MICA gene related symptoms and diseases

All the information presented here about the MICA gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,NCBIGENE,HGNC, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to MICA gene

Symptoms // Phenotype % Cases
Flexion contracture Very Common - Between 80% and 100% cases
Narrow mouth Very Common - Between 80% and 100% cases
Trismus Very Common - Between 80% and 100% cases
Cheilitis Very Common - Between 80% and 100% cases
Abnormality of the pharynx Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with MICA gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Abnormal oral cavity morphology
  • Oropharyngeal squamous cell carcinoma

Rare diseases associated to MICA gene

Here you will find a list of rare diseases related to the MICA. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


Alternate names

ORAL SUBMUCOUS FIBROSIS Is also known as osmf


Oral submucous fibrosis (OSMF) is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in India and Southeast Asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro-pharynx (leading to trismus and a progressive reduction in mouth opening) and an increased risk of developing oral squamous cell cancer (3-19%). It is usually associated with the chewing of the areca nut (an ingredient in betel quid) but the exact etiology is unknown and there is currently no effective treatment.

Most common symptoms of ORAL SUBMUCOUS FIBROSIS

  • Flexion contracture
  • Narrow mouth
  • Trismus
  • Cheilitis
  • Abnormality of the pharynx



Potential gene panels for MICA gene

MICA Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the MICA gene.

More info about this panel
United States.

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