LRRK2 gene related symptoms and diseases

All the information presented here about the LRRK2 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,ORPHANET,OMIM, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to LRRK2 gene

Symptoms // Phenotype % Cases
Shuffling gait Common - Between 50% and 80% cases
Parkinsonism Common - Between 50% and 80% cases
Akinesia Common - Between 50% and 80% cases
Lewy bodies Common - Between 50% and 80% cases
Bradykinesia Common - Between 50% and 80% cases

Other less frequent symptoms and clinical features

Patients with LRRK2 gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Hyposmia
  • Resting tremor
  • Gliosis
  • Postural instability
  • Mental deterioration
  • Rigidity
  • Cerebral cortical atrophy
  • Dementia

And 38 more phenotypes, you can get all of them using our tools for rare diseases.

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Rare diseases associated to LRRK2 gene

Here you will find a list of rare diseases related to the LRRK2. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


PARKINSON DISEASE 8, AUTOSOMAL DOMINANT; PARK8


Most common symptoms of PARKINSON DISEASE 8, AUTOSOMAL DOMINANT; PARK8

  • Seizures
  • Cognitive impairment
  • Delayed speech and language development
  • Tremor
  • Dementia


More info about PARKINSON DISEASE 8, AUTOSOMAL DOMINANT; PARK8

SOURCES: OMIM

YOUNG-ONSET PARKINSON DISEASE


Alternate names

YOUNG-ONSET PARKINSON DISEASE Is also known as yopd, early-onset parkinson disease

Description

Young-onset Parkinson disease (YOPD) is a form of Parkinson disease (PD), characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms.


More info about YOUNG-ONSET PARKINSON DISEASE

SOURCES: ORPHANET

HEREDITARY LATE-ONSET PARKINSON DISEASE


Alternate names

HEREDITARY LATE-ONSET PARKINSON DISEASE Is also known as autosomal dominant late-onset parkinson disease, lopd

Description

Hereditary late-onset Parkinson disease (LOPD) is a form of Parkinson disease (PD), characterized by an age of onset of more than 50 years, tremor at rest, gait complaints and falls, bradykinesia, rigidity and painful cramps. Patients usually present a low risk of developing non motor symptoms, dystonia, dyskinesia and levodopa-induced dyskinesia (LID).

Most common symptoms of HEREDITARY LATE-ONSET PARKINSON DISEASE

  • Dysphagia
  • Dystonia
  • Depressivity
  • Dementia
  • Cerebral cortical atrophy


More info about HEREDITARY LATE-ONSET PARKINSON DISEASE

SOURCES: ORPHANET


Potential gene panels for LRRK2 gene

LRRK2 DNA Sequencing Test Panel

United States.

By Athena Diagnostics Inc

This panel specifically test the LRRK2 gene.

More info about this panel

Complete Parkinsonism Evaluation Panel

United States.

By Athena Diagnostics Inc Complete Parkinsonism Evaluation that also includes the following genes: SNCA PINK1 PARK7 LRRK2 PRKN

More info about this panel

LRRK2 DNA Test Panel

United States.

By Athena Diagnostics Inc

This panel specifically test the LRRK2 gene.

More info about this panel

Movement Disorders Panel Panel

United States.

By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University Movement Disorders Panel that also includes the following genes: SCP2 SGCE SLC20A2 SLC2A1 SLC6A3 SNCA SPR SQSTM1 SUCLA2 SUOX

More info about this panel

Parkinson's Disease Panel

United States.

By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University Parkinson's Disease that also includes the following genes: SLC6A3 SNCA TAF1 TH VPS35 FBXO7 PINK1 PARK7 LRRK2 CSF1R

More info about this panel

LRRK2 Panel

Germany.

By Institute for Human Genetics University Clinic Freiburg

This panel specifically test the LRRK2 gene.

More info about this panel

Detection of the G2019S mutation in exon 41 of the LRRK2 gene Panel

Cyprus.

By Neurogenetics Department Cyprus Institute of Neurology and Genetics

This panel specifically test the LRRK2 gene.

More info about this panel

LRRK2. Sequencing of the exons 31, 35 and 41 Panel

Spain.

By Instituto de Medicina Genomica Instituto de Medicina Genomica

This panel specifically test the LRRK2 gene.

More info about this panel

LRRK2. Complete sequencing Panel

Spain.

By Instituto de Medicina Genomica Instituto de Medicina Genomica

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson disease (NGS panel for 10 genes) Panel

Portugal.

By CGC Genetics Parkinson disease (NGS panel for 10 genes) that also includes the following genes: SNCA VPS35 FBXO7 PINK1 DNAJC6 PARK7 LRRK2 ATP13A2 PRKN PLA2G6

More info about this panel

Parkinson disease (NGS panel for 33 genes) Panel

Portugal.

By CGC Genetics Parkinson disease (NGS panel for 33 genes) that also includes the following genes: SLC6A3 SNCA SNCAIP SNCB SYNJ1 TAF1 TH GIGYF2 UCHL1 VPS35

More info about this panel

Parkinson disease 8 (PARK8, sequence analysis of LRRK2 gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson disease type 8 (PARK8, sequence analysis of exon 41 of LRRK2 gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson disease 8 (PARK8, deletion/duplication analysis on LRRK2 gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson disease ( Gly19 ser mutation ) Panel

India.

By Institute of Medical Genetics and Genomics Sir Ganga Ram Hospital

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson Disease via LRRK2 Gene Sequencing with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson Disease Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Parkinson Disease Sequencing Panel with CNV Detection that also includes the following genes: SLC6A3 SNCA SPR SYNJ1 TAF1 GIGYF2 UCHL1 VPS35 FBXO7 HTRA2

More info about this panel

Parkinson Disease and Parkinsonism Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Parkinson Disease and Parkinsonism Sequencing Panel with CNV Detection that also includes the following genes: SLC20A2 SLC6A3 SNCA SNCB SPG11 SPR SYNJ1 TAF1 TARDBP TWNK

More info about this panel

Neurogenetic Disorders - panels Panel

Germany.

By MGZ Medical Genetics Center Neurogenetic Disorders - panels that also includes the following genes: BCS1L RTN2 RYR1 SACS SCN1A SCN1B SCN2A SCN8A SCO1 SCO2

More info about this panel

PARK8 Parkinsonism Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the LRRK2 gene.

More info about this panel

AllNeuro panel Panel

Germany.

By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1

More info about this panel

Parkinsons disease panel Panel

Germany.

By Centogene AG - the Rare Disease Company Parkinsons disease panel that also includes the following genes: SLC6A3 SNCA SNCB SPR SYNJ1 TAF1 TH GIGYF2 UCHL1 VPS35

More info about this panel

Parkinson Syndrome, autosomal dominant Panel Panel

Germany.

By CeGaT GmbH Parkinson Syndrome, autosomal dominant Panel that also includes the following genes: SNCA VPS35 HTRA2 LRRK2 CHCHD2 DNAJC13 EIF4G1 GBA PRKAR1B RAB29

More info about this panel

Parkinson all Panel Panel

Germany.

By CeGaT GmbH Parkinson all Panel that also includes the following genes: ATXN2 SLC6A3 SNCA SPG11 SPR SYNJ1 TAF1 TH VPS35 FBXO7

More info about this panel

Single gene testing LRRK2 Panel

Germany.

By CeGaT GmbH

This panel specifically test the LRRK2 gene.

More info about this panel

Test for LRRK2-Related Parkinson Disease Panel

United Kingdom.

By All Wales Genetics Laboratory Institute of Medical Genetics

This panel specifically test the LRRK2 gene.

More info about this panel

Ashkenazi Jewish diseases Panel

Estonia.

By Asper Biogene Asper Biogene LLC Ashkenazi Jewish diseases that also includes the following genes: BLM BRCA1 BRCA2 SMN1 SMPD1 CLRN1 MCOLN1 PCDH15 LRRK2 CFTR

More info about this panel

Parkinson Disease Panel

Estonia.

By Asper Biogene Asper Biogene LLC Parkinson Disease that also includes the following genes: SLC6A3 SNCA SPR SYNJ1 TAF1 TH GIGYF2 UCHL1 VPS35 FBXO7

More info about this panel

Parkinson disease 8 Panel

Austria.

By Praxis fuer Humangenetik Wien

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson disease 8 Panel

Slovakia.

By MedGene

This panel specifically test the LRRK2 gene.

More info about this panel

Invitae Hereditary Parkinson's Disease and Parkinsonism Panel Panel

United States.

By Invitae Invitae Hereditary Parkinson's Disease and Parkinsonism Panel that also includes the following genes: SLC6A3 SNCA SPR TH VPS35 FBXO7 PINK1 DNAJC6 PARK7 LRRK2

More info about this panel

Parkinson disease: LRRK2 gene (exons 31, 41) and PINK1 gene (exon 4) screening Panel

Spain.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases Parkinson disease: LRRK2 gene (exons 31, 41) and PINK1 gene (exon 4) screening that also includes the following genes: PINK1 LRRK2

More info about this panel

Parkinson disease 8: LRRK2 (PARK8) gene screening Panel

Spain.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson disease (Park-8): LRRK2 gene sequence analysis Panel

Spain.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases

This panel specifically test the LRRK2 gene.

More info about this panel

PARKINSON DISEASE Panel

Spain.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases PARKINSON DISEASE that also includes the following genes: SNCA TAF1 VPS35 FBXO7 PINK1 PARK7 LRRK2 ATP13A2 PRKN PLA2G6

More info about this panel

NGS panel - Parkinson Panel

Netherlands.

By Genome Diagnostics VU University Medical Center NGS panel - Parkinson that also includes the following genes: ATXN2 SLC18A2 SLC6A3 SNCA SPR SYNJ1 TAF1 TH GIGYF2 UCHL1

More info about this panel

LRRK2(PARK8) - Gene Sequencing & Del/Dup analysis Panel

Netherlands.

By Genome Diagnostics VU University Medical Center

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson-Alzheimer-Dementia NGS Panel Panel

United States.

By Fulgent Genetics Fulgent Genetics Parkinson-Alzheimer-Dementia NGS Panel that also includes the following genes: SLC6A3 SNCA SNCB TAF1 TH TYROBP UCHL1 VPS35 FBXO7 AAAS

More info about this panel

Nuclear-Mito NGS Panel Panel

United States.

By Fulgent Genetics Fulgent Genetics Nuclear-Mito NGS Panel that also includes the following genes: RNASEL BCS1L RPL35A MRPL3 RYR1 RYR2 SACS ACSM3 SARDH ATXN7

More info about this panel

LRRK2 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson Disease Panel Panel

Finland.

By Blueprint Genetics Parkinson Disease Panel that also includes the following genes: SLC20A2 SLC6A3 SNCA SPR SYNJ1 TH VPS35 FBXO7 PINK1 DNAJC6

More info about this panel

Parkinson disease type 8 Panel

Spain.

By Bioarray

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson Disease (LRRK2 gene) Panel

Belgium.

By Diagnostic Service Facility University of Antwerp

This panel specifically test the LRRK2 gene.

More info about this panel

FoundationOne® Heme Panel

United States.

By Foundation Medicine, Inc. FoundationOne® Heme that also includes the following genes: BCL6 BCL7A ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1

More info about this panel

PARKINSON NGS PANEL Panel

Spain.

By Laboratorio de Genetica Clinica SL PARKINSON NGS PANEL that also includes the following genes: SLC6A3 SMPD1 SNCA SYNJ1 UCHL1 VPS35 FBXO7 HTRA2 PINK1 DNAJC6

More info about this panel

Parkinson Disease Type 8, Sequencing LRRK2 (PARK8) Gene Panel

Spain.

By Reference Laboratory Genetics

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson Disease Type 8, Screening Frequent Mutations LRRK2 (PARK8) Gene Panel

Spain.

By Reference Laboratory Genetics

This panel specifically test the LRRK2 gene.

More info about this panel

Parkinson Disease , Deletions-Duplications (MLPA) SNCA, PARK2, PINK1, PARK7, LRRK2, UCHL1 Genes Panel

Spain.

By Reference Laboratory Genetics Parkinson Disease , Deletions-Duplications (MLPA) SNCA, PARK2, PINK1, PARK7, LRRK2, UCHL1 Genes that also includes the following genes: SNCA UCHL1 PINK1 PARK7 LRRK2 PRKN

More info about this panel

Parkinson Disease , Panel Massive Sequencing (NGS) 11 Genes Panel

Spain.

By Reference Laboratory Genetics Parkinson Disease , Panel Massive Sequencing (NGS) 11 Genes that also includes the following genes: SLC6A3 SNCA TAF1 VPS35 FBXO7 PINK1 PARK7 LRRK2 ATP13A2 PRKN

More info about this panel

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel

CEN4GEN Gastric cancer: Extended gene sequencing Panel Panel

Canada.

By CEN4GEN Institute for Genomics and Molecular Diagnostics CEN4GEN Gastric cancer: Extended gene sequencing Panel that also includes the following genes: BRCA2 SSTR1 STK11 TP53 TRIO TRRAP WNK2 CCNE1 FBXW7 SPEG

More info about this panel

Parkinson Disease: gene sequencing panel Panel

Canada.

By CEN4GEN Institute for Genomics and Molecular Diagnostics Parkinson Disease: gene sequencing panel that also includes the following genes: SLC6A3 SNCA TAF1 VPS35 FBXO7 PINK1 PARK7 LRRK2 ATP13A2 PRKN

More info about this panel

LRRK2-Related Parkinson Disease: gene sequencing Panel

Canada.

By CEN4GEN Institute for Genomics and Molecular Diagnostics

This panel specifically test the LRRK2 gene.

More info about this panel


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