Arthritis, and Thin skin

Diseases related with Arthritis and Thin skin

In the following list you will find some of the most common rare diseases related to Arthritis and Thin skin that can help you solving undiagnosed cases.


Top matches:

Medium match EHLERS-DANLOS SYNDROME DUE TO TENASCIN-X DEFICIENCY


Ehlers-Danlos syndrome due to tenascin-X deficiency is a type of Ehlers-Danlos syndrome characterized by generalized joint hypermobility, skin hyperextensibility and easy bruising without atrophic scarring. Other common features include foot and hand deformities (piezogenic papules, pes planus, broad forefeet, brachydactyly, and acrogenic skin of hands), severe fatigue and neuromuscular symptoms including muscle weakness and myalgia.

EHLERS-DANLOS SYNDROME DUE TO TENASCIN-X DEFICIENCY Is also known as eds, classic-like type|ehlers-danlos syndrome, classic-like type|ehlers-danlos syndrome due to tenascin-x deficiency|eds due to tnx deficiency|tnx deficiency

Related symptoms:

  • Muscle weakness
  • Muscular hypotonia
  • Pain
  • Peripheral neuropathy
  • Skeletal muscle atrophy


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about EHLERS-DANLOS SYNDROME DUE TO TENASCIN-X DEFICIENCY

Medium match EHLERS-DANLOS SYNDROME, PERIODONTITIS TYPE


Ehlers-Danlos syndromes (EDS) form a heterogeneous group of hereditary connective tissue diseases characterized by joint hyperlaxity, cutaneous hyperelasticity and tissue fragility.

EHLERS-DANLOS SYNDROME, PERIODONTITIS TYPE Is also known as ehlers-danlos syndrome, periodontitis type|ehlers-danlos syndrome, periodontosis type|ehlers-danlos syndrome, type viii|ehlers-danlos syndrome type 8|eds viii|eds8

Related symptoms:

  • Short stature
  • Scoliosis
  • Neoplasm
  • Micrognathia
  • Pain


SOURCES: ORPHANET OMIM MENDELIAN

More info about EHLERS-DANLOS SYNDROME, PERIODONTITIS TYPE

Medium match EHLERS-DANLOS SYNDROME, HYPERMOBILITY TYPE


Ehlers-Danlos syndrome, hypermobility type (HT-EDS) is the most frequent form of EDS (see this term), a group of hereditary connective tissue diseases, and is characterized by joint hyperlaxity, mild skin hyperextensibility, tissue fragility and extra-musculoskeletal manifestations.

EHLERS-DANLOS SYNDROME, HYPERMOBILITY TYPE Is also known as benign joint hypermobility syndrome|ehlers-danlos syndrome, hypermobile type|ht-eds|ehlers-danlos syndrome, type iii|benign hypermobility syndrome|ehlers-danlos syndrome type 3|eds iii|eds3|bjhs

Related symptoms:

  • Scoliosis
  • Pain
  • Ptosis
  • Epicanthus
  • Fatigue


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about EHLERS-DANLOS SYNDROME, HYPERMOBILITY TYPE

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Other less relevant matches:

Medium match EHLERS-DANLOS SYNDROME, VASCULAR TYPE


Ehlers-Danlos syndrome type IV, also known as the vascular type of Ehlers-Danlos syndrome (EDS), is an inherited connective tissue disorder defined by characteristic facial features (acrogeria) in most patients, translucent skin with highly visible subcutaneous vessels on the trunk and lower back, easy bruising, and severe arterial, digestive and uterine complications, which are rarely, if at all, observed in the other forms of EDS.

EHLERS-DANLOS SYNDROME, VASCULAR TYPE Is also known as ehlers-danlos syndrome, type iv, autosomal dominant|eds type 4|ehlers-danlos syndrome type 4|ehlers-danlos syndrome type iv|ehlers-danlos syndrome, ecchymotic type|ehlers-danlos syndrome, arterial type|eds4|sack-barabas syndrome|eds iv|ehlers-danlos syndr

Related symptoms:

  • Global developmental delay
  • Short stature
  • Hypertelorism
  • Pain
  • Cryptorchidism


SOURCES: ORPHANET OMIM MENDELIAN

More info about EHLERS-DANLOS SYNDROME, VASCULAR TYPE

Medium match HUTCHINSON-GILFORD PROGERIA SYNDROME


Hutchinson-Gilford progeria syndrome is a rare, fatal, autosomal dominant and premature aging disease, beginning in childhood and characterized by growth reduction, failure to thrive, a typical facial appearance (prominent forehead, protuberant eyes, thin nose with a beaked tip, thin lips, micrognathia and protruding ears) and distinct dermatologic features (generalized alopecia, aged-looking skin, sclerotic and dimpled skin over the abdomen and extremities, prominent cutaneous vasculature, dyspigmentation, nail hypoplasia and loss of subcutaneous fat).

HUTCHINSON-GILFORD PROGERIA SYNDROME Is also known as progeria|hgps

Related symptoms:

  • Intellectual disability
  • Short stature
  • Hearing impairment
  • Scoliosis
  • Growth delay


SOURCES: OMIM ORPHANET MENDELIAN

More info about HUTCHINSON-GILFORD PROGERIA SYNDROME

Low match PSORIASIS 2; PSORS2


Related symptoms:

  • Fever
  • Hyperkeratosis
  • Arthralgia
  • Arthritis
  • Ichthyosis


SOURCES: OMIM MENDELIAN

More info about PSORIASIS 2; PSORS2

Low match EHLERS-DANLOS SYNDROME TYPE 7A


EHLERS-DANLOS SYNDROME TYPE 7A Is also known as eds viia

Related symptoms:

  • Short stature
  • Muscle weakness
  • Joint hyperflexibility
  • Thin skin
  • Hyperextensible skin


SOURCES: ORPHANET MENDELIAN

More info about EHLERS-DANLOS SYNDROME TYPE 7A

Low match ABSENCE OF FINGERPRINTS-CONGENITAL MILIA SYNDROME


Absence of fingerprints-congenital milia syndrome is characterized by neonatal blisters and milia (small white papules, especially on the face) and congenital absence of dermatoglyphics on the hands and feet. It has been reported in two kindreds (one of which contained 13 affected individuals spanning three generations) and in an unrelated individual. Some affected patients also showed bilateral partial flexion contractures of the fingers and toes, and webbing of the toes. The syndrome is inherited as an autosomal dominant trait.

ABSENCE OF FINGERPRINTS-CONGENITAL MILIA SYNDROME Is also known as baird syndrome|absence of dermatoglyphics-congenital milia syndrome

Related symptoms:

  • Camptodactyly of finger
  • Skin rash
  • Abnormal blistering of the skin
  • Thin skin
  • Thickened skin


SOURCES: ORPHANET MENDELIAN

More info about ABSENCE OF FINGERPRINTS-CONGENITAL MILIA SYNDROME

Low match ULERYTHEMA OPHRYOGENESIS


Ulerythema ophryogenesis is characterised by inflammatory keratotic papules occurring on the face, which may be followed by scars, atrophy and alopecia. Prevalence is unknown but the disease, affecting mainly children and young adults, is rare. Erythema with mild hyperkeratosis of the hair follicles resulting in rough papules is observed on the cheeks and lateral aspects of the eyebrows. The disorder occasionally extends to the adjacent scalp, ears and forehead and rarely to the extensor surfaces of the limbs. Symptoms regress with age, although loss of the lateral aspects of the eyebrows can occur. Many cases occur sporadically; autosomal dominant inheritance has also been reported. There is no particular treatment, but patients should avoid sun exposure without UV protection.

Related symptoms:

  • Skeletal muscle atrophy
  • Pectus excavatum
  • Alopecia
  • Arthritis
  • Erythema


SOURCES: ORPHANET OMIM MENDELIAN

More info about ULERYTHEMA OPHRYOGENESIS

Low match MELORHEOSTOSIS


Melorheostosis is a rare connective tissue disorder characterized by a sclerosing bone dysplasia, usually limited to one side of the body (rarely bilateral), that manifests with pain, stiffness, joint contractures and deformities.

MELORHEOSTOSIS Is also known as mel

Related symptoms:

  • Failure to thrive
  • Pain
  • Flexion contracture
  • Hypertension
  • Skeletal muscle atrophy


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about MELORHEOSTOSIS

Top 5 symptoms//phenotypes associated to Arthritis and Thin skin

Symptoms // Phenotype % cases
Pain Common - Between 50% and 80% cases
Joint hyperflexibility Uncommon - Between 30% and 50% cases
Arthralgia Uncommon - Between 30% and 50% cases
Osteolysis Uncommon - Between 30% and 50% cases
Flexion contracture Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Arthritis and Thin skin. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Abnormality of the dentition Dilatation Dermal atrophy Hyperextensible skin Osteoarthritis Joint hypermobility Short stature Skeletal muscle atrophy Mitral valve prolapse Rheumatoid arthritis Scoliosis Joint dislocation Hip dislocation Alopecia Inguinal hernia Osteoporosis Soft skin Atrophic scars Umbilical hernia Scarring Scleroderma Bruising susceptibility Gingivitis Gingival overgrowth Hypertension Carious teeth Microdontia Joint laxity

Rare Symptoms - Less than 30% cases


Periodontitis Cigarette-paper scars Premature loss of primary teeth Chronic pain Striae distensae Fragile skin Atopic dermatitis Thin vermilion border Inflammatory abnormality of the skin Premature loss of teeth Ichthyosis Subarachnoid hemorrhage Abnormal joint morphology Muscle weakness Gingival recession Atypical scarring of skin Proptosis Narrow mouth Pectus excavatum Prominent superficial veins Lack of skin elasticity Macrocephaly Cystocele Arterial dissection Abnormality of the gingiva Ascending tubular aorta aneurysm Aplasia/Hypoplasia of the abdominal wall musculature Keratoconjunctivitis sicca Aplasia/Hypoplasia of the earlobes Keratoconus Subcutaneous nodule Migraine Limitation of joint mobility Alopecia of scalp Abnormality of the foot Increased bone mineral density Transient ischemic attack Epicanthus Ptosis Osteolytic defects of the phalanges of the hand Hypohidrosis Vertigo Absent eyelashes Arteriosclerosis Myalgia Failure to thrive Poor wound healing Hypotrichosis Joint stiffness Arachnodactyly Stroke Peripheral arteriovenous fistula Neoplasm Micrognathia Precocious atherosclerosis Edema Pes planus Abnormality of the skeletal system Erythema Arrhythmia Blue sclerae Hernia Psoriasiform dermatitis Fatigue Dementia Metaphyseal widening Nasal speech Dyspnea Intracranial hemorrhage Premature ovarian insufficiency Lipodystrophy Prominent forehead Hyperinsulinemia Hypogonadism Abnormality of the thorax Cyanosis Heart murmur Thin ribs Abnormal EKG Thrombocytosis Short clavicles Renal cell carcinoma Malar flattening Hypoplastic nipples Lipoatrophy Midface retrusion Exertional dyspnea Macrotia Prolonged QT interval Premature graying of hair High pitched voice Multiple joint contractures Relative macrocephaly Conductive hearing impairment Osteopenia Delayed eruption of teeth Delayed puberty Dental crowding Infertility Left ventricular hypertrophy Decreased body weight Hepatic steatosis Broad-based gait Insulin resistance Hypodontia Chest pain Growth hormone deficiency Nail dysplasia Convex nasal ridge Myocardial infarction Cardiomegaly Narrow chest Sparse and thin eyebrow Hypercholesterolemia Aminoaciduria Acanthosis nigricans Hyperlipidemia Atherosclerosis Abnormality of the cardiovascular system Carcinoma Hypertrophic cardiomyopathy Coxa valga Aortic valve stenosis Sparse hair Hypogonadotrophic hypogonadism Microtia Hypergonadotropic hypogonadism Dilated cardiomyopathy Hypermetropia Aspiration Hypertriglyceridemia Bird-like facies Fragile nails Abnormal dermatoglyphics Aplasia/Hypoplasia of the skin Epiphora Spinal muscular atrophy Sparse eyebrow Papule Amniotic constriction ring Milia Thickened skin Follicular hyperkeratosis Abnormal blistering of the skin Skin rash Camptodactyly of finger Diffuse skin atrophy Orthokeratosis Parakeratosis Scaling skin Abnormal eyebrow morphology Folliculitis Hyperkeratosis Growth abnormality Osteopoikilosis Subcutaneous calcification Upper limb asymmetry Lower limb asymmetry Abnormality of the vasculature Joint swelling Hyperostosis Hemangioma Comedo Cranial nerve paralysis Bone pain Lymphedema Nevus Skeletal dysplasia Abnormal perifollicular morphology Sunken cheeks Epidermal acanthosis Fever Down-sloping shoulders Prolonged prothrombin time Premature coronary artery atherosclerosis Thin nail Absence of subcutaneous fat Hip pain Aplastic clavicle Narrow nasal ridge Carcinoid tumor Decreased serum estradiol Sinus tachycardia Thin bony cortex Enlarged joints Small face Generalized osteoporosis Angina pectoris Ovoid vertebral bodies Hyperphosphatemia Decreased testosterone in males Corneal arcus Tapering pointed ends of distal finger phalanges Bilateral coxa valga Arteriosclerosis of small cerebral arteries Regional abnormality of skin Abnormal trabecular bone morphology Insulin-resistant diabetes mellitus at puberty Absence of pubertal development Carotid artery stenosis Narrow nasal tip Craniofacial disproportion Intermittent claudication Old-aged sensorineural hearing impairment Reticulated skin pigmentation Hypoplastic facial bones Prominent scalp veins Kyphosis Mitral valve calcification Parietal bossing Widely patent fontanelles and sutures Short nose Varicose veins Congestive heart failure Gastroesophageal reflux Abdominal distention Sleep disturbance Nausea Paresthesia Malabsorption Nausea and vomiting Apnea Constipation Abnormal palate morphology Depressivity Vomiting Alveolar bone loss around teeth Atrophy of alveolar ridges Severe periodontitis Intestinal perforation Premature loss of permanent teeth Wormian bones Decreased nerve conduction velocity Mitral stenosis Premature rupture of membranes Talipes equinovarus Cognitive impairment Cryptorchidism Hypertelorism Global developmental delay Genital hernia Tendon rupture Anorectal anomaly Elbow dislocation Abnormality of the menstrual cycle Venous insufficiency Gastrointestinal dysmotility Abnormality of the wrist Acrocyanosis Aortic root aneurysm Decreased fertility Palmoplantar cutis laxa Generalized joint laxity Hydrocephalus Spina bifida Bicornuate uterus Proximal amyotrophy Adrenal hyperplasia Hiatus hernia Adrenal hypoplasia Unilateral renal agenesis Spina bifida occulta Ambiguous genitalia Muscle fiber splitting Gastrointestinal hemorrhage Vesicoureteral reflux Bifid uvula Single transverse palmar crease Sensory neuropathy Proximal muscle weakness Peripheral neuropathy Increased connective tissue Rectal prolapse Gingival bleeding Hoarse voice Skin vesicle Long nose Agenesis of permanent teeth Hypermelanotic macule Urticaria Cutis laxa Vasculitis Tall stature Congenital adrenal hyperplasia Mitral regurgitation Fine hair Autoimmunity Recurrent infections Quadricuspid aortic valve Premature arteriosclerosis Ambiguous genitalia, female Respiratory insufficiency Abnormality of cardiovascular system morphology Cardiomyopathy Dermal translucency Renovascular hypertension Absent earlobe Arteriovenous fistula Internal hemorrhage Colonic diverticula Abnormal oral frenulum morphology Gastrointestinal infarctions Excessive wrinkled skin Pulmonary artery aneurysm Abnormality of hair texture Ocular pain Arterial stenosis Periorbital edema Pneumothorax Bladder diverticulum Abnormal pupil morphology Normal pressure hydrocephalus Coronary artery aneurysm Muscular hypotonia Hemothorax Cataract Abnormal facial shape Sensorineural hearing impairment Growth delay Hearing impairment Intellectual disability Hypermobility of distal interphalangeal joints Premature delivery because of cervical insufficiency or membrane fragility Molluscoid pseudotumors Hypoplastic lacrimal duct Arteriovenous fistulas of celiac and mesenteric vessels Uterine prolapse Uterine rupture Arterial rupture Foot acroosteolysis Spontaneous pneumothorax Reduced consciousness/confusion Hematochezia Hypospadias Premature birth Abnormal intestine morphology Short chin Congenital hip dislocation Cardiac arrest Telangiectasia Abnormality of the face Abnormality of the skin Abnormal bleeding Tinnitus High, narrow palate Flat face Abnormality of skin pigmentation Protruding ear Telecanthus Deeply set eye Glaucoma Sleep apnea Abnormality of the urinary system Abnormally large globe Prematurely aged appearance Aortic dissection Narrow nose Abnormal eyelash morphology Dilatation of the cerebral artery Sprengel anomaly Esophageal atresia Hemoptysis Abnormal heart valve morphology Hypokalemia Telangiectasia of the skin Narrow nasal bridge Macule Aplasia/Hypoplasia of the eyebrow Melanocytic nevus Aortic aneurysm Redundant skin Ectopic ossification in muscle tissue



If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Frontal bossing and Ventricular hypertrophy, related diseases and genetic alterations

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