Arthritis, and Diabetes mellitus

Diseases related with Arthritis and Diabetes mellitus

In the following list you will find some of the most common rare diseases related to Arthritis and Diabetes mellitus that can help you solving undiagnosed cases.


Top matches:

Low match PYOGENIC STERILE ARTHRITIS, PYODERMA GANGRENOSUM, AND ACNE


PYOGENIC STERILE ARTHRITIS, PYODERMA GANGRENOSUM, AND ACNE Is also known as papas|familial recurrent arthritis|papa syndrome|fra

Related symptoms:

  • Diabetes mellitus
  • Arthritis
  • Proteinuria
  • Type I diabetes mellitus
  • Acne


SOURCES: OMIM MENDELIAN

More info about PYOGENIC STERILE ARTHRITIS, PYODERMA GANGRENOSUM, AND ACNE

Low match CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2; ADCAD2


Related symptoms:

  • Hypertension
  • Osteoporosis
  • Diabetes mellitus
  • Stroke
  • Sudden cardiac death


SOURCES: OMIM MESH MENDELIAN

More info about CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2; ADCAD2

Low match HEREDITARY ARTERIAL AND ARTICULAR MULTIPLE CALCIFICATION SYNDROME


Hereditary arterial and articular multiple calcification syndrome is a very rare genetic vascular disease of autosomal recessive inheritance, described in less than 20 patients to date, characterized by adult-onset (as early as the second decade of life) isolated calcification of the arteries of the lower extremities (including the iliac, femoral, and tibial arteries) as well as the capsule joints of the fingers, wrists, ankles and feet, and that usually manifests with mild paresthesias of the lower extremities, intense joint pain and swelling, and early onset arthritis of affected joints.

HEREDITARY ARTERIAL AND ARTICULAR MULTIPLE CALCIFICATION SYNDROME Is also known as calcification of joints and arteries|calja|acdc|arterial calcification due to deficiency of cd73

Related symptoms:

  • Pain
  • Diabetes mellitus
  • Arthralgia
  • Arthritis
  • Paresthesia


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about HEREDITARY ARTERIAL AND ARTICULAR MULTIPLE CALCIFICATION SYNDROME

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Other less relevant matches:

Low match PYOGENIC ARTHRITIS-PYODERMA GANGRENOSUM-ACNE SYNDROME


Pyogenic arthritis-pyoderma gangrenosum-acne syndrome is a rare pleiotropic autoinflammatory disorder of childhood, primarily affecting the joints and skin.

PYOGENIC ARTHRITIS-PYODERMA GANGRENOSUM-ACNE SYNDROME Is also known as familial recurrent arthritis|papa syndrome|fra

Related symptoms:

  • Fever
  • Fatigue
  • Arthralgia
  • Arthritis
  • Proteinuria


SOURCES: ORPHANET MENDELIAN

More info about PYOGENIC ARTHRITIS-PYODERMA GANGRENOSUM-ACNE SYNDROME

Low match IMMUNE DYSREGULATION-POLYENDOCRINOPATHY-ENTEROPATHY-X-LINKED SYNDROME


Immunodysregulation - polyendocrinopathy - enteropathy - X-linked (IPEX) syndrome is a severe congenital systemic autoimmune disease characterized by refractory diarrhea, endocrinopathies, cutaneous involvement, and infections.

IMMUNE DYSREGULATION-POLYENDOCRINOPATHY-ENTEROPATHY-X-LINKED SYNDROME Is also known as enteropathy, autoimmune, with hemolytic anemia and polyendocrinopathy|ipex|autoimmune enteropathy type 1|iddm-secretory diarrhea syndrome|x-linked autoimmunity-allergic dysregulation syndrome|polyendocrinopathy, immune dysfunction, and diarrhea, x-linked|

Related symptoms:

  • Growth delay
  • Failure to thrive
  • Anemia
  • Intrauterine growth retardation
  • Diarrhea


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about IMMUNE DYSREGULATION-POLYENDOCRINOPATHY-ENTEROPATHY-X-LINKED SYNDROME

Low match HEMOCHROMATOSIS TYPE 2


Hemochromatosis type 2 (juvenile) is the early-onset and most severe form of rare hereditary hemochromatosis (HH; see this term), a group of diseases characterized by excessive tissue iron deposition of genetic origin.

HEMOCHROMATOSIS TYPE 2 Is also known as juvenile hemochromatosis

Related symptoms:

  • Muscle weakness
  • Pain
  • Hypertension
  • Hepatomegaly
  • Cardiomyopathy


SOURCES: OMIM ORPHANET MENDELIAN

More info about HEMOCHROMATOSIS TYPE 2

Low match STAT3-RELATED EARLY-ONSET MULTISYSTEM AUTOIMMUNE DISEASE


Infantile-onset multisystem autoimmune disease-1 is characterized by early childhood onset of a spectrum of autoimmune disorders affecting multiple organs. Common manifestations include insulin-dependent diabetes mellitus and autoimmune enteropathy, or celiac disease, and autoimmune hematologic disorders. Other features include short stature and nonspecific dermatitis. More variable features include hypothyroidism, autoimmune arthritis, and delayed puberty. Some patients may show recurrent infections. The disorder results from an inborn error of cytokine signaling (summary by Flanagan et al., 2014 and Milner et al., 2015). Genetic Heterogeneity of Infantile-Onset Multisystem Autoimmune DiseaseSee also ADMIO2 (OMIM ), caused by mutation in the ZAP70 gene (OMIM ) on chromosome 2q12.

Related symptoms:

  • Short stature
  • Pain
  • Anemia
  • Abnormality of the dentition
  • Immunodeficiency


SOURCES: OMIM ORPHANET MENDELIAN

More info about STAT3-RELATED EARLY-ONSET MULTISYSTEM AUTOIMMUNE DISEASE

Low match RAMON SYNDROME


A slowly progressive syndrome of cherubic facies (fullness of the cheeks, producing a typical chubby face suggestive of a cherub) maxillary fibrous dysplasia, gingival enlargement, radiolucent lesions of the jaws, seizures, delayed mental development, stunted growth, and other defects. Insulin dependent diabetes mellitus and vascular skin lesions may occur.

RAMON SYNDROME Is also known as cherubism-gingival fibromatosis-intellectual disability syndrome|cherubism, gingival fibromatosis, epilepsy, mental deficiency, hypertrichosis, and stunted growth

Related symptoms:

  • Intellectual disability
  • Seizures
  • Short stature
  • Hearing impairment
  • Scoliosis


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about RAMON SYNDROME

Low match MULTIPLE SYMMETRIC LIPOMATOSIS


Multiple symmetric lipomatosis (MSL) is a rare subcutaneous tissue disease characterized by growth of symmetric non-encapsulated masses of adipose tissue mostly around the face and neck with variable clinical repercussions (e.g. reduced neck mobility, compression of respiratory structures).

MULTIPLE SYMMETRIC LIPOMATOSIS Is also known as launois-bensaude lipomatosis|familial benign cervical lipomatosis|madelung disease|cephalothoracic lipodystrophy|lipomatosis, familial benign cervical|lipodystrophy, cephalothoracic

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Hypertension
  • Peripheral neuropathy


SOURCES: ORPHANET OMIM MENDELIAN

More info about MULTIPLE SYMMETRIC LIPOMATOSIS

Top 5 symptoms//phenotypes associated to Arthritis and Diabetes mellitus

Symptoms // Phenotype % cases
Pain Uncommon - Between 30% and 50% cases
Arthralgia Uncommon - Between 30% and 50% cases
Type I diabetes mellitus Uncommon - Between 30% and 50% cases
Hypothyroidism Uncommon - Between 30% and 50% cases
Anemia Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Arthritis and Diabetes mellitus. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Hypertension Lymphadenopathy

Rare Symptoms - Less than 30% cases


Arthropathy Short stature Failure to thrive Immunodeficiency Recurrent infections Thrombocytopenia Hemolytic anemia Autoimmunity Eczema Abnormal intestine morphology Autoimmune hemolytic anemia Hepatomegaly Abnormality of the liver Inflammatory abnormality of the skin Delayed puberty Rheumatoid arthritis Acne Paresthesia Juvenile rheumatoid arthritis Myocardial infarction Type II diabetes mellitus Gout Osteoporosis Proteinuria Hyperkeratosis Seizures Hearing impairment Scoliosis Sensorineural hearing impairment Kyphosis Pigmentary retinopathy Full cheeks Conductive hearing impairment Intellectual disability Pallor Retinopathy Abnormality of skin pigmentation Delayed eruption of teeth Optic disc pallor Recurrent ear infections Interstitial pneumonitis Decreased antibody level in blood Abnormality of the dentition Pneumonia Recurrent respiratory infections Hepatosplenomegaly Respiratory tract infection Leukemia Neutropenia Abnormal lung morphology Primary hypothyroidism Lymphopenia Interstitial pulmonary abnormality Colitis Celiac disease Scleroderma Autoimmune thrombocytopenia Atopic dermatitis Decreased body weight Hypertrichosis Generalized hirsutism Telangiectasia Multiple lipomas Hoarse voice Reduced tendon reflexes Ragged-red muscle fibers Abnormality of mitochondrial metabolism Oral-pharyngeal dysphagia Coronary artery atherosclerosis Axonal degeneration Macrocytic anemia Abnormality of the skin Lipoma Oligomenorrhea Hyperlipoproteinemia Alcoholism Decreased LDL cholesterol concentration Neuropathic arthropathy Increased HDL cholesterol concentration Insulin resistance Muscle cramps Abnormality of retinal pigmentation Angiokeratoma Elevated transferrin saturation Narrow palate Abnormality of dental enamel Osteolysis Telangiectasia of the skin Gingival fibromatosis Abnormal anterior chamber morphology Axenfeld anomaly Polyneuropathy Enlarged labia minora Neoplasm Peripheral neuropathy Gait disturbance Babinski sign Pes cavus Joint stiffness Tachycardia Abnormality of endocrine pancreas physiology Congenital hepatic fibrosis Abnormality of the anterior pituitary Hyperlipidemia Crohn's disease Increased inflammatory response Growth delay Glucose intolerance Intrauterine growth retardation Diarrhea Hypercholesterolemia Atherosclerosis Pustule Hypertriglyceridemia Sepsis Sudden cardiac death Hepatitis Nephrotic syndrome Stroke Cardiac arrest Myositis Increased antibody level in blood Nephritis Arterial occlusion Abnormal joint morphology Gangrene Arterial tortuosity Abnormality of cardiovascular system physiology Intermittent claudication Ectopic ossification Arterial calcification Generalized arterial calcification Skin ulcer Coronary artery calcification Periarticular calcification Abnormal vascular morphology Decreased serum creatinine Fever Fatigue Limitation of joint mobility Eosinophilia Erythroderma Abnormality of iron homeostasis Hyperpigmentation of the skin Elevated hepatic transaminase Pyoderma Dilated cardiomyopathy Lethargy Infertility Cirrhosis Amenorrhea Hypogonadotrophic hypogonadism Hypogonadism Azoospermia Portal hypertension Impotence Generalized hyperpigmentation Increased serum ferritin Abnormality of the vertebral column Increased serum iron Abdominal pain Arrhythmia Hyperglycemia Immune dysregulation Abnormality of the coagulation cascade Malnutrition Abnormality of the thyroid gland Sterile arthritis Thyroiditis Ketoacidosis Villous atrophy Ileus Splenomegaly Pancreatic hypoplasia Intractable diarrhea Secretory diarrhea Muscle weakness Pyoderma gangrenosum Cardiomyopathy Congestive heart failure Abnormal adipose tissue morphology



If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Frontal bossing and Joint hyperflexibility, related diseases and genetic alterations

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