Arthritis, and Syncope

Diseases related with Arthritis and Syncope

In the following list you will find some of the most common rare diseases related to Arthritis and Syncope that can help you solving undiagnosed cases.


Top matches:

Low match LOEYS-DIETZ SYNDROME 5; LDS5


Loeys-Dietz syndrome-5 (LDS5), also known as Rienhoff (pronounced REENhoff) syndrome, is characterized by syndromic presentation of aortic aneurysms involving the thoracic and/or abdominal aorta, with risk of dissection and rupture. Other systemic features include cleft palate, bifid uvula, mitral valve disease, skeletal overgrowth, cervical spine instability, and clubfoot deformity; however, not all clinical features occur in all patients. In contrast to other forms of LDS (see {609192}), no striking aortic or arterial tortuosity is present in these patients, and there is no strong evidence for early aortic dissection (summary by Bertoli-Avella et al., 2015).For a general phenotypic description and a discussion of genetic heterogeneity of Loeys-Dietz syndrome, see LDS1 (OMIM ).

LOEYS-DIETZ SYNDROME 5; LDS5 Is also known as rienhoff syndrome|rnhf

Related symptoms:

  • Short stature
  • Generalized hypotonia
  • Scoliosis
  • Growth delay
  • Hypertelorism


SOURCES: OMIM MENDELIAN

More info about LOEYS-DIETZ SYNDROME 5; LDS5

Low match SARCOIDOSIS


Sarcoidosis is a multisystemic disorder of unknown cause characterized by the formation of immune granulomas in involved organs.

SARCOIDOSIS Is also known as boeck sarcoid|besnier-boeck-schaumann disease|sarcoidosis|boeck's sarcoid

Related symptoms:

  • Seizures
  • Pain
  • Cataract
  • Anemia
  • Visual impairment


SOURCES: ORPHANET OMIM MENDELIAN

More info about SARCOIDOSIS

Low match GAUCHER DISEASE TYPE 1


Gaucher disease type 1 is the chronic non-neurological form of Gaucher disease (GD; see this term) characterized by organomegaly, bone involvement and cytopenia.

GAUCHER DISEASE TYPE 1 Is also known as gaucher disease, juvenile and adult, cerebral|gd iii|gaucher disease, chronic neuronopathic type|non-cerebral juvenile gaucher disease|gaucher disease, subacute neuronopathic type

Related symptoms:

  • Seizures
  • Global developmental delay
  • Short stature
  • Scoliosis
  • Ataxia


SOURCES: ORPHANET OMIM MENDELIAN

More info about GAUCHER DISEASE TYPE 1

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Other less relevant matches:

Low match FABRY DISEASE


Fabry disease (FD) is a progressive, inherited, multisystemic lysosomal storage disease characterized by specific neurological, cutaneous, renal, cardiovascular, cochleo-vestibular and cerebrovascular manifestations.

FABRY DISEASE Is also known as ceramide trihexosidase deficiency|hereditary dystopic lipidosis|fd|alpha-galactosidase a deficiency|diffuse angiokeratoma|gla deficiency|angiokeratoma corporis diffusum|anderson-fabry disease

Related symptoms:

  • Seizures
  • Short stature
  • Hearing impairment
  • Sensorineural hearing impairment
  • Pain


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about FABRY DISEASE

Low match SINOATRIAL NODE DYSFUNCTION AND DEAFNESS


Sinoatrial node dysfunction and deafness is a rare genetic disease characterized by congenital severe to profound deafness with no evidence of vestibular dysfunction, associated with sinoatrial node dysfunction with pronounced bradycardia and increased variability of heart rate at rest and episodic syncopes that may be triggered by enhanced physical activity and stress.

Related symptoms:

  • Hearing impairment
  • Syncope
  • Bradycardia
  • Vestibular dysfunction
  • Abnormal atrioventricular conduction


SOURCES: OMIM ORPHANET MENDELIAN

More info about SINOATRIAL NODE DYSFUNCTION AND DEAFNESS

Low match CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 2; CMH2


Related symptoms:

  • Pain
  • Cardiomyopathy
  • Dyspnea
  • Hypertrophic cardiomyopathy
  • Chest pain


SOURCES: MESH OMIM MENDELIAN

More info about CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 2; CMH2

Low match PROGRESSIVE SENSORINEURAL HEARING LOSS-HYPERTROPHIC CARDIOMYOPATHY SYNDROME


Progressive sensorineural hearing loss - hypertrophic cardiomyopathy is an extremely rare disorder described in one family to date that is characterized by progressive, late onset, autosomal dominant sensorineural hearing loss, QT interval prolongation, and mild cardiac hypertrophy.

PROGRESSIVE SENSORINEURAL HEARING LOSS-HYPERTROPHIC CARDIOMYOPATHY SYNDROME Is also known as progressive neurosensory deafness-hypertrophic cardiomyopathy syndrome|progressive neurosensory hearing loss-hypertrophic cardiomyopathy syndrome|progressive sensorineural deafness-hypertrophic cardiomyopathy syndrome

Related symptoms:

  • Sensorineural hearing impairment
  • Dyspnea
  • Hypertrophic cardiomyopathy
  • Chest pain
  • Syncope


SOURCES: ORPHANET MENDELIAN

More info about PROGRESSIVE SENSORINEURAL HEARING LOSS-HYPERTROPHIC CARDIOMYOPATHY SYNDROME

Low match BRUGADA SYNDROME 9; BRGDA9


Brugada syndrome is characterized by ST segment elevation in the right precordial electrocardiogram leads (so-called type 1 ECG) and a high incidence of sudden death in patients with structurally normal hearts. The syndrome typically manifests during adulthood, with a mean age of sudden death of 41 +/- 15 years, but also occurs in infants and children (summary by Antzelevitch et al., 2005).For a discussion of genetic heterogeneity of Brugada syndrome, see BRGDA1 (OMIM ).

Related symptoms:

  • Arrhythmia
  • Sudden cardiac death
  • Syncope
  • Palpitations
  • ST segment elevation


SOURCES: OMIM MENDELIAN

More info about BRUGADA SYNDROME 9; BRGDA9

Low match BRUGADA SYNDROME 4; BRGDA4


Brugada syndrome is characterized by an ST segment elevation in the right precordial electrocardiogram leads (so-called type 1 ECG) and a high incidence of sudden death in patients with structurally normal hearts. The syndrome typically manifests during adulthood, with a mean age of sudden death of 41 +/- 15 years, but also occurs in infants and children (summary by Antzelevitch et al., 2005).For a discussion of the genetic heterogeneity in Brugada syndrome, see BRGDA1 (OMIM ).

Related symptoms:

  • Tachycardia
  • Sudden cardiac death
  • Syncope
  • Atrial fibrillation
  • Myocardial infarction


SOURCES: OMIM MESH MENDELIAN

More info about BRUGADA SYNDROME 4; BRGDA4

Low match SHORT QT SYNDROME 2; SQT2


Short QT syndrome is a cardiac channelopathy associated with a predisposition to atrial fibrillation and sudden cardiac death. Patients have a structurally normal heart, but electrocardiography (ECG) exhibits abbreviated QTc (Bazett's corrected QT) intervals of less than 360 ms (summary by Moreno et al., 2015).For a discussion of genetic heterogeneity of short QT syndrome, see SQT1 (OMIM ).

Related symptoms:

  • Arrhythmia
  • Sudden cardiac death
  • Syncope
  • Atrial fibrillation
  • Bradycardia


SOURCES: OMIM MESH MENDELIAN

More info about SHORT QT SYNDROME 2; SQT2

Top 5 symptoms//phenotypes associated to Arthritis and Syncope

Symptoms // Phenotype % cases
Dyspnea Uncommon - Between 30% and 50% cases
Arrhythmia Uncommon - Between 30% and 50% cases
Sudden cardiac death Uncommon - Between 30% and 50% cases
Chest pain Uncommon - Between 30% and 50% cases
Ventricular tachycardia Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Arthritis and Syncope. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Palpitations Congestive heart failure Fatigue Anorexia Shortened QT interval Short stature Left ventricular hypertrophy Hypertrophic cardiomyopathy Seizures Interstitial pulmonary abnormality Pain Anemia Atrial fibrillation Bradycardia

Rare Symptoms - Less than 30% cases


Corneal opacity Edema Tachycardia Peripheral neuropathy Splenomegaly Cataract Abdominal pain Renal insufficiency Headache Thrombocytopenia Fever Hepatomegaly Delayed puberty Lymphadenopathy Hypothyroidism Osteolysis Abnormality of the gastrointestinal tract Tubulointerstitial nephritis Elevated erythrocyte sedimentation rate Increased antibody level in blood Emphysema Diabetes insipidus Sinus bradycardia Portal hypertension Leukopenia Myocardial infarction Cough Cognitive impairment Ventricular hypertrophy Subcutaneous nodule Abnormal lung morphology Pancytopenia Diarrhea Depressivity Abdominal distention Papule Hematuria Proteinuria Sensorineural hearing impairment Atrioventricular block Dilatation Hearing impairment Motor delay Cardiomyopathy Abnormal myocardium morphology ST segment elevation Clubbing Bruising susceptibility Reduced bone mineral density Edema of the lower limbs Mitral valve prolapse Osteoarthritis Mitral regurgitation Aortic regurgitation Midface retrusion Growth delay Abnormality of the cardiovascular system Aortic root aneurysm Celiac disease Scoliosis Vascular calcification Tricuspid regurgitation Hypohidrosis Lymphedema Erlenmeyer flask deformity of the femurs Impaired vibratory sensation Spontaneous abortion Biliary tract obstruction Heart murmur Fasciculations Orthopnea Polyuria Personality changes Polydipsia Abnormal autonomic nervous system physiology Arthralgia of the hip Abnormal platelet function Abnormality of the hand Chronic kidney disease Easy fatigability Tinnitus Ventricular arrhythmia Ischemic stroke Prominent supraorbital ridges Corneal dystrophy Exercise intolerance Hemiplegia Glomerulosclerosis Abnormal intestine morphology Hyperlipidemia Purpura Aminoaciduria Flank pain Progressive hearing impairment Prominent nasal bridge Puberty and gonadal disorders Abnormality of the kidney Arthralgia Coarse facial features Myalgia Loss of consciousness Carcinoma Nausea Anxiety Abnormality of the nervous system Developmental regression Bulbous nose Skin rash Stage 5 chronic kidney disease Vertigo Paresthesia Nausea and vomiting Malabsorption Stroke Abnormality of the cerebral white matter Mandibular prognathia Thick eyebrow Thick lower lip vermilion Nephrotic syndrome Decreased beta-glucocerebrosidase protein and activity Hematological neoplasm Cardiac valve calcification Horizontal supranuclear gaze palsy Pruritus Hypertension Optic atrophy Respiratory insufficiency Vomiting Hyperkeratosis Behavioral abnormality Constipation Hypotension Urinary incontinence Muscle cramps Posteriorly rotated ears Nephropathy Thick vermilion border Hyperhidrosis Anhidrosis Clubbing of fingers Bundle branch block Reduced sperm motility Mucosal telangiectasiae Concentric hypertrophic cardiomyopathy Coronary artery stenosis Shortened PR interval Decreased lacrimation Angiokeratoma corporis diffusum Hyposthenuria Impaired temperature sensation Obstructive lung disease Angiokeratoma Increased blood urea nitrogen ST segment depression Distal renal tubular acidosis Vascular tortuosity Decreased glomerular filtration rate Nephrogenic diabetes insipidus Abnormality of temperature regulation Limb pain Corneal crystals Retinal vascular tortuosity Vascular skin abnormality Decreased female libido Unexplained fevers Functional abnormality of the gastrointestinal tract Abnormal endocardium morphology Abnormality of the common coagulation pathway Aborted sudden cardiac death Polymorphic ventricular tachycardia Presyncope Left bundle branch block Prolonged QT interval Abnormal electrophysiology of sinoatrial node origin Abnormal atrioventricular conduction Vestibular dysfunction Cornea verticillata Abnormal glomerular filtration rate Increased glomerular filtration rate Impaired renal concentrating ability Increased carotid artery intimal medial thickness Abnormal ST segment Abnormal common carotid artery morphology Acroparesthesia Heavy proteinuria Tenesmus Left ventricular septal hypertrophy Tortuosity of conjunctival vessels Hyperkeratotic papule Abnormality of the forehead Abnormality of glycosphingolipid metabolism Abnormality of cardiovascular system physiology Biventricular hypertrophy Impotence Xerostomia Peripheral arterial stenosis Reduced ejection fraction Heat intolerance Supraventricular tachycardia Large earlobe Oligospermia Tubular atrophy Elevated serum creatinine Renal tubular dysfunction Transient ischemic attack Abnormal EKG Angina pectoris Abnormality of lipid metabolism Wheezing Renal tubular acidosis Glycosuria Abnormal heart valve morphology Glomerulopathy Telangiectasia of the skin Orthostatic hypotension Progressive sensorineural hearing impairment Coronary artery atherosclerosis Spontaneous hematomas Chronic obstructive pulmonary disease Primary hypothyroidism Miosis Microalbuminuria Conjunctival telangiectasia Supraventricular arrhythmia Dysesthesia Abnormal cornea morphology Abnormality of the renal tubule Abnormal thrombosis Tubulointerstitial fibrosis Chronic pain Abnormal renal physiology T-wave inversion Achalasia Abnormal aortic valve morphology Gastrointestinal dysmotility Periorbital fullness Abnormal mitral valve morphology Asymmetric septal hypertrophy High-frequency hearing impairment Restrictive cardiomyopathy Abnormality of the nose Abnormality of femur morphology Chronic fatigue Myocardial fibrosis Abnormality of bone marrow cell morphology Increased bone mineral density Fractures of the long bones Photophobia Bronchiectasis Nephrolithiasis Hypopigmentation of the skin Hemolytic anemia Hepatic failure Scarring Erythema Facial palsy Proximal muscle weakness Weight loss Decreased liver function Glaucoma Alopecia Blindness Respiratory distress Skeletal muscle atrophy Visual impairment Increased arm span Cervical spine instability Bilateral coxa valga Arterial dissection Hyperpigmentation of the skin Nephrocalcinosis Arterial tortuosity Keratoconjunctivitis sicca Macular edema Upper airway obstruction Hypothermia Increased CSF protein Heart block Joint swelling Uveitis Optic neuropathy Hemoptysis Hyperuricemia Eosinophilia Hyperthyroidism Abnormality of the musculature Chorioretinal atrophy Blurred vision Pulmonary fibrosis Epiphora Inflammation of the large intestine Pleural effusion Hypercalcemia Hypercalciuria Ascending aortic dissection Graves disease Bone cyst Hyporeflexia Pectus carinatum Abnormal cardiac septum morphology Neonatal hypotonia Pes planus Retrognathia Kyphoscoliosis Proptosis Brachycephaly Inguinal hernia Pectus excavatum Dolichocephaly Hernia Talipes equinovarus Ventricular septal defect Downslanted palpebral fissures High palate Flexion contracture Ptosis Cleft palate Muscular hypotonia Hypertelorism Small for gestational age Arthrogryposis multiplex congenita Cleft soft palate Cerebral hemorrhage Spondylolisthesis Broad face Aortic dissection Hiatus hernia Soft skin Long palpebral fissure Abnormality of the sternum Reduced subcutaneous adipose tissue Decreased muscle mass Ectopia lentis Smooth philtrum Patent foramen ovale Joint contracture of the hand Exotropia Tall stature Blue sclerae Overgrowth Bifid uvula Joint hypermobility Long face Arachnodactyly Immune dysregulation Skin nodule Hypersplenism Pulmonary arterial hypertension Oculomotor apraxia Spastic paraparesis Meningitis Generalized hypotonia Bone pain Hepatic fibrosis Decreased body weight Progressive neurologic deterioration Epistaxis Apraxia Cholelithiasis Cyanosis Parkinsonism Generalized myoclonic seizures Abnormal bleeding Ascites Cirrhosis Abnormality of skin pigmentation Abnormality of eye movement Neurological speech impairment Abnormality of the eye Increased susceptibility to fractures Abnormality of the thorax Hepatosplenomegaly Bipolar affective disorder Esodeviation Periorbital edema Generalized osteosclerosis Abnormality of the spleen Avascular necrosis of the capital femoral epiphysis Multiple myeloma Supranuclear gaze palsy Vertebral compression fractures Increased serum ferritin Hepatocellular carcinoma Leukocytosis Gingival bleeding Protuberant abdomen Aseptic necrosis Exertional dyspnea Pathologic fracture Pericardial effusion Petechiae Abnormality of coagulation Osteomyelitis Menorrhagia EEG abnormality Osteopenia Night sweats Abnormality of the adrenal glands Abnormal reproductive system morphology Vitritis Vitreous floaters Abnormal conjunctiva morphology Iridocyclitis Abnormal salivary gland morphology Anterior uveitis Dacryocystitis Chorioretinitis Abnormality of the lymph nodes Posterior vitreous detachment Skin plaque Generalized lymphadenopathy Erythema nodosum Abnormality of the cerebrospinal fluid Cystoid macular edema Chylothorax Vitreous hemorrhage Abnormality of the pleura Pneumothorax Anterior synechiae of the anterior chamber Abnormality of skin morphology Enlargement of parotid gland Osteoporosis Global developmental delay Myoclonus Dementia Recurrent respiratory infections Delayed skeletal maturation Kyphosis Myopia Spasticity Strabismus Failure to thrive Ataxia Abnormal trabecular meshwork morphology Abnormality of T cell physiology Pulmonary granulomatosis Vitreous snowballs Enlarged lacrimal glands Maculopapular exanthema Abnormality of the nasal mucosa Increased T cell count Abnormal cardiac ventricular function Parotitis Abnormal liver parenchyma morphology Non-caseating epithelioid cell granulomatosis Ventricular fibrillation



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