LIPC gene related symptoms and diseases

All the information presented here about the LIPC gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,HGNC,OMIM,NCBIGENE, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to LIPC gene

Symptoms // Phenotype % Cases
Hypertriglyceridemia Uncommon - Between 30% and 50% cases
Atherosclerosis Uncommon - Between 30% and 50% cases
Angina pectoris Uncommon - Between 30% and 50% cases
Premature coronary artery atherosclerosis Uncommon - Between 30% and 50% cases
Eruptive xanthomas Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with LIPC gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • Increased HDL cholesterol concentration
  • Diabetes mellitus
  • Type II diabetes mellitus
  • Insulin resistance
  • Type I diabetes mellitus
  • Hyperinsulinemia
  • Hyperglycemia
  • Glucose intolerance

And 2 more phenotypes, you can get all of them using our tools for rare diseases.

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Rare diseases associated to LIPC gene

Here you will find a list of rare diseases related to the LIPC. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


HYPERLIPIDEMIA DUE TO HEPATIC TRIACYLGLYCEROL LIPASE DEFICIENCY


Alternate names

HYPERLIPIDEMIA DUE TO HEPATIC TRIACYLGLYCEROL LIPASE DEFICIENCY Is also known as lipc deficiency, hyperlipidemia due to hepatic lipase deficiency, hyperlipidemia due to htgl deficiency, hyperlipidemia due to hl deficiency, hyperlipidemia due to hepatic triglyceride lipase deficiency, hl deficiency

Description

Hyperlipidemia due to hepatic triacylglycerol lipase deficiency is a rare, genetic hyperalphalipoproteinemia disorder characterized by elevated plasma cholesterol and triglyceride (TG) levels with a marked TG enrichment of low- and high-density lipoproteins (HDL), presence of circulating beta-very low density lipoproteins and elevated HDL cholesterol levels, in the presence of a very low, or undetectable, postheparin plasma hepatic lipase activity. Premature atherosclerosis and/or coronary heart disease may be associated.

Most common symptoms of HYPERLIPIDEMIA DUE TO HEPATIC TRIACYLGLYCEROL LIPASE DEFICIENCY

  • Hypertriglyceridemia
  • Atherosclerosis
  • Angina pectoris
  • Premature coronary artery atherosclerosis
  • Eruptive xanthomas


More info about HYPERLIPIDEMIA DUE TO HEPATIC TRIACYLGLYCEROL LIPASE DEFICIENCY

SOURCES: ORPHANET OMIM

DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM


Alternate names

DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM Is also known as noninsulin-dependent diabetes mellitus, maturity-onset diabetes, diabetes mellitus, type ii, t2d

Most common symptoms of DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM

  • Diabetes mellitus
  • Type II diabetes mellitus
  • Insulin resistance
  • Type I diabetes mellitus
  • Hyperinsulinemia


More info about DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM

SOURCES: OMIM ORPHANET

HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 12; HDLCQ12



More info about HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 12; HDLCQ12

SOURCES: OMIM


Potential gene panels for LIPC gene

LIPC Panel

Germany.

By Institute for Human Genetics University Clinic Freiburg

This panel specifically test the LIPC gene.

More info about this panel

Dyslipidemia NGS panel (29 genes), Sequence & CNV analysis Panel

Netherlands.

By Laboratory of genome diagnostics Academic Medical Center, University of Amsterdam Dyslipidemia NGS panel (29 genes), Sequence & CNV analysis that also includes the following genes: SAR1B SLCO1B1 ABCG5 ABCG8 LMF1 SCARB1 APOA5 LDLRAP1 CETP PCSK9

More info about this panel

High density lipoprotein cholesterol level QTL 12 Panel

Germany.

By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders

This panel specifically test the LIPC gene.

More info about this panel

Hepatic lipase deficiency Panel

Germany.

By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders

This panel specifically test the LIPC gene.

More info about this panel

Cardiovascular Diseases_General Panel Panel

Spain.

By Health in Code Cardiovascular Diseases_General Panel that also includes the following genes: RIT1 MRPL3 RRAS RYR1 RYR2 SAR1B BLK SCN10A SCN1B SCN2B

More info about this panel

Dyslipidemias / Early atherosclerosis Panel

Spain.

By Health in Code Dyslipidemias / Early atherosclerosis that also includes the following genes: RYR1 SAR1B BLK SLCO1B1 SLC22A8 SLC2A2 HNF1A HNF1B KLF11 WFS1

More info about this panel

LIPC Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the LIPC gene.

More info about this panel


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