Arthritis, and Sensory neuropathy

Diseases related with Arthritis and Sensory neuropathy

In the following list you will find some of the most common rare diseases related to Arthritis and Sensory neuropathy that can help you solving undiagnosed cases.


Top matches:

Low match HEREDITARY ARTERIAL AND ARTICULAR MULTIPLE CALCIFICATION SYNDROME


Hereditary arterial and articular multiple calcification syndrome is a very rare genetic vascular disease of autosomal recessive inheritance, described in less than 20 patients to date, characterized by adult-onset (as early as the second decade of life) isolated calcification of the arteries of the lower extremities (including the iliac, femoral, and tibial arteries) as well as the capsule joints of the fingers, wrists, ankles and feet, and that usually manifests with mild paresthesias of the lower extremities, intense joint pain and swelling, and early onset arthritis of affected joints.

HEREDITARY ARTERIAL AND ARTICULAR MULTIPLE CALCIFICATION SYNDROME Is also known as calcification of joints and arteries|calja|acdc|arterial calcification due to deficiency of cd73

Related symptoms:

  • Pain
  • Diabetes mellitus
  • Arthralgia
  • Arthritis
  • Paresthesia


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about HEREDITARY ARTERIAL AND ARTICULAR MULTIPLE CALCIFICATION SYNDROME

Low match AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA TYPE 36


Autosomal dominant spastic paraplegia type 36 (SPG36) is a complex form of hereditary spastic paraplegia, characterized by an onset in childhood or adulthood of progressive spastic paraplegia (with spastic gait, spasticity, lower limb weakness, pes cavus and urinary urgency) associated with the additional manifestation of peripheral sensorimotor neuropathy.

AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA TYPE 36 Is also known as spg36

Related symptoms:

  • Strabismus
  • Spasticity
  • Peripheral neuropathy
  • Hyperreflexia
  • Babinski sign


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA TYPE 36

Low match FAMILIAL COLD URTICARIA


Familial cold urticaria (FCAS) is the mildest form of cryopyrin-associated periodic syndrome (CAPS; see this term) and is characterized by recurrent episodes of urticaria-like skin rash triggered by exposure to cold associated with low-grade fever, general malaise, eye redness and arthralgia/myalgia.

FAMILIAL COLD URTICARIA Is also known as fcas|familial cold autoinflammatory syndrome|fcu

Related symptoms:

  • Sensorineural hearing impairment
  • Fever
  • Fatigue
  • Headache
  • Hyperhidrosis


SOURCES: ORPHANET MENDELIAN

More info about FAMILIAL COLD URTICARIA

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Other less relevant matches:

Low match MULTIPLE SYMMETRIC LIPOMATOSIS


Multiple symmetric lipomatosis (MSL) is a rare subcutaneous tissue disease characterized by growth of symmetric non-encapsulated masses of adipose tissue mostly around the face and neck with variable clinical repercussions (e.g. reduced neck mobility, compression of respiratory structures).

MULTIPLE SYMMETRIC LIPOMATOSIS Is also known as launois-bensaude lipomatosis|familial benign cervical lipomatosis|madelung disease|cephalothoracic lipodystrophy|lipomatosis, familial benign cervical|lipodystrophy, cephalothoracic

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Hypertension
  • Peripheral neuropathy


SOURCES: ORPHANET OMIM MENDELIAN

More info about MULTIPLE SYMMETRIC LIPOMATOSIS

Low match EHLERS-DANLOS SYNDROME DUE TO TENASCIN-X DEFICIENCY


Ehlers-Danlos syndrome due to tenascin-X deficiency is a type of Ehlers-Danlos syndrome characterized by generalized joint hypermobility, skin hyperextensibility and easy bruising without atrophic scarring. Other common features include foot and hand deformities (piezogenic papules, pes planus, broad forefeet, brachydactyly, and acrogenic skin of hands), severe fatigue and neuromuscular symptoms including muscle weakness and myalgia.

EHLERS-DANLOS SYNDROME DUE TO TENASCIN-X DEFICIENCY Is also known as eds, classic-like type|ehlers-danlos syndrome, classic-like type|ehlers-danlos syndrome due to tenascin-x deficiency|eds due to tnx deficiency|tnx deficiency

Related symptoms:

  • Muscle weakness
  • Muscular hypotonia
  • Pain
  • Peripheral neuropathy
  • Skeletal muscle atrophy


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about EHLERS-DANLOS SYNDROME DUE TO TENASCIN-X DEFICIENCY

Low match HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS


Hypocomplementemic urticarial vasculitis (HUV) is an immune complex-mediated small vessel vasculitis characterized by urticaria and hypocomplementemia (low C1q with or without low C3 and C4), and usually associated with circulating anti-C1q autoantibodies. Arthritis, pulmonary disease, ocular inflammation, and glomerulonephritis are common systemic manifestations.

HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS Is also known as mac duffie syndrome|mac duffie hypocomplementemic urticarial vasculitis|anti-c1q vasculitis|mcduffie hypocomplementemic urticarial vasculitis|mcduffie syndrome

Related symptoms:

  • Seizures
  • Ataxia
  • Sensorineural hearing impairment
  • Pain
  • Peripheral neuropathy


SOURCES: ORPHANET MENDELIAN

More info about HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS

Low match FAMILIAL PRIMARY HYPOMAGNESEMIA WITH HYPERCALCIURIA AND NEPHROCALCINOSIS WITHOUT SEVERE OCULAR INVOLVEMENT


Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis without severe ocular involvement (FHHN) is a form of familial primary hypomagnesemia (FPH; see this term), characterized by recurrent urinary tract infections, nephrolithiasis, bilateral nephrocalcinosis, renal magnesium (Mg) wasting, hypercalciuria and kidney failure.

FAMILIAL PRIMARY HYPOMAGNESEMIA WITH HYPERCALCIURIA AND NEPHROCALCINOSIS WITHOUT SEVERE OCULAR INVOLVEMENT Is also known as fhhnc without severe ocular involvement|homg3|hypomagnesemia, isolated renal|hypomagnesemia, primary, due to defect in renal tubular transport of magnesium|renal hypomagnesemia type 3|hypomagnesemia, familial, with hypercalciuria and nephrocalcinosis

Related symptoms:

  • Seizures
  • Hearing impairment
  • Nystagmus
  • Failure to thrive
  • Strabismus


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about FAMILIAL PRIMARY HYPOMAGNESEMIA WITH HYPERCALCIURIA AND NEPHROCALCINOSIS WITHOUT SEVERE OCULAR INVOLVEMENT

Low match ATTRV30M AMYLOIDOSIS


Familial amyloid polyneuropathy (FAP) or transthyretin (TTR) amyloid polyneuropathy is a progressive sensorimotor and autonomic neuropathy of adulthood onset. Weight loss and cardiac involvement are frequent; ocular or renal complications may also occur.

ATTRV30M AMYLOIDOSIS Is also known as familial amyloid polyneuropathy type i|ttr amyloid neuropathy|attrv30m-related amyloidosis|hereditary amyloidosis, transthyretin-related|transthyretin amyloid polyneuropathy|familial amyloid polyneuropathy, portuguese-swedish-japanese type|fap|amyloid pol

Related symptoms:

  • Seizures
  • Hearing impairment
  • Ataxia
  • Nystagmus
  • Sensorineural hearing impairment


SOURCES: OMIM ORPHANET MENDELIAN

More info about ATTRV30M AMYLOIDOSIS

Low match CHONDRODYSPLASIA, GREBE TYPE


Grebe chondrodysplasia is an autosomal recessive disorder characterized by severe abnormality of the limbs and limb joints. The severity of limb shortening progresses in a proximal-distal gradient, with the hands and feet being most affected. The fingers and toes lack articulation and appear as skin appendages. In contrast, axial skeletal structures and the craniofacial skeleton are not affected. Heterozygous individuals are of average stature and have mild skeletal abnormalities (summary by Thomas et al., 1997).

CHONDRODYSPLASIA, GREBE TYPE Is also known as grebe chondrodysplasia|grebe dysplasia|achondrogenesis, brazilian|acromesomelic dysplasia, grebe type|amdg|achondrogenesis, type ii, formerly

Related symptoms:

  • Intellectual disability
  • Short stature
  • Hearing impairment
  • Scoliosis
  • Growth delay


SOURCES: OMIM MENDELIAN

More info about CHONDRODYSPLASIA, GREBE TYPE

Low match TUMOR NECROSIS FACTOR RECEPTOR 1 ASSOCIATED PERIODIC SYNDROME


Tumor necrosis factor receptor 1 associated periodic syndrome (TRAPS) is a periodic fever syndrome, characterized by recurrent fever, arthralgia, myalgia and tender skin lesions lasting for 1 to 3 weeks, associated with skin, joint, ocular and serosal inflammation and complicated by secondary amyloidosis (see this term).

TUMOR NECROSIS FACTOR RECEPTOR 1 ASSOCIATED PERIODIC SYNDROME Is also known as tnf receptor 1-associated periodic syndrome|fpf|traps syndrome|hibernian fever, familial|familial hibernian fever|fhf|tnf receptor-associated periodic syndrome|tumor necrosis factor receptor-associated periodic syndrome|traps

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Fever
  • Edema


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about TUMOR NECROSIS FACTOR RECEPTOR 1 ASSOCIATED PERIODIC SYNDROME

Top 5 symptoms//phenotypes associated to Arthritis and Sensory neuropathy

Symptoms // Phenotype % cases
Pain Common - Between 50% and 80% cases
Paresthesia Common - Between 50% and 80% cases
Arthralgia Common - Between 50% and 80% cases
Peripheral neuropathy Uncommon - Between 30% and 50% cases
Myalgia Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Arthritis and Sensory neuropathy. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Sensorineural hearing impairment Abdominal pain Fever Conjunctivitis Vasculitis Muscle weakness Hernia Arrhythmia Seizures Diarrhea Renal insufficiency Headache Hearing impairment Rheumatoid arthritis

Rare Symptoms - Less than 30% cases


Cranial nerve paralysis Polyneuropathy Inguinal hernia Edema Erythema Pruritus Nausea and vomiting Constrictive median neuropathy Urticaria Polydipsia Neoplasm Anemia Hypertension Hepatomegaly Axonal degeneration Reduced tendon reflexes Meningitis Amyloidosis Peripheral demyelination Migraine Constipation Bruising susceptibility Vomiting Ataxia Malabsorption Diabetes mellitus Skin rash Uveitis Lymphadenopathy Hematuria Splenomegaly Nystagmus Paraplegia Urinary incontinence Fatigue Strabismus Proximal muscle weakness Dementia Pes cavus Babinski sign Spasticity Stroke-like episode Multiple myeloma Restrictive cardiomyopathy Increased CSF protein Hyperhidrosis Syringomyelia Gangrene Myelopathy Decreased number of peripheral myelinated nerve fibers Orthostatic hypotension Aphasia Malnutrition Abnormal joint morphology Orthostatic hypotension due to autonomic dysfunction Abnormal renal physiology Sensory ataxia Urinary retention Psychomotor deterioration Cerebral hemorrhage Vitreous floaters Cardiac amyloidosis Amyloid deposition in the vitreous humor Intellectual disability Short stature Scoliosis Growth delay Flexion contracture Brachydactyly Abnormality of the skeletal system Impotence Atrioventricular block Cachexia Dysarthria Areflexia Congestive heart failure Ectopic ossification Cardiomyopathy Hydrocephalus Tremor Visual impairment Intermittent claudication Impaired urinary acidification Hypocitraturia Renal calcium wasting Medullary nephrocalcinosis Hypermagnesiuria Renal magnesium wasting Renal potassium wasting Hyporeflexia Weight loss Abnormality of the vertebral column Bilateral sensorineural hearing impairment Spastic paraparesis Paraparesis Abnormal autonomic nervous system physiology Hallucinations Hemiparesis Cardiomegaly Arterial tortuosity Facial palsy Neuronal loss in central nervous system Hypotension Abnormality of cardiovascular system physiology Gliosis Coma Nephropathy Peripheral axonal neuropathy Talipes equinovarus Type II diabetes mellitus Kyphosis Muscle stiffness Cellulitis Macule Elevated erythrocyte sedimentation rate Hypermelanotic macule Leukocytosis Intestinal obstruction Chest pain Episodic fever Hepatic failure Nausea Vertigo Papule Behavioral abnormality Valgus hand deformity Aplasia/Hypoplasia of metatarsal bones Pericarditis Reticulocytosis Short digit Neuritis Hepatic amyloidosis Orchitis Abnormality of the sacroiliac joint Conjunctival hyperemia Optic neuritis Erysipelas Pleuritis Myositis Chills Lymphocytosis Periorbital edema Elevated C-reactive protein level Recurrent pharyngitis Peritonitis Abnormal myocardium morphology Acromesomelia Aplasia/Hypoplasia involving the metacarpal bones Chorioretinitis Hirsutism Abnormality of the ribs Postaxial hand polydactyly Limb undergrowth Macroglossia Short foot Postaxial polydactyly Talipes Short phalanx of finger Genu valgum Pectus carinatum Hepatosplenomegaly Jaundice Umbilical hernia Polydactyly Severe short stature Osteoarthritis Hydrops fetalis Pes valgus Prolonged neonatal jaundice Aplasia/Hypoplasia of the patella Short 1st metacarpal Short femur Dysostosis multiplex Short tibia Fibular hypoplasia Short humerus Hallux valgus Aortic regurgitation Metatarsus adductus Hypoplasia of the ulna Short middle phalanx of finger Heart murmur Hypoplasia of the radius Recurrent upper respiratory tract infections Disproportionate short-limb short stature Hyposthenuria Enuresis Enuresis nocturna Joint laxity Spastic paraplegia Joint hypermobility Arachnodactyly Joint hyperflexibility Stroke Scarring Limb muscle weakness Bifid uvula Skeletal muscle atrophy Muscular hypotonia Lower limb muscle weakness Abnormal adipose tissue morphology Increased HDL cholesterol concentration Neuropathic arthropathy Single transverse palmar crease Vesicoureteral reflux Alcoholism Unilateral renal agenesis Proximal amyotrophy Adrenal hyperplasia Hiatus hernia Adrenal hypoplasia Soft skin Atrophic scars Psoriasiform dermatitis Gastrointestinal hemorrhage Hyperextensible skin Spina bifida occulta Spina bifida Thin skin Ambiguous genitalia Mitral valve prolapse Decreased LDL cholesterol concentration Hyperlipoproteinemia Precocious atherosclerosis Dysesthesia Hypothyroidism Gait disturbance Urinary urgency Progressive spastic paraplegia Impaired vibration sensation in the lower limbs Impaired distal vibration sensation Impaired temperature sensation Abnormality of the liver Impaired distal proprioception Demyelinating motor neuropathy Dehydration Demyelinating sensory neuropathy Impaired distal tactile sensation Abnormal brainstem MRI signal intensity Joint stiffness Tachycardia Gout Oral-pharyngeal dysphagia Oligomenorrhea Lipoma Macrocytic anemia Arthropathy Multiple lipomas Coronary artery atherosclerosis Abnormality of mitochondrial metabolism Spastic gait Ragged-red muscle fibers Lower limb spasticity Hoarse voice Insulin resistance Myocardial infarction Abnormality of the skin Muscle cramps Bicornuate uterus Increased connective tissue Persistence of primary teeth Feeding difficulties in infancy Nephrolithiasis Recurrent urinary tract infections Astigmatism Infertility Arterial calcification Hypermetropia Acidosis Hypocalcemia Myopia Failure to thrive Arterial occlusion Generalized arterial calcification Small vessel vasculitis Obstructive lung disease Gingival overgrowth Nephrocalcinosis Immunologic hypersensitivity Amelogenesis imperfecta Tetany Chondrocalcinosis Oligospermia Hypomagnesemia Hypoparathyroidism Ankylosis Abnormality of lipid metabolism Chronic kidney disease Acute kidney injury Renal tubular acidosis Hyperuricemia Male infertility Polyuria Hypercalciuria Episcleritis Complement deficiency Muscle fiber splitting Distal muscle weakness Ascites Cough Hyperreflexia Autoimmunity Proteinuria Dyspnea Quadricuspid aortic valve Decreased serum creatinine Premature arteriosclerosis Ambiguous genitalia, female Congenital adrenal hyperplasia Arteriosclerosis Rectal prolapse Poor wound healing Lymphoma Abnormal vascular morphology Angioedema Pericardial effusion Inflammatory abnormality of the eye Coronary artery calcification Irregular hyperpigmentation Hemoptysis Glomerulopathy Abnormal heart valve morphology Restrictive ventilatory defect Recurrent bacterial infections Emphysema Hemiplegia/hemiparesis Nephritis Pleural effusion Cerebral palsy Periarticular calcification Joint dislocation Fasciitis



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