Autoimmunity, and Atrial fibrillation

Diseases related with Autoimmunity and Atrial fibrillation

In the following list you will find some of the most common rare diseases related to Autoimmunity and Atrial fibrillation that can help you solving undiagnosed cases.


Top matches:

Low match MELAS


MELAS (Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke) syndrome is a rare progressive multisystemic disorder characterized by encephalomyopathy, lactic acidosis, and stroke-like episodes. Other features include endocrinopathy, heart disease, diabetes, hearing loss, and neurological and psychiatric manifestations.

MELAS Is also known as mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes|melas syndrome|mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Hearing impairment


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about MELAS

Low match ATRIAL FIBRILLATION, FAMILIAL, 15; ATFB15


Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterized by uncoordinated atrial activation with consequent deterioration of atrial mechanical function. It is the most common sustained cardiac rhythm disturbance, and its prevalence increases as the population ages. An estimated 70,000 strokes each year are caused by atrial fibrillation (summary by Oberti et al., 2004).For a discussion of genetic heterogeneity of atrial fibrillation, see {608583}.

Related symptoms:

  • Cardiomyopathy
  • Abnormal heart morphology
  • Tachycardia
  • Atrial fibrillation
  • Supraventricular tachycardia


SOURCES: OMIM MENDELIAN

More info about ATRIAL FIBRILLATION, FAMILIAL, 15; ATFB15

Low match COUMARIN RESISTANCE


Warfarin is a widely prescribed anticoagulant for the prevention of thromboembolic diseases for subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement (Yuan et al., 2005). The dose requirement is highly variable, both interindividually and interethnically.Variation in the VKORC1 gene is believed to be the most important individual predictor of warfarin dose, accounting for about 30% of the variance observed in dosing (Ross et al., 2010).

COUMARIN RESISTANCE Is also known as coumarin, poor metabolism of|warfarin resistance

Related symptoms:

  • Abnormality of metabolism/homeostasis
  • Atrial fibrillation
  • Abnormality of blood and blood-forming tissues
  • Deep venous thrombosis


SOURCES: OMIM MENDELIAN

More info about COUMARIN RESISTANCE

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Other less relevant matches:

Low match ATRIAL SEPTAL DEFECT 6; ASD6


Related symptoms:

  • Atrial septal defect
  • Atrial fibrillation
  • Bradycardia


SOURCES: OMIM MESH MENDELIAN

More info about ATRIAL SEPTAL DEFECT 6; ASD6

Low match EMERY-DREIFUSS MUSCULAR DYSTROPHY 7, AUTOSOMAL DOMINANT; EDMD7


Emery-Dreifuss muscular dystrophy is a genetically heterogeneous muscular disease that presents with muscular dystrophy, joint contractures, and cardiomyopathy with conduction defects (summary by Liang et al., 2011).For a discussion of genetic heterogeneity of EDMD, see {310300}.

Related symptoms:

  • Muscle weakness
  • Flexion contracture
  • Cardiomyopathy
  • Arrhythmia
  • Proximal muscle weakness


SOURCES: OMIM MENDELIAN

More info about EMERY-DREIFUSS MUSCULAR DYSTROPHY 7, AUTOSOMAL DOMINANT; EDMD7

Low match ATRIAL FIBRILLATION, FAMILIAL, 18; ATFB18


Related symptoms:

  • Arrhythmia
  • Atrial fibrillation
  • Palpitations
  • Bradycardia
  • Sinus bradycardia


SOURCES: OMIM MENDELIAN

More info about ATRIAL FIBRILLATION, FAMILIAL, 18; ATFB18

Low match SHORT QT SYNDROME 3; SQT3


Short QT syndrome is a cardiac channelopathy associated with a predisposition to atrial fibrillation and sudden cardiac death. Patients have a structurally normal heart, but electrocardiography (ECG) exhibits abbreviated QTc (Bazett's corrected QT) intervals of less than 360 ms (summary by Moreno et al., 2015).For a discussion of genetic heterogeneity of short QT syndrome, see SQT1 (OMIM ).

Related symptoms:

  • Tachycardia
  • Sudden cardiac death
  • Atrial fibrillation
  • Palpitations
  • Shortened QT interval


SOURCES: OMIM MESH MENDELIAN

More info about SHORT QT SYNDROME 3; SQT3

Low match BRUGADA SYNDROME 4; BRGDA4


Brugada syndrome is characterized by an ST segment elevation in the right precordial electrocardiogram leads (so-called type 1 ECG) and a high incidence of sudden death in patients with structurally normal hearts. The syndrome typically manifests during adulthood, with a mean age of sudden death of 41 +/- 15 years, but also occurs in infants and children (summary by Antzelevitch et al., 2005).For a discussion of the genetic heterogeneity in Brugada syndrome, see BRGDA1 (OMIM ).

Related symptoms:

  • Tachycardia
  • Sudden cardiac death
  • Syncope
  • Atrial fibrillation
  • Myocardial infarction


SOURCES: OMIM MESH MENDELIAN

More info about BRUGADA SYNDROME 4; BRGDA4

Low match SHORT QT SYNDROME 2; SQT2


Short QT syndrome is a cardiac channelopathy associated with a predisposition to atrial fibrillation and sudden cardiac death. Patients have a structurally normal heart, but electrocardiography (ECG) exhibits abbreviated QTc (Bazett's corrected QT) intervals of less than 360 ms (summary by Moreno et al., 2015).For a discussion of genetic heterogeneity of short QT syndrome, see SQT1 (OMIM ).

Related symptoms:

  • Arrhythmia
  • Sudden cardiac death
  • Syncope
  • Atrial fibrillation
  • Bradycardia


SOURCES: OMIM MESH MENDELIAN

More info about SHORT QT SYNDROME 2; SQT2

Low match CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED


Loss-of-function mutations in ANK2 can result in a broad spectrum of clinical cardiac phenotypes. Carriers of some mutations (e.g., E1425G, {106410.0001}) display QT interval prolongation, stress- and/or exercise-induced polymorphic ventricular arrhythmia, syncope, and sudden cardiac death. Patients with other variants show clinical phenotypes, sometimes mild, extending beyond LQTS, leading to the label 'ankyrin-B syndrome.' These phenotypes include bradycardia, sinus arrhythmia, delayed conduction/conduction block, idiopathic ventricular fibrillation, and catecholaminergic polymorphic ventricular tachycardia (Mohler et al., 2007).

CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED Is also known as ankyrin-b syndrome

Related symptoms:

  • Arrhythmia
  • Tachycardia
  • Sudden cardiac death
  • Syncope
  • Atrial fibrillation


SOURCES: OMIM MENDELIAN

More info about CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED

Top 5 symptoms//phenotypes associated to Autoimmunity and Atrial fibrillation

Symptoms // Phenotype % cases
Bradycardia Uncommon - Between 30% and 50% cases
Sudden cardiac death Uncommon - Between 30% and 50% cases
Arrhythmia Uncommon - Between 30% and 50% cases
Tachycardia Uncommon - Between 30% and 50% cases
Sinus bradycardia Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Autoimmunity and Atrial fibrillation. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Shortened QT interval Cardiomyopathy Syncope

Rare Symptoms - Less than 30% cases


Ventricular tachycardia Muscle weakness Polymorphic ventricular tachycardia Palpitations Ventricular fibrillation Prolonged QT interval Hyperthyroidism Primary adrenal insufficiency Abnormality of immune system physiology Thyroiditis Rhabdomyolysis Intellectual disability Basal ganglia calcification Glomerulopathy Progressive sensorineural hearing impairment Vertebral fusion Multiple lipomas Visual field defect Hyperkalemia Pulmonary embolism Abnormality of visual evoked potentials Distal arthrogryposis Mitochondrial myopathy Aortic dissection Facial diplegia Cardiorespiratory arrest Delusions Transient ischemic attack Posterior subcapsular cataract Progressive external ophthalmoplegia Hypoparathyroidism Drowsiness Heart block Xerostomia Vitiligo Neonatal hypoglycemia Vestibular dysfunction Hashimoto thyroiditis Atopic dermatitis Dysphasia Focal segmental glomerulosclerosis Aphasia Schizophrenia Atrioventricular block Chronic kidney disease Growth abnormality Easy fatigability Hyperkinesis Goiter Mutism Decreased nerve conduction velocity Hypopigmented skin patches Ischemic stroke Ragged-red muscle fibers Reduced tendon reflexes External ophthalmoplegia Pancreatitis Cachexia Hypercalciuria Bundle branch block Bifid scrotum Adrenal insufficiency Overlapping toe Abnormality of neuronal migration Tubulointerstitial nephritis Hemiplegia/hemiparesis Mask-like facies Aplasia/Hypoplasia of the cerebellum Bilateral ptosis Intestinal obstruction Personality changes Ophthalmoparesis Hyponatremia Abnormality of mitochondrial metabolism Aortic aneurysm Hemiplegia Renal tubular dysfunction Anterior hypopituitarism Visual hallucinations Homonymous hemianopia Prominent ear helix Morphological abnormality of the inner ear Morphological abnormality of the vestibule of the inner ear Bilateral intracranial calcifications Episodic quadriplegia Abnormality of acid-base homeostasis Abnormal cochlea morphology Supraventricular tachycardia Paralytic ileus Abnormal mitochondrial shape Cochlear degeneration Progressive night blindness Cochlear malformation Edema of the dorsum of hands Abnormal heart morphology Atrial flutter Paronychia Proximal amyotrophy Aborted sudden cardiac death ST segment elevation Myocardial infarction Permanent atrial fibrillation Atrial arrhythmia Paroxysmal atrial fibrillation Neck muscle weakness Abnormality of metabolism/homeostasis Progressive muscle weakness Muscular dystrophy Proximal muscle weakness Flexion contracture Atrial septal defect Deep venous thrombosis Abnormality of blood and blood-forming tissues Abnormal mitochondrial morphology Spotty hypopigmentation Increased CSF lactate Speech apraxia Abnormality of the renal tubule Hemianopia Ileus Proximal tubulopathy Abnormality of peripheral nerve conduction Retinal pigment epithelial atrophy Left ventricular failure Motor polyneuropathy Seborrheic dermatitis Stroke-like episode Purpura Gait imbalance Reduced consciousness/confusion Cerebral ischemia Wolff-Parkinson-White syndrome Episodic vomiting Dysesthesia Abnormal macular morphology Abnormal nerve conduction velocity Hemeralopia Crohn's disease Abnormality of the cerebellar vermis Psychotic episodes Tubulointerstitial abnormality Renal Fanconi syndrome Auditory hallucinations Psychomotor deterioration Amaurosis fugax Gastroparesis Spontaneous hematomas Leber optic atrophy Persistence of primary teeth Writer's cramp Muscle fiber atrophy Macular degeneration Generalized hirsutism Exercise intolerance Depressivity Delayed skeletal maturation Elevated serum creatine phosphokinase Hyporeflexia Areflexia Visual loss Encephalopathy Cerebral atrophy Cerebellar hypoplasia Headache Renal insufficiency Kyphosis Dystonia Hypertonia Abnormality of the dentition Congestive heart failure Constipation Rod-cone dystrophy Vomiting Autism EEG abnormality Photophobia Jaundice Gastroesophageal reflux Acidosis Dyspnea Hypothyroidism Weight loss Dementia Gait ataxia Cerebral cortical atrophy Abdominal pain Diabetes mellitus Hypogonadism Osteoporosis Myoclonus Diarrhea Cerebellar atrophy Anxiety Failure to thrive Anemia Cognitive impairment Ptosis Cataract Pain Muscular hypotonia Sensorineural hearing impairment Nystagmus Visual impairment Hypertelorism Growth delay Ataxia Microcephaly Hearing impairment Short stature Global developmental delay Feeding difficulties Motor delay Myopathy Gait disturbance Blindness Respiratory distress Short neck Respiratory insufficiency Ventriculomegaly Dysphagia Fatigue Tremor Hypertension Optic atrophy Skeletal muscle atrophy Fever Dysarthria Hyperreflexia Hepatomegaly Peripheral neuropathy Myalgia Proteinuria Type I diabetes mellitus Cerebral calcification Type II diabetes mellitus Nephrotic syndrome Bilateral sensorineural hearing impairment Generalized-onset seizure Abnormality of the cardiovascular system Pigmentary retinopathy Amenorrhea Status epilepticus Specific learning disability Hip dysplasia Memory impairment Increased serum lactate Migraine Sensory impairment Generalized myoclonic seizures Pulmonary arterial hypertension Psychosis Muscle cramps Hallucinations Hypogonadotrophic hypogonadism Seizures EMG abnormality Truncal ataxia Cardiac arrest Clonus Cerebral visual impairment Abnormality of retinal pigmentation Ventricular hypertrophy Gingival overgrowth Anorexia Left ventricular hypertrophy Decreased body weight Involuntary movements Hypertrichosis Hemiparesis Abnormal cerebellum morphology Postural instability Hypertrophic cardiomyopathy Nyctalopia Lethargy Generalized tonic-clonic seizures Pruritus Dilated cardiomyopathy Neurological speech impairment Stroke Attention deficit hyperactivity disorder Abnormality of the liver Ophthalmoplegia Erythema Protruding ear Abnormality of the pinna Developmental regression Feeding difficulties in infancy Mental deterioration Apnea Arthrogryposis multiplex congenita Congenital cataract Coma Vertigo Polyneuropathy Nephropathy Hirsutism Polymicrogyria Nausea Lactic acidosis Peripheral axonal neuropathy Ichthyosis Carious teeth Confusion Paresthesia Dysmetria Anal atresia Delayed puberty Malabsorption Nausea and vomiting Ventricular arrhythmia



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