MN1 gene related symptoms and diseases

All the information presented here about the MN1 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,OMIM,ORPHANET, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to MN1 gene

Symptoms // Phenotype % Cases
Neoplasm Uncommon - Between 30% and 50% cases
Meningioma Uncommon - Between 30% and 50% cases
Medulloblastoma Uncommon - Between 30% and 50% cases
Neoplasm of the central nervous system Uncommon - Between 30% and 50% cases

Rare diseases associated to MN1 gene

Here you will find a list of rare diseases related to the MN1. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


MENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO


Description

Meningiomas are, in general, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man. The vast majority of meningiomas are sporadic; familial occurrence of meningioma is rare (Zang, 2001).Familial or multiple meningiomas may also be seen in tumor predisposition syndromes. Some patients with schwannomatosis (OMIM ), caused by mutation in the SMARCB1 gene, may develop meningiomas. One patient with malignant gliomas (GLM2 ) associated with a mutation in the PTEN gene (OMIM ) developed a meningioma (Staal et al., 2002).

Most common symptoms of MENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO

  • Neoplasm
  • Meningioma
  • Medulloblastoma
  • Neoplasm of the central nervous system


More info about MENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO

SOURCES: OMIM MESH

FAMILIAL MULTIPLE MENINGIOMA


Description

Familial multiple meningioma is a rare, benign neoplasm of the central nervous system characterized by the development of multiple or, rarely, solitary meningiomas in two or more blood relatives, without other apparent syndromic manifestations. Depending on the localization, growth rate and size of the tumors, patients can present with subtle, gradually worsening or abrupt and severe neurological compromise or can be completely asymptomatic.


More info about FAMILIAL MULTIPLE MENINGIOMA

SOURCES: ORPHANET


Potential gene panels for MN1 gene

RT-PCR t(12;22) (TEL/MN1) Panel

Portugal.

By CGC Genetics RT-PCR t(12;22) (TEL/MN1) that also includes the following genes: ETV6 MN1

More info about this panel

Meningioma Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the MN1 gene.

More info about this panel

FAMILIAL MULTIPLE MENINGIOMA Panel

Spain.

By Hereditary Cancer Group - Genetic Diagnostic Unit Germans Trias I Pujol Research Institute FAMILIAL MULTIPLE MENINGIOMA that also includes the following genes: SMARCE1 SUFU MN1 NF2 PDGFB PTEN

More info about this panel

Meningioma, Familial multiple: MN1 gene sequence analysis Panel

Spain.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases

This panel specifically test the MN1 gene.

More info about this panel

Solid Tumor Gene Set Panel

United States.

By Genomics and Pathology Services Washington University in St. Louis Solid Tumor Gene Set that also includes the following genes: RIT1 ROS1 RXRA FOXL2 BRAF BRCA1 BRCA2 SMARCA4 SMARCB1 KDM5C

More info about this panel

CNS Tumor Gene Set Panel

United States.

By Genomics and Pathology Services Washington University in St. Louis CNS Tumor Gene Set that also includes the following genes: SHH BRAF SMARCA4 SMARCB1 SMO TERT MED12 TP53 WNT1 WT1

More info about this panel

Caris MI TumorSeek 592-Gene NGS Panel Panel

United States.

By Caris Life Sciences Caris MI TumorSeek 592-Gene NGS Panel that also includes the following genes: BCL6 BCL7A BCL9 BCR ROS1 RPL10 RPL22 RPL5 RPN1 RUNX1

More info about this panel

Familiy Multiple Meningioma , Sequencing MN1 Gene Panel

Spain.

By Reference Laboratory Genetics

This panel specifically test the MN1 gene.

More info about this panel

Familial Meningioma , Panel Massive Sequencing (NGS) 6 Genes Panel

Spain.

By Reference Laboratory Genetics Familial Meningioma , Panel Massive Sequencing (NGS) 6 Genes that also includes the following genes: SMARCE1 SUFU MN1 NF2 PDGFB PTEN

More info about this panel

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel


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