Carcinoma, and Proteinuria

Diseases related with Carcinoma and Proteinuria

In the following list you will find some of the most common rare diseases related to Carcinoma and Proteinuria that can help you solving undiagnosed cases.


Top matches:

High match LIPOPROTEIN GLOMERULOPATHY


Lipoprotein glomerulopathy is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries (Saito et al., 2006). It mainly affects people of Japanese and Chinese origin; in these populations, it is associated with mutations in the gene that encodes apolipoprotein E (APOE ). The disorder had rarely been described in Caucasians.

LIPOPROTEIN GLOMERULOPATHY Is also known as lpg

Related symptoms:

  • Edema
  • Renal insufficiency
  • Carcinoma
  • Proteinuria
  • Abnormality of the kidney


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about LIPOPROTEIN GLOMERULOPATHY

High match KARYOMEGALIC INTERSTITIAL NEPHRITIS


Karyomegalic interstitial nephritis is a rare, genetic renal disease characterized by slowly progressive, chronic, tubulointerstitial nephritis, leading to end-stage renal disease before the age of 50 years, manifesting with mild proteinuria, glucosuria and, occasionally, urinary sediment abnormalities (mainly hematuria). Mild extrarenal manifestations, such as recurrent upper respiratory tract infections and abnormal liver function tests, may be associated. Renal biopsy reveals severe, chronic, interstitial fibrosis and tubular changes, as well as hallmark karyomegalic tubular epithelial cells which line the proximal and distal tubules and have enlarged, hyperchromatic nuclei.

KARYOMEGALIC INTERSTITIAL NEPHRITIS Is also known as kin|systemic karyomegaly

Related symptoms:

  • Anemia
  • Hypertension
  • Renal insufficiency
  • Recurrent infections
  • Pneumonia


SOURCES: OMIM ORPHANET MENDELIAN

More info about KARYOMEGALIC INTERSTITIAL NEPHRITIS

High match PHEOCHROMOCYTOMA


Pheochromocytomas are catecholamine-secreting tumors that usually arise within the adrenal medulla. Approximately 10% arise in extraadrenal sympathetic ganglia, and are referred to as 'paragangliomas.' Approximately 10% are malignant, and approximately 10% are hereditary (Maher and Eng, 2002; Dluhy, 2002).Bolande (1974) introduced the concept and designation of the neurocristopathies, and identified 'simple,' including pheochromocytoma and medullary carcinoma of the thyroid, and 'complex' neurocristopathies and neurocristopathic syndromes, including NF1 and MEN2.Knudson and Strong (1972) applied Knudson's 2-mutation theory to pheochromocytoma (see discussion in {180200}) and concluded that it fits.Maher and Eng (2002) reviewed the clinical entities and genes associated with pheochromocytoma.

PHEOCHROMOCYTOMA Is also known as pheochromocytoma, susceptibility to

Related symptoms:

  • Neoplasm
  • Hypertension
  • Tremor
  • Fatigue
  • Congestive heart failure


SOURCES: ORPHANET OMIM MENDELIAN

More info about PHEOCHROMOCYTOMA

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Other less relevant matches:

Medium match GLYCOGEN STORAGE DISEASE IA; GSD1A


Glycogen storage disease type I, also known as von Gierke disease, typically manifests during the first year of life with severe hypoglycemia and hepatomegaly caused by the accumulation of glycogen. Affected individuals exhibit growth retardation, delayed puberty, lactic acidemia, hyperlipidemia, hyperuricemia, and in adults a high incidence of hepatic adenomas (summary by Lei et al., 1993).

GLYCOGEN STORAGE DISEASE IA; GSD1A Is also known as gsd1|hepatorenal form of glycogen storage disease|hepatorenal glycogenosis|glucose-6-phosphatase deficiency|gsd ia|von gierke disease|glycogen storage disease i

Related symptoms:

  • Seizures
  • Short stature
  • Growth delay
  • Neoplasm
  • Muscular hypotonia


SOURCES: ORPHANET OMIM MENDELIAN

More info about GLYCOGEN STORAGE DISEASE IA; GSD1A

Medium match BASAL CELL NEVUS SYNDROME; BCNS


BASAL CELL NEVUS SYNDROME; BCNS Is also known as nevoid basal cell carcinoma syndrome|gorlin-goltz syndrome|gorlin syndrome|nbccs|multiple basal cell nevi, odontogenic keratocysts, and skeletal anomalies

Related symptoms:

  • Intellectual disability
  • Hearing impairment
  • Microcephaly
  • Scoliosis
  • Ataxia


SOURCES: OMIM MENDELIAN

More info about BASAL CELL NEVUS SYNDROME; BCNS

Medium match FABRY DISEASE


Fabry disease (FD) is a progressive, inherited, multisystemic lysosomal storage disease characterized by specific neurological, cutaneous, renal, cardiovascular, cochleo-vestibular and cerebrovascular manifestations.

FABRY DISEASE Is also known as ceramide trihexosidase deficiency|hereditary dystopic lipidosis|fd|alpha-galactosidase a deficiency|diffuse angiokeratoma|gla deficiency|angiokeratoma corporis diffusum|anderson-fabry disease

Related symptoms:

  • Seizures
  • Short stature
  • Hearing impairment
  • Sensorineural hearing impairment
  • Pain


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about FABRY DISEASE

Low match MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A


Multiple endocrine neoplasia type IIA is an autosomal dominant syndrome of multiple endocrine neoplasms, including medullary thyroid carcinoma (MTC), pheochromocytoma, and parathyroid adenomas. MEN2B (OMIM ), characterized by MTC with or without pheochromocytoma and with characteristic clinical abnormalities such as ganglioneuromas of the lips, tongue and colon, but without hyperparathyroidism, is also caused by mutation in the RET gene (summary by Lore et al., 2001).For a discussion of genetic heterogeneity of multiple endocrine neoplasia, see MEN1 (OMIM ).

MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A Is also known as pheochromocytoma and amyloid-producing medullary thyroid carcinoma|sipple syndrome|ptc syndrome

Related symptoms:

  • Neoplasm
  • Hypertension
  • Carcinoma
  • Aganglionic megacolon
  • Hyperparathyroidism


SOURCES: OMIM MENDELIAN

More info about MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A

Low match HEPATITIS B VIRUS, SUSCEPTIBILITY TO


HBV is a DNA virus that enters the liver via the bloodstream, and replication occurs only in liver tissue. Transmission occurs by percutaneous or mucosal exposure to infected blood or other body fluids. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma (HCC ) can be attributed to chronic HBV infection. Worldwide, 2 billion people have been infected with HBV, 360 million have chronic infection, and 600,000 die each year from HBV-related liver disease or HCC. However, there is marked geographic variability in HBV prevalence, with chronic infection affecting less than 2% of the populations of North America and western and northern Europe; between 2 and 7% of the populations of eastern and central Europe, the Amazon basin, the Middle East, and the Indian subcontinent; and more than 8% of the populations of Asia, sub-Saharan Africa, and the Pacific (Seeff and Hoofnagle, 2006; Shepard et al., 2006).

HEPATITIS B VIRUS, SUSCEPTIBILITY TO Is also known as hbv, susceptibility to

Related symptoms:

  • Pain
  • Hepatomegaly
  • Fever
  • Vomiting
  • Splenomegaly


SOURCES: OMIM MENDELIAN

More info about HEPATITIS B VIRUS, SUSCEPTIBILITY TO

Low match PARAGANGLIOMAS 4; PGL4


PARAGANGLIOMAS 4; PGL4 Is also known as paraganglioma, familial malignant|pheochromocytoma, extraadrenal, and cervical paraganglioma|carotid body tumors and multiple extraadrenal pheochromocytomas|pheochromocytoma, familial extraadrenal|paragangliomas, hereditary extraadrenal

Related symptoms:

  • Neoplasm
  • Pain
  • Hypertension
  • Congestive heart failure
  • Headache


SOURCES: OMIM MENDELIAN

More info about PARAGANGLIOMAS 4; PGL4

Low match HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CANCER; HLRCC


Hereditary leiomyomatosis and renal cell cancer is an autosomal dominant tumor predisposition syndrome characterized by the variable development of 3 tumors: cutaneous piloleiomyomata that develop in essentially all patients by age 40 years; leiomyomata (fibroids) of the uterus, and rarely leiomyosarcomas, at a mean age of 30 years (range, 18 to 52 years); and type 2 papillary renal cell carcinoma at a mean age of 46 years (range, 17 to 75 years), which occurs in about 20% of patients. Type 2 papillary renal cell carcinoma is a pathologic subtype characterized by large tumor cells with eosinophilic cytoplasm and pseudostratified nuclei; it shows an aggressive clinical course. Some patients with FH mutations may develop collecting duct renal cell carcinoma. The main focus of management in HLRCC is prevention of disease and death due to renal cancer (summary by Gardie et al., 2011; Smit et al., 2011; and Lehtonen, 2011).For a general discussion of papillary renal cell carcinoma, see RCCP1 (OMIM ).

HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CANCER; HLRCC Is also known as mcl|multiple cutaneous and uterine leiomyomata 1, with or without renal cell carcinoma|mcul1|lrcc|leiomyoma, multiple cutaneous|leiomyomatosis and renal cell cancer, hereditary

Related symptoms:

  • Neoplasm
  • Pain
  • Cataract
  • Carcinoma
  • Skin rash


SOURCES: MESH OMIM MENDELIAN

More info about HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CANCER; HLRCC

Top 5 symptoms//phenotypes associated to Carcinoma and Proteinuria

Symptoms // Phenotype % cases
Neoplasm Common - Between 50% and 80% cases
Hypertension Common - Between 50% and 80% cases
Pain Uncommon - Between 30% and 50% cases
Hematuria Uncommon - Between 30% and 50% cases
Renal insufficiency Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Carcinoma and Proteinuria. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Pheochromocytoma Hyperhidrosis Abdominal pain Neoplasm of the endocrine system Nausea Tachycardia Palpitations Chronic kidney disease Congestive heart failure Glomerulosclerosis Anemia Abnormality of the kidney Nephropathy Renal cell carcinoma Papule Cataract

Rare Symptoms - Less than 30% cases


Elevated urinary epinephrine Extraadrenal pheochromocytoma Paraganglioma of head and neck Episodic paroxysmal anxiety Recurrent paroxysmal headache Paraganglioma Seizures Short stature Hypertension associated with pheochromocytoma Cognitive impairment Pulsatile tinnitus Adrenal pheochromocytoma Edema Diarrhea Decreased glomerular filtration rate Mandibular prognathia Coarse facial features Hypotension Hearing impairment Anxiety Distal renal tubular acidosis Bradycardia Microalbuminuria Arthritis Neoplasm of the skin Glomerulonephritis Hepatocellular carcinoma Basal cell carcinoma Hyperlipidemia Hepatitis Delayed puberty Renal tubular acidosis Hepatomegaly Pruritus Skin rash Elevated serum creatinine Tubulointerstitial nephritis Glycosuria Increased blood urea nitrogen Nephritis Stage 5 chronic kidney disease Abnormality of the liver Elevated hepatic transaminase Tubular atrophy Headache Vomiting Recurrent infections Chest pain Fatigue Fever Gastrointestinal stroma tumor Glomerulopathy Angina pectoris Prominent nasal bridge Interstitial pulmonary abnormality Elevated erythrocyte sedimentation rate Coronary artery atherosclerosis Corneal opacity Impotence Loss of consciousness Bundle branch block Clubbing of fingers Emphysema Chronic obstructive pulmonary disease Anhidrosis Polyuria Diabetes insipidus Tricuspid regurgitation Achalasia Progressive sensorineural hearing impairment Orthostatic hypotension Abnormality of the gastrointestinal tract Abnormal EKG Oligospermia Edema of the lower limbs Renal tubular dysfunction Large earlobe Stroke Transient ischemic attack Supraventricular tachycardia Xerostomia Abnormality of lipid metabolism Celiac disease Heat intolerance Aortic root aneurysm Reduced ejection fraction Wheezing Peripheral arterial stenosis Cough Abnormal heart valve morphology Developmental regression Telangiectasia of the skin Abnormality of the cardiovascular system Heart murmur Impaired vibratory sensation Mitral regurgitation Paresthesia Lymphedema Hypohidrosis Vertigo Anorexia Left ventricular hypertrophy Bulbous nose Subcutaneous nodule Abnormal lung morphology Thick eyebrow Myocardial infarction Abnormal autonomic nervous system physiology Atrial fibrillation Thick vermilion border Muscle cramps Abdominal distention Sudden cardiac death Thick lower lip vermilion Ventricular hypertrophy Nephrotic syndrome Mitral valve prolapse Syncope Fasciculations Spontaneous abortion Clubbing Reduced bone mineral density Urinary incontinence Personality changes Polydipsia Hemiplegia Abnormality of the hand Prominent supraorbital ridges Atrioventricular block Easy fatigability Tinnitus Ventricular arrhythmia Ischemic stroke Exercise intolerance Abnormality of the cerebral white matter Corneal dystrophy Progressive hearing impairment Abnormal intestine morphology Aortic regurgitation Ventricular tachycardia Malabsorption Nausea and vomiting Purpura Aminoaciduria Sinus bradycardia Abnormality of cardiovascular system physiology Myocardial fibrosis Parathyroid adenoma Membranoproliferative glomerulonephritis Cirrhosis Jaundice Splenomegaly Abnormality of the integument Elevated calcitonin Medullary thyroid carcinoma Parathyroid hyperplasia Carcinoid tumor Thyroid carcinoma Upper limb undergrowth Chronic infection Increased circulating cortisol level Hyperparathyroidism Aganglionic megacolon Cornea verticillata Abnormal glomerular filtration rate Abnormality of the common coagulation pathway Increased glomerular filtration rate Increased carotid artery intimal medial thickness Abnormal ST segment Abnormal common carotid artery morphology Acroparesthesia Dark urine Membranous nephropathy Tenesmus Low back pain Decreased fumarate hydratase activity Papillary renal cell carcinoma type 2 Multiple cutaneous leiomyomas Cutaneous leiomyoma Uterine leiomyosarcoma Vaginal neoplasm Barrett esophagus Uterine leiomyoma Papillary renal cell carcinoma Bladder neoplasm Leiomyosarcoma Renal neoplasm Acute hepatitis Abnormality of the musculature Nephroblastoma Back pain Breast carcinoma Leukemia Elevated urinary catecholamines Glomus jugular tumor Chemodectoma Neuroblastoma Cranial nerve paralysis Fulminant hepatitis Heavy proteinuria Left ventricular septal hypertrophy Chronic fatigue Abnormal renal physiology Biventricular hypertrophy Primary hypothyroidism Conjunctival telangiectasia Supraventricular arrhythmia Dysesthesia Abnormal cornea morphology Abnormality of the renal tubule Abnormal thrombosis Tubulointerstitial fibrosis Chronic pain Miosis Decreased female libido T-wave inversion Abnormal aortic valve morphology Gastrointestinal dysmotility Periorbital fullness Abnormal mitral valve morphology Asymmetric septal hypertrophy High-frequency hearing impairment Abnormal myocardium morphology Restrictive cardiomyopathy Abnormality of the nose Abnormality of femur morphology Abnormal endocardium morphology Vascular skin abnormality Tortuosity of conjunctival vessels Decreased lacrimation Hyperkeratotic papule Abnormality of the forehead Abnormality of glycosphingolipid metabolism Impaired renal concentrating ability Functional abnormality of the gastrointestinal tract ST segment depression Unexplained fevers Mucosal telangiectasiae Concentric hypertrophic cardiomyopathy Coronary artery stenosis Shortened PR interval Angiokeratoma corporis diffusum Retinal vascular tortuosity Shortened QT interval Hyposthenuria Impaired temperature sensation Obstructive lung disease Angiokeratoma Reduced sperm motility Vascular tortuosity Nephrogenic diabetes insipidus Abnormality of temperature regulation Limb pain Corneal crystals Hypertrophic cardiomyopathy Short distal phalanx of the thumb Abnormality of the nervous system Hyperuricemia Pyelonephritis Enterocolitis Skeletal myopathy Fasting hypoglycemia Breathing dysregulation Neoplasm of the liver Xanthomatosis Gout Enlarged kidney Protuberant abdomen Prolonged bleeding time Xanthelasma Decreased muscle mass Focal segmental glomerulosclerosis Portal hypertension Elevated alkaline phosphatase Hypercalciuria Venous thrombosis Atherosclerosis Pancreatitis Nephrocalcinosis Nephrolithiasis Hypoglycemic seizures Intermittent diarrhea Epistaxis Micrognathia Macrocephaly Wide nasal bridge Brachydactyly Dysarthria Epicanthus Motor delay Spasticity Cryptorchidism Cleft palate Strabismus Hypertelorism Hepatoblastoma Ataxia Scoliosis Microcephaly Intellectual disability Hypocitraturia Hepatocellular adenoma Doll-like facies Lipemia retinalis Chronic pancreatitis Chronic hepatitis Hypertriglyceridemia Full cheeks Frontal bossing Conductive hearing impairment Episodic abdominal pain Aniridia Cerebral hemorrhage Hypercalcemia Dysphonia Hemangioma Cafe-au-lait spot Congenital cataract Retinopathy Pallor Weight loss Raynaud phenomenon Tremor Chronic tubulointerstitial nephritis Mild proteinuria Normocytic anemia Nephronophthisis Cholestasis Respiratory tract infection Pneumonia Mesangial hypercellularity Hyperlipoproteinemia Vocal cord paralysis Flushing Abnormal bleeding Growth delay Metabolic acidosis Hepatic failure Lactic acidosis Hypoglycemia Osteopenia Acidosis Osteoporosis Recurrent respiratory infections Myopathy Muscular hypotonia Episodic hypertension Sinus tachycardia Elevated urinary norepinephrine Paroxysmal vertigo Positive regitine blocking test Elevated urinary dopamine Episodic hyperhidrosis Panic attack Hypertensive retinopathy Renal artery stenosis Albuminuria Cranial nerve compression Downslanted palpebral fissures Abnormality of the skeletal system Myalgia Fibroma Histiocytoma Calcification of falx cerebri Orbital cyst Palmar pits Severe hydrocephalus Multiple impacted teeth Ovarian carcinoma Parietal bossing Vertebral wedging Abnormality of the sense of smell Hamartomatous polyposis Bifid ribs Cervical ribs Supernumerary ribs Ectopic calcification Medulloblastoma Astrocytoma Brain neoplasm Ulcerative colitis Broad face Abnormality of the neck Short 4th metacarpal Curved fingers Cardiac rhabdomyoma Down-sloping shoulders Behavioral abnormality Arthralgia Dyspnea Hypothyroidism Hyperkeratosis Posteriorly rotated ears Constipation Arrhythmia Depressivity Midface retrusion Dilatation Cardiomyopathy Odontogenic keratocysts of the jaw Respiratory insufficiency Optic atrophy Peripheral neuropathy Sensorineural hearing impairment Hamartomatous stomach polyps Irregular ossification of hand bones Cardiac fibroma Bridged sella turcica Plantar pits Ovarian fibroma Skin tags Fragile nails Hydrocephalus EEG abnormality Oral cleft Cleft upper lip Arachnodactyly Carious teeth Hypotrichosis Coloboma Sparse hair Facial palsy Cleft lip Telecanthus Retrognathia Postaxial polydactyly Kyphoscoliosis Proptosis Polydactyly Glaucoma Brachycephaly Visual loss Pectus excavatum Microphthalmia Syndactyly Abnormality of the dentition Iris coloboma Palmoplantar keratoderma Narrow nose Melanocytic nevus Sprengel anomaly Thoracic scoliosis Abnormality of the sternum Colitis Vertebral fusion Agenesis of permanent teeth Long fingers Milia Disproportionate tall stature Inflammation of the large intestine Relative macrocephaly Nevus Spina bifida occulta Hemivertebrae Hypogonadotrophic hypogonadism Muscle stiffness Short ribs Spina bifida Hyperpigmentation of the skin Exotropia Hemiparesis Abnormality of the ribs Cerebral calcification Cutaneous leiomyosarcoma



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