HLA-C gene related symptoms and diseases
All the information presented here about the HLA-C gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,NCBIGENE,HGNC,OMIM, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to HLA-C gene
|Symptoms // Phenotype||% Cases|
|Skin rash||Uncommon - Between 30% and 50% cases|
|Fever||Uncommon - Between 30% and 50% cases|
|Anemia||Rare - less than 30% cases|
|Acantholysis||Rare - less than 30% cases|
|Macule||Rare - less than 30% cases|
Other less frequent symptoms and clinical featuresPatients with HLA-C gene alterations may also develop some of the following symptoms and phenotypes:
Rarely - Less than 30% cases
- Corneal erosion
- Acute hepatic failure
- Abnormal myocardium morphology
- Excessive salivation
- Abnormality of the pleura
- Esophageal stricture
And 38 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to HLA-C gene
Here you will find a list of rare diseases related to the HLA-C. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
STEVENS-JOHNSON SYNDROME Is also known as dermatostomatitis, stevens johnson type
Stevens-Johnson syndrome is a limited form of toxic epidermal necrolysis (see this term) characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area.
Most common symptoms of STEVENS-JOHNSON SYNDROME
- Visual impairment
More info about STEVENS-JOHNSON SYNDROME
PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA Is also known as b-all, precursor b-cell acute lymphocytic leukemia, precursor b-cell acute lymphocytic leukemia/lymphoma, precursor b-cell acute lymphoblastic leukemia/lymphoma
More info about PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO Is also known as hiv-1, susceptibility to
The pathogenesis of HIV infection and the progression from infection to AIDS vary significantly between exposed individuals. Infection occurs after the virus, which has macrophage (M)- and T lymphocyte (T)-tropic strains and more than 12 subtypes, survives an array of nonspecific, nongenetic environmental and host factors.
More info about HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
PSORIASIS 1, SUSCEPTIBILITY TO; PSORS1
Psoriasis (psoriasis vulgaris; PV) is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin patches that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age (summary by Matthews et al., 1996).Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein (OMIM ) (summary by Marrakchi et al., 2011). GPP often presents in patients with existing or prior psoriasis vulgaris; however, GPP can develop without a history of PV (Sugiura et al., 2013). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP (summary by Setta-Kaffetzi et al., 2013).Nestle et al. (2009) provided a detailed review of the pathogenesis and genetics of psoriasis.
Most common symptoms of PSORIASIS 1, SUSCEPTIBILITY TO; PSORS1
- Skin rash
- Scaling skin
- Psoriasiform dermatitis
More info about PSORIASIS 1, SUSCEPTIBILITY TO; PSORS1
Search interest in HLA-C
Potential gene panels for HLA-C gene
Tempus xT assay Panel
By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRAMore info about this panel
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