Arthritis, and Hodgkin lymphoma

Diseases related with Arthritis and Hodgkin lymphoma

In the following list you will find some of the most common rare diseases related to Arthritis and Hodgkin lymphoma that can help you solving undiagnosed cases.


Top matches:

Medium match B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA


B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma (see this term), and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia (see these terms). The clinical course is extremely heterogeneous with survival ranging from a few months to several decades.

B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA Is also known as b-cll|small lymphocytic lymphoma|b-cell chronic lymphoid leukemia|leukemia, chronic lymphatic

Related symptoms:

  • Neoplasm
  • Anemia
  • Splenomegaly
  • Recurrent infections
  • Thrombocytopenia


SOURCES: OMIM ORPHANET MENDELIAN

More info about B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA

Medium match WISKOTT-ALDRICH SYNDROME


Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disease characterized by microthrombocytopenia, eczema, infections and an increased risk for autoimmune manifestations and malignancies.

WISKOTT-ALDRICH SYNDROME Is also known as aldrich syndrome|imd2|immunodeficiency 2|eczema-thrombocytopenia-immunodeficiency syndrome|was|was1|wiskott-aldrich syndrome 1

Related symptoms:

  • Neoplasm
  • Anemia
  • Peripheral neuropathy
  • Fever
  • Fatigue


SOURCES: OMIM ORPHANET MENDELIAN

More info about WISKOTT-ALDRICH SYNDROME

Low match DDX41-RELATED HEMATOLOGIC MALIGNANCY PREDISPOSITION SYNDROME


Familial myeloproliferative/lymphoproliferative neoplasms is an autosomal dominant cancer predisposition syndrome characterized by adult-onset of hematologic malignancies mainly affecting the myeloid line. Most patients present with myelodysplastic syndrome (MDS ) and/or acute myeloid leukemia (AML ). Rare lymphoid malignancies, including lymphoma, can also occur. Some mutation carriers, even if unaffected by a hematologic malignancy, may have evidence of immune dysregulation disorders, including asthma, eczema, or juvenile arthritis. The disorder shows incomplete penetrance (summary by Lewinsohn et al., 2016). Patients may show a favorable response to treatment with lenalidomide (summary by Polprasert et al., 2015).

Related symptoms:

  • Neoplasm
  • Anemia
  • Arthritis
  • Leukemia
  • Asthma


SOURCES: ORPHANET OMIM MENDELIAN

More info about DDX41-RELATED HEMATOLOGIC MALIGNANCY PREDISPOSITION SYNDROME

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Other less relevant matches:

Low match OSTEOCHONDRODYSPLASIA, BRACHYDACTYLY, AND OVERLAPPING MALFORMED DIGITS; OCBMD


Osteochondrodysplasia, brachydactyly, and overlapping malformed digits (OCBMD) is characterized by bilateral symmetric skeletal defects that primarily affect the limbs. Affected individuals have mild short stature due to shortening of the lower leg bones, as well as hand and foot malformations, predominantly brachydactyly and overlapping digits. Other skeletal defects include scoliosis, dislocated patellae and fibulae, and pectus excavatum (Shabbir et al., 2018).

Related symptoms:

  • Short stature
  • Scoliosis
  • Neoplasm
  • Pain
  • Brachydactyly


SOURCES: OMIM MENDELIAN

More info about OSTEOCHONDRODYSPLASIA, BRACHYDACTYLY, AND OVERLAPPING MALFORMED DIGITS; OCBMD

Low match IMMUNODEFICIENCY 36; IMD36


IMD36 is a primary immunodeficiency with a highly heterogeneous clinical phenotype, characterized primarily by recurrent respiratory tract infections, lymphoproliferation, and antibody deficiency. Other features include growth retardation, mild neurodevelopmental delay, and autoimmunity. The major complication is development of B-cell lymphoma (Elkaim et al., 2016).

Related symptoms:

  • Growth delay
  • Diarrhea
  • Splenomegaly
  • Immunodeficiency
  • Recurrent respiratory infections


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY 36; IMD36

Low match EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 2; EDSPD2


Related symptoms:

  • Scoliosis
  • Neoplasm
  • Fever
  • Inguinal hernia
  • Arthralgia


SOURCES: OMIM MENDELIAN

More info about EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 2; EDSPD2

Low match WHIM SYNDROME


WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a congenital autosomal dominant immune deficiency characterized by abnormal retention of mature neutrophils in the bone marrow (myelokathexis) and occasional hypogammaglobulinemia, associated with an increased risk for bacterial infections and a susceptibility to human papillomavirus (HPV) induced lesions (cutaneous warts, genital dysplasia and invasive mucosal carcinoma).

WHIM SYNDROME Is also known as warts, hypogammaglobulinemia, infections, and myelokathexis syndrome|warts-infections-leukopenia-myelokatexis syndrome|wilm|warts-hypogammaglobulinemia-infections-myelokathexis syndrome

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Fever
  • Congestive heart failure
  • Immunodeficiency


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about WHIM SYNDROME

Low match HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS


Hypocomplementemic urticarial vasculitis (HUV) is an immune complex-mediated small vessel vasculitis characterized by urticaria and hypocomplementemia (low C1q with or without low C3 and C4), and usually associated with circulating anti-C1q autoantibodies. Arthritis, pulmonary disease, ocular inflammation, and glomerulonephritis are common systemic manifestations.

HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS Is also known as mac duffie syndrome|mac duffie hypocomplementemic urticarial vasculitis|anti-c1q vasculitis|mcduffie hypocomplementemic urticarial vasculitis|mcduffie syndrome

Related symptoms:

  • Seizures
  • Ataxia
  • Sensorineural hearing impairment
  • Pain
  • Peripheral neuropathy


SOURCES: ORPHANET MENDELIAN

More info about HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS

Low match COMBINED IMMUNODEFICIENCY DUE TO LRBA DEFICIENCY


Common variable immunodeficiency-8 with autoimmunity is an autosomal recessive disorder of immune dysregulation. Affected individuals have early childhood onset of recurrent infections, particularly respiratory infections, and also develop variable autoimmune disorders, including idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and inflammatory bowel disease. The presentation and phenotype are highly variable, even within families (summary by Lopez-Herrera et al., 2012 and Alangari et al., 2012). Immunologic findings are also variable and may include decreased B cells, hypogammaglobulinemia, and deficiency of CD4+ T regulatory (Treg) cells (Charbonnier et al., 2015).For a general description and a discussion of genetic heterogeneity of common variable immunodeficiency, see CVID1 (OMIM ).

COMBINED IMMUNODEFICIENCY DUE TO LRBA DEFICIENCY Is also known as cid due to lrba deficiency

Related symptoms:

  • Growth delay
  • Neoplasm
  • Failure to thrive
  • Anemia
  • Diarrhea


SOURCES: OMIM ORPHANET MENDELIAN

More info about COMBINED IMMUNODEFICIENCY DUE TO LRBA DEFICIENCY

Low match ACHONDROPLASIA; ACH


Achondroplasia is the most frequent form of short-limb dwarfism. Affected individuals exhibit short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and midface hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, genu varum, and trident hand (summary by Bellus et al., 1995).

Related symptoms:

  • Intellectual disability
  • Short stature
  • Generalized hypotonia
  • Hearing impairment
  • Scoliosis


SOURCES: MESH OMIM MENDELIAN

More info about ACHONDROPLASIA; ACH

Top 5 symptoms//phenotypes associated to Arthritis and Hodgkin lymphoma

Symptoms // Phenotype % cases
Lymphoma Very Common - Between 80% and 100% cases
Neoplasm Common - Between 50% and 80% cases
Anemia Uncommon - Between 30% and 50% cases
Splenomegaly Uncommon - Between 30% and 50% cases
Autoimmunity Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Arthritis and Hodgkin lymphoma. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Leukemia Lymphadenopathy Otitis media Respiratory tract infection Recurrent upper respiratory tract infections Immunodeficiency Diarrhea Arthralgia Combined immunodeficiency Inflammation of the large intestine Scoliosis Thrombocytopenia Pain Chronic diarrhea Recurrent respiratory infections Pneumonia Neutropenia Recurrent infections Osteoarthritis Growth delay Fever Decreased antibody level in blood Bronchiectasis Recurrent bacterial infections Meningitis Chronic lymphatic leukemia Conjunctivitis B-cell lymphoma Recurrent otitis media

Rare Symptoms - Less than 30% cases


Gingival bleeding IgM deficiency Verrucae Glomerulopathy Cellulitis Chronic otitis media Recurrent ear infections Short stature Interstitial pneumonitis Generalized lymphadenopathy Small vessel vasculitis Asthma Myeloid leukemia Immune dysregulation Respiratory failure Brachydactyly Cor pulmonale Abnormal lung morphology Obstructive lung disease Periodontitis Hearing impairment Congestive heart failure Urticaria Recurrent urinary tract infections Sinusitis Lymphopenia Systemic lupus erythematosus Pancytopenia Bruising susceptibility Cough Eczema Proteinuria Dyspnea Rheumatoid arthritis Hemolytic anemia Lymphoproliferative disorder Peripheral neuropathy Vasculitis Acute leukemia Renal insufficiency Purpura Macrocephaly Frontal bossing Abnormality of the skeletal system Chronic kidney disease Hyperreflexia Hypertension Hydrocephalus Depressed nasal bridge Motor delay Ventriculomegaly Skeletal dysplasia Malar flattening Midface retrusion Obesity Severe short stature Weight loss Gastroesophageal reflux Rigidity Conductive hearing impairment Abnormality of the nervous system Cleft lip Apnea Delayed speech and language development Follicular hyperplasia Flexion contracture Interstitial pulmonary abnormality Uveitis Inflammatory abnormality of the eye Angioedema Complement deficiency Immunologic hypersensitivity Episcleritis Failure to thrive Diabetes mellitus Hypothyroidism Hepatosplenomegaly Inflammatory abnormality of the skin Type I diabetes mellitus Abnormal intestine morphology Clubbing Colitis Generalized hypotonia Villous atrophy Intellectual disability Burkitt lymphoma Scarring Gastritis Neurodegeneration Brain neoplasm Clubbing of fingers Autoimmune hemolytic anemia Chronic lung disease Exocrine pancreatic insufficiency Autoimmune thrombocytopenia Fatigable weakness IgA deficiency Recurrent sinusitis Hyperlordosis Overgrowth Joint hyperflexibility Myelopathy Abnormality of the elbow Obstructive sleep apnea Spinal cord compression Megalencephaly Osteopetrosis Generalized joint laxity Communicating hydrocephalus Upper airway obstruction Dysuria Central apnea Abnormality of femur morphology Multiple epiphyseal dysplasia Hypoxemia Thoracolumbar kyphosis Hip contracture Chronic myelogenous leukemia Neonatal short-limb short stature Central sleep apnea Cervical myelopathy Hypopnea Cervical cord compression Iritis Small foramen magnum Childhood onset short-limb short stature Brain stem compression Limited hip extension Trident hand Spinal stenosis with reduced interpedicular distance Myelitis Spinal canal stenosis Neuroblastoma Micromelia Acanthosis nigricans Confusion Oral cleft Sleep disturbance Hemoptysis Lumbar hyperlordosis Epidermal acanthosis Tetraparesis Abnormal form of the vertebral bodies Abnormality of the metaphysis Rhizomelia Short toe Clonus Paraparesis Sleep apnea Disproportionate short stature Infantile muscular hypotonia Short long bone Disproportionate short-limb short stature Tinnitus Abnormality of pelvic girdle bone morphology Genu varum Back pain Epiphyseal dysplasia Spondyloepiphyseal dysplasia Flared metaphysis Short femoral neck Bowel incontinence Limited elbow extension Tibial bowing Irregular hyperpigmentation Cerebral palsy Abnormal heart valve morphology Sepsis Abnormal platelet morphology Congenital thrombocytopenia Reduced delayed hypersensitivity Large vessel vasculitis Abnormal bleeding Recurrent intrapulmonary hemorrhage Chronic leukemia Absent microvilli on the surface of peripheral blood lymphocytes Abnormal delayed hypersensitivity skin test Reduced lymphocyte surface expression of CD43 Specific anti-polysaccharide antibody deficiency Oral bleeding Bone marrow hypocellularity Abnormal platelet function Leukopenia Melanoma Myelodysplasia Nephropathy Acute myeloid leukemia Acute monocytic leukemia Refractory anemia Monocytosis Chronic myelomonocytic leukemia Erythroid dysplasia Pectus excavatum Polydactyly Arrhythmia Decreased mean platelet volume Internal hemorrhage Adducted thumb Recurrent lower respiratory tract infections Intracranial hemorrhage Glomerulosclerosis Glomerulonephritis Skin ulcer Hyperostosis Keratitis Focal segmental glomerulosclerosis Petechiae Prolonged bleeding time Microcytic anemia Epistaxis Iron deficiency anemia Blepharitis Hematochezia Abnormal eosinophil morphology Chronic obstructive pulmonary disease Hypoplasia of the thymus Specific learning disability Increased IgE level Abnormality of the menstrual cycle Membranoproliferative glomerulonephritis Sudden cardiac death Increased IgA level Hematemesis Melena Spontaneous hematomas Bloody diarrhea Chest pain Postaxial polydactyly Mild short stature Pericardial effusion Skin rash Abnormality of bone marrow cell morphology Folliculitis Septic arthritis Tonsillitis Hypersegmentation of neutrophil nuclei Bone marrow hypercellularity Myelokathexis Seizures Ataxia Sensorineural hearing impairment Hepatomegaly Abdominal pain Myalgia Pruritus Abnormality of female internal genitalia Nausea and vomiting Hematuria Sensory neuropathy Ascites Joint dislocation Cranial nerve paralysis Sarcoma Reduced tendon reflexes Pleural effusion Nephritis Hemiplegia/hemiparesis Emphysema Restrictive ventilatory defect Abnormality of female external genitalia Atelectasis Broad hallux Irritability Abnormality of digit Patellar dislocation T-cell lymphoma Short 2nd finger Fatigue Non-Hodgkin lymphoma Lung adenocarcinoma Neurodevelopmental delay Allergy Recurrent sinopulmonary infections Enlarged tonsils Inguinal hernia Umbilical hernia Joint hypermobility Hyperthyroidism Hyperextensible skin Nephroblastoma Atrophic scars Fragile skin Premature loss of teeth Lymphocytosis Gingival recession Cellular immunodeficiency Carcinoma Carious teeth Leukocytosis Osteomyelitis IgG deficiency Lumbar kyphosis in infancy



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