Autoimmunity, and Bradycardia

Diseases related with Autoimmunity and Bradycardia

In the following list you will find some of the most common rare diseases related to Autoimmunity and Bradycardia that can help you solving undiagnosed cases.


Top matches:

Low match ATRIAL SEPTAL DEFECT 6; ASD6


Related symptoms:

  • Atrial septal defect
  • Atrial fibrillation
  • Bradycardia


SOURCES: OMIM MESH MENDELIAN

More info about ATRIAL SEPTAL DEFECT 6; ASD6

Low match SINOATRIAL NODE DYSFUNCTION AND DEAFNESS


Sinoatrial node dysfunction and deafness is a rare genetic disease characterized by congenital severe to profound deafness with no evidence of vestibular dysfunction, associated with sinoatrial node dysfunction with pronounced bradycardia and increased variability of heart rate at rest and episodic syncopes that may be triggered by enhanced physical activity and stress.

Related symptoms:

  • Hearing impairment
  • Syncope
  • Bradycardia
  • Vestibular dysfunction
  • Abnormal atrioventricular conduction


SOURCES: OMIM ORPHANET MENDELIAN

More info about SINOATRIAL NODE DYSFUNCTION AND DEAFNESS

Low match EMERY-DREIFUSS MUSCULAR DYSTROPHY 7, AUTOSOMAL DOMINANT; EDMD7


Emery-Dreifuss muscular dystrophy is a genetically heterogeneous muscular disease that presents with muscular dystrophy, joint contractures, and cardiomyopathy with conduction defects (summary by Liang et al., 2011).For a discussion of genetic heterogeneity of EDMD, see {310300}.

Related symptoms:

  • Muscle weakness
  • Flexion contracture
  • Cardiomyopathy
  • Arrhythmia
  • Proximal muscle weakness


SOURCES: OMIM MENDELIAN

More info about EMERY-DREIFUSS MUSCULAR DYSTROPHY 7, AUTOSOMAL DOMINANT; EDMD7

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Other less relevant matches:

Low match SUDDEN CARDIAC FAILURE, INFANTILE; SCFI


Related symptoms:

  • Seizures
  • Generalized hypotonia
  • Failure to thrive
  • Feeding difficulties
  • Cardiomyopathy


SOURCES: OMIM MENDELIAN

More info about SUDDEN CARDIAC FAILURE, INFANTILE; SCFI

Low match ATRIAL FIBRILLATION, FAMILIAL, 18; ATFB18


Related symptoms:

  • Arrhythmia
  • Atrial fibrillation
  • Palpitations
  • Bradycardia
  • Sinus bradycardia


SOURCES: OMIM MENDELIAN

More info about ATRIAL FIBRILLATION, FAMILIAL, 18; ATFB18

Low match SHORT QT SYNDROME 2; SQT2


Short QT syndrome is a cardiac channelopathy associated with a predisposition to atrial fibrillation and sudden cardiac death. Patients have a structurally normal heart, but electrocardiography (ECG) exhibits abbreviated QTc (Bazett's corrected QT) intervals of less than 360 ms (summary by Moreno et al., 2015).For a discussion of genetic heterogeneity of short QT syndrome, see SQT1 (OMIM ).

Related symptoms:

  • Arrhythmia
  • Sudden cardiac death
  • Syncope
  • Atrial fibrillation
  • Bradycardia


SOURCES: OMIM MESH MENDELIAN

More info about SHORT QT SYNDROME 2; SQT2

Low match CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED


Loss-of-function mutations in ANK2 can result in a broad spectrum of clinical cardiac phenotypes. Carriers of some mutations (e.g., E1425G, {106410.0001}) display QT interval prolongation, stress- and/or exercise-induced polymorphic ventricular arrhythmia, syncope, and sudden cardiac death. Patients with other variants show clinical phenotypes, sometimes mild, extending beyond LQTS, leading to the label 'ankyrin-B syndrome.' These phenotypes include bradycardia, sinus arrhythmia, delayed conduction/conduction block, idiopathic ventricular fibrillation, and catecholaminergic polymorphic ventricular tachycardia (Mohler et al., 2007).

CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED Is also known as ankyrin-b syndrome

Related symptoms:

  • Arrhythmia
  • Tachycardia
  • Sudden cardiac death
  • Syncope
  • Atrial fibrillation


SOURCES: OMIM MENDELIAN

More info about CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED

Low match VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 2; CPVT2


VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 2; CPVT2 Is also known as ventricular tachycardia, stress-induced polymorphic|vtsip

Related symptoms:

  • Seizures
  • Tachycardia
  • Syncope
  • Bradycardia
  • Ventricular tachycardia


SOURCES: OMIM MENDELIAN

More info about VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 2; CPVT2

Low match LONG QT SYNDROME 9; LQT9


Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999).For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (OMIM ).

LONG QT SYNDROME 9; LQT9 Is also known as long qt syndrome 2/9, digenic, included|long qt syndrome 9, acquired, susceptibility to, included|lqt2/9, digenic, included

Related symptoms:

  • Seizures
  • Arrhythmia
  • Syncope
  • Cardiac arrest
  • Ventricular arrhythmia


SOURCES: MESH OMIM MENDELIAN

More info about LONG QT SYNDROME 9; LQT9

Low match ROMANO-WARD SYNDROME


Romano-Ward syndrome (RWS) is an autosomal dominant variant of the long QT syndrome (LQTS, see this term) characterized by syncopal episodes and electrocardiographic abnormalities (QT prolongation, T-wave abnormalities and torsade de pointes (TdP) ventricular tachycardia).

ROMANO-WARD SYNDROME Is also known as romano-ward long qt syndrome

Related symptoms:

  • Seizures
  • Arrhythmia
  • Sudden cardiac death
  • Syncope
  • Bradycardia


SOURCES: ORPHANET OMIM MENDELIAN

More info about ROMANO-WARD SYNDROME

Top 5 symptoms//phenotypes associated to Autoimmunity and Bradycardia

Symptoms // Phenotype % cases
Arrhythmia Common - Between 50% and 80% cases
Syncope Common - Between 50% and 80% cases
Atrial fibrillation Uncommon - Between 30% and 50% cases
Sinus bradycardia Uncommon - Between 30% and 50% cases
Seizures Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Autoimmunity and Bradycardia. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Ventricular arrhythmia Sudden cardiac death Ventricular fibrillation Cardiac arrest Prolonged QT interval Ventricular tachycardia

Rare Symptoms - Less than 30% cases


Tachycardia Atrial arrhythmia Polymorphic ventricular tachycardia Torsade de pointes Cardiomyopathy Palpitations Myocardial fibrosis Myocarditis Atrial septal defect Paroxysmal atrial fibrillation Permanent atrial fibrillation Shortened QT interval Atrioventricular block Epileptic spasms Abnormal T-wave Nemaline bodies Dilated cardiomyopathy Otitis media Neck muscle weakness Hearing impairment Vestibular dysfunction Abnormal atrioventricular conduction Abnormal electrophysiology of sinoatrial node origin Muscle weakness Flexion contracture Proximal muscle weakness Muscular dystrophy Progressive muscle weakness Proximal amyotrophy Metabolic acidosis Generalized hypotonia Failure to thrive Feeding difficulties Myopathy Vomiting Congestive heart failure Acidosis Hypertrophic cardiomyopathy Lactic acidosis T-wave alternans



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