Osteoarthritis Susceptibility 1; Os1
Description
Osteoarthritis (OA) is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis (Meulenbelt et al., 2006). Clinical problems include pain and joint stiffness often leading to significant disability and joint replacement. Osteoarthritis exhibits a clear predilection for specific joints; it appears most commonly in the hip and knee joints and lumbar and cervical spine, as well as in the distal interphalangeal and the first carpometacarpal (base of thumb) and proximal interphalangeal joints of the hand; however, patients with osteoarthritis may have 1, a few, or all of these sites affected (Stefansson et al., 2003). According to a conservative estimate, greater than 70% of the population of the United States at age 65 years is affected by the disease, reflecting its age dependence.
Clinical Features
Phenotypes and symptoms related to Osteoarthritis Susceptibility 1; Os1
- Pain
- Joint stiffness
- Osteoarthritis
- Abnormality of pelvic girdle bone morphology
- Hip osteoarthritis
Incidence and onset information
— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)— No data available about the known clinical features onset.
Alternative names
Osteoarthritis Susceptibility 1; Os1 Is also known as oa, osteoarthrosis, osteoarthritis of hip, female-specific, susceptibility to.
Researches and researchers
Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.Osteoarthritis Susceptibility 1; Os1 Recommended genes panels
Panel Name, Specifity and genes Tested/covered |
---|
FRZB.
By Fulgent Genetics Fulgent Genetics (United States).
FRZB
Specificity
100 %
Genes
100 % |
You can get up to -7 more panels with our dedicated tool
Learn moreSources and references
You can check the following sources for additional information.
OMIM Rare Disease Search EngineIf you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like LERI-WEILL DYSCHONDROSTEOSIS; LWD MYOCLONIC-ASTASTIC EPILEPSY MORNING GLORY SYNDROME ARGININEMIA IRON-REFRACTORY IRON DEFICIENCY ANEMIA; IRIDA KOOLEN-DE VRIES SYNDROME; KDVS BRUCK SYNDROME 2; BRKS2