LEPR gene related symptoms and diseases
All the information presented here about the LEPR gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,ORPHANET,HGNC,NCBIGENE, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to LEPR gene
Symptoms // Phenotype | % Cases |
---|---|
Intellectual disability | Very Common - Between 80% and 100% cases |
Emotional lability | Very Common - Between 80% and 100% cases |
Decreased T cell activation | Very Common - Between 80% and 100% cases |
Decreased serum leptin | Very Common - Between 80% and 100% cases |
Hypoplasia of the ovary | Very Common - Between 80% and 100% cases |
Other less frequent symptoms and clinical features
Patients with LEPR gene alterations may also develop some of the following symptoms and phenotypes:Commonly - More than 50% cases
- Orthostatic hypotension due to autonomic dysfunction
- Decreased proportion of CD4-positive T cells
- Decreased testosterone in males
- Absence of secondary sex characteristics
- Decreased serum estradiol
- Immune dysregulation
- Pituitary hypothyroidism
- Insulin-resistant diabetes mellitus
And 16 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to LEPR gene
Here you will find a list of rare diseases related to the LEPR. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
OBESITY DUE TO LEPTIN RECEPTOR GENE DEFICIENCY
Alternate names
OBESITY DUE TO LEPTIN RECEPTOR GENE DEFICIENCY Is also known as obesity, morbid, nonsyndromic 2
Description
Deficiency or dysfunction of the leptin receptor, which is associated with loss-of-function mutation(s) in the LEPR gene.
Most common symptoms of OBESITY DUE TO LEPTIN RECEPTOR GENE DEFICIENCY
- Intellectual disability
- Obesity
- Hypogonadism
- Aggressive behavior
- Delayed puberty
More info about OBESITY DUE TO LEPTIN RECEPTOR GENE DEFICIENCY
Search interest in LEPR
Potential gene panels for LEPR gene
LEPR Sequence Analysis Panel
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By Baylor Miraca Genetics Laboratories
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/United-states.png)
LEPR Sequence Analysis (Familial Mutation/Variant Analysis) Panel
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By Baylor Miraca Genetics Laboratories
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/United-states.png)
Early Onset Obesity (LEPR) DNA Sequencing Test Panel
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By Athena Diagnostics Inc
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/United-states.png)
Early Onset Obesity Panel Panel
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By Athena Diagnostics Inc Early Onset Obesity Panel that also includes the following genes: LEPR MC4R
More info about this panel![](/img/flags/United-states.png)
Monogenic Obesity Sequencing Panel Panel
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By Genetic Services Laboratory University of Chicago Monogenic Obesity Sequencing Panel that also includes the following genes: SDCCAG8 SIM1 UCP3 ARL6 TRIM32 AFF4 PHF6 SETD2 BBS7 TTC8
More info about this panel![](/img/flags/United-states.png)
Non-syndromic Monogenic Obesity Sequencing Panel Panel
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By Genetic Services Laboratory University of Chicago Non-syndromic Monogenic Obesity Sequencing Panel that also includes the following genes: UCP3 DYRK1B LEP LEPR MC4R NR0B2 POMC
More info about this panel![](/img/flags/United-states.png)
Monogenic Obesity Deletion/Duplication Panel Panel
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By Genetic Services Laboratory University of Chicago Monogenic Obesity Deletion/Duplication Panel that also includes the following genes: SDCCAG8 SIM1 UCP3 ARL6 TRIM32 AFF4 PHF6 SETD2 BBS7 TTC8
More info about this panel![](/img/flags/United-states.png)
Non-Syndromic Monogenic Obesity Deletion/Duplication Panel Panel
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By Genetic Services Laboratory University of Chicago Non-Syndromic Monogenic Obesity Deletion/Duplication Panel that also includes the following genes: UCP3 DYRK1B LEP LEPR MC4R NR0B2 POMC
More info about this panel![](/img/flags/United-states.png)
LEPR. Complete sequencing Panel
![](/img/flags/Spain.png.pagespeed.ce.xXrgJ_nXfh.png)
By Instituto de Medicina Genomica Instituto de Medicina Genomica
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/Spain.png.pagespeed.ce.xXrgJ_nXfh.png)
Monogenic Non-Syndromic Obesity, AR (sequence analysis of LEPR gene) Panel
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By CGC Genetics
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/Portugal.png.pagespeed.ce.zPu4arfxQG.png)
Non-Syndromic Monogenic Obesity via LEPR Gene Sequencing with CNV Detection Panel
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By PreventionGenetics PreventionGenetics
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/United-states.png)
Hypogonadotropic Hypogonadism/Kallmann Sequencing Panel with CNV Detection Panel
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By PreventionGenetics PreventionGenetics Hypogonadotropic Hypogonadism/Kallmann Sequencing Panel with CNV Detection that also includes the following genes: SEMA3A SEMA3E SOX10 SOX2 SOX3 TAC3 TACR3 WDR11 SPRY4 PROKR2
More info about this panel![](/img/flags/United-states.png)
Non-Syndromic Monogenic Obesity Sequencing Panel with CNV Detection Panel
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By PreventionGenetics PreventionGenetics Non-Syndromic Monogenic Obesity Sequencing Panel with CNV Detection that also includes the following genes: SIM1 UCP3 KSR2 SH2B1 LEP LEPR MC4R NR0B2 NTRK2 PCSK1
More info about this panel![](/img/flags/United-states.png)
Female Infertility Sequencing Panel with CNV Detection Panel
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By PreventionGenetics PreventionGenetics Female Infertility Sequencing Panel with CNV Detection that also includes the following genes: BMP15 SEMA3A SEMA3E FOXL2 SOX10 SOX2 SOX3 SOX9 SRA1 SRD5A2
More info about this panel![](/img/flags/United-states.png)
Male Infertility Sequencing Panel with CNV Detection Panel
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By PreventionGenetics PreventionGenetics Male Infertility Sequencing Panel with CNV Detection that also includes the following genes: SEMA3A SEMA3E FOXL2 BRDT SOX10 SOX2 SOX3 SOX9 SRA1 SRD5A2
More info about this panel![](/img/flags/United-states.png)
Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection Panel
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By PreventionGenetics PreventionGenetics Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection that also includes the following genes: ROR2 SALL1 BMP15 BMP4 SEMA3A SEMA3E BMP7 FOXL2 BRDT SOS1
More info about this panel![](/img/flags/United-states.png)
Disorders of Sex Development (DSD) Sequencing Panel with CNV Detection Panel
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By PreventionGenetics PreventionGenetics Disorders of Sex Development (DSD) Sequencing Panel with CNV Detection that also includes the following genes: ROR2 SALL1 BMP15 BMP4 SEMA3A BMP7 FOXL2 SOS1 SOX10 SOX2
More info about this panel![](/img/flags/United-states.png)
Comprehensive Monogenic Obesity Panel with CNV Detection Panel
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By PreventionGenetics PreventionGenetics Comprehensive Monogenic Obesity Panel with CNV Detection that also includes the following genes: BDNF SDCCAG8 SIM1 TUB UCP3 KDM6A ARL6 RAB23 TRIM32 PHF6
More info about this panel![](/img/flags/United-states.png)
Leptin Receptor Deficiency Panel
![](/img/flags/Germany.png.pagespeed.ce.gZ_H9lXZoQ.png)
By Bioscientia GmbH Center for Human Genetics
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/Germany.png.pagespeed.ce.gZ_H9lXZoQ.png)
Obesity Panel
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By Synlab MVZ Humane Genetik München Synlab MVZ Humane Genetik München Obesity that also includes the following genes: LEP LEPR MC3R MC4R POMC
More info about this panel![](/img/flags/Germany.png.pagespeed.ce.gZ_H9lXZoQ.png)
LEPR Panel
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By Genome Diagnostics Laboratory University Medical Center Utrecht
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/Netherlands.png.pagespeed.ce.VVW97w9GfU.png)
LEPTIN RECEPTOR (LEPR) Panel
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By MVZ Dortmund Dr. Eberhard & Partner
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/Germany.png.pagespeed.ce.gZ_H9lXZoQ.png)
Obesity, morbid, with hypogonadism Panel
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By Praxis fuer Humangenetik Wien
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/Austria.png.pagespeed.ce.bmb2o24dtJ.png)
Obesity, morbid, with hypogonadism Panel
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By MedGene
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/Slovakia.png)
Congenital Obesity: Sequencing Panel Panel
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By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Congenital Obesity: Sequencing Panel that also includes the following genes: SDCCAG8 SIM1 ARL6 TRIM32 PHF6 BBS7 TTC8 VPS13B BBS10 BBS12
More info about this panel![](/img/flags/United-states.png)
Diabetes-Obesity NGS Panel Panel
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By Fulgent Genetics Fulgent Genetics Diabetes-Obesity NGS Panel that also includes the following genes: BDNF SDCCAG8 SIM1 HNF1A HNF1B WFS1 ARL6 NEUROG3 TRIM32 CEL
More info about this panel![](/img/flags/United-states.png)
LEPR Panel
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By Fulgent Genetics Fulgent Genetics
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/United-states.png)
Monogenic Obesity Panel Panel
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By Blueprint Genetics Monogenic Obesity Panel that also includes the following genes: SDCCAG8 SIM1 UCP3 ARL6 TRIM32 PHF6 KSR2 BBS7 TTC8 VPS13B
More info about this panel![](/img/flags/Finland.png.pagespeed.ce.96kqieeVAM.png)
Obesity due to leptin receptor gene deficiency Panel
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By Bioarray
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/Spain.png.pagespeed.ce.xXrgJ_nXfh.png)
Early Onset Obesity NGS and Deletion/Duplication Panel Panel
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By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children Early Onset Obesity NGS and Deletion/Duplication Panel that also includes the following genes: LEP LEPR MC4R PCSK1 POMC
More info about this panel![](/img/flags/United-states.png)
LEPR Gene Sequencing and Deletion/Duplication Analysis Panel
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By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/United-states.png)
MONOGENIC OBESITY DUE TO MELANOCORTIN-LEPTIN PATHWAY DEFICIENCY Panel
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By Laboratorio de Genetica Clinica SL MONOGENIC OBESITY DUE TO MELANOCORTIN-LEPTIN PATHWAY DEFICIENCY that also includes the following genes: LEP LEPR MC3R MC4R PCSK1 POMC
More info about this panel![](/img/flags/Spain.png.pagespeed.ce.xXrgJ_nXfh.png)
Morbid Obesity due to Leptin Receptor Deficiency , Sequencing LEPR Gene Panel
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By Reference Laboratory Genetics
This panel specifically test the LEPR gene.
More info about this panel![](/img/flags/Spain.png.pagespeed.ce.xXrgJ_nXfh.png)
Severe Obesity (Susceptibility to) , Panel Massive Sequencing (NGS) 18 Genes Panel
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By Reference Laboratory Genetics Severe Obesity (Susceptibility to) , Panel Massive Sequencing (NGS) 18 Genes that also includes the following genes: SDC3 SIM1 UCP1 UCP3 GHRL CARTPT ADRB3 PPARGC1B AGRP ENPP1
More info about this panel![](/img/flags/Spain.png.pagespeed.ce.xXrgJ_nXfh.png)
Tempus xO assay Panel
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By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2
More info about this panel![](/img/flags/United-states.png)
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