MAOA gene related symptoms and diseases

All the information presented here about the MAOA gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,ORPHANET,HGNC,NCBIGENE, Mendelian Rare Disease Search Engine.

Table of contents:

Main symptoms and clinical features
Other symptoms and clinical features
Related Diseases
Current trends
Suitable testing panels

Top 5 symptoms and clinical features associated to MAOA gene

Symptoms // Phenotype	% Cases
Intellectual disability	Very Common - Between 80% and 100% cases
Autism	Very Common - Between 80% and 100% cases
EEG abnormality	Uncommon - Between 30% and 50% cases
Vitreomacular adhesion	Uncommon - Between 30% and 50% cases
Violent behavior	Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with MAOA gene alterations may also develop some of the following symptoms and phenotypes:

Not very common - Between 30% and 50% cases
Seizures
Delayed speech and language development
Atrial septal defect
Autistic behavior
Kinetic tremor
Stereotypy
Increased serum serotonin
Impaired use of nonverbal behaviors

And 22 more phenotypes, you can get all of them using our tools for rare diseases.

Rare diseases associated to MAOA gene

Here you will find a list of rare diseases related to the MAOA. You can also use our tool to get a more accurate diagnosis based on your current symptoms.

MONOAMINE OXIDASE A DEFICIENCY

Alternate names

MONOAMINE OXIDASE A DEFICIENCY Is also known as brunner syndrome

Description

Monoamine oxidase-A deficiency is a very rare recessive X-linked biogenic amine metabolism disorder characterized clinically by mild intellectual deficit, impulsive aggressiveness, and sometimes violent behavior and presenting from childhood.

Most common symptoms of MONOAMINE OXIDASE A DEFICIENCY

Intellectual disability
Global developmental delay
Cognitive impairment
Motor delay
Tremor

More info about MONOAMINE OXIDASE A DEFICIENCY

SOURCES: MESH OMIM ORPHANET

AUTISM, SUSCEPTIBILITY TO, X-LINKED 2; AUTSX2

Description

Autism, the prototypic pervasive developmental disorder (PDD), is usually apparent by 3 years of age. It is characterized by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypic, and ritualized patterns of interests and behavior (Bailey et al., 1996; Risch et al., 1999). 'Autism spectrum disorder,' sometimes referred to as ASD, is a broader phenotype encompassing the less severe disorders Asperger syndrome (see ASPG1; {608638}) and pervasive developmental disorder, not otherwise specified (PDD-NOS). 'Broad autism phenotype' includes individuals with some symptoms of autism, but who do not meet the full criteria for autism or other disorders. Mental retardation coexists in approximately two-thirds of individuals with ASD, except for Asperger syndrome, in which mental retardation is conspicuously absent (Jones et al., 2008). Genetic studies in autism often include family members with these less stringent diagnoses (Schellenberg et al., 2006).For a discussion of genetic heterogeneity of autism, see {209850}.

Most common symptoms of AUTISM, SUSCEPTIBILITY TO, X-LINKED 2; AUTSX2

Intellectual disability
Seizures
Delayed speech and language development
Atrial septal defect
Autism

More info about AUTISM, SUSCEPTIBILITY TO, X-LINKED 2; AUTSX2

SOURCES: MESH OMIM

Search interest in MAOA

Potential gene panels for MAOA gene

MitoMet®Plus aCGH Analysis Panel

United States.

By Baylor Miraca Genetics Laboratories MitoMet®Plus aCGH Analysis that also includes the following genes: RGS9 RHO GRK1 RLBP1 RNASEL BCS1L RP1 RP2 RP9 RPE65

MAOA gene related symptoms and diseases

Top 5 symptoms and clinical features associated to MAOA gene

Other less frequent symptoms and clinical features

Not very common - Between 30% and 50% cases

Rare diseases associated to MAOA gene

MONOAMINE OXIDASE A DEFICIENCY

Alternate names

Description

Most common symptoms of MONOAMINE OXIDASE A DEFICIENCY

AUTISM, SUSCEPTIBILITY TO, X-LINKED 2; AUTSX2

Description

Most common symptoms of AUTISM, SUSCEPTIBILITY TO, X-LINKED 2; AUTSX2

Search interest in MAOA

Potential gene panels for MAOA gene

MitoMet®Plus aCGH Analysis Panel

NGS XLID Panel Panel

X-Linked Intellectual Disabilities Deletion/Duplication Panel

X-linked Intellectual Disabilities Sequencing Panel

X-Linked Intellectual Disabilities Sequencing and Deletion/Duplication Panel

Non-Specific Intellectual Disability Panel Panel

X-linked Non-Specific Intellectual Disability Panel Panel

CustomNext: Neuro Panel

MAOA gene sequence and deletion/duplication Panel

Neurodevelopment-Expanded Panel

IDNext Panel

Brunner syndrome (sequence analysis of MAOA gene) Panel

Mental retardation, X-linked (NGS panel for 89 genes) Panel

X-Linked Intellectual Disability Sequencing Panel with CNV Detection Panel

Autism Spectrum Disorders Sequencing Panel with CNV Detection Panel

Brunner Syndrome via MAOA Gene Sequencing with CNV Detection Panel

Mental retardation - different panels Panel

Mental Retardation and Dysmorphology - panels Panel

Syndromal Diseases - panels Panel

X-Linked Mental Retardation Panel

Brain Malformations / Neuronal Migration Disorders Panel

Oxidation Panel Panel

MAOA Sequencing Panel

Comprehensive mitochondrial disorders panel Panel

Brunner syndrome Panel

AllNeuro panel Panel

Nuclear encoded Mitochondriopathies Panel Panel

Invitae Neurotransmitter Disorders Panel Panel

Brunner Syndrome: MAOA Gene Sequencing Panel

Brunner Syndrome: MAOA Gene Deletion/Duplication Panel

X-linked Intellectual Disability: Gene Sequencing and Deletion/Duplication Panel Panel

Nuclear-Mito NGS Panel Panel

XLID NGS Panel Panel

MAOA Panel

X-chromosome High Resolution microarray analysis Panel

X-linked Intellectual Disability Panel Panel

Monoamine oxidase A deficiency Panel

Tempus xO assay Panel