multiple renal cysts Esophageal leukoplakia Hypocalcemia Renal cell carcinoma Abnormality of the ureter Macule Intestinal obstruction Restrictive ventilatory defect Abnormal large intestine morphology Esophageal stricture Abnormality of esophagus physiology Difficulty running Esophageal carcinoma Diffuse palmoplantar hyperkeratosis Abnormality of the mediastinum Clubbing of toes Plantar hyperkeratosis Lymphedema Hypoalbuminemia Abnormality of the fingernails Central apnea Hypoplastic superior helix Temporomandibular joint ankylosis Speech articulation difficulties Overfolding of the superior helices Snoring Long penis Asplenia Upper airway obstruction Question mark ear Glossoptosis Ankylosis Widow's peak Velopharyngeal insufficiency Preauricular skin tag Median cleft palate Upper eyelid coloboma Mandibular condyle hypoplasia Mandibular condyle aplasia Round face Anal atresia Bilateral talipes equinovarus Overfolded helix Cutaneous syndactyly Generalized hirsutism Wide anterior fontanel Choanal atresia Underdeveloped nasal alae Talipes Cleft at the superior portion of the pinna Narrow chest Short philtrum Microtia Cerebellar hypoplasia Midface retrusion Broad neck Short columella Dental crowding Flexion contracture Poor head control Severe muscular hypotonia Camptodactyly of finger Xerostomia Thromboembolism Generalized muscle weakness Decreased fetal movement Generalized hyperpigmentation Recurrent pneumonia Sparse body hair Hypomagnesemia Aplasia/Hypoplasia of the eyebrow Hypoplastic toenails Clubbing Prominent metopic ridge Hypokalemia Cachexia Abnormal intestine morphology Abnormality of the vasculature Paralysis Full cheeks Peripheral edema Myopathy Posteriorly rotated ears Encephalopathy Areflexia Decreased taste sensation Glossitis Respiratory arrest Protein-losing enteropathy Hematochezia Dystrophic fingernails Furrowed tongue Hyporeflexia Respiratory failure Clubbing of fingers Dystrophic toenail Respiratory tract infection Patchy alopecia Astrocytoma Hyperkeratosis Acute lymphoblastic leukemia Increased nuchal translucency Abnormal aortic morphology Rhabdomyosarcoma Subvalvular aortic stenosis Abnormality of the upper limb Duodenal atresia Abnormality of the skull Abnormal lung lobation Premature chromatid separation Abnormality of immune system physiology Multiple cafe-au-lait spots Atrioventricular canal defect Aplasia/Hypoplasia of the cerebellum Nephroblastoma Myelodysplasia Abnormality of vision Sleep apnea Epidermoid cyst Vaginal neoplasm Aortic regurgitation Proximal placement of thumb Strabismus Ataxia Duodenal stenosis Macrodontia Thick upper lip vermilion Chromosome breakage Ovarian neoplasm Narrow palate Anteverted nares Bone marrow hypocellularity Low anterior hairline Long eyelashes Hypopigmentation of the skin Hip dislocation Prominent nasal bridge Conductive hearing impairment Upslanted palpebral fissure Aplasia/Hypoplasia of the corpus callosum Holoprosencephaly Dysarthria Short nose High forehead Polyhydramnios Hypothyroidism Clinodactyly of the 5th finger Delayed skeletal maturation Abnormal heart morphology Abnormality of cardiovascular system morphology Intellectual disability, mild Abnormality of the eye Atrial septal defect Ventriculomegaly Ventricular septal defect Depressed nasal bridge Cognitive impairment Acrania Helicobacter pylori infection Chronic atrophic gastritis Deeply set eye Corneal opacity Microretrognathia Coarctation of aorta Osteolysis Finger clinodactyly Multicystic kidney dysplasia Cafe-au-lait spot Rhizomelia Depressed nasal ridge Short palpebral fissure Ambiguous genitalia Small for gestational age Sloping forehead Dandy-Walker malformation Growth hormone deficiency Triangular face Wide nose Bulbous nose Long face Dolichocephaly Spasticity Brachydactyly Hernia Neoplasm of the endocrine system Cervical ribs Supernumerary ribs Ectopic calcification Medulloblastoma Brain neoplasm Ulcerative colitis Broad face Abnormality of the neck Abnormality of the sense of smell Short 4th metacarpal Skin tags Down-sloping shoulders Fragile nails Narrow nose Sprengel anomaly Thoracic scoliosis Abnormality of the sternum Fibroma Vertebral wedging Vertebral fusion Cardiac rhabdomyoma Hamartomatous stomach polyps Irregular ossification of hand bones Cardiac fibroma Bridged sella turcica Plantar pits Ovarian fibroma Odontogenic keratocysts of the jaw Bifid ribs Parietal bossing Curved fingers Histiocytoma Calcification of falx cerebri Orbital cyst Palmar pits Short distal phalanx of the thumb Severe hydrocephalus Multiple impacted teeth Colitis Agenesis of permanent teeth Hydrocephalus Telecanthus Postaxial polydactyly Iris coloboma Arachnodactyly Carious teeth Hypotrichosis Papule Coloboma Proteinuria Hypotension EEG abnormality Retrognathia Kyphoscoliosis Mandibular prognathia Proptosis Polydactyly Visual loss Abnormality of the dentition Nevus Cerebral calcification Basal cell carcinoma Neoplasm of the skin Milia Disproportionate tall stature Inflammation of the large intestine Melanocytic nevus Nephritis Glomerulonephritis Relative macrocephaly Spina bifida occulta Abnormality of the ribs Hemivertebrae Hypogonadotrophic hypogonadism Muscle stiffness Short ribs Spina bifida Bradycardia Exotropia Hemiparesis Increased endomysial connective tissue



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