Arthritis, and Nail dystrophy

Diseases related with Arthritis and Nail dystrophy

In the following list you will find some of the most common rare diseases related to Arthritis and Nail dystrophy that can help you solving undiagnosed cases.


Top matches:

Low match GENERALIZED PUSTULAR PSORIASIS


Generalized pustular psoriasis is a severe inflammatory skin disease that can be life-threatening and that is characterized by recurrent episodes of high fever, fatigue, episodic erythematous cutaneous eruptions with sterile cutaneous pustules formation on various parts of the body, and neutrophil leukocytosis.

GENERALIZED PUSTULAR PSORIASIS Is also known as ditra|interleukin 36 receptor antagonist deficiency|acrodermatitis continua of hallopeau|generalized pustular psoriasis|psorp|gpp|palmoplantar pustulosis

Related symptoms:

  • Muscle weakness
  • Fever
  • Headache
  • Erythema
  • Skin rash


SOURCES: OMIM ORPHANET MENDELIAN

More info about GENERALIZED PUSTULAR PSORIASIS

Low match PARASTREMMATIC DWARFISM


Parastremmatic dwarfism is a very rare chondrodysplasia characterized by severe dwarfism, kyphoscoliosis, stiffness of large joints and distortion of lower limbs.

Related symptoms:

  • Short stature
  • Scoliosis
  • Flexion contracture
  • Brachydactyly
  • Short neck


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about PARASTREMMATIC DWARFISM

Low match KID SYNDROME


Keratitis (and hystrix-like) ichthyosis deafness (KID/HID) syndrome is a rare congenital ectodermal disorder characterized by vascularizing keratitis, hyperkeratotic skin lesions and hearing loss.

KID SYNDROME Is also known as ichthyosis hystrix rheydt type|keratitis-ichthyosis-deafness/hystrix-like ichthyosis-deafness syndrome|senter syndrome|kid/hid syndrome|kid syndrome, autosomal dominant

Related symptoms:

  • Intellectual disability
  • Short stature
  • Hearing impairment
  • Neoplasm
  • Sensorineural hearing impairment


SOURCES: OMIM ORPHANET MENDELIAN

More info about KID SYNDROME

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Other less relevant matches:

Low match NAIL DISORDER, NONSYNDROMIC CONGENITAL, 8; NDNC8


This form of isolated toenail dystrophy has been found to segregate as an autosomal dominant trait in families in which another member has the autosomal recessive skin disorder dystrophic epidermolysis bullosa (OMIM ) or transient bullous dermolysis of the newborn (OMIM ), the features of which include dystrophic nails. The nail changes in isolated toenail dystrophy are most severe in the great toes and consist of the nail plate being buried in the nail bed with a deformed and narrow free edge (summary by Sato-Matsumura et al., 2002). This form of toenail dystrophy is referred to here as nonsyndromic congenital nail disorder-8 (NDNC8).For a list of other nonsyndromic congenital nail disorders and a discussion of genetic heterogeneity, see NDNC1 (OMIM ).

NAIL DISORDER, NONSYNDROMIC CONGENITAL, 8; NDNC8 Is also known as toenail dystrophy, isolated

Related symptoms:

  • Nail dystrophy
  • Fragile skin


SOURCES: OMIM MESH MENDELIAN

More info about NAIL DISORDER, NONSYNDROMIC CONGENITAL, 8; NDNC8

Low match EPIDERMOLYSIS BULLOSA WITH CONGENITAL LOCALIZED ABSENCE OF SKIN AND DEFORMITY OF NAILS


EPIDERMOLYSIS BULLOSA WITH CONGENITAL LOCALIZED ABSENCE OF SKIN AND DEFORMITY OF NAILS Is also known as epidermolysis bullosa dystrophica, bart type

Related symptoms:

  • Nail dystrophy
  • Nail dysplasia
  • Fragile skin
  • Congenital localized absence of skin


SOURCES: MESH OMIM MENDELIAN

More info about EPIDERMOLYSIS BULLOSA WITH CONGENITAL LOCALIZED ABSENCE OF SKIN AND DEFORMITY OF NAILS

Low match EPIDERMOLYSIS BULLOSA SIMPLEX WITH NAIL DYSTROPHY; EBSND


Related symptoms:

  • Cardiomyopathy
  • Hyperkeratosis
  • Scarring
  • Muscular dystrophy
  • Papule


SOURCES: OMIM MENDELIAN

More info about EPIDERMOLYSIS BULLOSA SIMPLEX WITH NAIL DYSTROPHY; EBSND

Low match PSORIASIS-RELATED JUVENILE IDIOPATHIC ARTHRITIS


Juvenile psoriatic arthritis is a relatively rare form of juvenile idiopathic arthritis (JIA) representing less than 10% of all JIA cases.

PSORIASIS-RELATED JUVENILE IDIOPATHIC ARTHRITIS Is also known as psoriasis-related jia|juvenile psoriatic arthritis

Related symptoms:

  • Arthritis
  • Autoimmunity
  • Inflammatory abnormality of the skin
  • Psoriasiform dermatitis
  • Juvenile rheumatoid arthritis


SOURCES: OMIM ORPHANET MENDELIAN

More info about PSORIASIS-RELATED JUVENILE IDIOPATHIC ARTHRITIS

Low match PSORIASIS 1, SUSCEPTIBILITY TO; PSORS1


Psoriasis (psoriasis vulgaris; PV) is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin patches that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age (summary by Matthews et al., 1996).Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein (OMIM ) (summary by Marrakchi et al., 2011). GPP often presents in patients with existing or prior psoriasis vulgaris; however, GPP can develop without a history of PV (Sugiura et al., 2013). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP (summary by Setta-Kaffetzi et al., 2013).Nestle et al. (2009) provided a detailed review of the pathogenesis and genetics of psoriasis. Genetic Heterogeneity of Psoriasis and Psoriasis SusceptibilityPSORS2 (OMIM ) is caused by mutation in the CARD14 gene (OMIM ) on chromosome 17q25, and PSORS14 (OMIM ) is caused by mutation in the IL36RN gene (OMIM ) on chromosome 2q14.Psoriasis susceptibility loci include PSORS1 on 6p21.3; PSORS3 (OMIM ) on 4q; PSORS4 on 1q21; PSORS5 (OMIM ) on 3q21; PSORS6 (OMIM ) on 19p; PSORS7 (OMIM ) on 1p; PSORS8 (OMIM ) on 16q; PSORS9 (OMIM ) on 4q31; PSORS10 (OMIM ) on 18p11; PSORS11 (OMIM ) on 5q31-q33; PSORS12 (OMIM ) on 20q13; PSORS13 (OMIM ), conferred by variation in the TRAF3IP2 gene (OMIM ) on 6q21; and PSORS15 (OMIM ), conferred by variation in the AP1S3 gene (OMIM ) on 2q36.An additional putative psoriasis candidate locus has been reported on 20p (Nair et al., 1997).

Related symptoms:

  • Fever
  • Arthritis
  • Skin rash
  • Scaling skin
  • Psoriasiform dermatitis


SOURCES: OMIM MENDELIAN

More info about PSORIASIS 1, SUSCEPTIBILITY TO; PSORS1

Low match ICHTHYOSIS HYSTRIX OF CURTH-MACKLIN


Ichthyosis hystrix of Curth-Macklin (IHCM) is a rare type of keratinopathic ichthyosis (see this term) that is characterized by the presence of severe hyperkeratotic lesions and palmoplantar keratoderma (PPK, see this term).

ICHTHYOSIS HYSTRIX OF CURTH-MACKLIN Is also known as ichthyosis hystrix, curth-macklin type

Related symptoms:

  • Flexion contracture
  • Abnormality of metabolism/homeostasis
  • Hyperkeratosis
  • Nail dystrophy
  • Ichthyosis


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about ICHTHYOSIS HYSTRIX OF CURTH-MACKLIN

Low match HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE 2


Hereditary sensory and autonomic neuropathy, type 2 (HSAN2) is an inherited disorder characterized by profound and universal sensory loss involving large and small fiber nerves, and marked hypotonia.

HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE 2 Is also known as hsan2|autosomal recessive sensory radicular neuropathy|hereditary sensory and autonomic neuropathy type ii|neurogenic acroosteolysis

Related symptoms:

  • Skeletal muscle atrophy
  • Hyperhidrosis
  • Hyperlordosis
  • Tapered finger
  • Abnormality of epiphysis morphology


SOURCES: ORPHANET MENDELIAN

More info about HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE 2

Top 5 symptoms//phenotypes associated to Arthritis and Nail dystrophy

Symptoms // Phenotype % cases
Nail dysplasia Uncommon - Between 30% and 50% cases
Hyperkeratosis Uncommon - Between 30% and 50% cases
Psoriasiform dermatitis Uncommon - Between 30% and 50% cases
Fragile skin Rare - less than 30% cases
Alopecia Rare - less than 30% cases
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Other less frequent symptoms

Patients with Arthritis and Nail dystrophy. may also develop some of the following symptoms:

Rare Symptoms - Less than 30% cases


Nail pits Skin vesicle Hyperhidrosis Dystrophic toenail Short stature Scarring Palmoplantar pustulosis Ichthyosis Flexion contracture Scaling skin Osteolysis Erythema Skin rash Nausea Fever Pustule Dystrophic fingernails Furrowed tongue Corneal neovascularization Recurrent corneal erosions Keratoconjunctivitis sicca Abnormal eyelash morphology Alopecia of scalp Hypoplastic fingernail Oral leukoplakia Abnormality of the tongue Corneal erosion Muscle weakness Severe hearing impairment Cellulitis Macule Aplasia/Hypoplasia of the eyebrow Squamous cell carcinoma Hemiplegia/hemiparesis Keratoconjunctivitis Hypoplastic toenails Absent eyebrow Keratitis Congenital sensorineural hearing impairment Urticaria Reduced tendon reflexes Neoplasm of the skin Sparse eyelashes Squamous cell carcinoma of the skin Congenital localized absence of skin Corneal scarring Tapered finger Erythroderma Diffuse palmoplantar keratoderma Autoamputation of digits Bleeding with minor or no trauma Skeletal muscle atrophy Hyperlordosis Abnormality of epiphysis morphology Abnormality of metabolism/homeostasis Wormian bones Reduced bone mineral density Abnormality of the hip bone Abnormal cortical bone morphology Abnormality of the knee Abnormality of the ankles Recurrent skin infections Onychomadesis Recurrent bacterial skin infections Cardiomyopathy Generalized hyperkeratosis Corneal ulceration Moderate hearing impairment Trichiasis Abnormality of corneal stroma Knee flexion contracture Muscular dystrophy Acute monocytic leukemia Papule Pruritus Abnormal blistering of the skin Plantar hyperkeratosis Autoimmunity Inflammatory abnormality of the skin Juvenile rheumatoid arthritis Conjunctivitis Palmoplantar keratoderma Elbow flexion contracture Vomiting Abnormal intestine morphology Chronic diarrhea Bowing of the long bones Postural instability Genu valgum Malabsorption Nausea and vomiting Platyspondyly Kyphoscoliosis Hypothyroidism Abdominal pain Severe short stature Kyphosis Diarrhea Edema Rheumatoid arthritis Chills Headache Epidermal acanthosis Leukocytosis Osteomyelitis Parakeratosis Cholangitis Neutrophilia Short neck Asthenia Periostitis Geographic tongue Oligoarthritis Scoliosis Brachydactyly Cachexia Malnutrition Skin ulcer Carious teeth Cerebellar hypoplasia Pes cavus Photophobia Carcinoma Sparse hair Severe global developmental delay Delayed eruption of teeth Visual loss Progressive visual loss Fine hair Aganglionic megacolon Thickened skin Hypohidrosis Sparse and thin eyebrow Delayed skeletal maturation Abnormality of the dentition Scleroderma Intestinal polyp Thoracic kyphosis Thoracolumbar scoliosis Protein-losing enteropathy Mucopolysacchariduria Stiff neck Peripheral edema Intellectual disability Blindness Hearing impairment Neoplasm Sensorineural hearing impairment Pain Cryptorchidism Visual impairment Foot acroosteolysis



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