Arthritis, and Pruritus

Diseases related with Arthritis and Pruritus

In the following list you will find some of the most common rare diseases related to Arthritis and Pruritus that can help you solving undiagnosed cases.


Top matches:

Low match FAMILIAL COLD URTICARIA


Familial cold urticaria (FCAS) is the mildest form of cryopyrin-associated periodic syndrome (CAPS; see this term) and is characterized by recurrent episodes of urticaria-like skin rash triggered by exposure to cold associated with low-grade fever, general malaise, eye redness and arthralgia/myalgia.

FAMILIAL COLD URTICARIA Is also known as fcas|familial cold autoinflammatory syndrome|fcu

Related symptoms:

  • Sensorineural hearing impairment
  • Fever
  • Fatigue
  • Headache
  • Hyperhidrosis


SOURCES: ORPHANET MENDELIAN

More info about FAMILIAL COLD URTICARIA

Low match REYNOLDS SYNDROME


Reynolds syndrome (RS) is an autoimmune disorder characterized by the association of primary biliary cirrhosis (PBC) with limited cutaneous systemic sclerosis (lcSSc) (see these terms).

REYNOLDS SYNDROME Is also known as primary biliary cirrhosis and systemic scleroderma|primary biliary cirrhosis, scleroderma, raynaud disease, and telangiectasia

Related symptoms:

  • Pain
  • Hepatomegaly
  • Fever
  • Fatigue
  • Dysphagia


SOURCES: OMIM ORPHANET MENDELIAN

More info about REYNOLDS SYNDROME

Low match HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS


Hypocomplementemic urticarial vasculitis (HUV) is an immune complex-mediated small vessel vasculitis characterized by urticaria and hypocomplementemia (low C1q with or without low C3 and C4), and usually associated with circulating anti-C1q autoantibodies. Arthritis, pulmonary disease, ocular inflammation, and glomerulonephritis are common systemic manifestations.

HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS Is also known as mac duffie syndrome|mac duffie hypocomplementemic urticarial vasculitis|anti-c1q vasculitis|mcduffie hypocomplementemic urticarial vasculitis|mcduffie syndrome

Related symptoms:

  • Seizures
  • Ataxia
  • Sensorineural hearing impairment
  • Pain
  • Peripheral neuropathy


SOURCES: ORPHANET MENDELIAN

More info about HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS

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Other less relevant matches:

Low match WILSON DISEASE


Wilson disease is a very rare inherited multisystemic disease presenting non-specific neurological, hepatic, psychiatric or osseo-muscular manifestations due to excessive copper deposition in the body.

WILSON DISEASE Is also known as wd|hepatolenticular degeneration|wnd

Related symptoms:

  • Intellectual disability
  • Growth delay
  • Neoplasm
  • Failure to thrive
  • Spasticity


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about WILSON DISEASE

Low match FABRY DISEASE


Fabry disease (FD) is a progressive, inherited, multisystemic lysosomal storage disease characterized by specific neurological, cutaneous, renal, cardiovascular, cochleo-vestibular and cerebrovascular manifestations.

FABRY DISEASE Is also known as ceramide trihexosidase deficiency|hereditary dystopic lipidosis|fd|alpha-galactosidase a deficiency|diffuse angiokeratoma|gla deficiency|angiokeratoma corporis diffusum|anderson-fabry disease

Related symptoms:

  • Seizures
  • Short stature
  • Hearing impairment
  • Sensorineural hearing impairment
  • Pain


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about FABRY DISEASE

Low match DYSCHROMATOSIS UNIVERSALIS HEREDITARIA 3; DUH3


Dyschromatosis universalis hereditaria (DUH) is a rare autosomal dominant genodermatosis characterized by irregularly shaped asymptomatic hyper- and hypopigmented macules that appear in infancy or early childhood and occur in a generalized distribution over the trunk, limbs, and sometimes the face. Involvement of the palms or soles is unusual. Abnormalities of hair and nails have been reported, and DUH may be associated with abnormalities of dermal connective tissue, nerve tissue, or other systemic complications (summary by Zhang et al., 2013).For a discussion of genetic heterogeneity of DUH, see DUH1 (OMIM ).

Related symptoms:

  • Neoplasm
  • Pain
  • Coloboma
  • Pruritus
  • Hypopigmentation of the skin


SOURCES: OMIM MENDELIAN

More info about DYSCHROMATOSIS UNIVERSALIS HEREDITARIA 3; DUH3

Low match PSORIASIS-RELATED JUVENILE IDIOPATHIC ARTHRITIS


Juvenile psoriatic arthritis is a relatively rare form of juvenile idiopathic arthritis (JIA) representing less than 10% of all JIA cases.

PSORIASIS-RELATED JUVENILE IDIOPATHIC ARTHRITIS Is also known as psoriasis-related jia|juvenile psoriatic arthritis

Related symptoms:

  • Arthritis
  • Autoimmunity
  • Inflammatory abnormality of the skin
  • Psoriasiform dermatitis
  • Juvenile rheumatoid arthritis


SOURCES: OMIM ORPHANET MENDELIAN

More info about PSORIASIS-RELATED JUVENILE IDIOPATHIC ARTHRITIS

Low match SEBORRHEA-LIKE DERMATITIS WITH PSORIASIFORM ELEMENTS


Seborrhea-like dermatitis with psoriasiform elements is a rare, genetic, epidermal disorder characterized by a chronic, diffuse, fine, scaly erythematous rash on the face (predominantly the chin, nasolabial folds, eyebrows), around the earlobes and over the scalp, associated with hyperkeratosis over elbows, knees, palms, soles and metacarpophalangeal joints, in the absence of associated rheumatological or neurological disorders. Cold weather, emotional stress and strenuous physical activity may exacerbate symptoms.

Related symptoms:

  • Hyperkeratosis
  • Arthralgia
  • Arthritis
  • Skin rash
  • Overgrowth


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about SEBORRHEA-LIKE DERMATITIS WITH PSORIASIFORM ELEMENTS

Low match PSORIASIS 2; PSORS2


Related symptoms:

  • Fever
  • Hyperkeratosis
  • Arthralgia
  • Arthritis
  • Ichthyosis


SOURCES: OMIM MENDELIAN

More info about PSORIASIS 2; PSORS2

Low match PSORIASIS 1, SUSCEPTIBILITY TO; PSORS1


Psoriasis (psoriasis vulgaris; PV) is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin patches that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age (summary by Matthews et al., 1996).Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein (OMIM ) (summary by Marrakchi et al., 2011). GPP often presents in patients with existing or prior psoriasis vulgaris; however, GPP can develop without a history of PV (Sugiura et al., 2013). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP (summary by Setta-Kaffetzi et al., 2013).Nestle et al. (2009) provided a detailed review of the pathogenesis and genetics of psoriasis. Genetic Heterogeneity of Psoriasis and Psoriasis SusceptibilityPSORS2 (OMIM ) is caused by mutation in the CARD14 gene (OMIM ) on chromosome 17q25, and PSORS14 (OMIM ) is caused by mutation in the IL36RN gene (OMIM ) on chromosome 2q14.Psoriasis susceptibility loci include PSORS1 on 6p21.3; PSORS3 (OMIM ) on 4q; PSORS4 on 1q21; PSORS5 (OMIM ) on 3q21; PSORS6 (OMIM ) on 19p; PSORS7 (OMIM ) on 1p; PSORS8 (OMIM ) on 16q; PSORS9 (OMIM ) on 4q31; PSORS10 (OMIM ) on 18p11; PSORS11 (OMIM ) on 5q31-q33; PSORS12 (OMIM ) on 20q13; PSORS13 (OMIM ), conferred by variation in the TRAF3IP2 gene (OMIM ) on 6q21; and PSORS15 (OMIM ), conferred by variation in the AP1S3 gene (OMIM ) on 2q36.An additional putative psoriasis candidate locus has been reported on 20p (Nair et al., 1997).

Related symptoms:

  • Fever
  • Arthritis
  • Skin rash
  • Scaling skin
  • Psoriasiform dermatitis


SOURCES: OMIM MENDELIAN

More info about PSORIASIS 1, SUSCEPTIBILITY TO; PSORS1

Top 5 symptoms//phenotypes associated to Arthritis and Pruritus

Symptoms // Phenotype % cases
Arthralgia Common - Between 50% and 80% cases
Skin rash Uncommon - Between 30% and 50% cases
Fever Uncommon - Between 30% and 50% cases
Nausea and vomiting Uncommon - Between 30% and 50% cases
Fatigue Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Arthritis and Pruritus. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Psoriasiform dermatitis Myalgia Pain Splenomegaly Sensorineural hearing impairment Ascites Hyperkeratosis Proteinuria Peripheral neuropathy Hepatomegaly Inflammatory abnormality of the skin Abdominal pain

Rare Symptoms - Less than 30% cases


Abnormality of the nervous system Mucosal telangiectasiae Seizures Abnormality of the hand Diarrhea Renal insufficiency Dyspnea Personality changes Autoimmunity Cough Hematuria Aminoaciduria Glycosuria Anxiety Emphysema Abnormal heart valve morphology Glomerulopathy Nausea Obstructive lung disease Paresthesia Neoplasm Anemia Renal tubular dysfunction Vomiting Abnormality of the cerebral white matter Depressivity Edema Spontaneous abortion Polydipsia Respiratory insufficiency Cholestasis Conjunctivitis Dysesthesia Jaundice Dysphagia Scaling skin Cirrhosis Hyperhidrosis Urticaria Telangiectasia of the skin Elevated erythrocyte sedimentation rate Parakeratosis Xerostomia Esophageal varix Epidermal acanthosis Nail pits Abnormality of the liver Elevated hepatic transaminase Irregular hyperpigmentation Headache Progressive sensorineural hearing impairment Interstitial pulmonary abnormality Transient ischemic attack Abnormality of lipid metabolism Orthostatic hypotension Abnormal EKG Aortic root aneurysm Wheezing Renal tubular acidosis Celiac disease Hypohidrosis Tubular atrophy Edema of the lower limbs Peripheral arterial stenosis Chronic fatigue Myocardial fibrosis Sinus bradycardia Achalasia Chronic obstructive pulmonary disease Angina pectoris Clubbing of fingers Reduced ejection fraction Tubulointerstitial nephritis Heat intolerance Nephrotic syndrome Supraventricular tachycardia Large earlobe Oligospermia Abnormality of the gastrointestinal tract Ventricular hypertrophy Elevated serum creatinine Thick lower lip vermilion Anhidrosis Coronary artery atherosclerosis Subcutaneous nodule Ischemic stroke Progressive hearing impairment Abnormal intestine morphology Aortic regurgitation Ventricular tachycardia Abnormal lung morphology Hyperlipidemia Left ventricular hypertrophy Reduced bone mineral density Purpura Exercise intolerance Abnormal autonomic nervous system physiology Fasciculations Bradycardia Lymphedema Anorexia Mitral regurgitation Ventricular arrhythmia Impotence Heart murmur Bundle branch block Loss of consciousness Polyuria Diabetes insipidus Tricuspid regurgitation Impaired vibratory sensation Clubbing Glomerulosclerosis Tinnitus Hemiplegia Prominent supraorbital ridges Atrial fibrillation Chronic kidney disease Atrioventricular block Myocardial infarction Easy fatigability Palpitations Corneal dystrophy Abnormality of cardiovascular system physiology Abnormality of femur morphology Abnormality of the forehead Abnormal common carotid artery morphology Acroparesthesia Heavy proteinuria Tenesmus Left ventricular septal hypertrophy Tortuosity of conjunctival vessels Hyperkeratotic papule Abnormality of glycosphingolipid metabolism Increased carotid artery intimal medial thickness Impaired renal concentrating ability Functional abnormality of the gastrointestinal tract ST segment depression Unexplained fevers Concentric hypertrophic cardiomyopathy Coronary artery stenosis Shortened PR interval Abnormal ST segment Increased glomerular filtration rate Angiokeratoma corporis diffusum Dermal atrophy Palmoplantar pustulosis Acute monocytic leukemia Pustule Diffuse skin atrophy Orthokeratosis Atopic dermatitis Rheumatoid arthritis Ichthyosis Abnormality of the common coagulation pathway Seborrheic dermatitis Overgrowth Juvenile rheumatoid arthritis Neoplasm of the skin Hypopigmentation of the skin Coloboma Cornea verticillata Abnormal glomerular filtration rate Decreased lacrimation Shortened QT interval Abnormality of the nose T-wave inversion Abnormal cornea morphology Abnormality of the renal tubule Abnormal thrombosis Tubulointerstitial fibrosis Chronic pain Abnormal renal physiology Miosis Abnormal aortic valve morphology Conjunctival telangiectasia Gastrointestinal dysmotility Periorbital fullness Abnormal mitral valve morphology Asymmetric septal hypertrophy High-frequency hearing impairment Abnormal myocardium morphology Restrictive cardiomyopathy Supraventricular arrhythmia Microalbuminuria Hyposthenuria Nephrogenic diabetes insipidus Impaired temperature sensation Angiokeratoma Reduced sperm motility Increased blood urea nitrogen Distal renal tubular acidosis Vascular tortuosity Decreased glomerular filtration rate Abnormality of temperature regulation Primary hypothyroidism Limb pain Corneal crystals Retinal vascular tortuosity Vascular skin abnormality Decreased female libido Abnormality of the cardiovascular system Abnormal endocardium morphology Biventricular hypertrophy Mitral valve prolapse Midface retrusion Hypotension Failure to thrive Dementia Thrombocytopenia Cerebral atrophy Dystonia Tremor Dysarthria Spasticity Growth delay Weight loss Intellectual disability Small vessel vasculitis Episcleritis Immunologic hypersensitivity Complement deficiency Angioedema Inflammatory abnormality of the eye Osteoporosis Hepatosplenomegaly Hemoptysis Bruising susceptibility Progressive neurologic deterioration Psychosis Hepatitis Coma Polyneuropathy Hepatic steatosis Hemolytic anemia Hepatic failure Difficulty walking Joint hypermobility Peripheral axonal neuropathy Confusion Poor speech Infertility Aggressive behavior Rigidity Uveitis Pericardial effusion Clumsiness Elevated alkaline phosphatase Biliary cirrhosis Calcinosis Antinuclear antibody positivity Raynaud phenomenon Keratoconjunctivitis sicca Scleroderma Steatorrhea Encephalitis Abnormality of the gastric mucosa Hyperbilirubinemia Skin ulcer Telangiectasia Gastrointestinal hemorrhage Gastroesophageal reflux Dehydration Erythema Lichenification Sclerodactyly Restrictive ventilatory defect Recurrent bacterial infections Hemiplegia/hemiparesis Nephritis Pleural effusion Reduced tendon reflexes Cerebral palsy Cranial nerve paralysis Joint dislocation Vasculitis Lip telangiectasia Meningitis Lymphoma Sensory neuropathy Lymphadenopathy Ataxia Generalized abnormality of skin Calcinosis cutis Palmar telangiectasia Osteoarthritis Involuntary movements Urinary incontinence Dilatation Carcinoma Coarse facial features Mandibular prognathia Hypothyroidism Posteriorly rotated ears Constipation Arrhythmia Behavioral abnormality Abnormality of the kidney Congestive heart failure Cardiomyopathy Optic atrophy Hypertension Cognitive impairment Cataract Hearing impairment Hypertrophic cardiomyopathy Developmental regression Atypical or prolonged hepatitis Thick eyebrow Syncope Sudden cardiac death Chest pain Abdominal distention Muscle cramps Nephropathy Thick vermilion border Bulbous nose Stroke Tachycardia Stage 5 chronic kidney disease Vertigo Delayed puberty Malabsorption Papule Corneal opacity Prominent nasal bridge Short stature Kayser-Fleischer ring Nephrolithiasis Schizophrenia Osteomalacia Pathologic fracture Global brain atrophy Oral-pharyngeal dysphagia Abnormality of mitochondrial metabolism Hypercalciuria Back pain Drooling Abnormality of blood and blood-forming tissues Leukoencephalopathy Leukopenia Nephrocalcinosis Muscle stiffness Increased body weight Bone pain Decreased liver function Arthropathy Joint swelling Mixed demyelinating and axonal polyneuropathy Retinoblastoma High nonceruloplasmin-bound serum copper Acute hepatitis Hypersexuality Poor motor coordination Hypocupremia Premature osteoarthritis Abnormality of the menstrual cycle Proximal muscle weakness in lower limbs Hepatocellular carcinoma Menstrual irregularities Neoplasm of the liver Hyperphosphaturia Chondrocalcinosis Acute hepatic failure Increased reactive oxygen species production Hand tremor Hypoparathyroidism Onychomadesis



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