Immunoglobulin A Deficiency 1; Igad1
Description
Immunoglobulin (Ig) A deficiency (IGAD) is characterized by decreased or absent levels of serum IgA in the presence of normal serum levels of IgG and IgM in a patient older than 4 years of age in whom other causes of hypogammaglobulinemia have been excluded. IgA in the dimeric form is the dominant immunoglobulin in luminal secretions, such as saliva, tears, bronchial secretions, nasal mucosal secretions, and mucous secretions of the small intestine. Individuals with selective IgA deficiency may be asymptomatic or have recurrent sinopulmonary and gastrointestinal infections, allergic disorders, and autoimmune disorders. The diagnosis of IgA deficiency depends on the measurement of monomeric IgA concentrations in serum; thus individuals with IgA deficiency may have IgA in mucosal systems, which may offer some protection (review by Yel, 2010).
Clinical Features
Phenotypes and symptoms related to Immunoglobulin A Deficiency 1; Igad1
- Diarrhea
- Immunodeficiency
- Recurrent infections
- Recurrent respiratory infections
- Autoimmunity
- Malabsorption
- Decreased antibody level in blood
- IgA deficiency
- Recurrent infection of the gastrointestinal tract
Incidence and onset information
— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)— No data available about the known clinical features onset.
Alternative names
Immunoglobulin A Deficiency 1; Igad1 Is also known as immunoglobulin a, selective deficiency of, iga, selective deficiency of, gamma-a-globulin, selective deficiency of.
Researches and researchers
Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.Sources and references
You can check the following sources for additional information.
MESH OMIM ORPHANET Genetic Syndrome FinderIf you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like WEILL-MARCHESANI SYNDROME 1; WMS1 VON HIPPEL-LINDAU SYNDROME; VHL PIERPONT SYNDROME; PRPTS NEMALINE MYOPATHY 10; NEM10 ATRIAL STANDSTILL 2; ATRST2 ACROMICRIC DYSPLASIA; ACMICD MENTAL RETARDATION, X-LINKED 98; MRX98