FGB gene related symptoms and diseases

All the information presented here about the FGB gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,HGNC,NCBIGENE,ORPHANET, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to FGB gene

Symptoms // Phenotype % Cases
Abnormal bleeding Common - Between 50% and 80% cases
Epistaxis Common - Between 50% and 80% cases
Gingival bleeding Common - Between 50% and 80% cases
Gastrointestinal hemorrhage Uncommon - Between 30% and 50% cases
Menometrorrhagia Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with FGB gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • Hypofibrinogenemia
  • Dysfibrinogenemia
  • Rarely - Less than 30% cases

  • Venous thrombosis
  • Spontaneous abortion
  • Cerebral hemorrhage
  • Joint swelling
  • Abnormality of the liver
  • Intracranial hemorrhage

And 1 more phenotypes, you can get all of them using our tools for rare diseases.

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Rare diseases associated to FGB gene

Here you will find a list of rare diseases related to the FGB. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


FAMILIAL DYSFIBRINOGENEMIA


Description

Familial dysfibrinogenemia is a coagulation disorder characterized by a bleeding tendency due to a functional anomaly of circulating fibrinogen.

Most common symptoms of FAMILIAL DYSFIBRINOGENEMIA

  • Abnormal bleeding
  • Gastrointestinal hemorrhage
  • Epistaxis
  • Venous thrombosis
  • Gingival bleeding


More info about FAMILIAL DYSFIBRINOGENEMIA

SOURCES: ORPHANET

FAMILIAL AFIBRINOGENEMIA


Description

Familial afibrinogenemia is a coagulation disorder characterized by bleeding symptoms due to a complete absence of circulating fibrinogen.

Most common symptoms of FAMILIAL AFIBRINOGENEMIA

  • Abnormal bleeding
  • Epistaxis
  • Spontaneous abortion
  • Cerebral hemorrhage
  • Joint swelling


More info about FAMILIAL AFIBRINOGENEMIA

SOURCES: ORPHANET

FAMILIAL HYPODYSFIBRINOGENEMIA



More info about FAMILIAL HYPODYSFIBRINOGENEMIA

SOURCES: ORPHANET

FAMILIAL HYPOFIBRINOGENEMIA


Description

Familial hypofibrinogenemia is a coagulation disorder characterized by mild bleeding symptoms following trauma or surgery due to a reduced plasma fibrinogen concentration.

Most common symptoms of FAMILIAL HYPOFIBRINOGENEMIA

  • Abnormal bleeding
  • Gastrointestinal hemorrhage
  • Epistaxis
  • Gingival bleeding
  • Hypofibrinogenemia


More info about FAMILIAL HYPOFIBRINOGENEMIA

SOURCES: ORPHANET OMIM

AFIBRINOGENEMIA, CONGENITAL


Description

Inherited disorders of fibrinogen affect either the quantity (afibrinogenemia and hypofibrinogenemia; {202400}) or the quality (dysfibrinogenemia ) of the circulating fibrinogen or both (hypodysfibrinogenemia; see {616004}). Afibrinogenemia is characterized by the complete absence of immunoreactive fibrinogen. Bleeding due to afibrinogenemia usually manifests in the neonatal period, with 85% of cases presenting umbilical cord bleeding, but a later age of onst is not unusual. Bleeding may occur in the skin, gastrointestinal tract, genitourinary tract, or the central nervous system, with intracranial hemorrhage being reported as the major cause of death. Patients are susceptible to spontaneous rupture of the spleen. Menstruating women may experience menometrorrhagia. First-trimester abortion is common. Both arterial and venous thromboembolic complications have been reported (summary by de Moerloose and Neerman-Arbez, 2009).Hypofibrinogenemia is characterized by reduced amounts of immunoreactive fibrinogen. Patients are often heterozygous carriers of afibrinogenemia mutations and are usually asymptomatic. However, they may bleed when exposed to trauma or if they have a second associated hemostatic abnormality. Women may experience miscarriages. Liver disease occurs in rare cases (summary by de Moerloose and Neerman-Arbez, 2009).

Most common symptoms of AFIBRINOGENEMIA, CONGENITAL

  • Abnormality of the liver
  • Abnormal bleeding
  • Intracranial hemorrhage
  • Menometrorrhagia
  • Hypofibrinogenemia


More info about AFIBRINOGENEMIA, CONGENITAL

SOURCES: OMIM


Potential gene panels for FGB gene

Platelet Disorders Panel

United States.

By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University Platelet Disorders that also includes the following genes: RUNX1 STIM1 TBXA2R TBXAS1 USF1 VPS33B VWF WAS GP6 HPS3

More info about this panel

Congenital fibrinogen deficiency Panel

Germany.

By Institute of Human Genetics Uniklinik RWTH Aachen Congenital fibrinogen deficiency that also includes the following genes: FGA FGB FGG

More info about this panel

FGB. Complete sequencing Panel

Spain.

By Instituto de Medicina Genomica Instituto de Medicina Genomica

This panel specifically test the FGB gene.

More info about this panel

Familial afibrinogenemia (sequence analysis of FGB gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the FGB gene.

More info about this panel

Congenital dysfibrinogenemia (sequence analysis of FGB gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the FGB gene.

More info about this panel

Congenital dysfibrinogenemia (sequence analysis of FGB gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the FGB gene.

More info about this panel

Congenital Fibrinogen Deficiency Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Congenital Fibrinogen Deficiency Sequencing Panel with CNV Detection that also includes the following genes: FGA FGB FGG

More info about this panel

Bleeding Disorders Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Bleeding Disorders Sequencing Panel with CNV Detection that also includes the following genes: RUNX1 TBXA2R TBXAS1 VWF WAS ADAMTS13 ABCG5 ABCG8 GP6 HPS3

More info about this panel

Coagulation Factor Deficiency Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Coagulation Factor Deficiency Sequencing Panel with CNV Detection that also includes the following genes: VWF MCFD2 VKORC1 F10 F11 F12 F13A1 F13B F2 F5

More info about this panel

Congenital Fibrinogen Deficiency via FGB Gene Sequencing with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics

This panel specifically test the FGB gene.

More info about this panel

CentoICU platinum plus Panel

Germany.

By Centogene AG - the Rare Disease Company CentoICU platinum plus that also includes the following genes: RMRP BCS1L BDNF RPS19 RPS6KA3 SALL1 SCN1A SCN2A SFTPB SFTPC

More info about this panel

New Born testing (CentoICU) Panel

Germany.

By Centogene AG - the Rare Disease Company New Born testing (CentoICU) that also includes the following genes: RMRP BCS1L BDNF RPS19 RPS6KA3 SALL1 SCN1A SCN2A SFTPB SFTPC

More info about this panel

Afibrinogenemia panel Panel

Germany.

By Centogene AG - the Rare Disease Company Afibrinogenemia panel that also includes the following genes: FGA FGB FGG

More info about this panel

Fibrinogen gene analysis (FGA, FGB & FGG) Panel

United Kingdom.

By Molecular Haemostasis & Thrombosis GSTS Pathology - Guy's and St. Thomas' NHS Foundation Trust Fibrinogen gene analysis (FGA, FGB & FGG) that also includes the following genes: FGA FGB FGG

More info about this panel

aCGH Deletion/Duplication Analysis Panel

United States.

By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti aCGH Deletion/Duplication Analysis that also includes the following genes: CFB RUNX1 STXBP2 TBXA2R THBD VWF WAS C3 C4BPA C4BPB

More info about this panel

Afibrinogenemia, congenital Panel

Austria.

By Praxis fuer Humangenetik Wien

This panel specifically test the FGB gene.

More info about this panel

Dysfibrinogenemia Panel

Austria.

By Praxis fuer Humangenetik Wien

This panel specifically test the FGB gene.

More info about this panel

Afibrinogenemia, congenital Panel

Slovakia.

By MedGene

This panel specifically test the FGB gene.

More info about this panel

Dysfibrinogenemia Panel

Slovakia.

By MedGene

This panel specifically test the FGB gene.

More info about this panel

FGB Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the FGB gene.

More info about this panel

Bleeding Disorder/Coagulopathy Panel Panel

Finland.

By Blueprint Genetics Bleeding Disorder/Coagulopathy Panel that also includes the following genes: RUNX1 SRC TBXA2R THBD VWF WAS ADAMTS13 ABCG5 ABCG8 HPS3

More info about this panel

Coagulation Factor Deficiency Panel Panel

Finland.

By Blueprint Genetics Coagulation Factor Deficiency Panel that also includes the following genes: VWF VKORC1 F10 F11 F12 F13A1 F2 F5 F7 F8

More info about this panel

Comprehensive Hematology Panel Panel

Finland.

By Blueprint Genetics Comprehensive Hematology Panel that also includes the following genes: RHAG RIT1 RPL11 RPL15 RPL35A RPL5 RPS10 RPS19 RPS24 RPS26

More info about this panel

Afibrinogenemia, congenital Panel

Spain.

By Bioarray

This panel specifically test the FGB gene.

More info about this panel

AFIBRINOGENEMIA – DYSFIBRINOGENEMIA – HYPOFIBRINOGENEMIA Panel

Spain.

By Laboratorio de Genetica Clinica SL AFIBRINOGENEMIA – DYSFIBRINOGENEMIA – HYPOFIBRINOGENEMIA that also includes the following genes: FGA FGB FGG

More info about this panel

Bleeding Disorders , Panel Massive Sequencing (NGS) 23 Genes Panel

Spain.

By Reference Laboratory Genetics Bleeding Disorders , Panel Massive Sequencing (NGS) 23 Genes that also includes the following genes: VWF ADAMTS13 MCFD2 F10 F11 F12 F13A1 F2 F5 F7

More info about this panel

Congenital Fibrinogen Disorders , Panel Massive Sequencing (NGS) FGA, FGB, FGG Genes Panel

Spain.

By Reference Laboratory Genetics Congenital Fibrinogen Disorders , Panel Massive Sequencing (NGS) FGA, FGB, FGG Genes that also includes the following genes: FGA FGB FGG

More info about this panel

Afibrinogenemia, congenital Panel

Germany.

By Labor Dr. Wisplinghoff Afibrinogenemia, congenital that also includes the following genes: FGA FGB FGG

More info about this panel


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