Abnormality of the skeletal system, and Depressivity

Diseases related with Abnormality of the skeletal system and Depressivity

In the following list you will find some of the most common rare diseases related to Abnormality of the skeletal system and Depressivity that can help you solving undiagnosed cases.


Top matches:

Low match ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7


ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7 Is also known as adhd7

Related symptoms:

  • Depressivity


SOURCES: OMIM MENDELIAN

More info about ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7

Low match ANXIETY


Human personality is shaped by genetic and environmental factors, and evidence suggests that the genetic component is highly complex, polygenic, and epistatic. Genetic factors are thought to contribute to 40 to 60% of trait variance. Molecular genetics has tried to identify specific genes for quantitative traits, called quantitative trait loci (QTLs). The QTL concept suggests that complex personality traits or dimensions are not attributable to single genes, but to multiple interacting genes (Reif and Lesch, 2003).Fullerton et al. (2003) stated that psychologists were in agreement that the wide variation in human personalities can be explained by a small number of personality factors, including neuroticism (a measure of emotional stability), which manifests at one extreme as anxiety, depression, moodiness, low self-esteem, and diffidence. They cited a number of studies that had described a relationship between high scores on measures of neuroticism and major depressive disorder. They also noted that theoretical studies had suggested that large samples of randomly ascertained sibs could be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic linkage in complex traits.See also panic disorder (PAND1 ), which is a subtype of anxiety disorder.

Related symptoms:

  • Depressivity
  • Anxiety
  • Shyness


SOURCES: OMIM MENDELIAN

More info about ANXIETY

Low match ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 3; FASPS3


Advanced sleep phase syndrome is characterized by early sleep time (sleep onset) and early morning awakening (sleep offset) (summary by Zhang et al., 2016).For a discussion of genetic heterogeneity of advanced sleep phase syndrome, see FASPS1 (OMIM ).

Related symptoms:

  • Depressivity
  • Early chronotype


SOURCES: OMIM MENDELIAN

More info about ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 3; FASPS3

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Other less relevant matches:

Low match FAMILIAL ADVANCED SLEEP-PHASE SYNDROME


Familial advanced sleep-phase syndrome (FASPS) is a very rare circadian rhythm sleep disorder characterized by very early sleep onset and offset possibly resulting in emotional and physical disruptions.

FAMILIAL ADVANCED SLEEP-PHASE SYNDROME Is also known as fasps

Related symptoms:

  • Depressivity
  • Sleep-wake cycle disturbance
  • Early chronotype


SOURCES: ORPHANET OMIM MENDELIAN

More info about FAMILIAL ADVANCED SLEEP-PHASE SYNDROME

Low match OBSESSIVE-COMPULSIVE DISORDER; OCD


Obsessive-compulsive disorder (OCD) is characterized by recurring obsessions and/or compulsions and has been estimated to affect nearly 5 million people in the United States (Karno et al., 1988). Evidence for a strong genetic component in OCD comes from twin studies, family genetics studies, and segregation analyses, as reviewed by Alsobrook et al. (2002).Zhang et al. (2002) suggested that hoarding is likely to be an evolutionarily conserved trait that, in times of adversity, was associated with increased survival and reproductive fitness. However, extreme forms of this trait are associated with marked disability and poor response to treatment (Black et al., 1998; Mataix-Cols et al., 1999).

Related symptoms:

  • Depressivity
  • Anxiety
  • Obsessive-compulsive behavior
  • Tics
  • Collectionism


SOURCES: MESH OMIM MENDELIAN

More info about OBSESSIVE-COMPULSIVE DISORDER; OCD

Low match DRUG METABOLISM, POOR, CYP2D6-RELATED


Related symptoms:

  • Neoplasm
  • Hypertension
  • Abnormality of metabolism/homeostasis
  • Depressivity
  • Hypotension


SOURCES: MESH OMIM MENDELIAN

More info about DRUG METABOLISM, POOR, CYP2D6-RELATED

Low match ATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD


A behavior disorder in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity.

ATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD Is also known as hyperactivity of childhood

Related symptoms:

  • Depressivity
  • Hyperactivity
  • Autism
  • Anxiety
  • Attention deficit hyperactivity disorder


SOURCES: OMIM MENDELIAN

More info about ATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD

Low match TRICHOTILLOMANIA; TTM


Trichotillomania (TTM) is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. The activity causes distress to the individual and often interferes with functioning. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Tourette syndrome (GTS ) or obsessive-compulsive disorder (OCD ) (review by Novak et al., 2009).

Related symptoms:

  • Depressivity
  • Alopecia
  • Obsessive-compulsive behavior
  • Alopecia of scalp
  • Hair-pulling


SOURCES: MESH OMIM MENDELIAN

More info about TRICHOTILLOMANIA; TTM

Low match EPILEPSY, NOCTURNAL FRONTAL LOBE, 5; ENFL5


Nocturnal frontal lobe epilepsy-5 is an autosomal dominant focal epilepsy syndrome characterized by childhood onset of clusters of motor seizures during sleep. Some patients may develop behavioral or psychiatric manifestations and/or intellectual disability. The phenotype is more severe than observed in other genetic forms of ENFL (summary by Heron et al., 2012).For a general description and a discussion of genetic heterogeneity of ENFL, see ENFL1 (OMIM ).

Related symptoms:

  • Intellectual disability
  • Seizures
  • Cognitive impairment
  • Behavioral abnormality
  • Depressivity


SOURCES: OMIM MENDELIAN

More info about EPILEPSY, NOCTURNAL FRONTAL LOBE, 5; ENFL5

Low match PARKINSON DISEASE 22, AUTOSOMAL DOMINANT; PARK22


Related symptoms:

  • Hyperreflexia
  • Tremor
  • Gait disturbance
  • Depressivity
  • Rigidity


SOURCES: OMIM MENDELIAN

More info about PARKINSON DISEASE 22, AUTOSOMAL DOMINANT; PARK22

Top 5 symptoms//phenotypes associated to Abnormality of the skeletal system and Depressivity

Symptoms // Phenotype % cases
Anxiety Uncommon - Between 30% and 50% cases
Obsessive-compulsive behavior Rare - less than 30% cases
Early chronotype Rare - less than 30% cases
Resting tremor Rare - less than 30% cases
Focal-onset seizure Rare - less than 30% cases
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Other less frequent symptoms

Patients with Abnormality of the skeletal system and Depressivity. may also develop some of the following symptoms:

Rare Symptoms - Less than 30% cases


Seizures Cognitive impairment Behavioral abnormality Aggressive behavior Developmental regression Generalized tonic-clonic seizures Status epilepticus Psychosis Intellectual disability Hyperreflexia Tremor Gait disturbance Rigidity Bradykinesia Personality disorder Alopecia Hair-pulling Abnormality of metabolism/homeostasis Shyness Sleep-wake cycle disturbance Tics Collectionism Skin-picking Neoplasm Hypertension Hypotension Alopecia of scalp Schizophrenia Hyperactivity Autism Attention deficit hyperactivity disorder Falls Impulsivity Dyslexia Kinetic tremor



If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Frontal bossing and Short metacarpal, related diseases and genetic alterations

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