Arthritis, and B-cell lymphoma

Diseases related with Arthritis and B-cell lymphoma

In the following list you will find some of the most common rare diseases related to Arthritis and B-cell lymphoma that can help you solving undiagnosed cases.


Top matches:

Medium match B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA


B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma (see this term), and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia (see these terms). The clinical course is extremely heterogeneous with survival ranging from a few months to several decades.

B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA Is also known as b-cll|small lymphocytic lymphoma|b-cell chronic lymphoid leukemia|leukemia, chronic lymphatic

Related symptoms:

  • Neoplasm
  • Anemia
  • Splenomegaly
  • Recurrent infections
  • Thrombocytopenia


SOURCES: OMIM ORPHANET MENDELIAN

More info about B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA

Medium match IMMUNODEFICIENCY 36; IMD36


IMD36 is a primary immunodeficiency with a highly heterogeneous clinical phenotype, characterized primarily by recurrent respiratory tract infections, lymphoproliferation, and antibody deficiency. Other features include growth retardation, mild neurodevelopmental delay, and autoimmunity. The major complication is development of B-cell lymphoma (Elkaim et al., 2016).

Related symptoms:

  • Growth delay
  • Diarrhea
  • Splenomegaly
  • Immunodeficiency
  • Recurrent respiratory infections


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY 36; IMD36

Medium match WHIM SYNDROME


WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a congenital autosomal dominant immune deficiency characterized by abnormal retention of mature neutrophils in the bone marrow (myelokathexis) and occasional hypogammaglobulinemia, associated with an increased risk for bacterial infections and a susceptibility to human papillomavirus (HPV) induced lesions (cutaneous warts, genital dysplasia and invasive mucosal carcinoma).

WHIM SYNDROME Is also known as warts, hypogammaglobulinemia, infections, and myelokathexis syndrome|warts-infections-leukopenia-myelokatexis syndrome|wilm|warts-hypogammaglobulinemia-infections-myelokathexis syndrome

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Fever
  • Congestive heart failure
  • Immunodeficiency


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about WHIM SYNDROME

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Other less relevant matches:

Low match OSTEOCHONDRODYSPLASIA, BRACHYDACTYLY, AND OVERLAPPING MALFORMED DIGITS; OCBMD


Osteochondrodysplasia, brachydactyly, and overlapping malformed digits (OCBMD) is characterized by bilateral symmetric skeletal defects that primarily affect the limbs. Affected individuals have mild short stature due to shortening of the lower leg bones, as well as hand and foot malformations, predominantly brachydactyly and overlapping digits. Other skeletal defects include scoliosis, dislocated patellae and fibulae, and pectus excavatum (Shabbir et al., 2018).

Related symptoms:

  • Short stature
  • Scoliosis
  • Neoplasm
  • Pain
  • Brachydactyly


SOURCES: OMIM MENDELIAN

More info about OSTEOCHONDRODYSPLASIA, BRACHYDACTYLY, AND OVERLAPPING MALFORMED DIGITS; OCBMD

Low match DDX41-RELATED HEMATOLOGIC MALIGNANCY PREDISPOSITION SYNDROME


Familial myeloproliferative/lymphoproliferative neoplasms is an autosomal dominant cancer predisposition syndrome characterized by adult-onset of hematologic malignancies mainly affecting the myeloid line. Most patients present with myelodysplastic syndrome (MDS ) and/or acute myeloid leukemia (AML ). Rare lymphoid malignancies, including lymphoma, can also occur. Some mutation carriers, even if unaffected by a hematologic malignancy, may have evidence of immune dysregulation disorders, including asthma, eczema, or juvenile arthritis. The disorder shows incomplete penetrance (summary by Lewinsohn et al., 2016). Patients may show a favorable response to treatment with lenalidomide (summary by Polprasert et al., 2015).

Related symptoms:

  • Neoplasm
  • Anemia
  • Arthritis
  • Leukemia
  • Asthma


SOURCES: ORPHANET OMIM MENDELIAN

More info about DDX41-RELATED HEMATOLOGIC MALIGNANCY PREDISPOSITION SYNDROME

Low match COMBINED IMMUNODEFICIENCY DUE TO LRBA DEFICIENCY


Common variable immunodeficiency-8 with autoimmunity is an autosomal recessive disorder of immune dysregulation. Affected individuals have early childhood onset of recurrent infections, particularly respiratory infections, and also develop variable autoimmune disorders, including idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and inflammatory bowel disease. The presentation and phenotype are highly variable, even within families (summary by Lopez-Herrera et al., 2012 and Alangari et al., 2012). Immunologic findings are also variable and may include decreased B cells, hypogammaglobulinemia, and deficiency of CD4+ T regulatory (Treg) cells (Charbonnier et al., 2015).For a general description and a discussion of genetic heterogeneity of common variable immunodeficiency, see CVID1 (OMIM ).

COMBINED IMMUNODEFICIENCY DUE TO LRBA DEFICIENCY Is also known as cid due to lrba deficiency

Related symptoms:

  • Growth delay
  • Neoplasm
  • Failure to thrive
  • Anemia
  • Diarrhea


SOURCES: OMIM ORPHANET MENDELIAN

More info about COMBINED IMMUNODEFICIENCY DUE TO LRBA DEFICIENCY

Low match EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 2; EDSPD2


Related symptoms:

  • Scoliosis
  • Neoplasm
  • Fever
  • Inguinal hernia
  • Arthralgia


SOURCES: OMIM MENDELIAN

More info about EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 2; EDSPD2

Low match HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS


Hypocomplementemic urticarial vasculitis (HUV) is an immune complex-mediated small vessel vasculitis characterized by urticaria and hypocomplementemia (low C1q with or without low C3 and C4), and usually associated with circulating anti-C1q autoantibodies. Arthritis, pulmonary disease, ocular inflammation, and glomerulonephritis are common systemic manifestations.

HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS Is also known as mac duffie syndrome|mac duffie hypocomplementemic urticarial vasculitis|anti-c1q vasculitis|mcduffie hypocomplementemic urticarial vasculitis|mcduffie syndrome

Related symptoms:

  • Seizures
  • Ataxia
  • Sensorineural hearing impairment
  • Pain
  • Peripheral neuropathy


SOURCES: ORPHANET MENDELIAN

More info about HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS

Low match WISKOTT-ALDRICH SYNDROME


Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disease characterized by microthrombocytopenia, eczema, infections and an increased risk for autoimmune manifestations and malignancies.

WISKOTT-ALDRICH SYNDROME Is also known as aldrich syndrome|imd2|immunodeficiency 2|eczema-thrombocytopenia-immunodeficiency syndrome|was|was1|wiskott-aldrich syndrome 1

Related symptoms:

  • Neoplasm
  • Anemia
  • Peripheral neuropathy
  • Fever
  • Fatigue


SOURCES: OMIM ORPHANET MENDELIAN

More info about WISKOTT-ALDRICH SYNDROME

Low match ACHONDROPLASIA; ACH


Achondroplasia is the most frequent form of short-limb dwarfism. Affected individuals exhibit short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and midface hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, genu varum, and trident hand (summary by Bellus et al., 1995).

Related symptoms:

  • Intellectual disability
  • Short stature
  • Generalized hypotonia
  • Hearing impairment
  • Scoliosis


SOURCES: MESH OMIM MENDELIAN

More info about ACHONDROPLASIA; ACH

Top 5 symptoms//phenotypes associated to Arthritis and B-cell lymphoma

Symptoms // Phenotype % cases
Lymphoma Very Common - Between 80% and 100% cases
Neoplasm Common - Between 50% and 80% cases
Splenomegaly Uncommon - Between 30% and 50% cases
Anemia Uncommon - Between 30% and 50% cases
Autoimmunity Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Arthritis and B-cell lymphoma. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Leukemia Lymphadenopathy Diarrhea Arthralgia Recurrent upper respiratory tract infections Respiratory tract infection Immunodeficiency Otitis media Thrombocytopenia Pneumonia Fever Osteoarthritis Recurrent otitis media Pain Inflammation of the large intestine Neutropenia Recurrent bacterial infections Scoliosis Bronchiectasis Chronic diarrhea Decreased antibody level in blood Recurrent respiratory infections Conjunctivitis Meningitis Growth delay Recurrent infections Combined immunodeficiency Chronic lymphatic leukemia

Rare Symptoms - Less than 30% cases


Short stature Purpura Renal insufficiency Brachydactyly Peripheral neuropathy Glomerulopathy Hodgkin lymphoma Pancytopenia Abnormal lung morphology Dyspnea Small vessel vasculitis Hemolytic anemia Proteinuria Urticaria Asthma Eczema Cough Myeloid leukemia Vasculitis Immune dysregulation Obstructive lung disease Cellulitis Verrucae Respiratory failure Lymphoproliferative disorder Interstitial pneumonitis IgM deficiency Cor pulmonale Generalized lymphadenopathy Rheumatoid arthritis Systemic lupus erythematosus Lymphopenia Chronic otitis media Bruising susceptibility Recurrent ear infections Congestive heart failure Hearing impairment Acute leukemia Periodontitis Recurrent urinary tract infections Sinusitis Gingival bleeding Macrocephaly Malar flattening Skeletal dysplasia Depressed nasal bridge Ventriculomegaly Hypertension Abnormality of the skeletal system Midface retrusion Frontal bossing Severe short stature Hyperreflexia Gastroesophageal reflux Weight loss Delayed speech and language development Hydrocephalus Obesity Motor delay Abnormal platelet function Flexion contracture Hypoplasia of the thymus Melena Hematemesis Increased IgA level Membranoproliferative glomerulonephritis Abnormality of the menstrual cycle Increased IgE level Chronic obstructive pulmonary disease Bloody diarrhea Hematochezia Recurrent lower respiratory tract infections Blepharitis Iron deficiency anemia Microcytic anemia Prolonged bleeding time Spontaneous hematomas Abnormal eosinophil morphology Generalized hypotonia Chronic leukemia Intellectual disability Oral bleeding Specific anti-polysaccharide antibody deficiency Reduced lymphocyte surface expression of CD43 Abnormal delayed hypersensitivity skin test Absent microvilli on the surface of peripheral blood lymphocytes Recurrent intrapulmonary hemorrhage Internal hemorrhage Large vessel vasculitis Reduced delayed hypersensitivity Congenital thrombocytopenia Abnormal platelet morphology Decreased mean platelet volume Conductive hearing impairment Rigidity Sleep apnea Abnormality of the nervous system Hypoxemia Hip contracture Spinal canal stenosis Abnormality of the elbow Obstructive sleep apnea Spinal cord compression Megalencephaly Osteopetrosis Generalized joint laxity Communicating hydrocephalus Upper airway obstruction Dysuria Central apnea Abnormality of femur morphology Multiple epiphyseal dysplasia Myelopathy Disproportionate short stature Small foramen magnum Myelitis Spinal stenosis with reduced interpedicular distance Trident hand Limited hip extension Brain stem compression Childhood onset short-limb short stature Iritis Thoracolumbar kyphosis Cervical cord compression Hypopnea Cervical myelopathy Central sleep apnea Neonatal short-limb short stature Chronic myelogenous leukemia Neuroblastoma Tibial bowing Cleft lip Sleep disturbance Abnormality of the metaphysis Abnormal form of the vertebral bodies Tetraparesis Epidermal acanthosis Lumbar hyperlordosis Overgrowth Oral cleft Short toe Confusion Micromelia Joint hyperflexibility Scarring Hyperlordosis Apnea Rhizomelia Clonus Limited elbow extension Genu varum Bowel incontinence Short femoral neck Flared metaphysis Spondyloepiphyseal dysplasia Epiphyseal dysplasia Back pain Abnormality of pelvic girdle bone morphology Paraparesis Tinnitus Disproportionate short-limb short stature Short long bone Infantile muscular hypotonia Focal segmental glomerulosclerosis Acanthosis nigricans Petechiae Reduced tendon reflexes Keratitis Erythroid dysplasia Patellar dislocation T-cell lymphoma Short 2nd finger Bone marrow hypocellularity Leukopenia Melanoma Myelodysplasia Acute myeloid leukemia Acute monocytic leukemia Refractory anemia Monocytosis Chronic myelomonocytic leukemia Failure to thrive Broad hallux Diabetes mellitus Hypothyroidism Hepatosplenomegaly Inflammatory abnormality of the skin Type I diabetes mellitus Abnormal intestine morphology Clubbing Interstitial pulmonary abnormality Colitis Autoimmune hemolytic anemia Recurrent sinusitis IgA deficiency Fatigable weakness Abnormality of digit Mild short stature Exocrine pancreatic insufficiency Osteomyelitis Neurodegeneration Hyperthyroidism Cellular immunodeficiency Lymphocytosis Lung adenocarcinoma Non-Hodgkin lymphoma Neurodevelopmental delay Allergy Recurrent sinopulmonary infections Enlarged tonsils Carcinoma Carious teeth Leukocytosis IgG deficiency Adducted thumb Atelectasis Abnormality of female internal genitalia Abnormality of female external genitalia Abnormality of bone marrow cell morphology Folliculitis Septic arthritis Tonsillitis Hypersegmentation of neutrophil nuclei Bone marrow hypercellularity Myelokathexis Pectus excavatum Polydactyly Postaxial polydactyly Autoimmune thrombocytopenia Chronic lung disease Hyperostosis Fatigue Hemiplegia/hemiparesis Emphysema Restrictive ventilatory defect Pericardial effusion Abnormal heart valve morphology Hemoptysis Irregular hyperpigmentation Uveitis Inflammatory abnormality of the eye Angioedema Complement deficiency Immunologic hypersensitivity Episcleritis Arrhythmia Pleural effusion Nephropathy Sepsis Abnormal bleeding Chest pain Sudden cardiac death Specific learning disability Epistaxis Skin ulcer Chronic kidney disease Sarcoma Intracranial hemorrhage Glomerulosclerosis Glomerulonephritis Nephritis Cerebral palsy Clubbing of fingers Premature loss of teeth Villous atrophy Brain neoplasm Gastritis Follicular hyperplasia Burkitt lymphoma Inguinal hernia Umbilical hernia Irritability Joint hypermobility Hyperextensible skin Nephroblastoma Atrophic scars Fragile skin Gingival recession Cranial nerve paralysis Seizures Ataxia Sensorineural hearing impairment Hepatomegaly Abdominal pain Myalgia Skin rash Pruritus Nausea and vomiting Hematuria Sensory neuropathy Ascites Joint dislocation Lumbar kyphosis in infancy



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