Arthritis, and Eosinophilia

Diseases related with Arthritis and Eosinophilia

In the following list you will find some of the most common rare diseases related to Arthritis and Eosinophilia that can help you solving undiagnosed cases.


Top matches:

Medium match IMMUNE DYSREGULATION-POLYENDOCRINOPATHY-ENTEROPATHY-X-LINKED SYNDROME


Immunodysregulation - polyendocrinopathy - enteropathy - X-linked (IPEX) syndrome is a severe congenital systemic autoimmune disease characterized by refractory diarrhea, endocrinopathies, cutaneous involvement, and infections.

IMMUNE DYSREGULATION-POLYENDOCRINOPATHY-ENTEROPATHY-X-LINKED SYNDROME Is also known as enteropathy, autoimmune, with hemolytic anemia and polyendocrinopathy|ipex|autoimmune enteropathy type 1|iddm-secretory diarrhea syndrome|x-linked autoimmunity-allergic dysregulation syndrome|polyendocrinopathy, immune dysfunction, and diarrhea, x-linked|

Related symptoms:

  • Growth delay
  • Failure to thrive
  • Anemia
  • Intrauterine growth retardation
  • Diarrhea


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about IMMUNE DYSREGULATION-POLYENDOCRINOPATHY-ENTEROPATHY-X-LINKED SYNDROME

Low match SARCOIDOSIS


Sarcoidosis is a multisystemic disorder of unknown cause characterized by the formation of immune granulomas in involved organs.

SARCOIDOSIS Is also known as boeck sarcoid|besnier-boeck-schaumann disease|sarcoidosis|boeck's sarcoid

Related symptoms:

  • Seizures
  • Pain
  • Cataract
  • Anemia
  • Visual impairment


SOURCES: ORPHANET OMIM MENDELIAN

More info about SARCOIDOSIS

Low match B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA


B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma (see this term), and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia (see these terms). The clinical course is extremely heterogeneous with survival ranging from a few months to several decades.

B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA Is also known as b-cll|small lymphocytic lymphoma|b-cell chronic lymphoid leukemia|leukemia, chronic lymphatic

Related symptoms:

  • Neoplasm
  • Anemia
  • Splenomegaly
  • Recurrent infections
  • Thrombocytopenia


SOURCES: OMIM ORPHANET MENDELIAN

More info about B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA

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Other less relevant matches:

Low match GENERALIZED PUSTULAR PSORIASIS


Generalized pustular psoriasis is a severe inflammatory skin disease that can be life-threatening and that is characterized by recurrent episodes of high fever, fatigue, episodic erythematous cutaneous eruptions with sterile cutaneous pustules formation on various parts of the body, and neutrophil leukocytosis.

GENERALIZED PUSTULAR PSORIASIS Is also known as ditra|interleukin 36 receptor antagonist deficiency|acrodermatitis continua of hallopeau|generalized pustular psoriasis|psorp|gpp|palmoplantar pustulosis

Related symptoms:

  • Muscle weakness
  • Fever
  • Headache
  • Erythema
  • Skin rash


SOURCES: OMIM ORPHANET MENDELIAN

More info about GENERALIZED PUSTULAR PSORIASIS

Low match NLRP12-ASSOCIATED HEREDITARY PERIODIC FEVER SYNDROME


NLRP12-associated hereditary periodic fever syndrome is a rare autoinflammatory syndrome characterized by episodic and recurrent periods of fever combined with various systemic manifestations such as myalgia, arthralgia, joint swelling, urticaria, headache and skin rash. Common trigger of these episodes is cold.

NLRP12-ASSOCIATED HEREDITARY PERIODIC FEVER SYNDROME Is also known as familial cold autoinflammatory syndrome type 2|naps12|fcas2

Related symptoms:

  • Intellectual disability
  • Hearing impairment
  • Sensorineural hearing impairment
  • Pain
  • Fever


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about NLRP12-ASSOCIATED HEREDITARY PERIODIC FEVER SYNDROME

Low match LEUKOCYTE ADHESION DEFICIENCY, TYPE I; LAD


Leukocyte adhesion deficiency (LAD) is an autosomal recessive disorder of neutrophil function resulting from a deficiency of the beta-2 integrin subunit of the leukocyte cell adhesion molecule. The leukocyte cell adhesion molecule is present on the surface of peripheral blood mononuclear leukocytes and granulocytes and mediates cell-cell and cell-extracellular matrix adhesion. LAD is characterized by recurrent bacterial infections; impaired pus formation and wound healing; abnormalities of a wide variety of adhesion-dependent functions of granulocytes, monocytes, and lymphocytes; and a lack of beta-2/alpha-L, beta-2/alpha-M, and beta-2/alpha-X expression.

LEUKOCYTE ADHESION DEFICIENCY, TYPE I; LAD Is also known as lad1|lymphocyte function-associated antigen 1 immunodeficiency|lfa1 immunodeficiency

Related symptoms:

  • Intellectual disability
  • Short stature
  • Generalized hypotonia
  • Intellectual disability, severe
  • Immunodeficiency


SOURCES: OMIM MENDELIAN

More info about LEUKOCYTE ADHESION DEFICIENCY, TYPE I; LAD

Low match ECTODERMAL DYSPLASIA, ANHIDROTIC, WITH T-CELL IMMUNODEFICIENCY, AUTOSOMAL DOMINANT


Mutations in the NFKBIA gene result in functional impairment of NFKB1 (OMIM ), a master transcription factor required for normal activation of immune responses. Interruption of NFKB1 signaling results in decreased production of proinflammatory cytokines and certain interferons, rendering patients susceptible to infection (McDonald et al., 2007).

Related symptoms:

  • Growth delay
  • Failure to thrive
  • Delayed speech and language development
  • Frontal bossing
  • Diarrhea


SOURCES: OMIM MESH MENDELIAN

More info about ECTODERMAL DYSPLASIA, ANHIDROTIC, WITH T-CELL IMMUNODEFICIENCY, AUTOSOMAL DOMINANT

Low match AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE III; ALPS3


Autoimmune lymphoproliferative syndrome type III is an autosomal recessive disorder of immune dysregulation. The phenotype is variable, but most patients have significant lymphadenopathy associated with variable autoimmune manifestations. Some patients may have recurrent infections. Lymphocyte accumulation results from a combination of impaired apoptosis and excessive proliferation (summary by Oliveira, 2013).For a general description and a discussion of genetic heterogeneity of ALPS, see {601859}.

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE III; ALPS3 Is also known as cvid9, formerly|immunodeficiency, common variable, 9, formerly

Related symptoms:

  • Anemia
  • Hepatomegaly
  • Splenomegaly
  • Immunodeficiency
  • Recurrent infections


SOURCES: OMIM MENDELIAN

More info about AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE III; ALPS3

Low match WHIM SYNDROME


WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a congenital autosomal dominant immune deficiency characterized by abnormal retention of mature neutrophils in the bone marrow (myelokathexis) and occasional hypogammaglobulinemia, associated with an increased risk for bacterial infections and a susceptibility to human papillomavirus (HPV) induced lesions (cutaneous warts, genital dysplasia and invasive mucosal carcinoma).

WHIM SYNDROME Is also known as warts, hypogammaglobulinemia, infections, and myelokathexis syndrome|warts-infections-leukopenia-myelokatexis syndrome|wilm|warts-hypogammaglobulinemia-infections-myelokathexis syndrome

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Fever
  • Congestive heart failure
  • Immunodeficiency


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about WHIM SYNDROME

Low match MUCKLE-WELLS SYNDROME; MWS


Muckle-Wells syndrome (MWS) is characterized by episodic skin rash, arthralgias, and fever associated with late-onset sensorineural deafness and renal amyloidosis (Dode et al., 2002).See also familial cold-induced autoinflammatory syndrome-1 (FCAS1, CAPS1; {120100}), an allelic disorder with overlapping clinical features.

MUCKLE-WELLS SYNDROME; MWS Is also known as caps2|uda syndrome|urticaria-deafness-amyloidosis syndrome|cryopyrin-associated periodic syndrome 2

Related symptoms:

  • Seizures
  • Hearing impairment
  • Sensorineural hearing impairment
  • Pain
  • Anemia


SOURCES: OMIM MENDELIAN

More info about MUCKLE-WELLS SYNDROME; MWS

Top 5 symptoms//phenotypes associated to Arthritis and Eosinophilia

Symptoms // Phenotype % cases
Leukocytosis Common - Between 50% and 80% cases
Lymphadenopathy Common - Between 50% and 80% cases
Anemia Uncommon - Between 30% and 50% cases
Fever Uncommon - Between 30% and 50% cases
Immunodeficiency Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Arthritis and Eosinophilia. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Splenomegaly Lymphocytosis Skin rash Thrombocytopenia Recurrent infections Erythema Headache Pneumonia Bronchiectasis Arthralgia Fatigue Immune dysregulation Pain Nephrotic syndrome Hepatosplenomegaly Hemolytic anemia Autoimmunity Hearing impairment Diarrhea Elevated erythrocyte sedimentation rate

Rare Symptoms - Less than 30% cases


Myalgia Renal insufficiency Abdominal pain Meningitis Sensorineural hearing impairment Growth delay Urticaria Episodic fever Recurrent aphthous stomatitis Chest pain Generalized lymphadenopathy Sinusitis Recurrent bacterial infections Cellulitis Periodontitis Respiratory tract infection Increased antibody level in blood Otitis media Congestive heart failure Intellectual disability Thyroiditis Hypothyroidism Lymphoproliferative disorder B-cell lymphoma Rheumatoid arthritis Systemic lupus erythematosus Lymphoma Hepatomegaly Osteomyelitis Neoplasm Hyperthyroidism Failure to thrive Seizures Chills Bilateral sensorineural hearing impairment Juvenile rheumatoid arthritis Psoriasiform dermatitis Recurrent skin infections Vomiting Gingivitis Geographic tongue Peritonitis Epidermal acanthosis Abnormal thrombocyte morphology Epistaxis Nail dysplasia Recurrent bacterial skin infections Oligoarthritis Rectal abscess Nausea Decreased platelet glycoprotein IIb-IIIa Severe periodontitis Abnormal granulocyte morphology Abnormal bleeding Palmoplantar pustulosis Pustule Furrowed tongue Parakeratosis Elevated C-reactive protein level Lower limb pain Neuritis Limb pain Malar rash Optic neuritis Cholangitis Neutrophilia Asthenia Generalized hypotonia Intellectual disability, severe Periostitis Confusion Bruising susceptibility Short stature Hypohidrosis Recurrent staphylococcal infections Ichthyosis IgG deficiency Verrucae Atelectasis Abnormality of female internal genitalia Abnormality of female external genitalia Abnormality of bone marrow cell morphology Folliculitis Septic arthritis Tonsillitis Hypersegmentation of neutrophil nuclei Bone marrow hypercellularity Myelokathexis Abnormality of the skeletal system Stage 5 chronic kidney disease Recurrent upper respiratory tract infections Hematuria Nephropathy Coma Abnormality of the skin Vasculitis Conjunctivitis Progressive sensorineural hearing impairment Amyloidosis Abnormality of the mouth Papilledema Microscopic hematuria Cystinuria Band keratopathy Renal amyloidosis Combined immunodeficiency Recurrent urinary tract infections Recurrent gram-negative bacterial infections Concave nasal ridge Delayed speech and language development Frontal bossing Recurrent respiratory infections Sparse hair Dry skin Hypodontia Ectodermal dysplasia Fine hair Sparse scalp hair Chronic diarrhea Anhidrosis Agammaglobulinemia Heat intolerance Conical tooth Anhidrotic ectodermal dysplasia Decreased antibody level in blood Recurrent infection of the gastrointestinal tract Periorbital wrinkles Aplasia of the sweat glands Defective production of NFKB1-dependent cytokines Purpura Shock Glomerulonephritis Recurrent sinusitis Autoimmune thrombocytopenia Membranous nephropathy Respiratory failure Carcinoma Carious teeth Neutropenia Nail dystrophy Enlarged lacrimal glands Muscle weakness Abnormal lung morphology Dyspnea Photophobia Proximal muscle weakness Facial palsy Scarring Cough Papule Hepatic failure Hypopigmentation of the skin Sudden cardiac death Syncope Pancytopenia Palpitations Subcutaneous nodule Glaucoma Nephrolithiasis Anorexia Hyperpigmentation of the skin Decreased liver function Nephrocalcinosis Osteolysis Leukopenia Ventricular tachycardia Hypercalciuria Hypercalcemia Portal hypertension Pleural effusion Inflammation of the large intestine Weight loss Alopecia Diabetes insipidus Malnutrition Intrauterine growth retardation Diabetes mellitus Sepsis Eczema Hepatitis Inflammatory abnormality of the skin Cardiac arrest Type I diabetes mellitus Abnormal intestine morphology Nephritis Erythroderma Hyperglycemia Abnormality of the coagulation cascade Abnormality of the thyroid gland Arrhythmia Autoimmune hemolytic anemia Ketoacidosis Villous atrophy Ileus Pancreatic hypoplasia Intractable diarrhea Secretory diarrhea Cataract Visual impairment Peripheral neuropathy Skeletal muscle atrophy Respiratory distress Edema Blindness Epiphora Emphysema Non-Hodgkin lymphoma Parotitis Anterior uveitis Abnormal salivary gland morphology Iridocyclitis Abnormal conjunctiva morphology Vitreous floaters Vitritis Abnormal reproductive system morphology Abnormality of skin morphology Posterior vitreous detachment Enlargement of parotid gland Abnormality of T cell physiology Non-caseating epithelioid cell granulomatosis Abnormal liver parenchyma morphology Abnormal cardiac ventricular function Chorioretinitis Increased T cell count Abnormality of the nasal mucosa Maculopapular exanthema Vitreous snowballs Pulmonary granulomatosis Abnormal trabecular meshwork morphology Leukemia Neurodegeneration Hodgkin lymphoma Acute leukemia Chronic lymphatic leukemia Cellular immunodeficiency Lung adenocarcinoma Dacryocystitis Abnormality of the adrenal glands Pulmonary fibrosis Tubulointerstitial nephritis Blurred vision Chorioretinal atrophy Interstitial pulmonary abnormality Abnormality of the musculature Hyperuricemia Keratoconjunctivitis sicca Hemoptysis Optic neuropathy Uveitis Joint swelling Heart block Increased CSF protein Hypothermia Abnormality of the gastrointestinal tract Abnormality of the lymph nodes Upper airway obstruction Macular edema Bone cyst Skin nodule Night sweats Anterior synechiae of the anterior chamber Pneumothorax Abnormality of the pleura Vitreous hemorrhage Chylothorax Cystoid macular edema Abnormality of the cerebrospinal fluid Erythema nodosum Skin plaque Rigors



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