Cleft palate, and Migraine

Diseases related with Cleft palate and Migraine

In the following list you will find some of the most common rare diseases related to Cleft palate and Migraine that can help you solving undiagnosed cases.

Top matches:

ANEURYSM-OSTEOARTHRITIS SYNDROME Is also known as loeys-dietz syndrome with osteoarthritis|loeys-dietz syndrome, type 1c, formerly|lds1c, formerly|aneurysms-osteoarthritis syndrome

Related symptoms:

  • Scoliosis
  • Hypertelorism
  • Cleft palate
  • Pain
  • High palate


SOURCES: ORPHANET OMIM MENDELIAN

More info about ANEURYSM-OSTEOARTHRITIS SYNDROME

Blackfan-Diamond anemia (DBA) is a congenital aregenerative and often macrocytic anemia with erythroblastopenia.

BLACKFAN-DIAMOND ANEMIA Is also known as congenital hypoplastic anemia, blackfan-diamond type|congenital pure red cell aplasia|aase-smith syndrome ii|congenital prca|aase-smith ii syndrome|aase syndrome

Related symptoms:

  • Short stature
  • Growth delay
  • Hypertelorism
  • Neoplasm
  • Failure to thrive


SOURCES: ORPHANET OMIM MENDELIAN

More info about BLACKFAN-DIAMOND ANEMIA

Crouzon syndrome with acanthosis nigricans (CAN) is a very rare, clinically heterogeneous form of faciocraniostenosis with Crouzon-like features and premature synostosis of cranial sutures (Crouzon disease, see this term), associated with acanthosis nigricans (AN; see this term).

CROUZON SYNDROME-ACANTHOSIS NIGRICANS SYNDROME Is also known as crouzon-dermoskeletal syndrome|crouzonodermoskeletal syndrome

Related symptoms:

  • Short stature
  • Hypertelorism
  • Failure to thrive
  • Strabismus
  • Cleft palate


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about CROUZON SYNDROME-ACANTHOSIS NIGRICANS SYNDROME

Other less relevant matches:

Saethre-Chotzen syndrome (SCS) is an inherited craniosynostosis syndrome characterized by unilateral or bilateral coronal synostosis, facial asymmetry, ptosis, strabismus and small ears with prominent crus, among other less common manifestations.

SAETHRE-CHOTZEN SYNDROME Is also known as acs3|acrocephalosyndactyly type 3|scs|acrocephaly, skull asymmetry, and mild syndactyly|acs iii|acrocephalosyndactyly, type iii|chotzen syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Hearing impairment


SOURCES: OMIM ORPHANET MENDELIAN

More info about SAETHRE-CHOTZEN SYNDROME

Enlarged parietal foramina (EPF) is a developmental defect, characterized by variable intramembranous ossification defects of the parietal bones, which is either asymptomatic, symptomatic (headaches, nausea, vomiting, intellectual disability) or associated with other pathologies.

ENLARGED PARIETAL FORAMINA Is also known as fpp|cranium bifidum occultum|fenestrae parietales symmetricae|hereditary cranium bifidum|catlin marks|pfm|parietal foramina, symmetric|cranium bifidum, hereditary|symmetric parietal foramina|foramina parietalia permagna

Related symptoms:

  • Seizures
  • Cleft palate
  • Macrocephaly
  • Headache
  • Confusion


SOURCES: OMIM ORPHANET MENDELIAN

More info about ENLARGED PARIETAL FORAMINA

Phosphoglycerate kinase-1 deficiency is an X-linked recessive condition with a highly variable clinical phenotype that includes hemolytic anemia, myopathy, and neurologic involvement. Patients can express 1, 2, or all 3 of these manifestations (Shirakawa et al., 2006).

PHOSPHOGLYCERATE KINASE 1 DEFICIENCY Is also known as pgk1 deficiency

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Ataxia


SOURCES: MESH OMIM MENDELIAN

More info about PHOSPHOGLYCERATE KINASE 1 DEFICIENCY

Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy is a rare mitochondrial disease characterized by adult onset of progressive external ophthalmoplegia, exercise intolerance, muscle weakness, manifestations of spinocerebellar ataxia (e.g. impaired gait, dysarthria) and mild motor peripheral neuropathy. Respiratory insufficiency has been reported in some cases.

ADULT-ONSET CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL MYOPATHY Is also known as adult-onset cpeo with mitochondrial myopathy

Related symptoms:


SOURCES: ORPHANET MENDELIAN

More info about ADULT-ONSET CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL MYOPATHY

Craniosynostosis, Boston type is a form of syndromic craniosynostosis, characterized by a highly variable craniosynostosis with frontal bossing, turribrachycephaly and cloverleaf skull anomaly. Hypoplasia of the supraorbital ridges, cleft palate, extra teeth and limb anomalies (triphalangeal thumb, 3-4 syndactyly of the hands, a short first metatarsal, middle phalangeal agenesis in the feet) have also been described. Associated problems include headache, poor vision, and seizures. Intelligence is normal.

CRANIOSYNOSTOSIS, BOSTON TYPE Is also known as csb|warman-mulliken-hayward syndrome|craniosynostosis, warman type|craniosynostosis, boston-type

Related symptoms:

  • Seizures
  • Brachydactyly
  • Myopia
  • Downslanted palpebral fissures
  • Frontal bossing


SOURCES: OMIM ORPHANET MENDELIAN

More info about CRANIOSYNOSTOSIS, BOSTON TYPE

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular dysplasia leading to telangiectases and arteriovenous malformations of skin, mucosa, and viscera. Epistaxis and gastrointestinal bleeding are frequent complications of mucosal involvement. Visceral involvement includes that of the lung, liver, and brain. The most frequent form of hereditary hemorrhagic telangiectasia maps to the long arm of chromosome 9. Genetic Heterogeneity of Hereditary Hemorrhagic TelangiectasiaSee also HHT2 (OMIM ), caused by mutation in the ALK1 gene (ACVRL1 ) on chromosome 12q13; HHT3 (OMIM ), mapped to chromosome 5q31; HHT4 (OMIM ), mapped to chromosome 7p14; and HHT5 (OMIM ), caused by mutation in the GDF2 gene (OMIM ) on chromosome 10q11.See also juvenile polyposis/HHT syndrome (OMIM ), caused by mutation in the SMAD4 gene (OMIM ).

TELANGIECTASIA, HEREDITARY HEMORRHAGIC, TYPE 1; HHT1 Is also known as telangiectasia, hereditary hemorrhagic, of rendu, osler, and weber|orw disease|hht|osler-rendu-weber disease

Related symptoms:

  • Seizures
  • Anemia
  • Hypertension
  • Congestive heart failure
  • Headache


SOURCES: OMIM MENDELIAN

More info about TELANGIECTASIA, HEREDITARY HEMORRHAGIC, TYPE 1; HHT1

Top 5 symptoms//phenotypes associated to Cleft palate and Migraine

Symptoms // Phenotype % cases
Seizures Common - Between 50% and 80% cases
Short stature Uncommon - Between 30% and 50% cases
Brachydactyly Uncommon - Between 30% and 50% cases
Hypertelorism Uncommon - Between 30% and 50% cases
Headache Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Cleft palate and Migraine. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Anemia Dental malocclusion Craniosynostosis Triphalangeal thumb Subarachnoid hemorrhage Hypertension Brachycephaly

Rare Symptoms - Less than 30% cases

Strabismus Cleft soft palate Telangiectasia Ptosis Epistaxis Ischemic stroke Clubbing Optic atrophy Downslanted palpebral fissures Scoliosis Cerebral hemorrhage Polycythemia Frontal bossing Hematochezia Conjunctival telangiectasia Melena Hematemesis Spontaneous, recurrent epistaxis Cerebral arteriovenous malformation Lip telangiectasia Gastrointestinal angiodysplasia Right-to-left shunt Brain abscess Transient ischemic attack Midface retrusion Cyanosis Turricephaly Anterior plagiocephaly Parietal foramina Trigonocephaly Hypotelorism Encephalopathy Visual loss Global developmental delay Intellectual disability Bicoronal synostosis Brachyturricephaly Craniofacial dysostosis Cloverleaf skull Increased intracranial pressure Coronal craniosynostosis Abnormal form of the vertebral bodies Convex nasal ridge Hypoplasia of the maxilla Dyspnea Cirrhosis Conductive hearing impairment High forehead Proptosis Posteriorly rotated ears Cleft upper lip Malar flattening Renal insufficiency Spinal arteriovenous malformation Gastrointestinal hemorrhage Pulmonary arteriovenous malformation Neoplasm Hepatic arteriovenous malformation Patent ductus arteriosus Mitral valve prolapse Ventricular hypertrophy Mitral regurgitation Dilatation Atrial septal defect Abnormality of the skeletal system High palate Pain Osteoporosis Failure to thrive Gastrointestinal telangiectasia Cleft lip Tongue telangiectasia Gastrointestinal arteriovenous malformation Fatigue Nasal mucosa telangiectasia Fingerpad telangiectases Nail bed telangiectasia Palate telangiectasia Spina bifida occulta Delayed speech and language development Calvarial skull defect Spina bifida Aplasia cutis congenita of scalp Blepharospasm Symmetrical, oval parietal bone defects Ataxia Dilatation of mesenteric artery Myopathy Splenomegaly Confusion Rod-cone dystrophy Jaundice Venous varicosities of celiac and mesenteric vessels Hepatosplenomegaly Myalgia Mental deterioration Paralysis Muscular dystrophy Retinal dystrophy Encephalocele Partial duplication of the distal phalanx of the 2nd finger Macrocephaly Craniofacial asymmetry Bilateral cleft lip and palate Abnormal hair pattern Buphthalmos Oxycephaly Lambdoidal craniosynostosis Lacrimal duct stenosis Neoplasm of the breast Congenital adrenal hyperplasia Abnormal nasolacrimal system morphology Flat forehead Adrenogenital syndrome Mild hearing impairment Cleft of chin Narrow internal auditory canal Skull asymmetry Deviated nasal septum Duplication of the distal phalanx of hand Premature closure of fontanelles Hemolytic anemia Prominent crus of helix Renotubular dysgenesis Partial duplication of the distal phalanx of the 3rd finger Adrenal hyperplasia Absent first metatarsal Proximal radio-ulnar synostosis Hyperbilirubinemia Muscle cramps Stroke Abnormality of the vasculature Thrombocytosis Hemoptysis Scleroderma Pericardial effusion Portal hypertension Elevated alkaline phosphatase Atherosclerosis Ascites Hematuria Nausea Pulmonary arterial hypertension Hypoxemia Abnormality of the liver Congestive heart failure Unicoronal synostosis Metopic synostosis Increased number of teeth Visual field defect Wormian bones Narrow forehead Hypermetropia Dolichocephaly Myopia Choriocapillaris atrophy Esophageal varix Migraine with aura Visual auras Emotional lability High-output congestive heart failure Tetraparesis Exercise intolerance Arteriovenous fistulas of celiac and mesenteric vessels Coronary artery aneurysm Hemangiomatosis Purpura Pulmonary hemorrhage Spastic tetraparesis Polycystic liver disease Hemiplegia Aphasia Venous malformation Rhabdomyolysis Acute kidney injury Reticulocytosis Progressive encephalopathy Myoglobinuria Decreased mean corpuscular volume Increased muscle fatiguability Recurrent myoglobinuria Focal sensory seizure Exercise-induced muscle cramps Exercise-induced myoglobinuria Arteriovenous fistula Abnormality of the antihelix Amblyopia Short columella Pallor Thick lower lip vermilion Tetralogy of Fallot Bifid uvula Neutropenia Delayed puberty Autistic behavior Retrognathia Abnormality of the genital system Autism Arrhythmia Short nose Ventricular septal defect Intrauterine growth retardation Micrognathia Depressed nasal ridge Short thumb Knee osteoarthritis Reticulocytopenia Hydrocephalus Respiratory insufficiency Visual impairment Feeding difficulties Persistence of hemoglobin F Fetal distress Increased mean corpuscular volume Melanoma Esophagitis Acute leukemia Tracheomalacia Macrocytic anemia Abnormality of the hand Abnormality of the urinary system Growth delay Uterine prolapse Hypopigmentation of the skin Arachnodactyly Bicuspid aortic valve Aortic regurgitation Left ventricular hypertrophy Osteoarthritis Atrial fibrillation Bruising susceptibility Pulmonic stenosis Aortic aneurysm Camptodactyly Joint laxity Pes planus Umbilical hernia Inguinal hernia Hernia Back pain Disproportionate tall stature Intervertebral disc degeneration Osteochondritis Dissecans Protrusio acetabuli Abdominal aortic aneurysm Dural ectasia Arterial tortuosity Hip osteoarthritis Thoracic aortic aneurysm Low back pain Abnormality of the sternum Spondylolisthesis Aortic dissection Soft skin Dilatation of the cerebral artery Striae distensae Abnormal joint morphology Slender finger Dry skin Nevus Abnormality of the skull Broad thumb Plagiocephaly Narrow palate Coxa valga Elbow flexion contracture Bilateral single transverse palmar creases Low anterior hairline Single transverse palmar crease Sleep apnea Flat face Facial asymmetry Toe syndactyly Finger syndactyly Broad forehead Prominent nasal bridge Cutaneous syndactyly Abnormality of the genitourinary system Protruding ear Long nose Bilateral cleft lip Shallow orbits Narrow nose External ear malformation Abnormality of digit Vertebral fusion Delayed cranial suture closure Breast carcinoma Broad hallux Hallux valgus Open bite Epiphora Radioulnar synostosis Abnormality of pelvic girdle bone morphology Microtia Hyperlordosis Short metacarpal Glomerulonephritis Abnormal sacrum morphology Inflammatory abnormality of the eye Choanal stenosis Proportionate short stature Aplasia/Hypoplasia of the cerebellum Melanocytic nevus Laryngomalacia Short uvula Abnormality of the metacarpal bones Arnold-Chiari malformation Abnormal palate morphology Acanthosis nigricans Choanal atresia Epidermal acanthosis Membranous nephropathy Hearing impairment Low-set, posteriorly rotated ears Abnormality of cardiovascular system morphology Intellectual disability, moderate Telecanthus Mandibular prognathia Clinodactyly of the 5th finger Abnormal heart morphology Clinodactyly Syndactyly Microcephaly Epicanthus Depressed nasal bridge Flexion contracture Low-set ears Cryptorchidism Abnormal facial shape Sensorineural hearing impairment Dilatation of celiac artery


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