Arthritis, and Weight loss

Diseases related with Arthritis and Weight loss

In the following list you will find some of the most common rare diseases related to Arthritis and Weight loss that can help you solving undiagnosed cases.


Top matches:

Medium match IDIOPATHIC ACHALASIA


Idiopathic achalasia (IA) is a primary esophageal motor disorder characterized by loss of esophageal peristalsis and insufficient lower esophageal sphincter (LES) relaxation in response to deglutition.

IDIOPATHIC ACHALASIA Is also known as idiopathic achalasia of esophagus|achalasia cardia|primary achalasia

Related symptoms:

  • Pain
  • Dysphagia
  • Vomiting
  • Weight loss
  • Gastroesophageal reflux


SOURCES: ORPHANET OMIM MENDELIAN

More info about IDIOPATHIC ACHALASIA

Medium match PARASTREMMATIC DWARFISM


Parastremmatic dwarfism is a very rare chondrodysplasia characterized by severe dwarfism, kyphoscoliosis, stiffness of large joints and distortion of lower limbs.

Related symptoms:

  • Short stature
  • Scoliosis
  • Flexion contracture
  • Brachydactyly
  • Short neck


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about PARASTREMMATIC DWARFISM

Medium match YAO SYNDROME; YAOS


Yao syndrome is an autoinflammatory disease characterized by periodic fever, dermatitis, arthritis, and swelling of the distal extremities, as well as gastrointestinal and sicca-like symptoms. The disorder is associated with specific NOD2 variants (Yao and Shen, 2017).

Related symptoms:

  • Pain
  • Fever
  • Diarrhea
  • Abdominal pain
  • Weight loss


SOURCES: OMIM MENDELIAN

More info about YAO SYNDROME; YAOS

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Other less relevant matches:

Medium match DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS


Diffuse cutaneous systemic sclerosis (dcSSc) is a subtype of Systemic Sclerosis (SSc; see this term) characterized by truncal and acral skin fibrosis with an early and significant incidence of diffuse involvement (interstitial lung disease, oliguric renal failure, diffuse gastrointestinal disease, and myocardial involvement).

DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS Is also known as progressive cutaneous systemic scleroderma|diffuse cutaneous systemic scleroderma|progressive cutaneous systemic sclerosis

Related symptoms:

  • Muscle weakness
  • Pain
  • Flexion contracture
  • Hypertension
  • Dysphagia


SOURCES: ORPHANET MENDELIAN

More info about DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS

Medium match TAKAYASU ARTERITIS


Takayasu arteritis (TAK) is a rare inflammatory large-vessel vasculitis primarily affecting the aorta and its major branches, but also other large vessels, causing stenosis, occlusion, or aneurysm.

TAKAYASU ARTERITIS Is also known as young female arteritis|aortic arch syndrome|pulseless disease

Related symptoms:

  • Seizures
  • Muscle weakness
  • Anemia
  • Hypertension
  • Fever


SOURCES: ORPHANET OMIM MENDELIAN

More info about TAKAYASU ARTERITIS

Medium match JUVENILE HUNTINGTON DISEASE


Juvenile Huntington disease (JHD) is a form of Huntington disease (HD; see this term), characterized by onset of signs and symptoms before 20 years of age.

JUVENILE HUNTINGTON DISEASE Is also known as huntington chorea|jhd|juvenile huntington chorea

Related symptoms:

  • Seizures
  • Ataxia
  • Cognitive impairment
  • Anemia
  • Delayed speech and language development


SOURCES: OMIM ORPHANET MENDELIAN

More info about JUVENILE HUNTINGTON DISEASE

Medium match MULTICENTRIC CARPO-TARSAL OSTEOLYSIS WITH OR WITHOUT NEPHROPATHY


Idiopathic multicentric osteolysis is a very rare syndrome characterized by progressive loss of bone, usually the capsal and tarsal bones, resulting in deformity and disability, as well as chronic renal failure in many cases. The bone and renal disorders are sometimes associated with intellectual deficit and facial abnormalities.

MULTICENTRIC CARPO-TARSAL OSTEOLYSIS WITH OR WITHOUT NEPHROPATHY Is also known as multicentric osteolysis, autosomal dominant|idiopathic multicentric osteolysis with or without nephropathy|osteolysis, hereditary, of carpal bones with or without nephropathy

Related symptoms:

  • Intellectual disability
  • Micrognathia
  • Hypertension
  • Wide nasal bridge
  • Gait disturbance


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about MULTICENTRIC CARPO-TARSAL OSTEOLYSIS WITH OR WITHOUT NEPHROPATHY

Medium match RIDDLE SYNDROME


A rare, genetic, primary immunodeficiency disorder characterized by increased radiosensitivity(R), mild immunodeficiency (ID), dysmorphic features (D), and learning difficulties (LE).

RIDDLE SYNDROME Is also known as rnf168 deficiency|radiosensitivity-immunodeficiency-dysmorphic features-learning difficulties syndrome|radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties

Related symptoms:

  • Global developmental delay
  • Short stature
  • Microcephaly
  • Ataxia
  • Neoplasm


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about RIDDLE SYNDROME

Medium match ATTRV30M AMYLOIDOSIS


Familial amyloid polyneuropathy (FAP) or transthyretin (TTR) amyloid polyneuropathy is a progressive sensorimotor and autonomic neuropathy of adulthood onset. Weight loss and cardiac involvement are frequent; ocular or renal complications may also occur.

ATTRV30M AMYLOIDOSIS Is also known as familial amyloid polyneuropathy type i|ttr amyloid neuropathy|attrv30m-related amyloidosis|hereditary amyloidosis, transthyretin-related|transthyretin amyloid polyneuropathy|familial amyloid polyneuropathy, portuguese-swedish-japanese type|fap|amyloid pol

Related symptoms:

  • Seizures
  • Hearing impairment
  • Ataxia
  • Nystagmus
  • Sensorineural hearing impairment


SOURCES: OMIM ORPHANET MENDELIAN

More info about ATTRV30M AMYLOIDOSIS

Medium match GIANT CELL ARTERITIS


Giant cell arteritis (GCA) is a large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries.

GIANT CELL ARTERITIS Is also known as horton disease|giant cell arteritis|temporal arteritis|cranial arteritis|polymyalgia rheumatica|gca

Related symptoms:

  • Hearing impairment
  • Ataxia
  • Nystagmus
  • Muscle weakness
  • Ptosis


SOURCES: OMIM ORPHANET MENDELIAN

More info about GIANT CELL ARTERITIS

Top 5 symptoms//phenotypes associated to Arthritis and Weight loss

Symptoms // Phenotype % cases
Arthralgia Uncommon - Between 30% and 50% cases
Rheumatoid arthritis Uncommon - Between 30% and 50% cases
Diarrhea Uncommon - Between 30% and 50% cases
Abdominal pain Uncommon - Between 30% and 50% cases
Ataxia Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Arthritis and Weight loss. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Fever Renal insufficiency Hypertension Pain Muscle weakness Vomiting Skin ulcer Malabsorption Cachexia Seizures Headache Dysphagia Gait disturbance Cough Myalgia Chest pain Xerostomia Vasculitis

Rare Symptoms - Less than 30% cases


Telangiectasia Pulmonary arterial hypertension Retinopathy Osteolysis Pulmonary fibrosis Constipation Hypertensive crisis Anemia Fatigue Episodic fever Congestive heart failure Hyperhidrosis Gastrointestinal infarctions Migraine Depressivity Bronchitis Clumsiness Neuronal loss in central nervous system Gliosis Abnormality of the cerebral white matter Hearing impairment Nystagmus Visual impairment Dementia Peripheral neuropathy Anorexia Arrhythmia Tremor Dysarthria Arteritis Elevated erythrocyte sedimentation rate Amaurosis fugax Paresthesia Cerebral ischemia Gangrene Pericarditis Nephropathy Short stature Malnutrition Nausea and vomiting Gastroesophageal reflux Scleroderma Keratoconjunctivitis sicca Alopecia Autoimmunity Edema Asthma Flexion contracture Interstitial pulmonary abnormality Mild global developmental delay Double outlet right ventricle with subpulmonary ventricular septal defect without pulmonary stenosis Restrictive ventilatory defect Recurrent sinusitis Emotional lability IgA deficiency IgG deficiency Chronic sinusitis Glossitis Demyelinating peripheral neuropathy Recurrent viral infections Impaired mastication Recurrent pneumonia IgM deficiency Conjunctival telangiectasia Generalized lymphadenopathy Elevated alpha-fetoprotein Enuresis nocturna Intraventricular hemorrhage Increased sensitivity to ionizing radiation Neonatal asphyxia Chromosomal breakage induced by ionizing radiation Poor hand-eye coordination Abdominal aortic aneurysm Mediastinal lymphadenopathy Scaling skin Urinary retention Abnormal lung morphology Doll-like facies Limitation of joint mobility Hypotelorism Interphalangeal joint contracture of finger Abnormality of epiphysis morphology EMG abnormality Elevated alkaline phosphatase Slender long bone Abnormality of the wrist Juvenile rheumatoid arthritis Ulnar deviation of the hand Ulnar deviation of the hand or of fingers of the hand Azotemia Hypertensive retinopathy Ankle swelling Metacarpal osteolysis Specific learning disability Immunodeficiency Otitis media Sensorineural hearing impairment Retinal arteritis Erythema Respiratory failure Pneumonia Abnormal facial shape Metatarsal osteolysis Neoplasm Microcephaly Global developmental delay Osteolysis involving tarsal bones Wrist swelling Carpal osteolysis Dry skin Recurrent pharyngitis Spasticity Conductive hearing impairment Hepatic failure Cerebral hemorrhage Vertigo Impotence Aphasia Stroke Axonal degeneration Orthostatic hypotension Decreased number of peripheral myelinated nerve fibers Amyloidosis Syringomyelia Increased CSF protein Joint stiffness Visual loss Hematuria Blindness Optic atrophy Restrictive cardiomyopathy Multiple myeloma Stroke-like episode Ptosis Amyloid deposition in the vitreous humor Cardiac amyloidosis Vitreous floaters Constrictive median neuropathy Myelopathy Abnormal renal physiology Sensory ataxia Orthostatic hypotension due to autonomic dysfunction Atrioventricular block Spastic paraparesis Abnormality of the pleura Meningitis Psychomotor deterioration Hydrocephalus Cardiomyopathy Abnormal thrombocyte morphology Arterial thrombosis Areflexia Hyporeflexia Facial palsy Aortic dissection Paraplegia Visual field defect Diabetes insipidus Ophthalmoparesis Peripheral axonal neuropathy Sudden cardiac death Polyneuropathy Coma Urinary incontinence Hypotension Peripheral demyelination Diplopia Bilateral sensorineural hearing impairment Cardiomegaly Hemiparesis Hallucinations Epistaxis Optic disc pallor Abnormal autonomic nervous system physiology Triangular face Paraparesis Hypokinesia Hypoplasia of the maxilla Narrow foramen obturatorium Blurred vision Uveitis Episodic abdominal pain Oral ulcer Pleuritis Dyspnea Carious teeth Abnormality of the skin Telangiectasia of the skin Pulmonary infiltrates Osteolytic defects of the phalanges of the hand Oliguria Dyspareunia Decreased urine output Abnormal bowel sounds Inflammatory abnormality of the skin Dilatation Hypertrophic cardiomyopathy Neurological speech impairment Myocardial infarction Subcutaneous nodule Aortic regurgitation Psoriasiform dermatitis Abnormal heart valve morphology Hemoptysis Reduced consciousness/confusion Abnormal aortic valve morphology Inflammatory abnormality of the eye Abnormal pattern of respiration Arterial stenosis Nephrolithiasis Ventricular hypertrophy Abnormal endocardium morphology Platyspondyly Aspiration Hoarse voice Oral-pharyngeal dysphagia Adrenal insufficiency Achalasia Keratoconjunctivitis Scoliosis Brachydactyly Short neck Kyphosis Severe short stature Hypothyroidism Kyphoscoliosis Nail dystrophy Genu valgum Papule Nausea Postural instability Bowing of the long bones Chronic diarrhea Abnormal intestine morphology Thoracic kyphosis Thoracolumbar scoliosis Protein-losing enteropathy Mucopolysacchariduria Stiff neck Peripheral edema Intestinal polyp Camptodactyly Skin rash Ascending tubular aorta aneurysm Increased inflammatory response Downturned corners of mouth Suicidal ideation Obsessive-compulsive behavior Akinesia Muscle fibrillation Cerebellar vermis atrophy Restlessness Upper limb undergrowth Head tremor Chronic bronchitis Dilated fourth ventricle Testicular atrophy Paranoia Mania Abnormal involuntary eye movements Neuronal loss in basal ganglia Frequent temper tantrums Slurred speech Oral motor hypotonia Intellectual disability Micrognathia Wide nasal bridge Pes cavus Proptosis Polyhydramnios Osteopenia Proteinuria Telecanthus Camptodactyly of finger Corneal opacity Pulmonic stenosis Stage 5 chronic kidney disease Personality changes Incoordination Cognitive impairment Irritability Delayed speech and language development Hyperreflexia Ventriculomegaly Cerebellar atrophy Behavioral abnormality Dystonia Myoclonus Diabetes mellitus Hyperactivity Gait ataxia Rigidity Anxiety Aggressive behavior Mental deterioration Abnormality of eye movement Hyperkinesis Bradykinesia Schizophrenia Involuntary movements Broad-based gait Progressive neurologic deterioration Type II diabetes mellitus Generalized-onset seizure Brain atrophy Infertility Chorea Progressive cerebellar ataxia Abnormal cerebellum morphology Neurodegeneration Falls Abnormality of movement Jaw claudication



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