Arthritis, and Inflammatory abnormality of the skin

Diseases related with Arthritis and Inflammatory abnormality of the skin

In the following list you will find some of the most common rare diseases related to Arthritis and Inflammatory abnormality of the skin that can help you solving undiagnosed cases.


Top matches:

Low match PSORIASIS-RELATED JUVENILE IDIOPATHIC ARTHRITIS


Juvenile psoriatic arthritis is a relatively rare form of juvenile idiopathic arthritis (JIA) representing less than 10% of all JIA cases.

PSORIASIS-RELATED JUVENILE IDIOPATHIC ARTHRITIS Is also known as psoriasis-related jia|juvenile psoriatic arthritis

Related symptoms:

  • Arthritis
  • Autoimmunity
  • Inflammatory abnormality of the skin
  • Psoriasiform dermatitis
  • Juvenile rheumatoid arthritis


SOURCES: OMIM ORPHANET MENDELIAN

More info about PSORIASIS-RELATED JUVENILE IDIOPATHIC ARTHRITIS

Low match SEBORRHEA-LIKE DERMATITIS WITH PSORIASIFORM ELEMENTS


Seborrhea-like dermatitis with psoriasiform elements is a rare, genetic, epidermal disorder characterized by a chronic, diffuse, fine, scaly erythematous rash on the face (predominantly the chin, nasolabial folds, eyebrows), around the earlobes and over the scalp, associated with hyperkeratosis over elbows, knees, palms, soles and metacarpophalangeal joints, in the absence of associated rheumatological or neurological disorders. Cold weather, emotional stress and strenuous physical activity may exacerbate symptoms.

Related symptoms:

  • Hyperkeratosis
  • Arthralgia
  • Arthritis
  • Skin rash
  • Overgrowth


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about SEBORRHEA-LIKE DERMATITIS WITH PSORIASIFORM ELEMENTS

Low match PSORIASIS 2; PSORS2


Related symptoms:

  • Fever
  • Hyperkeratosis
  • Arthralgia
  • Arthritis
  • Ichthyosis


SOURCES: OMIM MENDELIAN

More info about PSORIASIS 2; PSORS2

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Other less relevant matches:

Low match PSORIASIS 1, SUSCEPTIBILITY TO; PSORS1


Psoriasis (psoriasis vulgaris; PV) is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin patches that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age (summary by Matthews et al., 1996).Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein (OMIM ) (summary by Marrakchi et al., 2011). GPP often presents in patients with existing or prior psoriasis vulgaris; however, GPP can develop without a history of PV (Sugiura et al., 2013). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP (summary by Setta-Kaffetzi et al., 2013).Nestle et al. (2009) provided a detailed review of the pathogenesis and genetics of psoriasis. Genetic Heterogeneity of Psoriasis and Psoriasis SusceptibilityPSORS2 (OMIM ) is caused by mutation in the CARD14 gene (OMIM ) on chromosome 17q25, and PSORS14 (OMIM ) is caused by mutation in the IL36RN gene (OMIM ) on chromosome 2q14.Psoriasis susceptibility loci include PSORS1 on 6p21.3; PSORS3 (OMIM ) on 4q; PSORS4 on 1q21; PSORS5 (OMIM ) on 3q21; PSORS6 (OMIM ) on 19p; PSORS7 (OMIM ) on 1p; PSORS8 (OMIM ) on 16q; PSORS9 (OMIM ) on 4q31; PSORS10 (OMIM ) on 18p11; PSORS11 (OMIM ) on 5q31-q33; PSORS12 (OMIM ) on 20q13; PSORS13 (OMIM ), conferred by variation in the TRAF3IP2 gene (OMIM ) on 6q21; and PSORS15 (OMIM ), conferred by variation in the AP1S3 gene (OMIM ) on 2q36.An additional putative psoriasis candidate locus has been reported on 20p (Nair et al., 1997).

Related symptoms:

  • Fever
  • Arthritis
  • Skin rash
  • Scaling skin
  • Psoriasiform dermatitis


SOURCES: OMIM MENDELIAN

More info about PSORIASIS 1, SUSCEPTIBILITY TO; PSORS1

Low match PYOGENIC STERILE ARTHRITIS, PYODERMA GANGRENOSUM, AND ACNE


PYOGENIC STERILE ARTHRITIS, PYODERMA GANGRENOSUM, AND ACNE Is also known as papas|familial recurrent arthritis|papa syndrome|fra

Related symptoms:

  • Diabetes mellitus
  • Arthritis
  • Proteinuria
  • Type I diabetes mellitus
  • Acne


SOURCES: OMIM MENDELIAN

More info about PYOGENIC STERILE ARTHRITIS, PYODERMA GANGRENOSUM, AND ACNE

Low match HYPERZINCEMIA AND HYPERCALPROTECTINEMIA


Hyperzincemia and hypercalprotectinemia is a rare inborn error of zinc metabolism characterized by recurrent infections, hepatosplenomegaly, anemia (unresponsive to iron supplementation) and chronic systemic inflammation in the presence of high plasma concentrations of zinc and calprotectin. Patients typically present dermal ulcers or other cutaneous manifestations (e.g. inflammation) and arthralgia. Severe epistaxis and spontaneous hematomas have also been reported.

HYPERZINCEMIA AND HYPERCALPROTECTINEMIA Is also known as recurrent infections-inflammatory syndrome due to zinc metabolism disorder syndrome|albumin binding of zinc, elevated|hyperzincemia, familial dysalbuminemic

Related symptoms:

  • Growth delay
  • Anemia
  • Recurrent infections
  • Abnormality of metabolism/homeostasis
  • Hepatosplenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about HYPERZINCEMIA AND HYPERCALPROTECTINEMIA

Low match DDX41-RELATED HEMATOLOGIC MALIGNANCY PREDISPOSITION SYNDROME


Familial myeloproliferative/lymphoproliferative neoplasms is an autosomal dominant cancer predisposition syndrome characterized by adult-onset of hematologic malignancies mainly affecting the myeloid line. Most patients present with myelodysplastic syndrome (MDS ) and/or acute myeloid leukemia (AML ). Rare lymphoid malignancies, including lymphoma, can also occur. Some mutation carriers, even if unaffected by a hematologic malignancy, may have evidence of immune dysregulation disorders, including asthma, eczema, or juvenile arthritis. The disorder shows incomplete penetrance (summary by Lewinsohn et al., 2016). Patients may show a favorable response to treatment with lenalidomide (summary by Polprasert et al., 2015).

Related symptoms:

  • Neoplasm
  • Anemia
  • Arthritis
  • Leukemia
  • Asthma


SOURCES: ORPHANET OMIM MENDELIAN

More info about DDX41-RELATED HEMATOLOGIC MALIGNANCY PREDISPOSITION SYNDROME

Low match COMPLEMENT COMPONENT 7 DEFICIENCY; C7D


COMPLEMENT COMPONENT 7 DEFICIENCY; C7D Is also known as c7 deficiency

Related symptoms:

  • Fever
  • Arthritis
  • Telangiectasia
  • Meningitis
  • Vasculitis


SOURCES: OMIM MESH MENDELIAN

More info about COMPLEMENT COMPONENT 7 DEFICIENCY; C7D

Low match SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 6; SLEB6


Related symptoms:

  • Arthritis
  • Abnormality of the nervous system
  • Cutaneous photosensitivity
  • Spontaneous abortion
  • Systemic lupus erythematosus


SOURCES: OMIM MENDELIAN

More info about SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 6; SLEB6

Low match COMPLEMENT COMPONENT C1R/C1S DEFICIENCY


Lack of production of either functional C1r or C1s protein, due to a genetic defect. Approximately 60% of patients with a C1r/C1s deficiency will develop a severe systemic lupus erythematosus at an early age. Patients also present with frequent sinopulmonary infections often with Streptococcus pneumoniae.

COMPLEMENT COMPONENT C1R/C1S DEFICIENCY Is also known as c1r/c1s deficiency

Related symptoms:

  • Arthralgia
  • Arthritis
  • Autoimmunity
  • Nephritis
  • Recurrent bronchitis


SOURCES: OMIM MENDELIAN

More info about COMPLEMENT COMPONENT C1R/C1S DEFICIENCY

Top 5 symptoms//phenotypes associated to Arthritis and Inflammatory abnormality of the skin

Symptoms // Phenotype % cases
Psoriasiform dermatitis Uncommon - Between 30% and 50% cases
Arthralgia Uncommon - Between 30% and 50% cases
Fever Uncommon - Between 30% and 50% cases
Pyoderma Uncommon - Between 30% and 50% cases
Acute monocytic leukemia Rare - less than 30% cases
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Other less frequent symptoms

Patients with Arthritis and Inflammatory abnormality of the skin. may also develop some of the following symptoms:

Rare Symptoms - Less than 30% cases


Autoimmunity Hyperkeratosis Scaling skin Pyoderma gangrenosum Anemia Nail pits Complement deficiency Parakeratosis Epidermal acanthosis Skin rash Juvenile rheumatoid arthritis Systemic lupus erythematosus Sclerodactyly Raynaud phenomenon Vasculitis Chronic myelomonocytic leukemia Meningitis Telangiectasia Erythroid dysplasia Refractory anemia Immune dysregulation Acute myeloid leukemia Monocytosis Abnormality of the nervous system Vasculitis in the skin Subcutaneous calcification Recurrent meningococcal disease Recurrent meningitis C8 deficiency Cutaneous photosensitivity Spontaneous abortion Pericarditis Antinuclear antibody positivity Abnormal renal physiology Pleuritis Malar rash Nephritis Recurrent bronchitis Myeloid leukemia Neoplasm Myelodysplasia Proteinuria Overgrowth Seborrheic dermatitis Ichthyosis Dermal atrophy Rheumatoid arthritis Atopic dermatitis Orthokeratosis Diffuse skin atrophy Pustule Palmoplantar pustulosis Onychomadesis Diabetes mellitus Type I diabetes mellitus Melanoma Acne Sterile arthritis Growth delay Recurrent infections Abnormality of metabolism/homeostasis Hepatosplenomegaly Increased serum zinc Leukemia Asthma Lymphoma Eczema Bone marrow hypocellularity Leukopenia Discoid lupus rash



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