DLX4 gene related symptoms and diseases

All the information presented here about the DLX4 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,ORPHANET,OMIM,HGNC, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to DLX4 gene

Symptoms // Phenotype % Cases
Hypertelorism Uncommon - Between 30% and 50% cases
Sparse eyebrow Uncommon - Between 30% and 50% cases
Palate fistula Uncommon - Between 30% and 50% cases
Agenesis of lateral incisor Uncommon - Between 30% and 50% cases
Bilateral cleft palate Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with DLX4 gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • Euryblepharon
  • Ectropion of lower eyelids
  • High anterior hairline
  • Bilateral cleft lip and palate
  • Bilateral cleft lip
  • Ectropion
  • Sparse eyelashes
  • Abnormal facial shape

And 11 more phenotypes, you can get all of them using our tools for rare diseases.


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Rare diseases associated to DLX4 gene

Here you will find a list of rare diseases related to the DLX4. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


Most common symptoms of OROFACIAL CLEFT 15; OFC15

  • Hypertelorism
  • Abnormal facial shape
  • Cryptorchidism
  • Low-set ears
  • Epicanthus

More info about OROFACIAL CLEFT 15; OFC15



Alternate names

CLEFT LIP/PALATE Is also known as flp, cleft lip-alveolus-palate syndrome, alveolar cleft lip and palate, cleft lip and palate


Cleft lip and palate is a fissure type embryopathy extending across the upper lip, nasal base, alveolar ridge and the hard and soft palate.

More info about CLEFT LIP/PALATE


Potential gene panels for DLX4 gene

qGenEx Craniofacial Anomalies Panel


By Quantitative Genomic Medicine Laboratories, SL qGenEx Craniofacial Anomalies that also includes the following genes: RUNX2 SALL1 TSHZ1 BMP4 SEMA3E SF3B4 SH3BP2 SHH SIX1 SIX3

More info about this panel

If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like GSTM2 DDX6 CR1

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