PGR gene related symptoms and diseases
All the information presented here about the PGR gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,OMIM, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to PGR gene
|Symptoms // Phenotype||% Cases|
|Abnormality of metabolism/homeostasis||Very Common - Between 80% and 100% cases|
|Infertility||Very Common - Between 80% and 100% cases|
|Female infertility||Very Common - Between 80% and 100% cases|
Rare diseases associated to PGR gene
Here you will find a list of rare diseases related to the PGR. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
PROGESTERONE RESISTANCE Is also known as pseudocorpus luteum insufficiency
Progesterone prepares the endometrium for blastocyst implantation and allows maintenance of pregnancy. The major sources of progesterone are the corpus luteum during the second half of the menstrual cycle and at the beginning of pregnancy, and the placenta. The main hormones responsible for stimulation of progesterone secretion are luteinizing hormone (LH) for the corpus luteum of the menstrual cycle and chorionic gonadotropin for the corpus luteum of pregnancy. Complete end-organ resistance to progesterone would be incompatible with reproductive competence in females. Males would not be expected to be affected since progesterone has no known function in men. Failure of the uterus to respond to progesterone would lead to the development of a 'constantly proliferative' endometrium incompatible with blastocyst implantation. Partial resistance to progesterone, on the other hand, would be expected to be associated with various degrees of incomplete maturation of the endometrium, perhaps expressed clinically as infertility or early abortions. The syndrome would present with the clinical and histologic picture of a luteal phase defect in which the life span of the corpus luteum and the plasma progesterone concentrations would be normal or elevated.
Most common symptoms of PROGESTERONE RESISTANCE
- Abnormality of metabolism/homeostasis
- Female infertility
More info about PROGESTERONE RESISTANCE
Search interest in PGR
Potential gene panels for PGR gene
By Fulgent Genetics Fulgent Genetics
This panel specifically test the PGR gene.More info about this panel
Tempus xO assay Panel
By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2More info about this panel