Autoimmunity, and Memory impairment

Diseases related with Autoimmunity and Memory impairment

In the following list you will find some of the most common rare diseases related to Autoimmunity and Memory impairment that can help you solving undiagnosed cases.


Top matches:

Low match MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO; MS


MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO; MS Is also known as disseminated sclerosis

Related symptoms:

  • Seizures
  • Hearing impairment
  • Nystagmus
  • Neoplasm
  • Muscle weakness


SOURCES: OMIM MENDELIAN

More info about MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO; MS

Low match SNEDDON SYNDROME


Sneddon's syndrome (SS) is a rare non-inflammatory thrombotic vasculopathy characterized by the combination of cerebrovascular disease with livedo racemosa.

SNEDDON SYNDROME Is also known as livedo reticularis-cerebrovascular accident syndrome|livedo racemosa-cerebrovascular accident syndrome|livedo reticularis and cerebrovascular accidents|ehrmann-sneddon syndrome

Related symptoms:

  • Seizures
  • Muscle weakness
  • Pain
  • Visual impairment
  • Motor delay


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about SNEDDON SYNDROME

Low match SYSTEMIC LUPUS ERYTHEMATOSUS


Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by Oishi et al., 2008). Genetic Heterogeneity of Systemic Lupus ErythematosusAn autosomal recessive form of systemic lupus erythematosus (SLEB16 ) is caused by mutation in the DNASE1L3 gene (OMIM ) on chromosome 3p14.3.See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.

SYSTEMIC LUPUS ERYTHEMATOSUS Is also known as disseminated lupus erythematosus|sle

Related symptoms:

  • Seizures
  • Short stature
  • Cognitive impairment
  • Anemia
  • Fatigue


SOURCES: OMIM ORPHANET MENDELIAN

More info about SYSTEMIC LUPUS ERYTHEMATOSUS

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Other less relevant matches:

Low match WALDENSTRÖM MACROGLOBULINEMIA


Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoproliferative disorder characterized by the accumulation of monoclonal cells in the bone marrow and peripheral lymphoid tissues, and associated with the production of serum immunoglobulin M (IgM) monoclonal protein.

Related symptoms:

  • Hearing impairment
  • Ataxia
  • Neoplasm
  • Anemia
  • Peripheral neuropathy


SOURCES: OMIM ORPHANET MENDELIAN

More info about WALDENSTRÖM MACROGLOBULINEMIA

Low match BEHÇET DISEASE


Behçet's disease (BD) is a chronic, relapsing, multisystemic vasculitis characterized by mucocutaneous lesions, as well as articular, vascular, ocular and central nervous system manifestations.

BEHÇET DISEASE Is also known as bd|behcet disease

Related symptoms:

  • Seizures
  • Ataxia
  • Neoplasm
  • Pain
  • Cataract


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about BEHÇET DISEASE

Low match MELAS


MELAS (Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke) syndrome is a rare progressive multisystemic disorder characterized by encephalomyopathy, lactic acidosis, and stroke-like episodes. Other features include endocrinopathy, heart disease, diabetes, hearing loss, and neurological and psychiatric manifestations.

MELAS Is also known as mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes|melas syndrome|mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Hearing impairment


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about MELAS

Low match BENIGN FAMILIAL NEONATAL EPILEPSY


Benign familial neonatal epilepsy (BFNE) is a rare genetic epilepsy syndrome characterized by the occurrence of afebrile seizures in otherwise healthy newborns with onset in the first few days of life.

BENIGN FAMILIAL NEONATAL EPILEPSY Is also known as bfns|benign familial neonatal convulsions|benign familial neonatal seizures

Related symptoms:

  • Seizures
  • Cognitive impairment
  • Hypertonia


SOURCES: ORPHANET MENDELIAN

More info about BENIGN FAMILIAL NEONATAL EPILEPSY

Low match MEGALOBLASTIC ANEMIA 1


Imerslund-Grasbeck syndrome is a form of congenital megaloblastic anemia due to vitamin B12 deficiency caused by a defect in the vitamin B12/intrinsic factor receptor. See also congenital pernicious anemia due to a defect in intrinsic factor (OMIM ).Adult pernicious anemia (OMIM ) is a distinct autoimmune disorder associated with plasma autoantibodies to gastric parietal cells or gastric intrinsic factor. In these cases, there is gastric atrophy and a relatively high frequency of associated thyroiditis and myxedema.

MEGALOBLASTIC ANEMIA 1 Is also known as pernicious anemia, juvenile, due to selective intestinal malabsorption of vitamin b12, with proteinuria|mga1|enterocyte intrinsic factor receptor, defect of|enterocyte cobalamin malabsorption|igs|imerslund-grasbeck syndrome

Related symptoms:

  • Anemia
  • Dementia
  • Proteinuria
  • Paralysis
  • Autoimmunity


SOURCES: OMIM ORPHANET MENDELIAN

More info about MEGALOBLASTIC ANEMIA 1

Low match RECESSIVE MITOCHONDRIAL ATAXIA SYNDROME


Recessive mitochondrial ataxia syndrome is a rare, mitochondrial DNA maintenance syndrome characterized by early-onset cerebellar ataxia, and variable combination of epilepsy, headache, dysarthria, ophthalmoplegia, peripheral neuropathy, intellectual disability, psychiatric symptoms and movement disorders.

RECESSIVE MITOCHONDRIAL ATAXIA SYNDROME Is also known as miras

Related symptoms:

  • Seizures
  • Generalized hypotonia
  • Ataxia
  • Cognitive impairment
  • Peripheral neuropathy


SOURCES: ORPHANET MENDELIAN

More info about RECESSIVE MITOCHONDRIAL ATAXIA SYNDROME

Low match IMMUNODEFICIENCY WITH HYPER-IGM, TYPE 1; HIGM1


HIGM is a rare immunodeficiency characterized by normal or elevated serum IgM levels associated with markedly decreased IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections and an increased susceptibility to opportunistic infections. Patients with X-linked HIGM also tend to have neutropenia, as well as a high rate of gastrointestinal and central nervous system infections, often resulting in severe liver disease and/or neurodegeneration (summary by Levy et al., 1997). Genetic Heterogeneity of Immunodeficiency with Hyper-IgMOther forms of HIGM include HIGM2 (OMIM ), which results from mutation in the AICDA gene (OMIM ), HIGM3 (OMIM ), which results from mutation in the CD40 gene (OMIM ), and HIGM5 (OMIM ), which results from mutation in the UNG gene (OMIM ). See also HIGM4 (OMIM ).

IMMUNODEFICIENCY WITH HYPER-IGM, TYPE 1; HIGM1 Is also known as hyper-igm immunodeficiency, x-linked|hyper-igm syndrome 1|ihis|hyper-igm syndrome|xhim|imd3|higm|immunodeficiency 3

Related symptoms:

  • Seizures
  • Global developmental delay
  • Failure to thrive
  • Cognitive impairment
  • Anemia


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY WITH HYPER-IGM, TYPE 1; HIGM1

Top 5 symptoms//phenotypes associated to Autoimmunity and Memory impairment

Symptoms // Phenotype % cases
Seizures Common - Between 50% and 80% cases
Headache Common - Between 50% and 80% cases
Cognitive impairment Uncommon - Between 30% and 50% cases
Confusion Uncommon - Between 30% and 50% cases
Anemia Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Autoimmunity and Memory impairment. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Ataxia Fever Diarrhea Malabsorption Vasculitis Migraine Vertigo Dysarthria Fatigue Weight loss Stroke Paresthesia Visual loss Pain Myalgia Tremor Splenomegaly Visual impairment Anorexia Hemiparesis Hepatomegaly Peripheral neuropathy Cerebral ischemia Hearing impairment Developmental regression Renal insufficiency Raynaud phenomenon Dementia Gait disturbance Purpura Neoplasm Behavioral abnormality Muscle weakness Thyroiditis Hashimoto thyroiditis Hyperreflexia

Rare Symptoms - Less than 30% cases


Pericarditis Proteinuria Pulmonary embolism Gangrene Respiratory insufficiency Stomatitis Rheumatoid arthritis Congestive heart failure Pleuritis Abnormality of the liver Gastrointestinal hemorrhage Recurrent infections Hypertonia Pancreatitis Nausea and vomiting Erythema Dysphagia Photophobia Dyspnea Abdominal pain Blindness Cataract Global developmental delay Lymphadenopathy Reduced consciousness/confusion Areflexia Hemolytic anemia Encephalitis Pulmonary infiltrates Pleural effusion Cranial nerve paralysis Glomerulopathy Failure to thrive Polyneuropathy Psychosis Aseptic necrosis Involuntary movements Sensory impairment Ophthalmoplegia Hemianopia Motor delay Constipation Nephropathy Paralysis Hemiplegia Mental deterioration Amaurosis fugax Depressivity Hyperkinesis Visual field defect Antiphospholipid antibody positivity Scarring Aphasia Cutis marmorata Myocardial infarction Short stature Systemic lupus erythematosus Hypertension Nystagmus Dysmetria Thrombocytopenia Personality changes Alopecia Arthritis Transient ischemic attack Progressive sensorineural hearing impairment Vertebral fusion Generalized hirsutism Multiple lipomas Prolonged QT interval Hyperkalemia Nephrotic syndrome Dysphasia Type II diabetes mellitus Vestibular dysfunction Bundle branch block Pulmonary arterial hypertension Adrenal insufficiency Status epilepticus Bilateral sensorineural hearing impairment Rhabdomyolysis Generalized-onset seizure Vitiligo Facial diplegia Cardiorespiratory arrest Delusions Posterior subcapsular cataract Progressive external ophthalmoplegia Mitochondrial myopathy Hypoparathyroidism Heart block Xerostomia Neonatal hypoglycemia Basal ganglia calcification Abnormality of visual evoked potentials Atopic dermatitis Drowsiness Distal arthrogryposis Primary adrenal insufficiency Pigmentary retinopathy Abnormality of immune system physiology Hyperthyroidism Abnormality of the cardiovascular system Ventricular hypertrophy Ophthalmoparesis Overlapping toe Renal tubular dysfunction Growth abnormality Easy fatigability Goiter Cerebral visual impairment Schizophrenia Clonus Cardiac arrest Mutism Hypopigmented skin patches Abnormality of retinal pigmentation Truncal ataxia Ischemic stroke Ragged-red muscle fibers Reduced tendon reflexes EMG abnormality External ophthalmoplegia Macular degeneration Exercise intolerance Type I diabetes mellitus Hallucinations Gingival overgrowth Abnormality of neuronal migration Hyponatremia Focal segmental glomerulosclerosis Hemiplegia/hemiparesis Mask-like facies Bifid scrotum Aplasia/Hypoplasia of the cerebellum Intestinal obstruction Atrial fibrillation Hypogonadotrophic hypogonadism Abnormality of mitochondrial metabolism Left ventricular hypertrophy Aortic aneurysm Hypertrichosis Bilateral ptosis Hypercalciuria Decreased nerve conduction velocity Cachexia Atrioventricular block Chronic kidney disease Decreased body weight Aortic dissection Spotty hypopigmentation Tubulointerstitial nephritis Limb dysmetria Recurrent otitis media Otitis media Decreased antibody level in blood Sepsis Neutropenia Neurodegeneration Carcinoma Immunodeficiency Abnormality of central motor conduction Positive Romberg sign Clumsiness Increased serum pyruvate ST segment elevation Sensory axonal neuropathy Impaired vibratory sensation Abnormality of movement Generalized hypotonia Malabsorption of Vitamin B12 Vitamin B12 deficiency Poikiloderma Choreoathetosis Chronic diarrhea Prominent ear helix Increased IgM level IgE deficiency Opportunistic infection Agranulocytosis Enlarged tonsils Absence of lymph node germinal center Impaired Ig class switch recombination Decreased T cell activation Cholangiocarcinoma Sclerosing cholangitis Dysgammaglobulinemia Recurrent bacterial infections Chronic hepatitis IgM deficiency Cholangitis Agammaglobulinemia Gingivitis Recurrent lower respiratory tract infections IgG deficiency Hepatocellular carcinoma IgA deficiency Leukoencephalopathy Megaloblastic anemia Morphological abnormality of the inner ear Visual hallucinations Ileus Leber optic atrophy Persistence of primary teeth Writer's cramp Muscle fiber atrophy Psychomotor deterioration Dysesthesia Motor polyneuropathy Episodic vomiting Abnormality of the renal tubule Proximal tubulopathy Gastroparesis Abnormality of peripheral nerve conduction Retinal pigment epithelial atrophy Speech apraxia Left ventricular failure Seborrheic dermatitis Stroke-like episode Anterior hypopituitarism Gait imbalance Wolff-Parkinson-White syndrome Increased CSF lactate Spontaneous hematomas Auditory hallucinations Morphological abnormality of the vestibule of the inner ear Cochlear malformation Bilateral intracranial calcifications Episodic quadriplegia Abnormality of acid-base homeostasis Homonymous hemianopia Abnormal cochlea morphology Paralytic ileus Abnormal mitochondrial shape Cochlear degeneration Progressive night blindness Edema of the dorsum of hands Abnormal nerve conduction velocity Abnormal mitochondrial morphology Paronychia Amenorrhea Abnormal macular morphology Hemeralopia Crohn's disease Abnormality of the cerebellar vermis Psychotic episodes Tubulointerstitial abnormality Renal Fanconi syndrome Cerebral calcification Elevated serum creatine phosphokinase Specific learning disability Retinal hemorrhage Reduced visual acuity Glaucoma Dilatation Polyclonal elevation of IgM Cryoglobulinemia Impaired lymphocyte transformation with phytohemagglutinin Monoclonal immunoglobulin M proteinemia Multifocal epileptiform discharges Abnormality of neutrophils Irritability Normocytic anemia Periorbital edema Abnormality of the retinal vasculature Lymphoproliferative disorder Hypercoagulability Edema of the lower limbs Gingival bleeding Elevated erythrocyte sedimentation rate Urticaria Arthralgia Joint stiffness Lymphoma Increased intracranial pressure Myositis Pustule Uveitis Hemoptysis Keratoconjunctivitis sicca Blurred vision Epiphora Inflammation of the large intestine Acne Venous thrombosis Retinopathy Aortic regurgitation Meningitis Subcutaneous nodule Mitral regurgitation Abnormal blistering of the skin Chest pain Papule Cough Abnormal pyramidal sign Epistaxis Leukemia Arterial thrombosis Facial palsy Peripheral arterial stenosis Arteriovenous malformation Acrocyanosis Thrombocytosis Atrophic scars Heart murmur Intracranial hemorrhage Chorea Urinary hesitancy Arterial stenosis CNS demyelination Brain neoplasm Emotional lability Incoordination Muscle stiffness Diplopia Urinary incontinence Difficulty walking Spasticity Facial paralysis Thromboembolic stroke Pallor Increased antibody level in blood Proptosis Serositis Malar rash Complement deficiency Antinuclear antibody positivity Epiphyseal stippling Autoimmune thrombocytopenia Autoimmune hemolytic anemia Abnormality of the thyroid gland Abnormality of coagulation Vascular skin abnormality Glomerulonephritis Nephritis Leukopenia Inflammatory abnormality of the skin Cutaneous photosensitivity Abnormality of the skin Skin rash Midface retrusion Lupus anticoagulant Abnormal myocardium morphology Recurrent aphthous stomatitis Hip dysplasia Jaundice Nyctalopia Protruding ear Abnormality of the pinna Feeding difficulties in infancy Apnea Hypertrophic cardiomyopathy Anxiety EEG abnormality Gastroesophageal reflux Neurological speech impairment Acidosis Hypothyroidism Autism Gait ataxia Cerebral cortical atrophy Diabetes mellitus Hypogonadism Osteoporosis Myoclonus Attention deficit hyperactivity disorder Dilated cardiomyopathy Cerebellar hypoplasia Nausea Increased serum lactate Sudden cardiac death Generalized myoclonic seizures Abnormal cerebellum morphology Muscle cramps Postural instability Coma Hirsutism Polymicrogyria Lactic acidosis Pruritus Peripheral axonal neuropathy Ichthyosis Anal atresia Delayed puberty Carious teeth Congenital cataract Arthrogryposis multiplex congenita Lethargy Generalized tonic-clonic seizures Rod-cone dystrophy Delayed skeletal maturation Alopecia areata Increased inflammatory response Decreased level of D-mannose in urine Epididymitis Genital ulcers Panuveitis Superficial thrombophlebitis Orchitis Retrobulbar optic neuritis Iritis Iridocyclitis Intellectual disability Posterior uveitis Anterior uveitis Optic neuritis Chorioretinitis Immunologic hypersensitivity Erythema nodosum Thrombophlebitis Oral ulcer Endocarditis Hypopyon Microcephaly Hyporeflexia Cardiomyopathy Arrhythmia Encephalopathy Cerebral atrophy Kyphosis Dystonia Abnormality of the dentition Vomiting Cerebellar atrophy Myopathy Respiratory distress Growth delay Short neck Ventriculomegaly Optic atrophy Skeletal muscle atrophy Feeding difficulties Ptosis Muscular hypotonia Sensorineural hearing impairment Hypertelorism Impaired memory B cell generation



If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Arthritis and Hirsutism, related diseases and genetic alterations

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