TLR2 gene related symptoms and diseases
All the information presented here about the TLR2 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,OMIM, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to TLR2 gene
Symptoms // Phenotype | % Cases |
---|---|
Pain | Uncommon - Between 30% and 50% cases |
Colitis | Uncommon - Between 30% and 50% cases |
Uterine leiomyosarcoma | Uncommon - Between 30% and 50% cases |
Neoplasm of the stomach | Uncommon - Between 30% and 50% cases |
Hereditary nonpolyposis colorectal carcinoma | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with TLR2 gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Transitional cell carcinoma of the bladder
- Colorectal polyposis
- Endometrial carcinoma
- Leiomyosarcoma
- Retinoblastoma
- Ulcerative colitis
- Renal cell carcinoma
- Colon cancer
And 12 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to TLR2 gene
Here you will find a list of rare diseases related to the TLR2. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
Description
Mycobacterium tuberculosis latently infects approximately one-third of humanity and is comparable only to human immunodeficiency virus (HIV; see {609423}) as a leading infectious cause of mortality worldwide. Obstacles for controlling TB infection include lengthy treatment regimens of 6 to 9 months, drug resistance, lack of a highly efficacious vaccine, and incomplete understanding of the factors that control infectivity and disease progression. Although only 10% of individuals infected with M. tuberculosis develop active disease, the immune responses associated with TB susceptibility or resistance are not known. In addition, it is not known why some individuals have disseminated TB that spreads to the meninges and central nervous system, while most people have localized disease in the lungs. A number of studies suggest that host genetic factors influence susceptibility and resistance to TB (review by Berrington and Hawn, 2007).
Most common symptoms of MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
- Pain
- Fever
- Fatigue
- Immunodeficiency
- Weight loss
More info about MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
COLORECTAL CANCER; CRC
Alternate names
COLORECTAL CANCER; CRC Is also known as colon cancer
Description
Colorectal cancer is a heterogeneous disease that is common in both men and women. In addition to lifestyle and environmental risk factors, gene defects can contribute to an inherited predisposition to CRC. CRC is caused by changes in different molecular pathogenic pathways, such as chromosomal instability, CpG island methylator phenotype, and microsatellite instability. Chromosome instability is the most common alteration and is present in almost 85% of all cases (review by Schweiger et al., 2013).
Most common symptoms of COLORECTAL CANCER; CRC
- Neoplasm
- Carcinoma
- Oligodontia
- Colon cancer
- Colitis
More info about COLORECTAL CANCER; CRC
SOURCES: OMIM
LEPROSY, SUSCEPTIBILITY TO, 3; LPRS3
Most common symptoms of LEPROSY, SUSCEPTIBILITY TO, 3; LPRS3
- Abnormality of the immune system
More info about LEPROSY, SUSCEPTIBILITY TO, 3; LPRS3
SOURCES: OMIM
Search interest in TLR2
Potential gene panels for TLR2 gene
TLR2 Panel
By Fulgent Genetics Fulgent Genetics
This panel specifically test the TLR2 gene.
More info about this panelFocus::MCL™ NGS Panel Panel
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::MCL™ NGS Panel that also includes the following genes: SALL3 SI SMARCA4 BTK TLR2 TP53 TRAF2 NSD2 XPO1 KMT2C
More info about this panelTempus xO assay Panel
By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2
More info about this panelIf you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like NARS2 HADHA COASY TDO2 MTHFS NPHS2 STIM1