HLA-B gene related symptoms and diseases
All the information presented here about the HLA-B gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,NCBIGENE,HGNC, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to HLA-B gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Fever | Common - Between 50% and 80% cases |
| Fatigue | Common - Between 50% and 80% cases |
| Myocardial infarction | Common - Between 50% and 80% cases |
| Arthritis | Common - Between 50% and 80% cases |
| Weight loss | Common - Between 50% and 80% cases |
Other less frequent symptoms and clinical features
Patients with HLA-B gene alterations may also develop some of the following symptoms and phenotypes:Commonly - More than 50% cases
- Photophobia
- Aortic regurgitation
Not very common - Between 30% and 50% cases
- Anemia
- Migraine
- Pain
- Dilatation
- Arthralgia
- Myalgia
And 150 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to HLA-B gene
Here you will find a list of rare diseases related to the HLA-B. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
STEVENS-JOHNSON SYNDROME
Alternate names
STEVENS-JOHNSON SYNDROME Is also known as dermatostomatitis, stevens johnson type
Description
Stevens-Johnson syndrome is a limited form of toxic epidermal necrolysis (see this term) characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area.
Most common symptoms of STEVENS-JOHNSON SYNDROME
- Anemia
- Visual impairment
- Fever
- Fatigue
- Dysphagia
More info about STEVENS-JOHNSON SYNDROME
BEHÇET DISEASE
Alternate names
BEHÇET DISEASE Is also known as bd, behcet disease
Description
Behçet's disease (BD) is a chronic, relapsing, multisystemic vasculitis characterized by mucocutaneous lesions, as well as articular, vascular, ocular and central nervous system manifestations.
Most common symptoms of BEHÇET DISEASE
- Seizures
- Ataxia
- Neoplasm
- Pain
- Cataract
More info about BEHÇET DISEASE
TAKAYASU ARTERITIS
Alternate names
TAKAYASU ARTERITIS Is also known as young female arteritis, aortic arch syndrome, pulseless disease
Description
Takayasu arteritis (TAK) is a rare inflammatory large-vessel vasculitis primarily affecting the aorta and its major branches, but also other large vessels, causing stenosis, occlusion, or aneurysm.
Most common symptoms of TAKAYASU ARTERITIS
- Seizures
- Muscle weakness
- Anemia
- Hypertension
- Fever
More info about TAKAYASU ARTERITIS
SPONDYLOARTHROPATHY, SUSCEPTIBILITY TO, 1; SPDA1
Alternate names
SPONDYLOARTHROPATHY, SUSCEPTIBILITY TO, 1; SPDA1 Is also known as ankylosing spondylitis, susceptibility to, marie-strumpell spondylitis, bechterew syndrome
Description
Spondyloarthropathy (SpA), one of the commonest chronic rheumatic diseases, includes a spectrum of related disorders comprising the prototype ankylosing spondylitis (AS), a subset of psoriatic arthritis (PsA), reactive arthritis (ReA), arthritis associated with inflammatory bowel disease, and undifferentiated spondyloarthropathy (Miceli-Richard et al., 2004). These phenotypes are difficult to differentiate because they may occur simultaneously or sequentially in the same patient. Studies have suggested that a predominant shared component, including HLA-B27, predisposes to all phenotypic subsets, and that these subsets should be considered as various phenotypic expressions of the same disease (Said-Nahal et al., 2000, Said-Nahal et al., 2001).Braun and Sieper (2007) provided a detailed review of ankylosing spondylitis, including clinical features, pathogenesis, and management.
Most common symptoms of SPONDYLOARTHROPATHY, SUSCEPTIBILITY TO, 1; SPDA1
- Pain
- Kyphosis
- Arrhythmia
- Photophobia
- Arthritis
More info about SPONDYLOARTHROPATHY, SUSCEPTIBILITY TO, 1; SPDA1
PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONNECTIVE TISSUE DISEASE
Alternate names
PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONNECTIVE TISSUE DISEASE Is also known as pah associated with connective tissue disease
Description
Pulmonary arterial hypertension (PAH, see this term) associated with connective tissue disease (PAH-CTD) is a form of pulmonary arterial hypertension (PAH, see this term) characterized by an elevated pulmonary arterial resistance leading to right heart failure observed as a complication of a connective tissue disease.
More info about PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONNECTIVE TISSUE DISEASE
SOURCES: ORPHANET
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