PGR gene related symptoms and diseases

All the information presented here about the PGR gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,OMIM, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to PGR gene

Symptoms // Phenotype % Cases
Abnormality of metabolism/homeostasis Very Common - Between 80% and 100% cases
Infertility Very Common - Between 80% and 100% cases
Female infertility Very Common - Between 80% and 100% cases

Rare diseases associated to PGR gene

Here you will find a list of rare diseases related to the PGR. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


PROGESTERONE RESISTANCE


Alternate names

PROGESTERONE RESISTANCE Is also known as pseudocorpus luteum insufficiency

Description

Progesterone prepares the endometrium for blastocyst implantation and allows maintenance of pregnancy. The major sources of progesterone are the corpus luteum during the second half of the menstrual cycle and at the beginning of pregnancy, and the placenta. The main hormones responsible for stimulation of progesterone secretion are luteinizing hormone (LH) for the corpus luteum of the menstrual cycle and chorionic gonadotropin for the corpus luteum of pregnancy. Complete end-organ resistance to progesterone would be incompatible with reproductive competence in females. Males would not be expected to be affected since progesterone has no known function in men. Failure of the uterus to respond to progesterone would lead to the development of a 'constantly proliferative' endometrium incompatible with blastocyst implantation. Partial resistance to progesterone, on the other hand, would be expected to be associated with various degrees of incomplete maturation of the endometrium, perhaps expressed clinically as infertility or early abortions. The syndrome would present with the clinical and histologic picture of a luteal phase defect in which the life span of the corpus luteum and the plasma progesterone concentrations would be normal or elevated.

Most common symptoms of PROGESTERONE RESISTANCE

  • Abnormality of metabolism/homeostasis
  • Infertility
  • Female infertility


More info about PROGESTERONE RESISTANCE

SOURCES: MESH OMIM


Potential gene panels for PGR gene

PGR Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the PGR gene.

More info about this panel

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel


If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like PHF21A RAD51B

Need help with a diagnosis?

Learn more about how to achieve it with Mendelian


Learn more