LRRK2 gene related symptoms and diseases
All the information presented here about the LRRK2 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,ORPHANET,OMIM, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to LRRK2 gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Shuffling gait | Common - Between 50% and 80% cases |
| Parkinsonism | Common - Between 50% and 80% cases |
| Akinesia | Common - Between 50% and 80% cases |
| Lewy bodies | Common - Between 50% and 80% cases |
| Bradykinesia | Common - Between 50% and 80% cases |
Other less frequent symptoms and clinical features
Patients with LRRK2 gene alterations may also develop some of the following symptoms and phenotypes:Commonly - More than 50% cases
- Hyposmia
- Resting tremor
- Gliosis
- Postural instability
- Mental deterioration
- Rigidity
- Cerebral cortical atrophy
- Dementia
And 38 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to LRRK2 gene
Here you will find a list of rare diseases related to the LRRK2. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
PARKINSON DISEASE 8, AUTOSOMAL DOMINANT; PARK8
Most common symptoms of PARKINSON DISEASE 8, AUTOSOMAL DOMINANT; PARK8
- Seizures
- Cognitive impairment
- Delayed speech and language development
- Tremor
- Dementia
More info about PARKINSON DISEASE 8, AUTOSOMAL DOMINANT; PARK8
SOURCES: OMIM
YOUNG-ONSET PARKINSON DISEASE
Alternate names
YOUNG-ONSET PARKINSON DISEASE Is also known as yopd, early-onset parkinson disease
Description
Young-onset Parkinson disease (YOPD) is a form of Parkinson disease (PD), characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms.
More info about YOUNG-ONSET PARKINSON DISEASE
SOURCES: ORPHANET
HEREDITARY LATE-ONSET PARKINSON DISEASE
Alternate names
HEREDITARY LATE-ONSET PARKINSON DISEASE Is also known as autosomal dominant late-onset parkinson disease, lopd
Description
Hereditary late-onset Parkinson disease (LOPD) is a form of Parkinson disease (PD), characterized by an age of onset of more than 50 years, tremor at rest, gait complaints and falls, bradykinesia, rigidity and painful cramps. Patients usually present a low risk of developing non motor symptoms, dystonia, dyskinesia and levodopa-induced dyskinesia (LID).
Most common symptoms of HEREDITARY LATE-ONSET PARKINSON DISEASE
- Dysphagia
- Dystonia
- Depressivity
- Dementia
- Cerebral cortical atrophy
More info about HEREDITARY LATE-ONSET PARKINSON DISEASE
SOURCES: ORPHANET
Search interest in LRRK2
Potential gene panels for LRRK2 gene
LRRK2 DNA Sequencing Test Panel
United States.
By Athena Diagnostics Inc
This panel specifically test the LRRK2 gene.
More info about this panel United States.
Complete Parkinsonism Evaluation Panel
United States.
By Athena Diagnostics Inc Complete Parkinsonism Evaluation that also includes the following genes: SNCA PINK1 PARK7 LRRK2 PRKN
More info about this panel United States.
LRRK2 DNA Test Panel
United States.
By Athena Diagnostics Inc
This panel specifically test the LRRK2 gene.
More info about this panel United States.
Movement Disorders Panel Panel
United States.
By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University Movement Disorders Panel that also includes the following genes: SCP2 SGCE SLC20A2 SLC2A1 SLC6A3 SNCA SPR SQSTM1 SUCLA2 SUOX
More info about this panel United States.
Parkinson's Disease Panel
United States.
By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University Parkinson's Disease that also includes the following genes: SLC6A3 SNCA TAF1 TH VPS35 FBXO7 PINK1 PARK7 LRRK2 CSF1R
More info about this panel United States.
LRRK2 Panel
Germany.
By Institute for Human Genetics University Clinic Freiburg
This panel specifically test the LRRK2 gene.
More info about this panel Germany.
Detection of the G2019S mutation in exon 41 of the LRRK2 gene Panel
Cyprus.
By Neurogenetics Department Cyprus Institute of Neurology and Genetics
This panel specifically test the LRRK2 gene.
More info about this panel Cyprus.
LRRK2. Sequencing of the exons 31, 35 and 41 Panel
Spain.
By Instituto de Medicina Genomica Instituto de Medicina Genomica
This panel specifically test the LRRK2 gene.
More info about this panel Spain.
LRRK2. Complete sequencing Panel
Spain.
By Instituto de Medicina Genomica Instituto de Medicina Genomica
This panel specifically test the LRRK2 gene.
More info about this panel Spain.
Parkinson disease (NGS panel for 10 genes) Panel
Portugal.
By CGC Genetics Parkinson disease (NGS panel for 10 genes) that also includes the following genes: SNCA VPS35 FBXO7 PINK1 DNAJC6 PARK7 LRRK2 ATP13A2 PRKN PLA2G6
More info about this panel Portugal.
Parkinson disease (NGS panel for 33 genes) Panel
Portugal.
By CGC Genetics Parkinson disease (NGS panel for 33 genes) that also includes the following genes: SLC6A3 SNCA SNCAIP SNCB SYNJ1 TAF1 TH GIGYF2 UCHL1 VPS35
More info about this panel Portugal.
Parkinson disease 8 (PARK8, sequence analysis of LRRK2 gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the LRRK2 gene.
More info about this panel Portugal.
Parkinson disease type 8 (PARK8, sequence analysis of exon 41 of LRRK2 gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the LRRK2 gene.
More info about this panel Portugal.
Parkinson disease 8 (PARK8, deletion/duplication analysis on LRRK2 gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the LRRK2 gene.
More info about this panel Portugal.
Parkinson disease ( Gly19 ser mutation ) Panel
India.
By Institute of Medical Genetics and Genomics Sir Ganga Ram Hospital
This panel specifically test the LRRK2 gene.
More info about this panel India.
Parkinson Disease via LRRK2 Gene Sequencing with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics
This panel specifically test the LRRK2 gene.
More info about this panel United States.
Parkinson Disease Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Parkinson Disease Sequencing Panel with CNV Detection that also includes the following genes: SLC6A3 SNCA SPR SYNJ1 TAF1 GIGYF2 UCHL1 VPS35 FBXO7 HTRA2
More info about this panel United States.
Parkinson Disease and Parkinsonism Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Parkinson Disease and Parkinsonism Sequencing Panel with CNV Detection that also includes the following genes: SLC20A2 SLC6A3 SNCA SNCB SPG11 SPR SYNJ1 TAF1 TARDBP TWNK
More info about this panel United States.
Neurogenetic Disorders - panels Panel
Germany.
By MGZ Medical Genetics Center Neurogenetic Disorders - panels that also includes the following genes: BCS1L RTN2 RYR1 SACS SCN1A SCN1B SCN2A SCN8A SCO1 SCO2
More info about this panel Germany.
PARK8 Parkinsonism Panel
Germany.
By Centogene AG - the Rare Disease Company
This panel specifically test the LRRK2 gene.
More info about this panel Germany.
AllNeuro panel Panel
Germany.
By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1
More info about this panel Germany.
Parkinsons disease panel Panel
Germany.
By Centogene AG - the Rare Disease Company Parkinsons disease panel that also includes the following genes: SLC6A3 SNCA SNCB SPR SYNJ1 TAF1 TH GIGYF2 UCHL1 VPS35
More info about this panel Germany.
Parkinson Syndrome, autosomal dominant Panel Panel
Germany.
By CeGaT GmbH Parkinson Syndrome, autosomal dominant Panel that also includes the following genes: SNCA VPS35 HTRA2 LRRK2 CHCHD2 DNAJC13 EIF4G1 GBA PRKAR1B RAB29
More info about this panel Germany.
Parkinson all Panel Panel
Germany.
By CeGaT GmbH Parkinson all Panel that also includes the following genes: ATXN2 SLC6A3 SNCA SPG11 SPR SYNJ1 TAF1 TH VPS35 FBXO7
More info about this panel Germany.
Single gene testing LRRK2 Panel
Germany.
By CeGaT GmbH
This panel specifically test the LRRK2 gene.
More info about this panel Germany.
Test for LRRK2-Related Parkinson Disease Panel
United Kingdom.
By All Wales Genetics Laboratory Institute of Medical Genetics
This panel specifically test the LRRK2 gene.
More info about this panel United Kingdom.
Ashkenazi Jewish diseases Panel
Estonia.
By Asper Biogene Asper Biogene LLC Ashkenazi Jewish diseases that also includes the following genes: BLM BRCA1 BRCA2 SMN1 SMPD1 CLRN1 MCOLN1 PCDH15 LRRK2 CFTR
More info about this panel Estonia.
Parkinson Disease Panel
Estonia.
By Asper Biogene Asper Biogene LLC Parkinson Disease that also includes the following genes: SLC6A3 SNCA SPR SYNJ1 TAF1 TH GIGYF2 UCHL1 VPS35 FBXO7
More info about this panel Estonia.
Parkinson disease 8 Panel
Austria.
By Praxis fuer Humangenetik Wien
This panel specifically test the LRRK2 gene.
More info about this panel Austria.
Parkinson disease 8 Panel
Slovakia.
By MedGene
This panel specifically test the LRRK2 gene.
More info about this panel Slovakia.
Invitae Hereditary Parkinson's Disease and Parkinsonism Panel Panel
United States.
By Invitae Invitae Hereditary Parkinson's Disease and Parkinsonism Panel that also includes the following genes: SLC6A3 SNCA SPR TH VPS35 FBXO7 PINK1 DNAJC6 PARK7 LRRK2
More info about this panel United States.
Parkinson disease: LRRK2 gene (exons 31, 41) and PINK1 gene (exon 4) screening Panel
Spain.
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases Parkinson disease: LRRK2 gene (exons 31, 41) and PINK1 gene (exon 4) screening that also includes the following genes: PINK1 LRRK2
More info about this panel Spain.
Parkinson disease 8: LRRK2 (PARK8) gene screening Panel
Spain.
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases
This panel specifically test the LRRK2 gene.
More info about this panel Spain.
Parkinson disease (Park-8): LRRK2 gene sequence analysis Panel
Spain.
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases
This panel specifically test the LRRK2 gene.
More info about this panel Spain.
PARKINSON DISEASE Panel
Spain.
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases PARKINSON DISEASE that also includes the following genes: SNCA TAF1 VPS35 FBXO7 PINK1 PARK7 LRRK2 ATP13A2 PRKN PLA2G6
More info about this panel Spain.
NGS panel - Parkinson Panel
Netherlands.
By Genome Diagnostics VU University Medical Center NGS panel - Parkinson that also includes the following genes: ATXN2 SLC18A2 SLC6A3 SNCA SPR SYNJ1 TAF1 TH GIGYF2 UCHL1
More info about this panel Netherlands.
LRRK2(PARK8) - Gene Sequencing & Del/Dup analysis Panel
Netherlands.
By Genome Diagnostics VU University Medical Center
This panel specifically test the LRRK2 gene.
More info about this panel Netherlands.
Parkinson-Alzheimer-Dementia NGS Panel Panel
United States.
By Fulgent Genetics Fulgent Genetics Parkinson-Alzheimer-Dementia NGS Panel that also includes the following genes: SLC6A3 SNCA SNCB TAF1 TH TYROBP UCHL1 VPS35 FBXO7 AAAS
More info about this panel United States.
Nuclear-Mito NGS Panel Panel
United States.
By Fulgent Genetics Fulgent Genetics Nuclear-Mito NGS Panel that also includes the following genes: RNASEL BCS1L RPL35A MRPL3 RYR1 RYR2 SACS ACSM3 SARDH ATXN7
More info about this panel United States.
LRRK2 Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the LRRK2 gene.
More info about this panel United States.
Parkinson Disease Panel Panel
Finland.
By Blueprint Genetics Parkinson Disease Panel that also includes the following genes: SLC20A2 SLC6A3 SNCA SPR SYNJ1 TH VPS35 FBXO7 PINK1 DNAJC6
More info about this panel Finland.
Parkinson disease type 8 Panel
Spain.
By Bioarray
This panel specifically test the LRRK2 gene.
More info about this panel Spain.
Parkinson Disease (LRRK2 gene) Panel
Belgium.
By Diagnostic Service Facility University of Antwerp
This panel specifically test the LRRK2 gene.
More info about this panel Belgium.
FoundationOne® Heme Panel
United States.
By Foundation Medicine, Inc. FoundationOne® Heme that also includes the following genes: BCL6 BCL7A ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1
More info about this panel United States.
PARKINSON NGS PANEL Panel
Spain.
By Laboratorio de Genetica Clinica SL PARKINSON NGS PANEL that also includes the following genes: SLC6A3 SMPD1 SNCA SYNJ1 UCHL1 VPS35 FBXO7 HTRA2 PINK1 DNAJC6
More info about this panel Spain.
Parkinson Disease Type 8, Sequencing LRRK2 (PARK8) Gene Panel
Spain.
By Reference Laboratory Genetics
This panel specifically test the LRRK2 gene.
More info about this panel Spain.
Parkinson Disease Type 8, Screening Frequent Mutations LRRK2 (PARK8) Gene Panel
Spain.
By Reference Laboratory Genetics
This panel specifically test the LRRK2 gene.
More info about this panel Spain.
Parkinson Disease , Deletions-Duplications (MLPA) SNCA, PARK2, PINK1, PARK7, LRRK2, UCHL1 Genes Panel
Spain.
By Reference Laboratory Genetics Parkinson Disease , Deletions-Duplications (MLPA) SNCA, PARK2, PINK1, PARK7, LRRK2, UCHL1 Genes that also includes the following genes: SNCA UCHL1 PINK1 PARK7 LRRK2 PRKN
More info about this panel Spain.
Parkinson Disease , Panel Massive Sequencing (NGS) 11 Genes Panel
Spain.
By Reference Laboratory Genetics Parkinson Disease , Panel Massive Sequencing (NGS) 11 Genes that also includes the following genes: SLC6A3 SNCA TAF1 VPS35 FBXO7 PINK1 PARK7 LRRK2 ATP13A2 PRKN
More info about this panel Spain.
Tempus xO assay Panel
United States.
By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2
More info about this panel United States.
CEN4GEN Gastric cancer: Extended gene sequencing Panel Panel
Canada.
By CEN4GEN Institute for Genomics and Molecular Diagnostics CEN4GEN Gastric cancer: Extended gene sequencing Panel that also includes the following genes: BRCA2 SSTR1 STK11 TP53 TRIO TRRAP WNK2 CCNE1 FBXW7 SPEG
More info about this panel Canada.
Parkinson Disease: gene sequencing panel Panel
Canada.
By CEN4GEN Institute for Genomics and Molecular Diagnostics Parkinson Disease: gene sequencing panel that also includes the following genes: SLC6A3 SNCA TAF1 VPS35 FBXO7 PINK1 PARK7 LRRK2 ATP13A2 PRKN
More info about this panel Canada.
LRRK2-Related Parkinson Disease: gene sequencing Panel
Canada.
By CEN4GEN Institute for Genomics and Molecular Diagnostics
This panel specifically test the LRRK2 gene.
More info about this panel Canada.
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