Autoimmunity, and Psoriasiform dermatitis

Diseases related with Autoimmunity and Psoriasiform dermatitis

In the following list you will find some of the most common rare diseases related to Autoimmunity and Psoriasiform dermatitis that can help you solving undiagnosed cases.


Top matches:

Medium match PSORIASIS-RELATED JUVENILE IDIOPATHIC ARTHRITIS


Juvenile psoriatic arthritis is a relatively rare form of juvenile idiopathic arthritis (JIA) representing less than 10% of all JIA cases.

PSORIASIS-RELATED JUVENILE IDIOPATHIC ARTHRITIS Is also known as psoriasis-related jia|juvenile psoriatic arthritis

Related symptoms:

  • Arthritis
  • Autoimmunity
  • Inflammatory abnormality of the skin
  • Psoriasiform dermatitis
  • Juvenile rheumatoid arthritis


SOURCES: OMIM ORPHANET MENDELIAN

More info about PSORIASIS-RELATED JUVENILE IDIOPATHIC ARTHRITIS

Medium match BULLOUS PEMPHIGOID


Bullous pemphigoid (BP) is the most common form of autoimmune bullous dermatosis.

Related symptoms:

  • Recurrent infections
  • Diabetes mellitus
  • Weight loss
  • Erythema
  • Autoimmunity


SOURCES: ORPHANET MESH MENDELIAN

More info about BULLOUS PEMPHIGOID

Medium match IDIOPATHIC CD4 LYMPHOCYTOPENIA


Idiopathic CD4 lymphocytopenia is a rare primary immunodeficiency disorder characterized by persistent CD4 T-cell lymphopenia (less than 300 cells/µL on multiple occasions) not associated with any other underlying primary or secondary immune deficiency. Patients typically present opportunistic infections (with cryptococcal, mycobacterial, candidal, varicella zoster virus infections and progressive multifocal leukoencephalopathy being the most prevalent), malignancies (mainly lymphoproliferative disorders), or autoimmune disorders. Some individuals are asymptomatic and incidentally diagnosed.

IDIOPATHIC CD4 LYMPHOCYTOPENIA Is also known as icl|idiopathic cd4 lymphopenia

Related symptoms:

  • Neoplasm
  • Anemia
  • Immunodeficiency
  • Pneumonia
  • Carcinoma


SOURCES: OMIM ORPHANET MENDELIAN

More info about IDIOPATHIC CD4 LYMPHOCYTOPENIA

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Other less relevant matches:

Medium match AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME DUE TO CTLA4 HAPLOINSUFFIENCY


Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency is a rare, primary immunodeficiency characterized by variable combination of enteropathy, hypogammaglobulinemia, recurrent respiratory infections, granulomatous lymphocytic interstitial lung disease, lymphocytic infiltration of non-lymphoid organs (intestine, lung, brain, bone marrow, kidney), autoimmune thrombocytopenia or neutropenia, autoimmune hemolytic anemia and lymphadenopathy.

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME DUE TO CTLA4 HAPLOINSUFFIENCY Is also known as alps due to ctla4 haploinsuffiency|chai|ctla4 haploinsufficiency with autoimmune infiltration|ctla-4 haploinsufficiency with autoimmune infiltration disease

Related symptoms:

  • Hepatomegaly
  • Diarrhea
  • Splenomegaly
  • Immunodeficiency
  • Recurrent infections


SOURCES: OMIM ORPHANET MENDELIAN

More info about AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME DUE TO CTLA4 HAPLOINSUFFIENCY

Medium match IMMUNODEFICIENCY DUE TO CD25 DEFICIENCY


Immunodeficiency due to CD25 deficiency is a rare, genetic, primary immunodeficiency due to a defect in adaptive immunity disorder characterized by severe immunodeficiency, presenting with profound susceptibility to viral, fungal and bacterial infections due to impaired CD25-mediated T-regulatory cell function, in association with severe autoimmune disease, such as alopecia universalis, erythrodermia, and autoimmune thyroiditis and enteropathy.

IMMUNODEFICIENCY DUE TO CD25 DEFICIENCY Is also known as cd25 deficiency|interleukin 2 receptor, alpha, deficiency of|interleukin-2 receptor alpha chain deficiency|il2ra deficiency

Related symptoms:

  • Anemia
  • Hepatomegaly
  • Respiratory insufficiency
  • Diarrhea
  • Splenomegaly


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about IMMUNODEFICIENCY DUE TO CD25 DEFICIENCY

Medium match COMBINED IMMUNODEFICIENCY-ENTEROPATHY SPECTRUM


COMBINED IMMUNODEFICIENCY-ENTEROPATHY SPECTRUM Is also known as cid-mia/early-onset ibd

Related symptoms:

  • Intrauterine growth retardation
  • Ventricular septal defect
  • Immunodeficiency
  • Polyhydramnios
  • Sparse hair


SOURCES: ORPHANET MENDELIAN

More info about COMBINED IMMUNODEFICIENCY-ENTEROPATHY SPECTRUM

Medium match IMMUNODEFICIENCY, COMMON VARIABLE, 10; CVID10


Common variable immunodeficiency-10 is an autosomal dominant primary immunodeficiency characterized by childhood-onset of recurrent infections, hypogammaglobulinemia, and decreased numbers of memory and marginal zone B cells. Some patients may develop autoimmune features and have circulating autoantibodies. An unusual feature is central adrenal insufficiency (summary by Chen et al., 2013).For a general description and a discussion of genetic heterogeneity of common variable immunodeficiency, see CVID1 (OMIM ).

IMMUNODEFICIENCY, COMMON VARIABLE, 10; CVID10 Is also known as deficit in anterior pituitary function and variable immunodeficiency|david|immunodeficiency, common variable, with central adrenal insufficiency

Related symptoms:

  • Global developmental delay
  • Spasticity
  • Gait disturbance
  • Dysphagia
  • Immunodeficiency


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY, COMMON VARIABLE, 10; CVID10

Medium match DEFICIENCY IN ANTERIOR PITUITARY FUNCTION-VARIABLE IMMUNODEFICIENCY SYNDROME


Deficiency in anterior pituitary function-variable immunodeficiency syndrome is a rare, genetic endocrine disease characterized by the association of common variable immunodeficiency, manifesting with hypogammaglobulinemia and recurrent or severe childhood-onset sinopulmonary infections, followed, possibly many years later, by symptomatic adrenocorticotropic hormone (ACTH) deficiency resulting from anterior pituitary hormone deficiency.

DEFICIENCY IN ANTERIOR PITUITARY FUNCTION-VARIABLE IMMUNODEFICIENCY SYNDROME Is also known as david syndrome

Related symptoms:

  • Global developmental delay
  • Failure to thrive
  • Fatigue
  • Alopecia
  • Nail dystrophy


SOURCES: ORPHANET MENDELIAN

More info about DEFICIENCY IN ANTERIOR PITUITARY FUNCTION-VARIABLE IMMUNODEFICIENCY SYNDROME

Medium match MULTIPLE INTESTINAL ATRESIA


Multiple intestinal atresia is a rare form of intestinal atresia characterized by the presence of numerous atresic segments in the small bowel (duodenum) or large bowel and leading to symptoms of intestinal obstruction: vomiting, abdominal bloating and inability to pass meconium in newborns.

MULTIPLE INTESTINAL ATRESIA Is also known as intestinal atresia, multiple|minat|intestinal atresia, multiple and/or inflammatory bowel disease with or without immunodeficiency|fipa|familial intestinal polyatresia syndrome

Related symptoms:

  • Growth delay
  • Anemia
  • Intrauterine growth retardation
  • Abnormality of the skeletal system
  • Ventricular septal defect


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about MULTIPLE INTESTINAL ATRESIA

Medium match PROLIDASE DEFICIENCY


Prolidase deficiency is an inherited disorder of peptide metabolism characterized by severe skin lesions, recurrent infections (involving mainly the skin and respiratory system), dysmorphic facial features, variable cognitive impairment, and splenomegaly.

PROLIDASE DEFICIENCY Is also known as hyperimidodipeptiduria

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Hearing impairment
  • Hypertelorism
  • Micrognathia


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about PROLIDASE DEFICIENCY

Top 5 symptoms//phenotypes associated to Autoimmunity and Psoriasiform dermatitis

Symptoms // Phenotype % cases
Immunodeficiency Common - Between 50% and 80% cases
Autoimmune hemolytic anemia Uncommon - Between 30% and 50% cases
Inflammatory abnormality of the skin Uncommon - Between 30% and 50% cases
Recurrent infections Uncommon - Between 30% and 50% cases
Anemia Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Autoimmunity and Psoriasiform dermatitis. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Thyroiditis Decreased antibody level in blood Recurrent respiratory infections Diarrhea Nail dystrophy Alopecia Global developmental delay Splenomegaly Hepatomegaly Abnormal lung morphology Abnormal intestine morphology Hepatitis Type I diabetes mellitus Lymphopenia Autoimmune thrombocytopenia Hemolytic anemia Eczema

Rare Symptoms - Less than 30% cases


Abnormality of the ductus choledochus Peritoneal abscess Vitiligo Bronchiectasis Chronic lung disease Alopecia totalis Congenital cystic adenomatoid malformation of the lung Growth hormone deficiency Asthma Gastrointestinal atresia Increased antibody level in blood Intrauterine growth retardation Ectopic calcification Jejunoileal ulceration Intestinal atresia Polyhydramnios Sparse hair Rectal abscess Abdominal distention Intestinal malrotation Omphalocele Thickened skin Absent eyebrow Hashimoto thyroiditis Alopecia of scalp Severe combined immunodeficiency Hypoplasia of the thymus Bloody diarrhea Ventricular septal defect Arthritis Hepatosplenomegaly Recurrent upper respiratory tract infections Diabetes mellitus Erythema Pneumonia Recurrent otitis media Sinusitis Recurrent sinusitis Bronchiolitis Thrombocytopenia Respiratory tract infection Lymphadenopathy Recurrent pneumonia Sepsis Delayed speech and language development Intellectual disability Proptosis Inflammation of the large intestine Combined immunodeficiency Abnormality of abdomen morphology Vomiting Hematochezia Duodenal atresia Duodenal stenosis Microcolon Downslanted palpebral fissures Jejunal atresia Decreased proportion of CD8-positive T cells Intellectual disability, mild Prominent forehead Short nose Hearing impairment Malar flattening Hypertelorism Abnormality of metabolism/homeostasis Micrognathia Intellectual disability, severe Ptosis High palate Depressed nasal bridge Obesity High forehead Visual impairment Hyperkeratosis Abnormal facial shape Genu valgum Elevated hepatic transaminase Abnormality of the immune system Reduced bone mineral density Systemic lupus erythematosus Osteomyelitis Petechiae Elevated erythrocyte sedimentation rate Abnormality of the hip bone Aplasia/Hypoplasia of the skin Prolonged neonatal jaundice Generalized hirsutism Hypoplasia of the zygomatic bone Concave nasal ridge White forelock Abnormality of the middle ear Poliosis Facial hirsutism Crusting erythematous dermatitis Diffuse telangiectasia Abnormality of the fingernails Bilateral single transverse palmar creases Skin rash Palmoplantar keratoderma Papule Pruritus Carious teeth Small for gestational age Arachnodactyly Dry skin Hirsutism Convex nasal ridge Low anterior hairline Dehydration Low posterior hairline Cutaneous photosensitivity Depressed nasal ridge Thin skin Abnormality of retinal pigmentation Lymphedema Skin ulcer Anal atresia Adrenal insufficiency Scarring Iron deficiency anemia Decreased proportion of CD4-positive T cells Respiratory insufficiency Hypothyroidism Chronic diarrhea Recurrent bacterial infections IgA deficiency Atopic dermatitis Verrucae Gingivitis Antinuclear antibody positivity Esophagitis Recurrent viral infections Villous atrophy Immune dysregulation Decrease in T cell count Impaired T cell function Interstitial pulmonary abnormality Granulocytopenia Neoplasm Juvenile rheumatoid arthritis Nail pits Weight loss Abnormal blistering of the skin Urticaria Macule Carcinoma Bronchiolitis obliterans organizing pneumonia Lymphoma Otitis media Squamous cell carcinoma Hodgkin lymphoma Papilloma Bronchiolitis obliterans Opportunistic infection Recurrent fungal infections Chronic hemolytic anemia Abnormality of the skeletal system Adrenocorticotropin deficient adrenal insufficiency Recurrent hypoglycemia Decreased circulating cortisol level Autoimmune antibody positivity Recurrent pharyngitis Decreased circulating ACTH level Hypoglycemic coma Decreased serum insulin-like growth factor 1 Hyperkalemia Severe viral infections Abnormal lymphocyte morphology Decreased circulating androgen level Abnormal size of pituitary gland Severe B lymphocytopenia Abnormality of the periungual region Growth delay Recurrent bronchitis Hyponatremia Recurrent abscess formation Chronic sinusitis Spasticity Gait disturbance Dysphagia Hypoglycemia Meningitis Purpura Adrenocorticotropic hormone deficiency Absence seizures Alopecia areata Central adrenal insufficiency Trachyonychia Failure to thrive Fatigue Hypotension Diplopia Recurrent cystitis



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