Carcinoma, and Cholestasis
Diseases related with Carcinoma and Cholestasis
In the following list you will find some of the most common rare diseases related to Carcinoma and Cholestasis that can help you solving undiagnosed cases.
PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 4 Is also known as pfic4|tjp2 deficitRelated symptoms:
- Abnormality of the liver
More info about PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 4
- Short stature
- Failure to thrive
More info about CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC, 2; PFIC2
Other less relevant matches:
High match HEPATITIS B VIRUS, SUSCEPTIBILITY TO
HBV is a DNA virus that enters the liver via the bloodstream, and replication occurs only in liver tissue. Transmission occurs by percutaneous or mucosal exposure to infected blood or other body fluids. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma (HCC ) can be attributed to chronic HBV infection. Worldwide, 2 billion people have been infected with HBV, 360 million have chronic infection, and 600,000 die each year from HBV-related liver disease or HCC. However, there is marked geographic variability in HBV prevalence, with chronic infection affecting less than 2% of the populations of North America and western and northern Europe; between 2 and 7% of the populations of eastern and central Europe, the Amazon basin, the Middle East, and the Indian subcontinent; and more than 8% of the populations of Asia, sub-Saharan Africa, and the Pacific (Seeff and Hoofnagle, 2006; Shepard et al., 2006).
HEPATITIS B VIRUS, SUSCEPTIBILITY TO Is also known as hbv, susceptibility toRelated symptoms:
More info about HEPATITIS B VIRUS, SUSCEPTIBILITY TO
High match KARYOMEGALIC INTERSTITIAL NEPHRITIS
Karyomegalic interstitial nephritis is a rare, genetic renal disease characterized by slowly progressive, chronic, tubulointerstitial nephritis, leading to end-stage renal disease before the age of 50 years, manifesting with mild proteinuria, glucosuria and, occasionally, urinary sediment abnormalities (mainly hematuria). Mild extrarenal manifestations, such as recurrent upper respiratory tract infections and abnormal liver function tests, may be associated. Renal biopsy reveals severe, chronic, interstitial fibrosis and tubular changes, as well as hallmark karyomegalic tubular epithelial cells which line the proximal and distal tubules and have enlarged, hyperchromatic nuclei.
KARYOMEGALIC INTERSTITIAL NEPHRITIS Is also known as kin|systemic karyomegalyRelated symptoms:
- Renal insufficiency
- Recurrent infections
More info about KARYOMEGALIC INTERSTITIAL NEPHRITIS
High match PANCREATIC CANCER
Pancreatic cancer shows among the highest mortality rates of any cancer, with a 5-year relative survival rate of less than 5%. By the time of initial diagnosis, metastatic disease is commonly present. Established risk factors include a family history of pancreatic cancer, a medical history of diabetes type 2, and cigarette smoking (summary by Amundadottir et al., 2009).
PANCREATIC CANCER Is also known as pancreatic carcinoma|pancreatic acinar carcinomaRelated symptoms:
- Diabetes mellitus
More info about PANCREATIC CANCER
High match BUDD-CHIARI SYNDROME
Budd-Chiari syndrome (BCS) is caused by obstruction of hepatic venous outflow involving either the hepatic veins or the terminal segment of the inferior vena cava.Related symptoms:
More info about BUDD-CHIARI SYNDROME
High match ALPHA-1-ANTITRYPSIN DEFICIENCY
Alpha-1-antitrypsin deficiency is a hereditary disease that develops in adulthood and is characterized by chronic liver disorders (cirrhosis), respiratory disorders (emphysema), and rarely panniculitis.
ALPHA-1-ANTITRYPSIN DEFICIENCY Is also known as deficiency in alpa-1-proteinase inhibitorRelated symptoms:
- Respiratory distress
More info about ALPHA-1-ANTITRYPSIN DEFICIENCY
Progressive familial intrahepatic cholestasis is a heterogeneous group of autosomal recessive liver disorders characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood (Alonso et al., 1994; Whitington et al., 1994; Klomp et al., 2004).
CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC, 1; PFIC1 Is also known as byler diseaseRelated symptoms:
- Short stature
- Hearing impairment
- Growth delay
- Failure to thrive
- Sensorineural hearing impairment
More info about CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC, 1; PFIC1
High match HEREDITARY CHRONIC PANCREATITIS
Hereditary chronic pancreatitis (HCP), a rare inherited form of pancreatitis is defined as recurrent acute pancreatitis and/or chronic pancreatitis in two first-degree relatives or 3 or more second-degree relatives in 2 or more generations, for which no predisposing factors are identified. HCP is characterized by irreversible damage to both exocrine and endocrine components of the pancreas.
HEREDITARY CHRONIC PANCREATITIS Is also known as hp|pancreatitis, chronic|hpcRelated symptoms:
- Diabetes mellitus
More info about HEREDITARY CHRONIC PANCREATITIS
Top 5 symptoms//phenotypes associated to Carcinoma and Cholestasis
|Symptoms // Phenotype||% cases|
|Jaundice||Common - Between 50% and 80% cases|
|Neoplasm||Common - Between 50% and 80% cases|
|Cirrhosis||Common - Between 50% and 80% cases|
|Hepatocellular carcinoma||Common - Between 50% and 80% cases|
|Hepatomegaly||Uncommon - Between 30% and 50% cases|
Other less frequent symptoms
Patients with Carcinoma and Cholestasis. may also develop some of the following symptoms:
Uncommon Symptoms - Between 30% and 50% casesAbnormality of the liver Pain Weight loss Hypertension Splenomegaly Abdominal pain Hepatitis Intermittent jaundice Nausea Elevated hepatic transaminase Intrahepatic cholestasis Fever Hepatic failure Portal hypertension Pancreatitis
Rare Symptoms - Less than 30% casesFatigue Exocrine pancreatic insufficiency Diabetes mellitus Portal vein thrombosis Steatorrhea Chronic pancreatitis Scarring Peritonitis Neoplasm of the pancreas Conjugated hyperbilirubinemia Short stature Acute hepatic failure Vomiting Pruritus Diarrhea Fat malabsorption Failure to thrive Neoplasm of the liver Severe short stature Pes cavus Areflexia Sensorineural hearing impairment Growth delay Hearing impairment Panniculitis Glomerulonephritis Chronic obstructive pulmonary disease Wheezing Emphysema Recurrent upper respiratory tract infections Vasculitis Bronchiectasis Abnormal lung morphology Nephrotic syndrome Dyspnea Respiratory distress Hepatic vein thrombosis Hemoptysis Hepatosplenomegaly Rod-cone dystrophy Type I diabetes mellitus Chronic calcifying pancreatitis Pancreatic pseudocyst Pancreatic calcification Abnormal enzyme/coenzyme activity Recurrent pancreatitis Elevated C-reactive protein level Abnormal thrombosis Hyperparathyroidism Leukocytosis Pleural effusion Aminoaciduria Intrahepatic cholestasis with episodic jaundice Budd-Chiari syndrome Increased serum bile acid concentration Civatte bodies Vitamin E deficiency Thrombocytosis Malnutrition Congenital sensorineural hearing impairment Hyperbilirubinemia Hepatic fibrosis Neuronal loss in central nervous system Sepsis Ophthalmoplegia Reduced protein C activity Esophageal varix Biliary atresia Respiratory tract infection Normocytic anemia Tubular atrophy Elevated serum creatinine Tubulointerstitial nephritis Glycosuria Nephronophthisis Nephritis Chronic kidney disease Hematuria Stage 5 chronic kidney disease Abnormality of the kidney Mild proteinuria Proteinuria Pneumonia Recurrent infections Renal insufficiency Anemia Fulminant hepatitis Acute hepatitis Membranous nephropathy Chronic infection Dark urine Increased blood urea nitrogen Chronic tubulointerstitial nephritis Gastrointestinal infarctions Malabsorption Cholecystitis Membranoproliferative glomerulonephritis Hypercoagulability Varicose veins Thromboembolism Polycythemia Intestinal obstruction Myocardial infarction Gastrointestinal hemorrhage Ascites Stroke Ataxia Increased level of L-fucose in urine Pancreatic adenocarcinoma Coma Ovarian neoplasm Colon cancer Breast carcinoma Melanoma Elevated alkaline phosphatase Telangiectasia Giant cell hepatitis Splanchnic vein thrombosis
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