Anemia, and Stomach cancer

Diseases related with Anemia and Stomach cancer

In the following list you will find some of the most common rare diseases related to Anemia and Stomach cancer that can help you solving undiagnosed cases.


Top matches:

Medium match PEUTZ-JEGHERS SYNDROME


Peutz-Jeghers syndrome (PJS) is an inherited gastrointestinal disorder characterized by development of characteristic hamartomatous polyps throughout the gastrointestinal (GI) tract, and by mucocutaneous pigmentation. PJS carries a considerably increased risk of GI and extra-GI malignancies.

PEUTZ-JEGHERS SYNDROME Is also known as hamartomatous intestinal polyposis|polyps and spots syndrome|pjs

Related symptoms:

  • Neoplasm
  • Anemia
  • Vomiting
  • Abdominal pain
  • Gastrointestinal hemorrhage


SOURCES: OMIM ORPHANET MENDELIAN

More info about PEUTZ-JEGHERS SYNDROME

Medium match CRONKHITE-CANADA SYNDROME


Cronkhite-Canada syndrome (CCS) is a rare gastrointestinal (GI) polyposis syndrome characterized by the association of non-hereditary GI polyposis with the cutaneous triad of alopecia, nail changes and hyperpigmentation.

CRONKHITE-CANADA SYNDROME Is also known as gastrointestinal polyposis-skin pigmentation-alopecia-fingernail changes syndrome|gastrointestinal polyposis-ectodermal changes syndrome|cronkhite-canada syndrome

Related symptoms:

  • Seizures
  • Neoplasm
  • Muscle weakness
  • Pain
  • Cataract


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about CRONKHITE-CANADA SYNDROME

Medium match JUVENILE POLYPOSIS SYNDROME; JPS


Juvenile polyposis syndrome is an autosomal dominant condition that predisposes gene carriers to various types of tumors. The diagnosis is based on the occurrence of hamartomatous gastrointestinal polyps that turn into malignant lesions in approximately 20% of cases (Handra-Luca et al., 2005).It had been suggested that juvenile polyposis can be caused by mutations in the PTEN gene (OMIM ), the same gene that is mutant in Cowden syndrome-1 (OMIM ). In a comprehensive review of PTEN, Waite and Eng (2002) concluded that juvenile intestinal polyposis is not a so-called PTEN hamartoma-tumor syndrome (PHTS). They suggested that the discovery of the germline PTEN mutation in an individual considered to have JPS should raise a suspicion that the clinical diagnosis is incorrect and that such an individual should be managed medically in the same manner as all patients with PHTS.

JUVENILE POLYPOSIS SYNDROME; JPS Is also known as polyposis, juvenile intestinal|pji|jip|juvenile intestinal polyposis|polyposis, familial, of entire gastrointestinal tract

Related symptoms:

  • Seizures
  • Neoplasm
  • Failure to thrive
  • Pain
  • Cryptorchidism


SOURCES: OMIM MENDELIAN

More info about JUVENILE POLYPOSIS SYNDROME; JPS

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Other less relevant matches:

Medium match FANCONI ANEMIA, COMPLEMENTATION GROUP S; FANCS


Fanconi anemia complementation group S is an autosomal recessive disorder characterized by developmental delay apparent from infancy, short stature, microcephaly, and coarse dysmorphic features. Laboratory studies show defective DNA repair and increased chromosomal breakage during stress. Some patients may have radial ray anomalies, anemia, and increased risk of cancer; patients often have a family history of cancer in family members who have heterozygous mutations (summary by Freire et al., 2018).For additional general information and a discussion of genetic heterogeneity of Fanconi anemia, see {227650}.

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Short stature
  • Hearing impairment
  • Microcephaly


SOURCES: OMIM MENDELIAN

More info about FANCONI ANEMIA, COMPLEMENTATION GROUP S; FANCS

Low match GASTROINTESTINAL STROMAL TUMOR


Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal (GI) tract, typically presenting in adults over the age of 40 (mean age 63), and only rarely in children, in various regions of the GI tract, most commonly the stomach or small intestine but also less commonly in the esophagus, appendix, rectum and colon. GISTs can be asymptomatic or present with various non-specific signs, depending on the location and size of tumor, such as loss of appetite, anemia, weight loss, fatigue, abdominal discomfort or fullness, nausea, vomiting, as well as an abdominal mass, blood in stool, and intestinal obstruction. GISTs can also be seen in familial syndromes such as Carney triad and neurofibromatosis type 1.

GASTROINTESTINAL STROMAL TUMOR Is also known as gastrointestinal stromal sarcoma|gist

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Fever
  • Fatigue


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about GASTROINTESTINAL STROMAL TUMOR

Low match BLOOD GROUP, SS; SS


Ss blood group antigens reside on the red-cell glycoprotein GYPB. The S and s antigens result from a polymorphism at amino acid 29 of GYPB, where S has met29 and s has thr29. The U antigen refers to a short extracellular sequence in GYPB located near the membrane. GYPB, glycophorin A (GYPA ), and glycophorin E (GYPE ) are closely linked on chromosome 4q31. Antigens of the MN blood group (OMIM ) reside on GYPA. The M and N antigens differ at amino acids 1 and 5 of GYPA, where M is ser-ser-thr-thr-gly, and N is leu-ser-thr-thr-glu. The N terminus of GYPB is essentially identical to that of GYPA except that it always expresses the N antigen, denoted 'N' or N-prime. Recombination and gene conversion between GYPA, GYPB, and GYPE lead to hybrid glycophorin molecules and generation of low-incidence antigens. Thus, the MN and Ss blood groups are together referred to as the MNSs blood group system (see {111300}). Recombination results in 3 glycophorin-null phenotypes: En(a-) cells lack GYPA due to recombination between GYPA and GYPB; GYPB-negative (S-s-U-) cells lack GYPB due to recombination in GYPB; and M(k) cells (M-N-S-s-U-) lack both GYPA and GYPB due to recombination between GYPA and GYPE. Individuals with glycophorin-null phenotypes have decreased sialic acid content and increased resistance to malarial infection (see {611162}). GYPA and GYPB are not essential for red-cell development or survival, and GYPA- and GYPB-null phenotypes are not associated with anemia or altered red-cell function (review by Cooling, 2015).

BLOOD GROUP, SS; SS Is also known as ss blood group

Related symptoms:

  • Neoplasm
  • Anemia


SOURCES: OMIM MENDELIAN

More info about BLOOD GROUP, SS; SS

Low match COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5; HNPCC5


Hereditary nonpolyposis colorectal cancer type 5 is a cancer predisposition syndrome characterized by onset of colorectal cancer and/or extracolonic cancers, particularly endometrial cancer, usually in mid-adulthood. The disorder shows autosomal dominant inheritance with incomplete penetrance (summary by Castellsague et al., 2015).For a phenotypic description and a discussion of genetic heterogeneity of hereditary nonpolyposis colorectal cancer (HNPCC), see HNPCC1 (OMIM ).

Related symptoms:

  • Neoplasm
  • Carcinoma
  • Lymphoma
  • Breast carcinoma
  • Colon cancer


SOURCES: MESH OMIM MENDELIAN

More info about COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5; HNPCC5

Low match LYNCH SYNDROME I


Hereditary nonpolyposis colorectal cancer (HNPCC) is subdivided into (1) Lynch syndrome I, or site-specific colonic cancer, and (2) Lynch syndrome II, or extracolonic cancer, particularly carcinoma of the stomach, endometrium (see {608089}), biliary and pancreatic system, and urinary tract (Lynch and Lynch, 1979; Lynch et al., 1985; Mecklin and Jarvinen, 1991). HNPCC disorders show a proclivity to early onset, predominant proximal location of colon cancer, a dominant pattern of inheritance, an excess of multiple primary cancers, and significantly improved survival when compared stage for stage with the American College of Surgeons Audit Series.Lynch et al. (1991) estimated that hereditary nonpolyposis colorectal cancer accounts for about 4 to 6% of colorectal cancer. The minimum criterion of HNPCC is that colorectal carcinoma is diagnosed and histologically verified in at least 3 relatives belonging to 2 or more successive generations. Moreover, the age of onset should be less than 50 years in at least 1 patient.The Muir-Torre syndrome (MRTES ) is a form of Lynch syndrome II associated with sebaceous skin tumors. Genetic Heterogeneity of HNPCCHNPCC is a genetically heterogeneous disease. See also HNPCC2 (OMIM ), caused by mutation in the MLH1 gene (OMIM ); HNPCC4 (OMIM ), caused by mutation in the PMS2 gene (OMIM ); HNPCC5 (OMIM ), caused by mutation in the MSH6 gene (OMIM ); HNPCC6 (OMIM ), caused by mutation in the TGFBR2 gene (OMIM ); HNPCC7 (OMIM ), caused by mutation in the MLH3 gene (OMIM ). HNPCC8 (OMIM ) results from epigenetic silencing of MSH2 caused by deletion of 3-prime exons of the EPCAM gene (OMIM ) and intergenic regions directly upstream of the MSH2 gene.Since defects in the MSH2 gene may account for as many as 60% of HNPCC cases, and defects in the MLH1 gene may play a role in up to 30%, defects in these 2 genes likely account for the vast majority of HNPCC cases.

LYNCH SYNDROME I Is also known as colorectal cancer, hereditary nonpolyposis, type 1|fcc1|hnpcc1|coca1|colon cancer, familial nonpolyposis, type 1

Related symptoms:

  • Neoplasm
  • Carcinoma
  • Leukemia
  • Neoplasm of the skin
  • Breast carcinoma


SOURCES: OMIM MENDELIAN

More info about LYNCH SYNDROME I

Low match FTH1-RELATED IRON OVERLOAD


FTH1-RELATED IRON OVERLOAD Is also known as fth1-associated iron overload|iron overload, autosomal dominant

Related symptoms:

  • Neoplasm
  • Increased serum ferritin
  • Stomach cancer


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about FTH1-RELATED IRON OVERLOAD

Low match LI-FRAUMENI SYNDROME 2; LFS2


Related symptoms:

  • Neoplasm
  • Breast carcinoma
  • Sarcoma
  • Meningioma
  • Stomach cancer


SOURCES: MESH OMIM MENDELIAN

More info about LI-FRAUMENI SYNDROME 2; LFS2

Top 5 symptoms//phenotypes associated to Anemia and Stomach cancer

Symptoms // Phenotype % cases
Neoplasm Very Common - Between 80% and 100% cases
Breast carcinoma Uncommon - Between 30% and 50% cases
Colon cancer Uncommon - Between 30% and 50% cases
Carcinoma Uncommon - Between 30% and 50% cases
Abdominal pain Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Anemia and Stomach cancer. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Ovarian neoplasm Gastrointestinal hemorrhage Ovarian carcinoma Sarcoma Fatigue Vomiting Pain

Rare Symptoms - Less than 30% cases


Intestinal obstruction Esophageal neoplasm Weight loss Failure to thrive Diarrhea Hamartomatous polyposis Macrocephaly Intestinal polyposis Coarse facial features Hyperpigmentation of the skin Seizures Clubbing of fingers Hypokalemia Hematochezia Neoplasm of the colon Gastrointestinal carcinoma Rectal prolapse Adenocarcinoma of the colon Endometrial carcinoma Neoplasm of the pancreas Clubbing Hypoalbuminemia Neoplasm of the small intestine Neoplasm of the rectum Low anterior hairline Proximal placement of thumb Bone marrow hypocellularity Long eyelashes Hepatic vascular malformations Intellectual disability Narrow palate Hypopigmentation of the skin Dental malocclusion Microcephaly Hip dislocation Anteverted nares Growth delay Hypertelorism Abnormal facial shape Delayed speech and language development Epicanthus Short stature Intrauterine growth retardation Microphthalmia Prominent nasal bridge Clinodactyly Upslanted palpebral fissure Chromosome breakage Conductive hearing impairment Hearing impairment Sparse hair Blepharophimosis Global developmental delay Pallor Thick upper lip vermilion Hereditary nonpolyposis colorectal carcinoma Mastocytosis Neoplasm of the stomach Gastrointestinal obstruction Neoplasm of the gastrointestinal tract Giant hypertrophic gastritis Lymphoma Hodgkin lymphoma Leukemia Leiomyosarcoma Neoplasm of the skin Prostate cancer Gastritis Bladder neoplasm Chronic atrophic gastritis Increased serum ferritin Meningioma Soft tissue sarcoma Gastrointestinal stroma tumor Macrodontia Nausea and vomiting Duodenal stenosis Fever Dysphagia Constipation Multiple gastric polyps Abnormality of the liver Skin rash Abdominal distention Schwannoma Eosinophilia Urticaria Large hands Hypermelanotic macule Neurofibromas Irregular hyperpigmentation Lipoma Paraganglioma Duodenal adenocarcinoma Vertigo Intussusception Malabsorption Cataract Hepatomegaly Edema Splenomegaly Alopecia Autoimmunity Nail dystrophy Paresthesia Neoplasm of the nose Abnormality of skin pigmentation Tapered finger Nail dysplasia Anorexia Lymphedema Hypocalcemia Abnormality of the fingernails Muscle weakness Cervix cancer Cachexia Nasal polyposis Abnormality of the ureter Renal cell carcinoma Neoplasm of the lung Multiple renal cysts Abnormality of the respiratory system Abnormality of the gastrointestinal tract Abnormality of the nose Enlarged polycystic ovaries Abnormal pigmentation of the oral mucosa Multiple lentigines Gastrointestinal infarctions Arteriovenous fistula Pancreatic adenocarcinoma Abnormality of the gallbladder Biliary tract neoplasm Melanonychia Abnormal intestine morphology Hypoplastic toenails Melena Cyanosis Dyspnea Umbilical hernia Jaundice Stroke Cough Macule Chest pain Epistaxis Headache Telangiectasia Diplopia Portal hypertension Hamartoma Polycythemia Hemoptysis Hematemesis Hernia Congestive heart failure Aplasia/Hypoplasia of the eyebrow Furrowed tongue Sparse body hair Generalized hyperpigmentation Thromboembolism Xerostomia Abnormality of the vasculature Hypomagnesemia Dystrophic toenail Dystrophic fingernails Respiratory distress Protein-losing enteropathy Peripheral edema Patchy alopecia Glossitis Decreased taste sensation Cryptorchidism Hypertension Glioma



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