Carcinoma, and Bradycardia

Diseases related with Carcinoma and Bradycardia

In the following list you will find some of the most common rare diseases related to Carcinoma and Bradycardia that can help you solving undiagnosed cases.


Top matches:

High match HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 2; CHNG2


In 80 to 85% of cases, congenital hypothyroidism is associated with, and presumably is a consequence of, thyroid dysgenesis (Macchia et al., 1998). In these cases, the thyroid gland can be absent (agenesis), ectopically located, and/or severely reduced in size (hypoplasia). When thyroid hormone therapy is not initiated within the first 2 months of life, congenital hypothyroidism can cause severe neurologic, mental, and motor damage (cretinism).

HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 2; CHNG2 Is also known as rtsh|thyroid agenesis|thyrotropin resistance|resistance to thyrotropin|thyroid, ectopic|hypothyroidism, athyreotic|athyreotic hypothyroidism|hypothyroidism, congenital, due to thyroid dysgenesis|thyroid hypoplasia|thyroid dysgenesis

Related symptoms:

  • Intellectual disability
  • Short stature
  • Generalized hypotonia
  • Growth delay
  • Muscular hypotonia


SOURCES: OMIM MENDELIAN

More info about HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 2; CHNG2

High match BASAL CELL NEVUS SYNDROME; BCNS


BASAL CELL NEVUS SYNDROME; BCNS Is also known as nevoid basal cell carcinoma syndrome|gorlin-goltz syndrome|gorlin syndrome|nbccs|multiple basal cell nevi, odontogenic keratocysts, and skeletal anomalies

Related symptoms:

  • Intellectual disability
  • Hearing impairment
  • Microcephaly
  • Scoliosis
  • Ataxia


SOURCES: OMIM MENDELIAN

More info about BASAL CELL NEVUS SYNDROME; BCNS

High match FABRY DISEASE


Fabry disease (FD) is a progressive, inherited, multisystemic lysosomal storage disease characterized by specific neurological, cutaneous, renal, cardiovascular, cochleo-vestibular and cerebrovascular manifestations.

FABRY DISEASE Is also known as ceramide trihexosidase deficiency|hereditary dystopic lipidosis|fd|alpha-galactosidase a deficiency|diffuse angiokeratoma|gla deficiency|angiokeratoma corporis diffusum|anderson-fabry disease

Related symptoms:

  • Seizures
  • Short stature
  • Hearing impairment
  • Sensorineural hearing impairment
  • Pain


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about FABRY DISEASE

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Other less relevant matches:

Medium match PARAGANGLIOMAS 4; PGL4


PARAGANGLIOMAS 4; PGL4 Is also known as paraganglioma, familial malignant|pheochromocytoma, extraadrenal, and cervical paraganglioma|carotid body tumors and multiple extraadrenal pheochromocytomas|pheochromocytoma, familial extraadrenal|paragangliomas, hereditary extraadrenal

Related symptoms:

  • Neoplasm
  • Pain
  • Hypertension
  • Congestive heart failure
  • Headache


SOURCES: OMIM MENDELIAN

More info about PARAGANGLIOMAS 4; PGL4

Medium match PORPHYRIA CUTANEA TARDA


Porphyria cutanea tarda (PCT) is characterized by light-sensitive dermatitis and the excretion of large amounts of uroporphyrin in urine (Elder et al., 1980).De Verneuil et al. (1978) and others classified porphyria cutanea tarda, the most common type of porphyria, into 2 types: type I (OMIM ), or 'sporadic' type, associated with approximately 50% level of uroporphyrinogen decarboxylase (UROD) in liver (Elder et al., 1978; Felsher et al., 1982), and type II, or 'familial' type, characterized by 50% deficient activity of the same enzyme in many tissues (Kushner et al., 1976; Elder et al., 1980).PCT type II is an autosomal dominant disorder with low penetrance and constitutes about 20% of cases of PCT. Recognized exacerbating factors of PCT include iron overload, excessive use of alcohol, exposure to polyhalogenated aromatic chemicals, exposure to estrogens, chronic viral hepatitis C, HIV infections, and mutation in the HFE gene (OMIM ) that are responsible for hereditary hemochromatosis (OMIM ) (review by Lambrecht et al., 2007).

PORPHYRIA CUTANEA TARDA Is also known as uroporphyrinogen decarboxylase deficiency|pct|pct, type ii|pct, 'familial' type|urod deficiency|porphyria cutanea tarda, type ii|porphyria, hepatocutaneous type

Related symptoms:

  • Anemia
  • Edema
  • Alopecia
  • Carcinoma
  • Erythema


SOURCES: OMIM ORPHANET MENDELIAN

More info about PORPHYRIA CUTANEA TARDA

Medium match ADRENOCORTICAL CARCINOMA


Adrenocortical carcinoma (ACC) is a cancer that arises from the adrenal cortex.

Related symptoms:

  • Neoplasm
  • Muscle weakness
  • Pain
  • Hypertension
  • Abnormality of metabolism/homeostasis


SOURCES: OMIM ORPHANET MENDELIAN

More info about ADRENOCORTICAL CARCINOMA

Low match ACUTE INTERMITTENT PORPHYRIA


Acute intermittent porphyria is the most frequent and the most severe form of the acute hepatic porphyrias (see this term). It is characterized by the occurrence of neuro-visceral attacks without cutaneous manifestations.

ACUTE INTERMITTENT PORPHYRIA Is also known as ups deficiency|porphyria, swedish type|pbgd deficiency|porphobilinogen deaminase deficiency|uroporphyrinogen synthase deficiency

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Muscle weakness
  • Pain


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about ACUTE INTERMITTENT PORPHYRIA

Low match PORPHYRIA VARIEGATA


Variegate porphyria is a form of acute hepatic porphyria (see this term) characterized by the occurrence of neuro-visceral attacks with or without the presence of cutaneous lesions.

PORPHYRIA VARIEGATA Is also known as variegate porphyria|ppox deficiency|porphyria, south african type|protoporphyrinogen oxidase deficiency|vp

Related symptoms:

  • Intellectual disability
  • Seizures
  • Short stature
  • Growth delay
  • Nystagmus


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about PORPHYRIA VARIEGATA

Low match HEMOCHROMATOSIS, TYPE 1; HFE1


Hereditary hemochromatosis is an autosomal recessive disorder of iron metabolism wherein the body accumulates excess iron (summary by Feder et al., 1996). Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading. Removal of excess iron by therapeutic phlebotomy decreases morbidity and mortality if instituted early in the course of the disease. Classic hemochromatosis (HFE) is most often caused by mutation in a gene designated HFE on chromosome 6p21.3.Adams and Barton (2007) reviewed the clinical features, pathophysiology, and management of hemochromatosis. Genetic Heterogeneity of HemochromatosisAt least 4 additional iron overload disorders labeled hemochromatosis have been identified on the basis of clinical, biochemical, and genetic characteristics. Juvenile hemochromatosis, or hemochromatosis type 2 (HFE2), is autosomal recessive and is divided into 2 forms: HFE2A (OMIM ), caused by mutation in the HJV gene (OMIM ) on chromosome 1q21, and HFE2B (OMIM ), caused by mutation in the HAMP gene (OMIM ) on chromosome 19q13. Hemochromatosis type 3 (HFE3 ), an autosomal recessive disorder, is caused by mutation in the TFR2 gene (OMIM ) on chromosome 7q22. Hemochromatosis type 4 (HFE4 ), an autosomal dominant disorder, is caused by mutation in the SLC40A1 gene (OMIM ) on chromosome 2q32. Hemochromatosis type 5 (HFE5 ) is caused by mutation in the FTH1 gene (OMIM ) on chromosome 11q12.

HEMOCHROMATOSIS, TYPE 1; HFE1 Is also known as hfe|hemochromatosis, hereditary|hemochromatosis|hh

Related symptoms:

  • Ataxia
  • Neoplasm
  • Pain
  • Anemia
  • Hepatomegaly


SOURCES: ORPHANET OMIM MENDELIAN

More info about HEMOCHROMATOSIS, TYPE 1; HFE1

Low match PHEOCHROMOCYTOMA


Pheochromocytomas are catecholamine-secreting tumors that usually arise within the adrenal medulla. Approximately 10% arise in extraadrenal sympathetic ganglia, and are referred to as 'paragangliomas.' Approximately 10% are malignant, and approximately 10% are hereditary (Maher and Eng, 2002; Dluhy, 2002).Bolande (1974) introduced the concept and designation of the neurocristopathies, and identified 'simple,' including pheochromocytoma and medullary carcinoma of the thyroid, and 'complex' neurocristopathies and neurocristopathic syndromes, including NF1 and MEN2.Knudson and Strong (1972) applied Knudson's 2-mutation theory to pheochromocytoma (see discussion in {180200}) and concluded that it fits.Maher and Eng (2002) reviewed the clinical entities and genes associated with pheochromocytoma.

PHEOCHROMOCYTOMA Is also known as pheochromocytoma, susceptibility to

Related symptoms:

  • Neoplasm
  • Hypertension
  • Tremor
  • Fatigue
  • Congestive heart failure


SOURCES: ORPHANET OMIM MENDELIAN

More info about PHEOCHROMOCYTOMA

Top 5 symptoms//phenotypes associated to Carcinoma and Bradycardia

Symptoms // Phenotype % cases
Pain Common - Between 50% and 80% cases
Neoplasm Common - Between 50% and 80% cases
Abdominal pain Common - Between 50% and 80% cases
Hypertension Common - Between 50% and 80% cases
Anxiety Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Carcinoma and Bradycardia. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Hyperhidrosis Tachycardia Palpitations Nausea Intellectual disability Hepatocellular carcinoma Constipation Anemia Congestive heart failure Depressivity Proteinuria Diarrhea Hyperpigmentation of the skin Vomiting Fatigue Arthralgia Nausea and vomiting Weight loss Cutaneous photosensitivity Muscle weakness Hypertrichosis Seizures Short stature Arrhythmia Abdominal distention

Rare Symptoms - Less than 30% cases


Hypotension Sudden cardiac death Panic attack Stage 5 chronic kidney disease Paraganglioma of head and neck Extraadrenal pheochromocytoma Neoplasm of the endocrine system Hematuria Nephropathy Chest pain Paralysis Psychosis Alopecia Hallucinations Hypertension associated with pheochromocytoma Urinary incontinence Adrenal pheochromocytoma Agitation Insomnia Episodic paroxysmal anxiety Milia Pulsatile tinnitus Recurrent paroxysmal headache Pheochromocytoma Cranial nerve paralysis Paresthesia Cirrhosis Abnormality of the liver Fever Hypopigmented skin patches Headache Renal insufficiency Behavioral abnormality Growth delay Restrictive cardiomyopathy Edema Cardiomyopathy Fragile skin Hypothyroidism Thin skin Peripheral neuropathy Anorexia Lethargy Myalgia Arthritis Alcoholism Porphyrinuria Abnormality of the kidney Diabetes mellitus Skin rash Hepatitis Abnormal blistering of the skin Hepatic steatosis Hypogonadotrophic hypogonadism Paraganglioma Mandibular prognathia Coarse facial features Glomerulosclerosis Hearing impairment Papule Abnormality of the skeletal system Ataxia Chronic kidney disease Neoplasm of the liver Impotence Hyperlipidemia Cataract Abnormality of the renal tubule Periorbital fullness Inflammatory abnormality of the skin Gastrointestinal dysmotility Increased blood urea nitrogen Distal renal tubular acidosis Abnormal aortic valve morphology Reduced sperm motility Angiokeratoma T-wave inversion Obstructive lung disease Impaired temperature sensation Hyposthenuria Vascular tortuosity Abnormality of temperature regulation Decreased glomerular filtration rate Microalbuminuria Abnormality of the nose Abnormal endocardium morphology Generalized hirsutism Abnormality of cardiovascular system physiology Decreased female libido Vascular skin abnormality Abnormal myocardium morphology Retinal vascular tortuosity Nephrogenic diabetes insipidus Corneal crystals Conjunctival telangiectasia Supraventricular arrhythmia Limb pain High-frequency hearing impairment Asymmetric septal hypertrophy Shortened QT interval Abnormal mitral valve morphology Hemolytic anemia Decreased lacrimation Angiokeratoma corporis diffusum Heavy proteinuria Left ventricular septal hypertrophy Tenesmus Gastrointestinal stroma tumor Biventricular hypertrophy Tubulointerstitial fibrosis Renal cell carcinoma Neuroblastoma Acroparesthesia Hyperkeratotic papule Cornea verticillata Abnormal common carotid artery morphology Abnormal glomerular filtration rate Abnormal thrombosis Abnormality of the common coagulation pathway Increased glomerular filtration rate Increased carotid artery intimal medial thickness Tortuosity of conjunctival vessels Abnormality of the forehead Erythema Coronary artery stenosis Miosis Abnormal ST segment Dysesthesia Elevated urinary catecholamines Shortened PR interval Abnormal renal physiology Chronic pain Glomus jugular tumor Abnormality of glycosphingolipid metabolism Concentric hypertrophic cardiomyopathy Mucosal telangiectasiae Chemodectoma Unexplained fevers Abnormal cornea morphology ST segment depression Functional abnormality of the gastrointestinal tract Impaired renal concentrating ability Primary hypothyroidism Facial hypertrichosis Cerebral palsy Insulin resistance Microvesicular hepatic steatosis Abnormal glucose tolerance Testicular atrophy Acute hepatic failure Increased reactive oxygen species production Increased serum ferritin Pericarditis Osteomalacia Arthropathy Abnormal joint morphology Pleural effusion Azoospermia Hepatic fibrosis Cholangiocarcinoma Telangiectasia Cardiomegaly Amenorrhea Ascites Hepatic failure Dilated cardiomyopathy Elevated hepatic transaminase Osteopenia Hypogonadism Osteoporosis Recurrent infections Splenomegaly Increased serum iron Constrictive pericarditis Premature adrenarche Raynaud phenomenon Elevated urinary norepinephrine Paroxysmal vertigo Positive regitine blocking test Elevated urinary dopamine Elevated urinary epinephrine Episodic hyperhidrosis Hypertensive retinopathy Renal artery stenosis Albuminuria Cranial nerve compression Sinus tachycardia Flushing Vocal cord paralysis Aceruloplasminemia Episodic abdominal pain Aniridia Cerebral hemorrhage Hypercalcemia Dysphonia Hemangioma Cafe-au-lait spot Congenital cataract Retinopathy Pallor Conductive hearing impairment Tremor Elevated transferrin saturation Hepatomegaly Dark urine Skin vesicle Increased circulating cortisol level Elevated serum 11-deoxycortisol Paradoxical increased cortisol secretion on dexamethasone suppression test Abnormality of reproductive system physiology Increased serum estradiol Abnormality of urine homeostasis Increased circulating androgen level Increased urinary cortisol level Lung adenocarcinoma Adrenocortical carcinoma Pollakisuria Adrenocorticotropic hormone deficiency Hyperaldosteronism Striae distensae Increased serum androstenedione Hypokalemia Increased body weight Irritability Abnormality of metabolism/homeostasis Hyperpigmentation in sun-exposed areas Viral hepatitis Chronic fatigue Congenital hypoplastic anemia Anemia of inadequate production Onycholysis Atypical scarring of skin Scleroderma Abnormal serum dehydroepiandrosterone level Global developmental delay Motor polyneuropathy Paralytic ileus Visual hallucinations Restlessness Aspiration Tetraplegia Hypopigmentation of the skin Confusion Scarring Clinodactyly Nystagmus Acute episodes of neuropathic symptoms Red urine Elevated urinary delta-aminolevulinic acid Respiratory paralysis Intellectual disability, mild Hypertensive crisis Psychotic episodes Delirium Abnormal urinary color Diaphragmatic paralysis Urinary retention Ileus Dysuria Apathy Hyponatremia Paraparesis Coma Hepatosplenomegaly Abnormality of femur morphology Progressive sensorineural hearing impairment Myocardial fibrosis Short ribs Basal cell carcinoma Disproportionate tall stature Inflammation of the large intestine Melanocytic nevus Nephritis Glomerulonephritis Relative macrocephaly Neoplasm of the skin Spina bifida occulta Hemivertebrae Muscle stiffness Spina bifida Agenesis of permanent teeth Exotropia Hemiparesis Abnormality of the ribs Cerebral calcification Nevus Palmoplantar keratoderma Postaxial polydactyly Iris coloboma Oral cleft Cleft upper lip Arachnodactyly Carious teeth Long fingers Vertebral fusion Coloboma Medulloblastoma Severe hydrocephalus Multiple impacted teeth Ovarian carcinoma Parietal bossing Vertebral wedging Abnormality of the sense of smell Fibroma Hamartomatous polyposis Cervical ribs Supernumerary ribs Ectopic calcification Astrocytoma Colitis Brain neoplasm Ulcerative colitis Broad face Abnormality of the neck Short 4th metacarpal Skin tags Down-sloping shoulders Fragile nails Narrow nose Sprengel anomaly Thoracic scoliosis Abnormality of the sternum Hypotrichosis Sparse hair Palmar pits Spondyloepiphyseal dysplasia Microcephaly Thyroid hemiagenesis Thyroid dysgenesis Large posterior fontanelle Thyroid agenesis Ectopic thyroid Hoarse cry Increased thyroid-stimulating hormone level Thyroid hypoplasia Hypothermia Congenital hypothyroidism Myotonia Hypertelorism Stridor Goiter Hyperbilirubinemia Abnormal vertebral morphology Growth hormone deficiency Macroglossia Dry skin Feeding difficulties in infancy Umbilical hernia Delayed skeletal maturation Muscular hypotonia Generalized hypotonia Scoliosis Micrognathia Facial palsy Syndactyly Cleft lip Telecanthus EEG abnormality Retrognathia Kyphoscoliosis Proptosis Polydactyly Glaucoma Brachycephaly Visual loss Pectus excavatum Microphthalmia Abnormality of the dentition Strabismus Hydrocephalus Frontal bossing Downslanted palpebral fissures Macrocephaly Wide nasal bridge Brachydactyly Dysarthria Epicanthus Motor delay Spasticity Cryptorchidism Cleft palate Short distal phalanx of the thumb Orbital cyst Sinus bradycardia Heart murmur Elevated erythrocyte sedimentation rate Coronary artery atherosclerosis Bundle branch block Loss of consciousness Emphysema Anhidrosis Polyuria Diabetes insipidus Tricuspid regurgitation Impaired vibratory sensation Clubbing Personality changes Orthostatic hypotension Polydipsia Hemiplegia Abnormality of the hand Prominent supraorbital ridges Atrioventricular block Easy fatigability Tinnitus Ventricular arrhythmia Reduced bone mineral density Ischemic stroke Corneal dystrophy Progressive hearing impairment Interstitial pulmonary abnormality Celiac disease Aortic regurgitation Elevated serum creatinine Achalasia Chronic obstructive pulmonary disease Angina pectoris Clubbing of fingers Peripheral arterial stenosis Reduced ejection fraction Heat intolerance Supraventricular tachycardia Large earlobe Oligospermia Abnormality of the gastrointestinal tract Tubular atrophy Tubulointerstitial nephritis Telangiectasia of the skin Edema of the lower limbs Renal tubular dysfunction Transient ischemic attack Xerostomia Abnormal EKG Abnormality of lipid metabolism Aortic root aneurysm Wheezing Renal tubular acidosis Glycosuria Abnormal heart valve morphology Glomerulopathy Abnormal intestine morphology Ventricular tachycardia Calcification of falx cerebri Optic atrophy Cough Stroke Developmental regression Hypertrophic cardiomyopathy Abnormality of the nervous system Dyspnea Hyperkeratosis Posteriorly rotated ears Midface retrusion Dilatation Respiratory insufficiency Cognitive impairment Corneal opacity Sensorineural hearing impairment Hamartomatous stomach polyps Irregular ossification of hand bones Cardiac fibroma Bridged sella turcica Plantar pits Ovarian fibroma Odontogenic keratocysts of the jaw Cardiac rhabdomyoma Bifid ribs Curved fingers Histiocytoma Prominent nasal bridge Pruritus Purpura Atrial fibrillation Aminoaciduria Exercise intolerance Spontaneous abortion Abnormal autonomic nervous system physiology Fasciculations Lymphedema Hypohidrosis Left ventricular hypertrophy Subcutaneous nodule Abnormal lung morphology Mitral regurgitation Myocardial infarction Thick lower lip vermilion Abnormality of the cerebral white matter Ventricular hypertrophy Nephrotic syndrome Mitral valve prolapse Abnormality of the cardiovascular system Syncope Muscle cramps Thick vermilion border Thick eyebrow Bulbous nose Vertigo Delayed puberty Malabsorption Episodic hypertension



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