HTR2A gene related symptoms and diseases

All the information presented here about the HTR2A gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,NCBIGENE,HGNC, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to HTR2A gene

Symptoms // Phenotype % Cases
Depressivity Very Common - Between 80% and 100% cases
Behavioral abnormality Common - Between 50% and 80% cases
Anxiety Common - Between 50% and 80% cases
Bipolar affective disorder Common - Between 50% and 80% cases
Personality disorder Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with HTR2A gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • Mania
  • Schizophrenia
  • Alcoholism
  • Rarely - Less than 30% cases

  • Neurofibrillary tangles
  • Psychosis
  • Dyskinesia
  • Auditory hallucinations
  • Chorea

And 32 more phenotypes, you can get all of them using our tools for rare diseases.

Mendelian

Accelerate your rare disease diagnosis with us

Learn more

Rare diseases associated to HTR2A gene

Here you will find a list of rare diseases related to the HTR2A. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


OBSESSIVE-COMPULSIVE DISORDER; OCD


Description

Obsessive-compulsive disorder (OCD) is characterized by recurring obsessions and/or compulsions and has been estimated to affect nearly 5 million people in the United States (Karno et al., 1988). Evidence for a strong genetic component in OCD comes from twin studies, family genetics studies, and segregation analyses, as reviewed by Alsobrook et al. (2002).Zhang et al. (2002) suggested that hoarding is likely to be an evolutionarily conserved trait that, in times of adversity, was associated with increased survival and reproductive fitness. However, extreme forms of this trait are associated with marked disability and poor response to treatment (Black et al., 1998; Mataix-Cols et al., 1999).

Most common symptoms of OBSESSIVE-COMPULSIVE DISORDER; OCD

  • Depressivity
  • Anxiety
  • Obsessive-compulsive behavior
  • Tics
  • Collectionism


More info about OBSESSIVE-COMPULSIVE DISORDER; OCD

SOURCES: MESH OMIM

MAJOR DEPRESSIVE DISORDER; MDD


Alternate names

MAJOR DEPRESSIVE DISORDER; MDD Is also known as unipolar depression

Most common symptoms of MAJOR DEPRESSIVE DISORDER; MDD

  • Neoplasm
  • Behavioral abnormality
  • Depressivity
  • Anxiety
  • Abnormality of the liver


More info about MAJOR DEPRESSIVE DISORDER; MDD

SOURCES: OMIM

ALCOHOL DEPENDENCE


Alternate names

ALCOHOL DEPENDENCE Is also known as alcoholism

Description

a disorder characterized by a pathological pattern of alcohol use that causes a serious impairment in social or occupational functioning.

Most common symptoms of ALCOHOL DEPENDENCE

  • Seizures
  • Behavioral abnormality
  • Depressivity
  • Hyperactivity
  • Abnormality of the nervous system


More info about ALCOHOL DEPENDENCE

SOURCES: OMIM

SCHIZOPHRENIA; SCZD


Alternate names

SCHIZOPHRENIA; SCZD Is also known as schizophrenia with or without an affective disorder

Description

Schizophrenia is a psychosis, a disorder of thought and sense of self. Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. There is no characteristic pathology, such as neurofibrillary tangles in Alzheimer disease (OMIM ). Schizophrenia is a common disorder with a lifetime prevalence of approximately 1%. It is highly heritable but the genetics are complex. This may not be a single entity.Schizophrenia and bipolar disorder (see {125480}) are generally considered to be separate entities, but patients who exhibit multiple symptoms of both disorders are often given the hybrid diagnosis schizoaffective disorder (Blacker and Tsuang, 1992). Genetic Heterogeneity of Schizophrenia with or without an Affective DisorderSCZD4 (OMIM ) is associated with variation in the PRODH gene (OMIM ); SCZD9 (OMIM ) with variation in the DISC1 gene (OMIM ); SCZD15 (OMIM ) with variation in the SHANK3 gene (OMIM ); SCZD16 (OMIM ) with a chromosome duplication involving the VIPR2 gene (OMIM ); SCZD17 (see {614332}) with variation in the NRXN1 gene (OMIM ); SCZD18 (OMIM ) with variation in the SLC1A1 gene (OMIM ); and SCZD19 (OMIM ) with variation in the RBM12 gene (OMIM ).For associations pending confirmation, see MAPPING and MOLECULAR GENETICS.

Most common symptoms of SCHIZOPHRENIA; SCZD

  • Intellectual disability
  • Microcephaly
  • Behavioral abnormality
  • Depressivity
  • Dementia


More info about SCHIZOPHRENIA; SCZD

SOURCES: OMIM


Potential gene panels for HTR2A gene

Serotonin Metabolism Deficiency NGS Panel Panel

United States.

By Fulgent Genetics Fulgent Genetics Serotonin Metabolism Deficiency NGS Panel that also includes the following genes: SLC6A4 TPH1 AANAT TPH2 HTR3C HTR3E DDC HTR1A HTR1B HTR2A

More info about this panel

HTR2A Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the HTR2A gene.

More info about this panel

HTR2A Panel

United States.

By Genelex

This panel specifically test the HTR2A gene.

More info about this panel

YouScript Psychotropic Panel

United States.

By Genelex YouScript Psychotropic that also includes the following genes: SLC6A4 CYP2C19 CYP2C9 CYP2D6 CYP3A4 CYP3A5 HTR2A

More info about this panel

GeneSight Psychotropic Panel

United States.

By Assurex Health, Inc. GeneSight Psychotropic that also includes the following genes: SLC6A4 UGT1A4 UGT2B15 CYP2B6 CYP2C19 CYP2C9 CYP2D6 CYP3A4 HLA-A HTR2A

More info about this panel

Comprehensive Pharmacogenomics (PGX) Panel Panel

United States.

By ApolloGen, Inc. Comprehensive Pharmacogenomics (PGX) Panel that also includes the following genes: SLCO1B1 VKORC1 CYP2C19 CYP2C9 CYP2D6 CYP3A4 CYP3A5 F5 HTR2A MTHFR

More info about this panel

OneOme RightMed comprehensive test Panel

United States.

By OneOme OneOme RightMed comprehensive test that also includes the following genes: SLCO1B1 SLC6A4 TPMT UGT1A1 IFNL3 NUDT15 VKORC1 CYP2B6 CYP2C18 CYP2C19

More info about this panel

Citalopram response Panel

India.

By Xcode Life Xcode Life Citalopram response that also includes the following genes: SLC6A4 CYP2C19 HTR2A

More info about this panel

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel


If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like BARX1 SOX9 COQ8B KCNH1 PLS3 MT-CYB DCHS1

Need help with a diagnosis?

Learn more about how to achieve it with Mendelian


Learn more